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Q9D168

- INT12_MOUSE

UniProt

Q9D168 - INT12_MOUSE

Protein

Integrator complex subunit 12

Gene

Ints12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri158 – 21457PHD-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. snRNA processing Source: HGNC

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrator complex subunit 12
    Short name:
    Int12
    Alternative name(s):
    PHD finger protein 22
    Gene namesi
    Name:Ints12
    Synonyms:Phf22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1919043. Ints12.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. integrator complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Integrator complex subunit 12PRO_0000059314Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei127 – 1271PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9D168.
    PRIDEiQ9D168.

    PTM databases

    PhosphoSiteiQ9D168.

    Expressioni

    Gene expression databases

    BgeeiQ9D168.
    CleanExiMM_INTS12.
    GenevestigatoriQ9D168.

    Interactioni

    Subunit structurei

    Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.By similarity

    Protein-protein interaction databases

    IntActiQ9D168. 1 interaction.
    MINTiMINT-4126517.

    Structurei

    Secondary structure

    1
    461
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi154 – 1574
    Beta strandi162 – 1643
    Beta strandi175 – 1773
    Beta strandi179 – 1813
    Beta strandi184 – 1863
    Turni187 – 1893
    Beta strandi190 – 1923
    Helixi196 – 2005
    Helixi209 – 2157

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WEVNMR-A150-224[»]
    ProteinModelPortaliQ9D168.
    SMRiQ9D168. Positions 148-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9D168.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 439171Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri158 – 21457PHD-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG247951.
    GeneTreeiENSGT00390000005218.
    HOGENOMiHOG000059634.
    HOVERGENiHBG081798.
    InParanoidiQ9D168.
    KOiK13149.
    OMAiKQEPKIS.
    OrthoDBiEOG7QNVN6.
    PhylomeDBiQ9D168.
    TreeFamiTF106418.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D168-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPT    50
    QKDVEPPKIS STKSLSIKQE PKTSSSLPSG SSNGKVLTAE KIKKEAEKRP 100
    ADKMKDVTEG IDVPKKPRLE KPETRSSPIT VQTSKDLSMA DLSSFEETSA 150
    DDFAMEMGLA CVVCRQMTVA SGNQLVECQE CHNLYHQDCH KPQVTDKEVN 200
    DPRLVWYCAR CTRQMKRMAQ KTQKPPQKPA PTVVSVTPTV KDPLVKKPET 250
    KLKQETTFLA FKRTEVKPST VISGNSSSNN VSSSVTSGLT GWAAFAAKTS 300
    SAGPSTAKLN SAAQNSSGKP AASSSNQKPV GLTGLATSSK GGIGSKIGSG 350
    NSTSPSVPLK PLPPLTLGKT GLSRSVSCDN VSKVGLPSPS SLVPGGSSQL 400
    SGNGNSATTG PSGSTTSKAT SETSSSTSAS LKGPTSQESQ LNAMKRLQMV 450
    KKKAAQKKLK K 461
    Length:461
    Mass (Da):48,568
    Last modified:June 1, 2001 - v1
    Checksum:i9230385FBD4A9425
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003874 mRNA. Translation: BAB23052.1.
    AK155162 mRNA. Translation: BAE33085.1.
    BC010657 mRNA. Translation: AAH10657.1.
    BC023801 mRNA. Translation: AAH23801.1.
    BC046996 mRNA. Translation: AAH46996.1.
    CCDSiCCDS17848.1.
    RefSeqiNP_082203.1. NM_027927.3.
    UniGeneiMm.246726.

    Genome annotation databases

    EnsembliENSMUST00000029650; ENSMUSP00000029650; ENSMUSG00000028016.
    GeneIDi71793.
    KEGGimmu:71793.
    UCSCiuc008rkj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003874 mRNA. Translation: BAB23052.1 .
    AK155162 mRNA. Translation: BAE33085.1 .
    BC010657 mRNA. Translation: AAH10657.1 .
    BC023801 mRNA. Translation: AAH23801.1 .
    BC046996 mRNA. Translation: AAH46996.1 .
    CCDSi CCDS17848.1.
    RefSeqi NP_082203.1. NM_027927.3.
    UniGenei Mm.246726.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WEV NMR - A 150-224 [» ]
    ProteinModelPortali Q9D168.
    SMRi Q9D168. Positions 148-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D168. 1 interaction.
    MINTi MINT-4126517.

    PTM databases

    PhosphoSitei Q9D168.

    Proteomic databases

    PaxDbi Q9D168.
    PRIDEi Q9D168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029650 ; ENSMUSP00000029650 ; ENSMUSG00000028016 .
    GeneIDi 71793.
    KEGGi mmu:71793.
    UCSCi uc008rkj.1. mouse.

    Organism-specific databases

    CTDi 57117.
    MGIi MGI:1919043. Ints12.

    Phylogenomic databases

    eggNOGi NOG247951.
    GeneTreei ENSGT00390000005218.
    HOGENOMi HOG000059634.
    HOVERGENi HBG081798.
    InParanoidi Q9D168.
    KOi K13149.
    OMAi KQEPKIS.
    OrthoDBi EOG7QNVN6.
    PhylomeDBi Q9D168.
    TreeFami TF106418.

    Miscellaneous databases

    EvolutionaryTracei Q9D168.
    NextBioi 334534.
    PROi Q9D168.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D168.
    CleanExi MM_INTS12.
    Genevestigatori Q9D168.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Eye, Mammary gland and Mammary tumor.
    3. "Solution structure of PHD domain in protein NP_082203."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 150-224.

    Entry informationi

    Entry nameiINT12_MOUSE
    AccessioniPrimary (citable) accession number: Q9D168
    Secondary accession number(s): Q3U2Q5, Q921U2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3