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Q9D114

- MESH1_MOUSE

UniProt

Q9D114 - MESH1_MOUSE

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Protein
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Gene
Hddc3, Mesh1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response By similarity.

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351Manganese By similarity
Metal bindingi61 – 611Manganese By similarity
Metal bindingi62 – 621Manganese By similarity
Active sitei65 – 651Nucleophile By similarity
Active sitei66 – 661Nucleophile By similarity
Metal bindingi122 – 1221Manganese By similarity

GO - Molecular functioni

  1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:Hddc3
Synonyms:Mesh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1915945. Hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 179178Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
PRO_0000263111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei25 – 251N6-acetyllysine By similarity
Modified residuei97 – 971N6-acetyllysine By similarity
Modified residuei123 – 1231N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9D114.
PRIDEiQ9D114.

PTM databases

PhosphoSiteiQ9D114.

Expressioni

Gene expression databases

BgeeiQ9D114.
CleanExiMM_HDDC3.
GenevestigatoriQ9D114.

Interactioni

Protein-protein interaction databases

IntActiQ9D114. 1 interaction.
MINTiMINT-4126505.

Structurei

3D structure databases

ProteinModelPortaliQ9D114.
SMRiQ9D114. Positions 2-179.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12796HD
Add
BLAST

Sequence similaritiesi

Belongs to the MESH1 family.
Contains 1 HD domain.

Phylogenomic databases

eggNOGiNOG113345.
GeneTreeiENSGT00390000011608.
HOVERGENiHBG081594.
InParanoidiQ9D114.
KOiK01139.
OMAiNRCTPEG.
OrthoDBiEOG7X3QTC.
PhylomeDBiQ9D114.
TreeFamiTF313524.

Family and domain databases

InterProiIPR003607. HD/PDEase_dom.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D114-1 [UniParc]FASTAAdd to Basket

« Hide

MGSEAAQLLE AADFAAHKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT    50
DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER 100
KRQQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPTGWSE HRVQEYFEWA 150
AQVVKGLQGT NQQLEEALKQ LFEERGLTL 179
Length:179
Mass (Da):20,262
Last modified:June 1, 2001 - v1
Checksum:iD52FF1DA540A6ED3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004078 mRNA. Translation: BAB23158.1.
BC038310 mRNA. Translation: AAH38310.1.
CCDSiCCDS21396.1.
RefSeqiNP_081088.1. NM_026812.2.
UniGeneiMm.21171.

Genome annotation databases

EnsembliENSMUST00000032747; ENSMUSP00000032747; ENSMUSG00000030532.
GeneIDi68695.
KEGGimmu:68695.
UCSCiuc009ian.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004078 mRNA. Translation: BAB23158.1 .
BC038310 mRNA. Translation: AAH38310.1 .
CCDSi CCDS21396.1.
RefSeqi NP_081088.1. NM_026812.2.
UniGenei Mm.21171.

3D structure databases

ProteinModelPortali Q9D114.
SMRi Q9D114. Positions 2-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D114. 1 interaction.
MINTi MINT-4126505.

PTM databases

PhosphoSitei Q9D114.

Proteomic databases

PaxDbi Q9D114.
PRIDEi Q9D114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032747 ; ENSMUSP00000032747 ; ENSMUSG00000030532 .
GeneIDi 68695.
KEGGi mmu:68695.
UCSCi uc009ian.1. mouse.

Organism-specific databases

CTDi 374659.
MGIi MGI:1915945. Hddc3.

Phylogenomic databases

eggNOGi NOG113345.
GeneTreei ENSGT00390000011608.
HOVERGENi HBG081594.
InParanoidi Q9D114.
KOi K01139.
OMAi NRCTPEG.
OrthoDBi EOG7X3QTC.
PhylomeDBi Q9D114.
TreeFami TF313524.

Miscellaneous databases

NextBioi 327714.
PROi Q9D114.
SOURCEi Search...

Gene expression databases

Bgeei Q9D114.
CleanExi MM_HDDC3.
Genevestigatori Q9D114.

Family and domain databases

InterProi IPR003607. HD/PDEase_dom.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.

Entry informationi

Entry nameiMESH1_MOUSE
AccessioniPrimary (citable) accession number: Q9D114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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