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Protein

Protein ARV1

Gene

Arv1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a mediator of sterol homeostasis.Curated

GO - Biological processi

  • bile acid metabolic process Source: MGI
  • cholesterol transport Source: MGI
  • intracellular sterol transport Source: GO_Central
  • regulation of cholesterol metabolic process Source: MGI
  • regulation of plasma membrane sterol distribution Source: GO_Central
  • sphingolipid metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-191273. Cholesterol biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ARV1
Gene namesi
Name:Arv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916115. Arv1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Protein ARV1PRO_0000228660Add
BLAST

Proteomic databases

EPDiQ9D0U9.
PaxDbiQ9D0U9.
PRIDEiQ9D0U9.

Expressioni

Gene expression databases

BgeeiQ9D0U9.
CleanExiMM_ARV1.
ExpressionAtlasiQ9D0U9. baseline and differential.
GenevisibleiQ9D0U9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034463.

Structurei

3D structure databases

ProteinModelPortaliQ9D0U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARV1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3134. Eukaryota.
COG5254. LUCA.
GeneTreeiENSGT00390000002675.
HOGENOMiHOG000013218.
HOVERGENiHBG080869.
InParanoidiQ9D0U9.
OMAiASCQYRC.
OrthoDBiEOG7NKKMC.
PhylomeDBiQ9D0U9.
TreeFamiTF105845.

Family and domain databases

InterProiIPR007290. Arv1.
[Graphical view]
PANTHERiPTHR14467. PTHR14467. 1 hit.
PfamiPF04161. Arv1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTGGRRGTR SGKGTEGAAA TSSSCLYRCI ECNREAQELY RDYSHGVLKI
60 70 80 90 100
TICKSCQKPV DKYIEYDPVI ILINAILCKT QAYRHILFNT KINIHGKLCM
110 120 130 140 150
FCLLCEAYLR WWQLQDSSQS PAPDDVIRYA KEWDFYRMFV IASFEQAAFL
160 170 180 190 200
TGIFAFLWVQ QPMTAKRAPD FVLLLKALLL SSYGKLLLIP AVIWEHDYTP
210 220 230 240 250
LCLRLIKVFV LTSNFQAVRV TLNTNRRLSL LVVLSGLLLE SIVVFFFQRM
260
EWDVSSDCAL YKSQDF
Length:266
Mass (Da):30,535
Last modified:June 1, 2001 - v1
Checksum:i8A7C7C1078F4BC76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004398 mRNA. Translation: BAB23288.1.
AK042561 mRNA. Translation: BAC31293.1.
CCDSiCCDS22774.1.
RefSeqiNP_081131.1. NM_026855.4.
XP_006531400.1. XM_006531337.2.
XP_006531401.1. XM_006531338.2.
XP_011246798.1. XM_011248496.1.
UniGeneiMm.22779.

Genome annotation databases

EnsembliENSMUST00000034463; ENSMUSP00000034463; ENSMUSG00000031982.
GeneIDi68865.
KEGGimmu:68865.
UCSCiuc009nxn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004398 mRNA. Translation: BAB23288.1.
AK042561 mRNA. Translation: BAC31293.1.
CCDSiCCDS22774.1.
RefSeqiNP_081131.1. NM_026855.4.
XP_006531400.1. XM_006531337.2.
XP_006531401.1. XM_006531338.2.
XP_011246798.1. XM_011248496.1.
UniGeneiMm.22779.

3D structure databases

ProteinModelPortaliQ9D0U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034463.

Proteomic databases

EPDiQ9D0U9.
PaxDbiQ9D0U9.
PRIDEiQ9D0U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034463; ENSMUSP00000034463; ENSMUSG00000031982.
GeneIDi68865.
KEGGimmu:68865.
UCSCiuc009nxn.1. mouse.

Organism-specific databases

CTDi64801.
MGIiMGI:1916115. Arv1.

Phylogenomic databases

eggNOGiKOG3134. Eukaryota.
COG5254. LUCA.
GeneTreeiENSGT00390000002675.
HOGENOMiHOG000013218.
HOVERGENiHBG080869.
InParanoidiQ9D0U9.
OMAiASCQYRC.
OrthoDBiEOG7NKKMC.
PhylomeDBiQ9D0U9.
TreeFamiTF105845.

Enzyme and pathway databases

ReactomeiR-MMU-191273. Cholesterol biosynthesis.

Miscellaneous databases

PROiQ9D0U9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D0U9.
CleanExiMM_ARV1.
ExpressionAtlasiQ9D0U9. baseline and differential.
GenevisibleiQ9D0U9. MM.

Family and domain databases

InterProiIPR007290. Arv1.
[Graphical view]
PANTHERiPTHR14467. PTHR14467. 1 hit.
PfamiPF04161. Arv1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.

Entry informationi

Entry nameiARV1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0U9
Secondary accession number(s): Q8BY08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.