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Protein

Interferon-induced transmembrane protein 1

Gene

Ifitm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.2 Publications

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • defense response to virus Source: MGI
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • ossification Source: UniProtKB-KW
  • positive regulation of osteoblast differentiation Source: UniProtKB
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to virus Source: UniProtKB
  • somitogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 1
Alternative name(s):
Dispanin subfamily A member 2a
Short name:
DSPA2a
Fragilis protein 2
Mouse ifitm-like protein 2
Short name:
Mil-2
Gene namesi
Name:Ifitm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915963. Ifitm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei36 – 5621HelicalBy similarityAdd
BLAST
Topological domaini57 – 8428CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Topological domaini106 – 1061ExtracellularSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Interferon-induced transmembrane protein 1PRO_0000398565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi49 – 491S-palmitoyl cysteineBy similarity
Lipidationi50 – 501S-palmitoyl cysteineBy similarity
Lipidationi83 – 831S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9D103.

Expressioni

Tissue specificityi

Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells.1 Publication

Developmental stagei

In migrating PGCs, expression is first detected during germ cell differentiation.2 Publications

Gene expression databases

BgeeiQ9D103.
GenevisibleiQ9D103. MM.

Interactioni

Subunit structurei

Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.By similarity

Protein-protein interaction databases

DIPiDIP-60824N.
STRINGi10090.ENSMUSP00000026564.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGispriNOG13868.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ9D103.
KOiK06566.
OMAiRETPHRD.
OrthoDBiEOG7288T5.
PhylomeDBiQ9D103.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. Dispanin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKEQQEVVV LGSPHISTSA TATTINMPEI STPDHVVWSL FNTLFMNFCC
60 70 80 90 100
LGFVAYAYSV KSRDRKMVGD TTGAQAFAST AKCLNISSLF FTILTAIVVI

VVCAIR
Length:106
Mass (Da):11,524
Last modified:June 1, 2001 - v1
Checksum:i7B0E7D8200D36631
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371V → I in AAH27285 (Ref. 3) Curated
Sequence conflicti54 – 541V → I in AAH27285 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004121 mRNA. Translation: BAB23181.1.
AK169960 mRNA. Translation: BAE41483.1.
CH466531 Genomic DNA. Translation: EDL17976.1.
BC027285 mRNA. Translation: AAH27285.1.
BC090258 mRNA. Translation: AAH90258.1.
BC090972 mRNA. Translation: AAH90972.1.
BK001123 mRNA. Translation: DAA01238.1.
CCDSiCCDS21995.1.
RefSeqiNP_001106186.1. NM_001112715.1.
NP_081096.3. NM_026820.3.
XP_006536301.1. XM_006536238.1.
UniGeneiMm.175661.

Genome annotation databases

EnsembliENSMUST00000026564; ENSMUSP00000026564; ENSMUSG00000025491.
ENSMUST00000106040; ENSMUSP00000101655; ENSMUSG00000025491.
ENSMUST00000106042; ENSMUSP00000101657; ENSMUSG00000025491.
GeneIDi68713.
KEGGimmu:68713.
UCSCiuc009kja.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004121 mRNA. Translation: BAB23181.1.
AK169960 mRNA. Translation: BAE41483.1.
CH466531 Genomic DNA. Translation: EDL17976.1.
BC027285 mRNA. Translation: AAH27285.1.
BC090258 mRNA. Translation: AAH90258.1.
BC090972 mRNA. Translation: AAH90972.1.
BK001123 mRNA. Translation: DAA01238.1.
CCDSiCCDS21995.1.
RefSeqiNP_001106186.1. NM_001112715.1.
NP_081096.3. NM_026820.3.
XP_006536301.1. XM_006536238.1.
UniGeneiMm.175661.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60824N.
STRINGi10090.ENSMUSP00000026564.

Proteomic databases

PRIDEiQ9D103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026564; ENSMUSP00000026564; ENSMUSG00000025491.
ENSMUST00000106040; ENSMUSP00000101655; ENSMUSG00000025491.
ENSMUST00000106042; ENSMUSP00000101657; ENSMUSG00000025491.
GeneIDi68713.
KEGGimmu:68713.
UCSCiuc009kja.2. mouse.

Organism-specific databases

CTDi8519.
MGIiMGI:1915963. Ifitm1.

Phylogenomic databases

eggNOGispriNOG13868.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiQ9D103.
KOiK06566.
OMAiRETPHRD.
OrthoDBiEOG7288T5.
PhylomeDBiQ9D103.
TreeFamiTF334894.

Enzyme and pathway databases

ReactomeiREACT_300990. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

NextBioi327746.
PROiQ9D103.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D103.
GenevisibleiQ9D103. MM.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. Dispanin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells."
    Tanaka S.S., Matsui Y.
    Mech. Dev. 119:S261-S267(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Colon, Heart, Lung and Mammary tumor.
  5. "The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice."
    Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.
    BMC Dev. Biol. 3:1-1(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
  6. "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion."
    Tanaka S.S., Yamaguchi Y.L., Tsoi B., Lickert H., Tam P.P.
    Dev. Cell 9:745-756(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  7. "Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster."
    Lange U.C., Adams D.J., Lee C., Barton S., Schneider R., Bradley A., Surani M.A.
    Mol. Cell. Biol. 28:4688-4696(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The small interferon-induced transmembrane genes and proteins."
    Siegrist F., Ebeling M., Certa U.
    J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. Cited for: FUNCTION.
  10. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
    Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
    PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiIFM1_MOUSE
AccessioniPrimary (citable) accession number: Q9D103
Secondary accession number(s): Q8R2S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It has been previously shown that mediates migration of early primordial germ cells (PGCs) (PubMed:16326387). But according to PubMed:16326387, have no detectable effects on development of the germ line or on the generation of live young, hence, is not essential for PGC migration.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.