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Q9D103

- IFM1_MOUSE

UniProt

Q9D103 - IFM1_MOUSE

Protein

Interferon-induced transmembrane protein 1

Gene

Ifitm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.2 Publications

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. defense response to virus Source: MGI
    3. negative regulation of cell migration Source: UniProtKB
    4. negative regulation of cell proliferation Source: UniProtKB
    5. negative regulation of viral entry into host cell Source: UniProtKB
    6. negative regulation of viral genome replication Source: UniProtKB
    7. ossification Source: UniProtKB-KW
    8. positive regulation of osteoblast differentiation Source: UniProtKB
    9. response to interferon-alpha Source: UniProtKB
    10. response to interferon-beta Source: UniProtKB
    11. response to interferon-gamma Source: UniProtKB
    12. response to virus Source: UniProtKB
    13. somitogenesis Source: MGI

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-induced transmembrane protein 1
    Alternative name(s):
    Dispanin subfamily A member 2a
    Short name:
    DSPA2a
    Fragilis protein 2
    Mouse ifitm-like protein 2
    Short name:
    Mil-2
    Gene namesi
    Name:Ifitm1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1915963. Ifitm1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 106106Interferon-induced transmembrane protein 1PRO_0000398565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi49 – 491S-palmitoyl cysteineBy similarity
    Lipidationi50 – 501S-palmitoyl cysteineBy similarity
    Lipidationi83 – 831S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ9D103.

    Expressioni

    Tissue specificityi

    Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells.1 Publication

    Developmental stagei

    In migrating PGCs, expression is first detected during germ cell differentiation.2 Publications

    Gene expression databases

    BgeeiQ9D103.
    GenevestigatoriQ9D103.

    Interactioni

    Subunit structurei

    Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.By similarity

    Protein-protein interaction databases

    DIPiDIP-60824N.
    STRINGi10090.ENSMUSP00000101657.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 8428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 1061ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD225/Dispanin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGispriNOG13868.
    GeneTreeiENSGT00390000003476.
    HOGENOMiHOG000115781.
    HOVERGENiHBG001182.
    InParanoidiQ9D103.
    KOiK06566.
    OMAiTITEITI.
    OrthoDBiEOG7288T5.
    PhylomeDBiQ9D103.
    TreeFamiTF334894.

    Family and domain databases

    InterProiIPR007593. CD225/Dispanin_fam.
    [Graphical view]
    PfamiPF04505. Dispanin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D103-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKEQQEVVV LGSPHISTSA TATTINMPEI STPDHVVWSL FNTLFMNFCC    50
    LGFVAYAYSV KSRDRKMVGD TTGAQAFAST AKCLNISSLF FTILTAIVVI 100
    VVCAIR 106
    Length:106
    Mass (Da):11,524
    Last modified:June 1, 2001 - v1
    Checksum:i7B0E7D8200D36631
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371V → I in AAH27285. 1 PublicationCurated
    Sequence conflicti54 – 541V → I in AAH27285. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004121 mRNA. Translation: BAB23181.1.
    AK169960 mRNA. Translation: BAE41483.1.
    CH466531 Genomic DNA. Translation: EDL17976.1.
    BC027285 mRNA. Translation: AAH27285.1.
    BC090258 mRNA. Translation: AAH90258.1.
    BC090972 mRNA. Translation: AAH90972.1.
    BK001123 mRNA. Translation: DAA01238.1.
    CCDSiCCDS21995.1.
    RefSeqiNP_001106186.1. NM_001112715.1.
    NP_081096.3. NM_026820.3.
    XP_006536301.1. XM_006536238.1.
    UniGeneiMm.175661.

    Genome annotation databases

    EnsembliENSMUST00000026564; ENSMUSP00000026564; ENSMUSG00000025491.
    ENSMUST00000106040; ENSMUSP00000101655; ENSMUSG00000025491.
    ENSMUST00000106042; ENSMUSP00000101657; ENSMUSG00000025491.
    GeneIDi68713.
    KEGGimmu:68713.
    UCSCiuc009kja.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004121 mRNA. Translation: BAB23181.1 .
    AK169960 mRNA. Translation: BAE41483.1 .
    CH466531 Genomic DNA. Translation: EDL17976.1 .
    BC027285 mRNA. Translation: AAH27285.1 .
    BC090258 mRNA. Translation: AAH90258.1 .
    BC090972 mRNA. Translation: AAH90972.1 .
    BK001123 mRNA. Translation: DAA01238.1 .
    CCDSi CCDS21995.1.
    RefSeqi NP_001106186.1. NM_001112715.1.
    NP_081096.3. NM_026820.3.
    XP_006536301.1. XM_006536238.1.
    UniGenei Mm.175661.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60824N.
    STRINGi 10090.ENSMUSP00000101657.

    Proteomic databases

    PRIDEi Q9D103.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026564 ; ENSMUSP00000026564 ; ENSMUSG00000025491 .
    ENSMUST00000106040 ; ENSMUSP00000101655 ; ENSMUSG00000025491 .
    ENSMUST00000106042 ; ENSMUSP00000101657 ; ENSMUSG00000025491 .
    GeneIDi 68713.
    KEGGi mmu:68713.
    UCSCi uc009kja.2. mouse.

    Organism-specific databases

    CTDi 8519.
    MGIi MGI:1915963. Ifitm1.

    Phylogenomic databases

    eggNOGi spriNOG13868.
    GeneTreei ENSGT00390000003476.
    HOGENOMi HOG000115781.
    HOVERGENi HBG001182.
    InParanoidi Q9D103.
    KOi K06566.
    OMAi TITEITI.
    OrthoDBi EOG7288T5.
    PhylomeDBi Q9D103.
    TreeFami TF334894.

    Enzyme and pathway databases

    Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    NextBioi 327746.
    PROi Q9D103.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D103.
    Genevestigatori Q9D103.

    Family and domain databases

    InterProi IPR007593. CD225/Dispanin_fam.
    [Graphical view ]
    Pfami PF04505. Dispanin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells."
      Tanaka S.S., Matsui Y.
      Mech. Dev. 119:S261-S267(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II and FVB/N.
      Tissue: Colon, Heart, Lung and Mammary tumor.
    5. "The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice."
      Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.
      BMC Dev. Biol. 3:1-1(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
    6. "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion."
      Tanaka S.S., Yamaguchi Y.L., Tsoi B., Lickert H., Tam P.P.
      Dev. Cell 9:745-756(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    7. "Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster."
      Lange U.C., Adams D.J., Lee C., Barton S., Schneider R., Bradley A., Surani M.A.
      Mol. Cell. Biol. 28:4688-4696(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "The small interferon-induced transmembrane genes and proteins."
      Siegrist F., Ebeling M., Certa U.
      J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    9. Cited for: FUNCTION.
    10. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
      Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
      PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiIFM1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D103
    Secondary accession number(s): Q8R2S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It has been previously shown that mediates migration of early primordial germ cells (PGCs) (PubMed:16326387). But according to PubMed:16326387, have no detectable effects on development of the germ line or on the generation of live young, hence, is not essential for PGC migration.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3