Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9D142

- NUD14_MOUSE

UniProt

Q9D142 - NUD14_MOUSE

Protein

Uridine diphosphate glucose pyrophosphatase

Gene

Nudt14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose By similarity.By similarity

    Catalytic activityi

    UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. ADP-ribose diphosphatase activity Source: MGI
    2. metal ion binding Source: InterPro
    3. UDP-sugar diphosphatase activity Source: MGI

    GO - Biological processi

    1. metabolic process Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
    Short name:
    UDPG pyrophosphatase
    Short name:
    UGPPase
    Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 14
    Short name:
    Nudix motif 14
    Gene namesi
    Name:Nudt14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1913424. Nudt14.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Uridine diphosphate glucose pyrophosphatasePRO_0000057114Add
    BLAST

    Proteomic databases

    PaxDbiQ9D142.
    PRIDEiQ9D142.

    PTM databases

    PhosphoSiteiQ9D142.

    Expressioni

    Gene expression databases

    BgeeiQ9D142.
    GenevestigatoriQ9D142.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D142.
    SMRiQ9D142. Positions 39-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 206169Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi111 – 12919Nudix boxAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family.Curated
    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0494.
    GeneTreeiENSGT00410000025889.
    HOGENOMiHOG000102292.
    HOVERGENiHBG052689.
    InParanoidiQ9D142.
    KOiK08077.
    OMAiIYARHFH.
    OrthoDBiEOG7JHM6K.
    PhylomeDBiQ9D142.
    TreeFamiTF313661.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR004385. NDP_pyrophosphatase.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D142-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIDGVAVG LCAHSPYLRP FTLHYRQDGV QKSWDFMKTH DSVTILMFNS    50
    SRRSLVLVKQ FRPAVYAGEV ERHFPGSLTA VNQDQPQELQ QALPGSAGVM 100
    VELCAGIVDQ PGLSLEEAAC KEAWEECGYR LVPTDLRRVA TYMSGVGLTS 150
    SRQTMFYAEV TDAQRGGPGG GLAEEGELIE VIHLNLDDAQ AFADNPDIPK 200
    TLGVIYAISW FFSQVVPHLS LQ 222
    Length:222
    Mass (Da):24,444
    Last modified:June 1, 2001 - v1
    Checksum:iD95555CDABBBC5D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti192 – 1921F → I in BAB28691. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003991 mRNA. Translation: BAB23110.1.
    AK013174 mRNA. Translation: BAB28691.2.
    BC025444 mRNA. Translation: AAH25444.1.
    CCDSiCCDS26201.1.
    RefSeqiNP_079675.1. NM_025399.3.
    UniGeneiMm.7070.

    Genome annotation databases

    EnsembliENSMUST00000002881; ENSMUSP00000002881; ENSMUSG00000002804.
    GeneIDi66174.
    KEGGimmu:66174.
    UCSCiuc007pfm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003991 mRNA. Translation: BAB23110.1 .
    AK013174 mRNA. Translation: BAB28691.2 .
    BC025444 mRNA. Translation: AAH25444.1 .
    CCDSi CCDS26201.1.
    RefSeqi NP_079675.1. NM_025399.3.
    UniGenei Mm.7070.

    3D structure databases

    ProteinModelPortali Q9D142.
    SMRi Q9D142. Positions 39-219.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D142.

    Proteomic databases

    PaxDbi Q9D142.
    PRIDEi Q9D142.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002881 ; ENSMUSP00000002881 ; ENSMUSG00000002804 .
    GeneIDi 66174.
    KEGGi mmu:66174.
    UCSCi uc007pfm.1. mouse.

    Organism-specific databases

    CTDi 256281.
    MGIi MGI:1913424. Nudt14.

    Phylogenomic databases

    eggNOGi COG0494.
    GeneTreei ENSGT00410000025889.
    HOGENOMi HOG000102292.
    HOVERGENi HBG052689.
    InParanoidi Q9D142.
    KOi K08077.
    OMAi IYARHFH.
    OrthoDBi EOG7JHM6K.
    PhylomeDBi Q9D142.
    TreeFami TF313661.

    Miscellaneous databases

    NextBioi 320858.
    PROi Q9D142.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D142.
    Genevestigatori Q9D142.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR004385. NDP_pyrophosphatase.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    TIGRFAMsi TIGR00052. TIGR00052. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiNUD14_MOUSE
    AccessioniPrimary (citable) accession number: Q9D142
    Secondary accession number(s): Q9CSD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3