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Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

Gene

Hddc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ppGpp hydrolyzing enzyme involved in starvation response.By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35ManganeseBy similarity1
Metal bindingi61ManganeseBy similarity1
Metal bindingi62ManganeseBy similarity1
Active sitei65NucleophileBy similarity1
Active sitei66NucleophileBy similarity1
Metal bindingi122ManganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC:3.1.7.2)
Alternative name(s):
HD domain-containing protein 3
Metazoan SpoT homolog 1
Short name:
MESH1
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:Hddc3
Synonyms:Mesh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915945. Hddc3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002631112 – 179Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei25N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineBy similarity1
Modified residuei123N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D114.
PaxDbiQ9D114.
PeptideAtlasiQ9D114.
PRIDEiQ9D114.

PTM databases

iPTMnetiQ9D114.
PhosphoSitePlusiQ9D114.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030532.
CleanExiMM_HDDC3.
ExpressionAtlasiQ9D114. baseline and differential.
GenevisibleiQ9D114. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D114. 1 interactor.
MINTiMINT-4126505.
STRINGi10090.ENSMUSP00000032747.

Structurei

3D structure databases

ProteinModelPortaliQ9D114.
SMRiQ9D114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 127HDAdd BLAST96

Sequence similaritiesi

Belongs to the MESH1 family.Curated
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiKOG1157. Eukaryota.
COG0317. LUCA.
GeneTreeiENSGT00390000011608.
HOVERGENiHBG081594.
InParanoidiQ9D114.
KOiK01139.
OMAiRCTPEGW.
OrthoDBiEOG091G0L17.
PhylomeDBiQ9D114.
TreeFamiTF313524.

Family and domain databases

Gene3Di1.10.3210.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF13328. HD_4. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSEAAQLLE AADFAAHKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT
60 70 80 90 100
DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER
110 120 130 140 150
KRQQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPTGWSE HRVQEYFEWA
160 170
AQVVKGLQGT NQQLEEALKQ LFEERGLTL
Length:179
Mass (Da):20,262
Last modified:June 1, 2001 - v1
Checksum:iD52FF1DA540A6ED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004078 mRNA. Translation: BAB23158.1.
BC038310 mRNA. Translation: AAH38310.1.
CCDSiCCDS21396.1.
RefSeqiNP_081088.1. NM_026812.2.
UniGeneiMm.21171.

Genome annotation databases

EnsembliENSMUST00000032747; ENSMUSP00000032747; ENSMUSG00000030532.
GeneIDi68695.
KEGGimmu:68695.
UCSCiuc009ian.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004078 mRNA. Translation: BAB23158.1.
BC038310 mRNA. Translation: AAH38310.1.
CCDSiCCDS21396.1.
RefSeqiNP_081088.1. NM_026812.2.
UniGeneiMm.21171.

3D structure databases

ProteinModelPortaliQ9D114.
SMRiQ9D114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D114. 1 interactor.
MINTiMINT-4126505.
STRINGi10090.ENSMUSP00000032747.

PTM databases

iPTMnetiQ9D114.
PhosphoSitePlusiQ9D114.

Proteomic databases

MaxQBiQ9D114.
PaxDbiQ9D114.
PeptideAtlasiQ9D114.
PRIDEiQ9D114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032747; ENSMUSP00000032747; ENSMUSG00000030532.
GeneIDi68695.
KEGGimmu:68695.
UCSCiuc009ian.1. mouse.

Organism-specific databases

CTDi374659.
MGIiMGI:1915945. Hddc3.

Phylogenomic databases

eggNOGiKOG1157. Eukaryota.
COG0317. LUCA.
GeneTreeiENSGT00390000011608.
HOVERGENiHBG081594.
InParanoidiQ9D114.
KOiK01139.
OMAiRCTPEGW.
OrthoDBiEOG091G0L17.
PhylomeDBiQ9D114.
TreeFamiTF313524.

Miscellaneous databases

PROiQ9D114.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030532.
CleanExiMM_HDDC3.
ExpressionAtlasiQ9D114. baseline and differential.
GenevisibleiQ9D114. MM.

Family and domain databases

Gene3Di1.10.3210.10. 2 hits.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF13328. HD_4. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMESH1_MOUSE
AccessioniPrimary (citable) accession number: Q9D114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.