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Protein

FXYD domain-containing ion transport regulator 6

Gene

Fxyd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 6
Alternative name(s):
PLM-like protein
Phosphohippolin
Gene namesi
Name:Fxyd6
Synonyms:Plp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1890226. Fxyd6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 3417ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5723HelicalSequence analysisAdd
BLAST
Topological domaini58 – 9437CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 9477FXYD domain-containing ion transport regulator 6PRO_0000010374Add
BLAST

Proteomic databases

MaxQBiQ9D164.
PaxDbiQ9D164.
PRIDEiQ9D164.

PTM databases

PhosphoSiteiQ9D164.
SwissPalmiQ9D164.

Expressioni

Gene expression databases

BgeeiQ9D164.
CleanExiMM_FXYD6.
GenevisibleiQ9D164. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083101.

Structurei

3D structure databases

ProteinModelPortaliQ9D164.
SMRiQ9D164. Positions 27-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ88. Eukaryota.
ENOG410YUN8. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ9D164.
KOiK13363.
OMAiEEDPFNY.
OrthoDBiEOG72NRRZ.
PhylomeDBiQ9D164.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D164-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METVLVLCSL LAPVVLASAA EKEKEKDPFY YDYQTLRIGG LVFAVVLFSV
60 70 80 90
GILLILSRRC KCSFNQKPRA PGDEEAQVEN LITTNAAEPQ KAEN
Length:94
Mass (Da):10,374
Last modified:January 23, 2002 - v2
Checksum:i02E22B0BE349CB51
GO
Isoform 2 (identifier: Q9D164-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.

Show »
Length:93
Mass (Da):10,303
Checksum:i0594A99EA56F2FF0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 201Missing in isoform 2. 2 PublicationsVSP_001585

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032010 mRNA. Translation: BAB40451.2.
AK003888 mRNA. Translation: BAB23058.1.
AK018354 mRNA. Translation: BAB31174.1.
BC042579 mRNA. Translation: AAH42579.1.
BC051127 mRNA. Translation: AAH51127.1.
CCDSiCCDS23133.1. [Q9D164-1]
RefSeqiNP_071287.1. NM_022004.6. [Q9D164-1]
UniGeneiMm.208287.

Genome annotation databases

EnsembliENSMUST00000085939; ENSMUSP00000083101; ENSMUSG00000066705. [Q9D164-1]
GeneIDi59095.
KEGGimmu:59095.
UCSCiuc009pfs.1. mouse. [Q9D164-1]
uc009pft.1. mouse. [Q9D164-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032010 mRNA. Translation: BAB40451.2.
AK003888 mRNA. Translation: BAB23058.1.
AK018354 mRNA. Translation: BAB31174.1.
BC042579 mRNA. Translation: AAH42579.1.
BC051127 mRNA. Translation: AAH51127.1.
CCDSiCCDS23133.1. [Q9D164-1]
RefSeqiNP_071287.1. NM_022004.6. [Q9D164-1]
UniGeneiMm.208287.

3D structure databases

ProteinModelPortaliQ9D164.
SMRiQ9D164. Positions 27-57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000083101.

PTM databases

PhosphoSiteiQ9D164.
SwissPalmiQ9D164.

Proteomic databases

MaxQBiQ9D164.
PaxDbiQ9D164.
PRIDEiQ9D164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085939; ENSMUSP00000083101; ENSMUSG00000066705. [Q9D164-1]
GeneIDi59095.
KEGGimmu:59095.
UCSCiuc009pfs.1. mouse. [Q9D164-1]
uc009pft.1. mouse. [Q9D164-2]

Organism-specific databases

CTDi53826.
MGIiMGI:1890226. Fxyd6.

Phylogenomic databases

eggNOGiENOG410IZ88. Eukaryota.
ENOG410YUN8. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ9D164.
KOiK13363.
OMAiEEDPFNY.
OrthoDBiEOG72NRRZ.
PhylomeDBiQ9D164.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiFxyd6. mouse.
NextBioi314752.
PROiQ9D164.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D164.
CleanExiMM_FXYD6.
GenevisibleiQ9D164. MM.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel PLM-like ion channel gene expressed in the nervous system."
    Saito S., Matoba R., Kato K., Matsubara K.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-37 AND 70-91, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiFXYD6_MOUSE
AccessioniPrimary (citable) accession number: Q9D164
Secondary accession number(s): Q99NC3, Q9CXD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: February 17, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.