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Protein

Peptidyl-prolyl cis-trans isomerase-like 1

Gene

Ppil1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Enzyme regulationi

Inhibited by Cyclosporin A.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119Cyclosporin ABy similarity1
Binding sitei125Cyclosporin ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 1 (EC:5.2.1.8By similarity)
Short name:
PPIase
Alternative name(s):
Rotamase PPIL1
Gene namesi
Name:Ppil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1916066 Ppil1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000641651 – 166Peptidyl-prolyl cis-trans isomerase-like 1Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei149PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0W5
MaxQBiQ9D0W5
PaxDbiQ9D0W5
PRIDEiQ9D0W5

PTM databases

iPTMnetiQ9D0W5
PhosphoSitePlusiQ9D0W5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024007
CleanExiMM_PPIL1
ExpressionAtlasiQ9D0W5 baseline and differential
GenevisibleiQ9D0W5 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with SNW1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213066, 1 interactor
STRINGi10090.ENSMUSP00000024802

Structurei

3D structure databases

ProteinModelPortaliQ9D0W5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 164PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 65Cyclosporin A bindingBy similarityAdd BLAST12
Regioni70 – 71Cyclosporin A bindingBy similarity2
Regioni99 – 104Cyclosporin A bindingBy similarity6
Regioni109 – 113Cyclosporin A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0881 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
InParanoidiQ9D0W5
KOiK12733
OMAiTSIYGQK
OrthoDBiEOG091G0NXS
PhylomeDBiQ9D0W5
TreeFamiTF300200

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIPPDTWQ PPNVYLETSM GVIVLELYWK HAPKTCKNFA ELARRGYYNG
60 70 80 90 100
TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM
110 120 130 140 150
ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ
160
DRPVDDVKIL KAYPSG
Length:166
Mass (Da):18,237
Last modified:June 1, 2001 - v1
Checksum:iA5C5B04FE29C52C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004331 mRNA Translation: BAB23265.1
AK150643 mRNA Translation: BAE29731.1
AK151572 mRNA Translation: BAE30513.1
BC058369 mRNA Translation: AAH58369.1
CCDSiCCDS28593.1
RefSeqiNP_081121.1, NM_026845.4
UniGeneiMm.328928

Genome annotation databases

EnsembliENSMUST00000024802; ENSMUSP00000024802; ENSMUSG00000024007
GeneIDi68816
KEGGimmu:68816
UCSCiuc008bsm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPIL1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0W5
Secondary accession number(s): Q3UA03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health