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Protein

Receptor-binding cancer antigen expressed on SiSo cells

Gene

Ebag9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-binding cancer antigen expressed on SiSo cells
Alternative name(s):
Cancer-associated surface antigen RCAS1
Estrogen receptor-binding fragment-associated gene 9 protein
Gene namesi
Name:Ebag9
Synonyms:Rcas1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859920 Ebag9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 27Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST20
Topological domaini28 – 213CytoplasmicSequence analysisAdd BLAST186

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971961 – 213Receptor-binding cancer antigen expressed on SiSo cellsAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineCombined sources1
Modified residuei41PhosphothreonineBy similarity1
Modified residuei94PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0V7
MaxQBiQ9D0V7
PaxDbiQ9D0V7
PeptideAtlasiQ9D0V7
PRIDEiQ9D0V7

PTM databases

iPTMnetiQ9D0V7
PhosphoSitePlusiQ9D0V7
SwissPalmiQ9D0V7

Expressioni

Tissue specificityi

Widely expressed. Expressed in heart, brain, spleen, liver, kidney and testis.1 Publication

Developmental stagei

Expressed in the developing embryo.1 Publication

Inductioni

By 17-beta-estradiol (E2).1 Publication

Gene expression databases

BgeeiENSMUSG00000022339
GenevisibleiQ9D0V7 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022964

Structurei

3D structure databases

ProteinModelPortaliQ9D0V7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili163 – 211Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 163Poly-Glu4

Domaini

The coiled coil domain is necessary for the homodimerization.By similarity

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE57 Eukaryota
ENOG41101KS LUCA
GeneTreeiENSGT00390000004040
HOGENOMiHOG000073537
HOVERGENiHBG059707
InParanoidiQ9D0V7
KOiK22455
OMAiFRLFKIC
OrthoDBiEOG091G0L0F
PhylomeDBiQ9D0V7
TreeFamiTF326584

Family and domain databases

InterProiView protein in InterPro
IPR017025 Cancer-assoc_antigen_RCAS1
PANTHERiPTHR15208 PTHR15208, 1 hit
PIRSFiPIRSF034247 RCAS1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITQFRLFK VCTCLATVFS FLKRLICRSG RGRKLSGDQI TLPTTVDYSS
60 70 80 90 100
VPKQTDVEEW TSWDEDAPTS VKIEGGNGNV ATQQNSLEQL EPDYFKDMTP
110 120 130 140 150
TIRKTQKIVI KKREPLNFGV PDGSTGFSSR LAATQDMPFI HQSSELGDLD
160 170 180 190 200
TWQENSNAWE EEEDAAWQAE EVLRQQKIAD REKRAAEQQR KKMEKEAQRL
210
MKKEQNKIGV KLS
Length:213
Mass (Da):24,319
Last modified:September 26, 2003 - v2
Checksum:i349FAD1E2AEFF529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11V → G in AAF23857 (PubMed:16141072).Curated1
Sequence conflicti115P → A in AAF23857 (PubMed:16141072).Curated1
Sequence conflicti150D → G in BAE35132 (PubMed:16141072).Curated1
Sequence conflicti157N → S in AAF23857 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009091 mRNA Translation: AAG41054.1
AF076524 mRNA Translation: AAF23857.1
AK004366 mRNA Translation: BAB23277.1
AK159499 mRNA Translation: BAE35132.1
AK160149 mRNA Translation: BAE35657.1
BC108397 mRNA Translation: AAI08398.1
BC119118 mRNA Translation: AAI19119.1
BC119120 mRNA Translation: AAI19121.1
BC144740 mRNA Translation: AAI44741.1
CCDSiCCDS27457.1
PIRiJC7696
RefSeqiNP_062353.3, NM_019480.4
XP_006521256.1, XM_006521193.2
XP_006521257.1, XM_006521194.3
XP_006521258.1, XM_006521195.3
UniGeneiMm.287896

Genome annotation databases

EnsembliENSMUST00000022964; ENSMUSP00000022964; ENSMUSG00000022339
ENSMUST00000226165; ENSMUSP00000153791; ENSMUSG00000022339
ENSMUST00000227691; ENSMUSP00000154361; ENSMUSG00000022339
GeneIDi55960
KEGGimmu:55960
UCSCiuc007vpz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRCAS1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0V7
Secondary accession number(s): Q0VET4
, Q3TVG2, Q3TWY4, Q9QYD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: April 25, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health