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Q9D168

- INT12_MOUSE

UniProt

Q9D168 - INT12_MOUSE

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Protein
Integrator complex subunit 12
Gene
Ints12, Phf22
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri158 – 21457PHD-type
Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. snRNA processing Source: HGNC
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 12
Short name:
Int12
Alternative name(s):
PHD finger protein 22
Gene namesi
Name:Ints12
Synonyms:Phf22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1919043. Ints12.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. integrator complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Integrator complex subunit 12
PRO_0000059314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D168.
PRIDEiQ9D168.

PTM databases

PhosphoSiteiQ9D168.

Expressioni

Gene expression databases

BgeeiQ9D168.
CleanExiMM_INTS12.
GenevestigatoriQ9D168.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12 By similarity.

Protein-protein interaction databases

IntActiQ9D168. 1 interaction.
MINTiMINT-4126517.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi154 – 1574
Beta strandi162 – 1643
Beta strandi175 – 1773
Beta strandi179 – 1813
Beta strandi184 – 1863
Turni187 – 1893
Beta strandi190 – 1923
Helixi196 – 2005
Helixi209 – 2157

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WEVNMR-A150-224[»]
ProteinModelPortaliQ9D168.
SMRiQ9D168. Positions 148-224.

Miscellaneous databases

EvolutionaryTraceiQ9D168.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi269 – 439171Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG247951.
GeneTreeiENSGT00390000005218.
HOGENOMiHOG000059634.
HOVERGENiHBG081798.
InParanoidiQ9D168.
KOiK13149.
OMAiKQEPKIS.
OrthoDBiEOG7QNVN6.
PhylomeDBiQ9D168.
TreeFamiTF106418.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D168-1 [UniParc]FASTAAdd to Basket

« Hide

MAATVNLELD PIFLKALGFL HSKSKDSAEK LKALLDESLA RGIDSSYRPT    50
QKDVEPPKIS STKSLSIKQE PKTSSSLPSG SSNGKVLTAE KIKKEAEKRP 100
ADKMKDVTEG IDVPKKPRLE KPETRSSPIT VQTSKDLSMA DLSSFEETSA 150
DDFAMEMGLA CVVCRQMTVA SGNQLVECQE CHNLYHQDCH KPQVTDKEVN 200
DPRLVWYCAR CTRQMKRMAQ KTQKPPQKPA PTVVSVTPTV KDPLVKKPET 250
KLKQETTFLA FKRTEVKPST VISGNSSSNN VSSSVTSGLT GWAAFAAKTS 300
SAGPSTAKLN SAAQNSSGKP AASSSNQKPV GLTGLATSSK GGIGSKIGSG 350
NSTSPSVPLK PLPPLTLGKT GLSRSVSCDN VSKVGLPSPS SLVPGGSSQL 400
SGNGNSATTG PSGSTTSKAT SETSSSTSAS LKGPTSQESQ LNAMKRLQMV 450
KKKAAQKKLK K 461
Length:461
Mass (Da):48,568
Last modified:June 1, 2001 - v1
Checksum:i9230385FBD4A9425
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003874 mRNA. Translation: BAB23052.1.
AK155162 mRNA. Translation: BAE33085.1.
BC010657 mRNA. Translation: AAH10657.1.
BC023801 mRNA. Translation: AAH23801.1.
BC046996 mRNA. Translation: AAH46996.1.
CCDSiCCDS17848.1.
RefSeqiNP_082203.1. NM_027927.3.
UniGeneiMm.246726.

Genome annotation databases

EnsembliENSMUST00000029650; ENSMUSP00000029650; ENSMUSG00000028016.
GeneIDi71793.
KEGGimmu:71793.
UCSCiuc008rkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003874 mRNA. Translation: BAB23052.1 .
AK155162 mRNA. Translation: BAE33085.1 .
BC010657 mRNA. Translation: AAH10657.1 .
BC023801 mRNA. Translation: AAH23801.1 .
BC046996 mRNA. Translation: AAH46996.1 .
CCDSi CCDS17848.1.
RefSeqi NP_082203.1. NM_027927.3.
UniGenei Mm.246726.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WEV NMR - A 150-224 [» ]
ProteinModelPortali Q9D168.
SMRi Q9D168. Positions 148-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D168. 1 interaction.
MINTi MINT-4126517.

PTM databases

PhosphoSitei Q9D168.

Proteomic databases

PaxDbi Q9D168.
PRIDEi Q9D168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029650 ; ENSMUSP00000029650 ; ENSMUSG00000028016 .
GeneIDi 71793.
KEGGi mmu:71793.
UCSCi uc008rkj.1. mouse.

Organism-specific databases

CTDi 57117.
MGIi MGI:1919043. Ints12.

Phylogenomic databases

eggNOGi NOG247951.
GeneTreei ENSGT00390000005218.
HOGENOMi HOG000059634.
HOVERGENi HBG081798.
InParanoidi Q9D168.
KOi K13149.
OMAi KQEPKIS.
OrthoDBi EOG7QNVN6.
PhylomeDBi Q9D168.
TreeFami TF106418.

Miscellaneous databases

EvolutionaryTracei Q9D168.
NextBioi 334534.
PROi Q9D168.
SOURCEi Search...

Gene expression databases

Bgeei Q9D168.
CleanExi MM_INTS12.
Genevestigatori Q9D168.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00628. PHD. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye, Mammary gland and Mammary tumor.
  3. "Solution structure of PHD domain in protein NP_082203."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 150-224.

Entry informationi

Entry nameiINT12_MOUSE
AccessioniPrimary (citable) accession number: Q9D168
Secondary accession number(s): Q3U2Q5, Q921U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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