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Protein

Leukocyte elastase inhibitor A

Gene

Serpinb1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the activity of the neutrophil proteases and thus, forms complexes with chymotrypsin, elastase, cathepsin G and proteinase-3.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344 – 345Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • regulation of protein catabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI04.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor A
Alternative name(s):
Serine protease inhibitor EIA
Serpin B1a
Gene namesi
Name:Serpinb1a
Synonyms:Serpinb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913472. Serpinb1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891201 – 379Leukocyte elastase inhibitor AAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D154.
MaxQBiQ9D154.
PaxDbiQ9D154.
PeptideAtlasiQ9D154.
PRIDEiQ9D154.

2D gel databases

UCD-2DPAGEQ9D154.

PTM databases

iPTMnetiQ9D154.
PhosphoSitePlusiQ9D154.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in pancreas, spleen and bone marrow.2 Publications

Gene expression databases

BgeeiENSMUSG00000044734.
ExpressionAtlasiQ9D154. baseline and differential.
GenevisibleiQ9D154. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi211307. 5 interactors.
IntActiQ9D154. 1 interactor.
MINTiMINT-4127525.
STRINGi10090.ENSMUSP00000075690.

Structurei

3D structure databases

ProteinModelPortaliQ9D154.
SMRiQ9D154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9D154.
KOiK13963.
OMAiKFMVEAT.
OrthoDBiEOG091G0ION.
PhylomeDBiQ9D154.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF180. PTHR11461:SF180. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSSANTL FALELFQTLN ESSPTGNIFF SPFSISSALA MVILGAKGST
60 70 80 90 100
AAQLSKTFHF DSVEDIHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF
110 120 130 140 150
LPEYLASTQK MYGADLAPVD FLHASEDARK EINQWVKGQT EGKIPELLSV
160 170 180 190 200
GVVDSMTKLV LVNAIYFKGM WEEKFMTEDT TDAPFRLSKK DTKTVKMMYQ
210 220 230 240 250
KKKFPFGYIS DLKCKVLEMP YQGGELSMVI LLPKDIEDES TGLKKIEKQI
260 270 280 290 300
TLEKLLEWTK RENLEFIDVH VKLPRFKIEE SYTLNSNLGR LGVQDLFSSS
310 320 330 340 350
KADLSGMSGS RDLFISKIVH KSFVEVNEEG TEAAAATGGI ATFCMLLPEE
360 370
EFTVDHPFIF FIRHNPTSNV LFLGRVCSP
Length:379
Mass (Da):42,575
Last modified:June 1, 2001 - v1
Checksum:iF492F1EEB88E80B1
GO

Sequence cautioni

The sequence BAB23335 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAI25648 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73L → Q in BAB25964 (PubMed:16141072).Curated1
Sequence conflicti146E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti154D → N in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti189K → R in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti193K → R in BAB25964 (PubMed:16141072).Curated1
Sequence conflicti261R → L in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti265E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti280E → K in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti290R → P in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti301K → E in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti313L → S in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti319V → P in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti324V → F in BAB23335 (PubMed:16141072).Curated1
Sequence conflicti341A → V in BAE35797 (PubMed:16141072).Curated1
Sequence conflicti362I → M in BAB23335 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426024 mRNA. Translation: AAL57486.1.
AF521697 Genomic DNA. Translation: AAM95933.1.
AK003930 mRNA. Translation: BAB23079.1.
AK004500 mRNA. Translation: BAB23335.1. Frameshift.
AK008914 mRNA. Translation: BAB25964.1.
AK160167 mRNA. Translation: BAE35668.1.
AK160456 mRNA. Translation: BAE35797.1.
AL645808 Genomic DNA. Translation: CAI25648.1. Sequence problems.
BC011140 mRNA. Translation: AAH11140.1.
BC104333 mRNA. Translation: AAI04334.1.
CCDSiCCDS26428.1.
RefSeqiNP_079705.2. NM_025429.2.
XP_006516787.1. XM_006516724.1.
UniGeneiMm.20144.

Genome annotation databases

EnsembliENSMUST00000076352; ENSMUSP00000075690; ENSMUSG00000044734.
GeneIDi66222.
KEGGimmu:66222.
UCSCiuc007pzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426024 mRNA. Translation: AAL57486.1.
AF521697 Genomic DNA. Translation: AAM95933.1.
AK003930 mRNA. Translation: BAB23079.1.
AK004500 mRNA. Translation: BAB23335.1. Frameshift.
AK008914 mRNA. Translation: BAB25964.1.
AK160167 mRNA. Translation: BAE35668.1.
AK160456 mRNA. Translation: BAE35797.1.
AL645808 Genomic DNA. Translation: CAI25648.1. Sequence problems.
BC011140 mRNA. Translation: AAH11140.1.
BC104333 mRNA. Translation: AAI04334.1.
CCDSiCCDS26428.1.
RefSeqiNP_079705.2. NM_025429.2.
XP_006516787.1. XM_006516724.1.
UniGeneiMm.20144.

3D structure databases

ProteinModelPortaliQ9D154.
SMRiQ9D154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211307. 5 interactors.
IntActiQ9D154. 1 interactor.
MINTiMINT-4127525.
STRINGi10090.ENSMUSP00000075690.

Protein family/group databases

MEROPSiI04.006.

PTM databases

iPTMnetiQ9D154.
PhosphoSitePlusiQ9D154.

2D gel databases

UCD-2DPAGEQ9D154.

Proteomic databases

EPDiQ9D154.
MaxQBiQ9D154.
PaxDbiQ9D154.
PeptideAtlasiQ9D154.
PRIDEiQ9D154.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076352; ENSMUSP00000075690; ENSMUSG00000044734.
GeneIDi66222.
KEGGimmu:66222.
UCSCiuc007pzu.1. mouse.

Organism-specific databases

CTDi66222.
MGIiMGI:1913472. Serpinb1a.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ9D154.
KOiK13963.
OMAiKFMVEAT.
OrthoDBiEOG091G0ION.
PhylomeDBiQ9D154.
TreeFamiTF352619.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9D154.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044734.
ExpressionAtlasiQ9D154. baseline and differential.
GenevisibleiQ9D154. MM.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF180. PTHR11461:SF180. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILEUA_MOUSE
AccessioniPrimary (citable) accession number: Q9D154
Secondary accession number(s): Q3TV23
, Q5SUV7, Q9D0S8, Q9D7S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.