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Q9D114

- MESH1_MOUSE

UniProt

Q9D114 - MESH1_MOUSE

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

Hddc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    ppGpp hydrolyzing enzyme involved in starvation response.By similarity

    Catalytic activityi

    Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

    Cofactori

    Manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi35 – 351ManganeseBy similarity
    Metal bindingi61 – 611ManganeseBy similarity
    Metal bindingi62 – 621ManganeseBy similarity
    Active sitei65 – 651NucleophileBy similarity
    Active sitei66 – 661NucleophileBy similarity
    Metal bindingi122 – 1221ManganeseBy similarity

    GO - Molecular functioni

    1. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
    Alternative name(s):
    HD domain-containing protein 3
    Metazoan SpoT homolog 1
    Short name:
    MESH1
    Penta-phosphate guanosine-3'-pyrophosphohydrolase
    Short name:
    (ppGpp)ase
    Gene namesi
    Name:Hddc3
    Synonyms:Mesh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1915945. Hddc3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 179178Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1PRO_0000263111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei25 – 251N6-acetyllysineBy similarity
    Modified residuei97 – 971N6-acetyllysineBy similarity
    Modified residuei123 – 1231N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9D114.
    PRIDEiQ9D114.

    PTM databases

    PhosphoSiteiQ9D114.

    Expressioni

    Gene expression databases

    BgeeiQ9D114.
    CleanExiMM_HDDC3.
    GenevestigatoriQ9D114.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9D114. 1 interaction.
    MINTiMINT-4126505.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D114.
    SMRiQ9D114. Positions 2-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12796HDAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MESH1 family.Curated
    Contains 1 HD domain.Curated

    Phylogenomic databases

    eggNOGiNOG113345.
    GeneTreeiENSGT00390000011608.
    HOVERGENiHBG081594.
    InParanoidiQ9D114.
    KOiK01139.
    OMAiNRCTPEG.
    OrthoDBiEOG7X3QTC.
    PhylomeDBiQ9D114.
    TreeFamiTF313524.

    Family and domain databases

    InterProiIPR003607. HD/PDEase_dom.
    [Graphical view]
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D114-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSEAAQLLE AADFAAHKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT    50
    DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER 100
    KRQQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPTGWSE HRVQEYFEWA 150
    AQVVKGLQGT NQQLEEALKQ LFEERGLTL 179
    Length:179
    Mass (Da):20,262
    Last modified:June 1, 2001 - v1
    Checksum:iD52FF1DA540A6ED3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004078 mRNA. Translation: BAB23158.1.
    BC038310 mRNA. Translation: AAH38310.1.
    CCDSiCCDS21396.1.
    RefSeqiNP_081088.1. NM_026812.2.
    UniGeneiMm.21171.

    Genome annotation databases

    EnsembliENSMUST00000032747; ENSMUSP00000032747; ENSMUSG00000030532.
    GeneIDi68695.
    KEGGimmu:68695.
    UCSCiuc009ian.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004078 mRNA. Translation: BAB23158.1 .
    BC038310 mRNA. Translation: AAH38310.1 .
    CCDSi CCDS21396.1.
    RefSeqi NP_081088.1. NM_026812.2.
    UniGenei Mm.21171.

    3D structure databases

    ProteinModelPortali Q9D114.
    SMRi Q9D114. Positions 2-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D114. 1 interaction.
    MINTi MINT-4126505.

    PTM databases

    PhosphoSitei Q9D114.

    Proteomic databases

    PaxDbi Q9D114.
    PRIDEi Q9D114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032747 ; ENSMUSP00000032747 ; ENSMUSG00000030532 .
    GeneIDi 68695.
    KEGGi mmu:68695.
    UCSCi uc009ian.1. mouse.

    Organism-specific databases

    CTDi 374659.
    MGIi MGI:1915945. Hddc3.

    Phylogenomic databases

    eggNOGi NOG113345.
    GeneTreei ENSGT00390000011608.
    HOVERGENi HBG081594.
    InParanoidi Q9D114.
    KOi K01139.
    OMAi NRCTPEG.
    OrthoDBi EOG7X3QTC.
    PhylomeDBi Q9D114.
    TreeFami TF313524.

    Miscellaneous databases

    NextBioi 327714.
    PROi Q9D114.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D114.
    CleanExi MM_HDDC3.
    Genevestigatori Q9D114.

    Family and domain databases

    InterProi IPR003607. HD/PDEase_dom.
    [Graphical view ]
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Lung.

    Entry informationi

    Entry nameiMESH1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D114
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3