ID   INT12_MOUSE             Reviewed;         461 AA.
AC   Q9D168; Q3U2Q5; Q921U2;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   14-OCT-2015, entry version 106.
DE   RecName: Full=Integrator complex subunit 12;
DE            Short=Int12;
DE   AltName: Full=PHD finger protein 22;
GN   Name=Ints12; Synonyms=Phf22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Eye, Mammary gland, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   STRUCTURE BY NMR OF 150-224.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of PHD domain in protein NP_082203.";
RL   Submitted (NOV-2004) to the PDB data bank.
CC   -!- FUNCTION: Component of the Integrator complex, a complex involved
CC       in the small nuclear RNAs (snRNA) U1 and U2 transcription and in
CC       their 3'-box-dependent processing. The Integrator complex is
CC       associated with the C-terminal domain (CTD) of RNA polymerase II
CC       largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs
CC       genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator, at least
CC       composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7,
CC       INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Contains 1 PHD-type zinc finger. {ECO:0000255|PROSITE-
CC       ProRule:PRU00146}.
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DR   EMBL; AK003874; BAB23052.1; -; mRNA.
DR   EMBL; AK155162; BAE33085.1; -; mRNA.
DR   EMBL; BC010657; AAH10657.1; -; mRNA.
DR   EMBL; BC023801; AAH23801.1; -; mRNA.
DR   EMBL; BC046996; AAH46996.1; -; mRNA.
DR   CCDS; CCDS17848.1; -.
DR   RefSeq; NP_082203.1; NM_027927.3.
DR   UniGene; Mm.246726; -.
DR   PDB; 1WEV; NMR; -; A=150-224.
DR   PDBsum; 1WEV; -.
DR   ProteinModelPortal; Q9D168; -.
DR   SMR; Q9D168; 148-224.
DR   IntAct; Q9D168; 1.
DR   MINT; MINT-4126517; -.
DR   STRING; 10090.ENSMUSP00000029650; -.
DR   PhosphoSite; Q9D168; -.
DR   MaxQB; Q9D168; -.
DR   PaxDb; Q9D168; -.
DR   PRIDE; Q9D168; -.
DR   Ensembl; ENSMUST00000029650; ENSMUSP00000029650; ENSMUSG00000028016.
DR   GeneID; 71793; -.
DR   KEGG; mmu:71793; -.
DR   UCSC; uc008rkj.1; mouse.
DR   CTD; 57117; -.
DR   MGI; MGI:1919043; Ints12.
DR   eggNOG; NOG247951; -.
DR   GeneTree; ENSGT00390000005218; -.
DR   HOGENOM; HOG000059634; -.
DR   HOVERGEN; HBG081798; -.
DR   InParanoid; Q9D168; -.
DR   KO; K13149; -.
DR   OMA; TQNNTGK; -.
DR   OrthoDB; EOG7QNVN6; -.
DR   PhylomeDB; Q9D168; -.
DR   TreeFam; TF106418; -.
DR   EvolutionaryTrace; Q9D168; -.
DR   NextBio; 334534; -.
DR   PRO; PR:Q9D168; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   Bgee; Q9D168; -.
DR   CleanEx; MM_INTS12; -.
DR   Genevisible; Q9D168; MM.
DR   GO; GO:0032039; C:integrator complex; ISS:HGNC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016180; P:snRNA processing; ISS:HGNC.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Isopeptide bond; Metal-binding;
KW   Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    461       Integrator complex subunit 12.
FT                                /FTId=PRO_0000059314.
FT   ZN_FING     158    214       PHD-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00146}.
FT   COMPBIAS    269    439       Ser-rich.
FT   MOD_RES     127    127       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q96CB8}.
FT   CROSSLNK     68     68       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q96CB8}.
FT   HELIX       154    157       {ECO:0000244|PDB:1WEV}.
FT   STRAND      162    164       {ECO:0000244|PDB:1WEV}.
FT   STRAND      175    177       {ECO:0000244|PDB:1WEV}.
FT   STRAND      179    181       {ECO:0000244|PDB:1WEV}.
FT   STRAND      184    186       {ECO:0000244|PDB:1WEV}.
FT   TURN        187    189       {ECO:0000244|PDB:1WEV}.
FT   STRAND      190    192       {ECO:0000244|PDB:1WEV}.
FT   HELIX       196    200       {ECO:0000244|PDB:1WEV}.
FT   HELIX       209    215       {ECO:0000244|PDB:1WEV}.
SQ   SEQUENCE   461 AA;  48568 MW;  9230385FBD4A9425 CRC64;
     MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPT QKDVEPPKIS
     STKSLSIKQE PKTSSSLPSG SSNGKVLTAE KIKKEAEKRP ADKMKDVTEG IDVPKKPRLE
     KPETRSSPIT VQTSKDLSMA DLSSFEETSA DDFAMEMGLA CVVCRQMTVA SGNQLVECQE
     CHNLYHQDCH KPQVTDKEVN DPRLVWYCAR CTRQMKRMAQ KTQKPPQKPA PTVVSVTPTV
     KDPLVKKPET KLKQETTFLA FKRTEVKPST VISGNSSSNN VSSSVTSGLT GWAAFAAKTS
     SAGPSTAKLN SAAQNSSGKP AASSSNQKPV GLTGLATSSK GGIGSKIGSG NSTSPSVPLK
     PLPPLTLGKT GLSRSVSCDN VSKVGLPSPS SLVPGGSSQL SGNGNSATTG PSGSTTSKAT
     SETSSSTSAS LKGPTSQESQ LNAMKRLQMV KKKAAQKKLK K
//