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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

Hddc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35ManganeseBy similarity1
Metal bindingi61ManganeseBy similarity1
Metal bindingi62ManganeseBy similarity1
Active sitei65NucleophileBy similarity1
Active sitei66NucleophileBy similarity1
Metal bindingi122ManganeseBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:Hddc3
Synonyms:Mesh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915945 Hddc3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002631112 – 179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei25N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineBy similarity1
Modified residuei123N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D114
PaxDbiQ9D114
PeptideAtlasiQ9D114
PRIDEiQ9D114

PTM databases

iPTMnetiQ9D114
PhosphoSitePlusiQ9D114

Expressioni

Gene expression databases

BgeeiENSMUSG00000030532
CleanExiMM_HDDC3
ExpressionAtlasiQ9D114 baseline and differential
GenevisibleiQ9D114 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D114, 1 interactor
MINTiQ9D114
STRINGi10090.ENSMUSP00000032747

Structurei

3D structure databases

ProteinModelPortaliQ9D114
SMRiQ9D114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 127HDPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the MESH1 family.Curated

Phylogenomic databases

eggNOGiKOG1157 Eukaryota
COG0317 LUCA
GeneTreeiENSGT00390000011608
HOVERGENiHBG081594
InParanoidiQ9D114
KOiK21138
OMAiRVQEYFE
OrthoDBiEOG091G0L17
PhylomeDBiQ9D114
TreeFamiTF313524

Family and domain databases

CDDicd00077 HDc, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
PfamiView protein in Pfam
PF13328 HD_4, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS51831 HD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEAAQLLE AADFAAHKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT
60 70 80 90 100
DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER
110 120 130 140 150
KRQQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPTGWSE HRVQEYFEWA
160 170
AQVVKGLQGT NQQLEEALKQ LFEERGLTL
Length:179
Mass (Da):20,262
Last modified:June 1, 2001 - v1
Checksum:iD52FF1DA540A6ED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004078 mRNA Translation: BAB23158.1
BC038310 mRNA Translation: AAH38310.1
CCDSiCCDS21396.1
RefSeqiNP_081088.1, NM_026812.2
UniGeneiMm.21171

Genome annotation databases

EnsembliENSMUST00000032747; ENSMUSP00000032747; ENSMUSG00000030532
GeneIDi68695
KEGGimmu:68695
UCSCiuc009ian.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMESH1_MOUSE
AccessioniPrimary (citable) accession number: Q9D114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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