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Protein

Uridine diphosphate glucose pyrophosphatase

Gene

Nudt14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).By similarity

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  • ADP-ribose diphosphatase activity Source: MGI
  • identical protein binding Source: MGI
  • metal ion binding Source: InterPro
  • UDP-sugar diphosphatase activity Source: MGI

Keywordsi

Molecular functionHydrolase
LigandMagnesium

Enzyme and pathway databases

BRENDAi3.6.1.45. 3474.
ReactomeiR-MMU-480985. Synthesis of dolichyl-phosphate-glucose.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
Short name:
UDPG pyrophosphatase
Short name:
UGPPase
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name:
Nudix motif 14
Gene namesi
Name:Nudt14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913424. Nudt14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571141 – 222Uridine diphosphate glucose pyrophosphataseAdd BLAST222

Proteomic databases

EPDiQ9D142.
MaxQBiQ9D142.
PaxDbiQ9D142.
PeptideAtlasiQ9D142.
PRIDEiQ9D142.

PTM databases

iPTMnetiQ9D142.
PhosphoSitePlusiQ9D142.

Expressioni

Gene expression databases

BgeeiENSMUSG00000002804.
GenevisibleiQ9D142. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002881.

Structurei

3D structure databases

ProteinModelPortaliQ9D142.
SMRiQ9D142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 206Nudix hydrolasePROSITE-ProRule annotationAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 129Nudix boxAdd BLAST19

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG4432. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00410000025889.
HOGENOMiHOG000102292.
HOVERGENiHBG052689.
InParanoidiQ9D142.
KOiK08077.
OMAiYTYELCA.
OrthoDBiEOG091G0Q7M.
PhylomeDBiQ9D142.
TreeFamiTF313661.

Family and domain databases

InterProiView protein in InterPro
IPR004385. NDP_pyrophosphatase.
IPR015797. NUDIX_hydrolase-like_dom_sf.
IPR000086. NUDIX_hydrolase_dom.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERIDGVAVG LCAHSPYLRP FTLHYRQDGV QKSWDFMKTH DSVTILMFNS
60 70 80 90 100
SRRSLVLVKQ FRPAVYAGEV ERHFPGSLTA VNQDQPQELQ QALPGSAGVM
110 120 130 140 150
VELCAGIVDQ PGLSLEEAAC KEAWEECGYR LVPTDLRRVA TYMSGVGLTS
160 170 180 190 200
SRQTMFYAEV TDAQRGGPGG GLAEEGELIE VIHLNLDDAQ AFADNPDIPK
210 220
TLGVIYAISW FFSQVVPHLS LQ
Length:222
Mass (Da):24,444
Last modified:June 1, 2001 - v1
Checksum:iD95555CDABBBC5D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192F → I in BAB28691 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003991 mRNA. Translation: BAB23110.1.
AK013174 mRNA. Translation: BAB28691.2.
BC025444 mRNA. Translation: AAH25444.1.
CCDSiCCDS26201.1.
RefSeqiNP_001303653.1. NM_001316724.1.
NP_079675.1. NM_025399.4.
UniGeneiMm.486922.
Mm.7070.

Genome annotation databases

EnsembliENSMUST00000221397; ENSMUSP00000152599; ENSMUSG00000002804.
GeneIDi66174.
KEGGimmu:66174.
UCSCiuc007pfm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNUD14_MOUSE
AccessioniPrimary (citable) accession number: Q9D142
Secondary accession number(s): Q9CSD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families