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Protein

Repressor of RNA polymerase III transcription MAF1 homolog

Gene

Maf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Repressor of RNA polymerase III transcription MAF1 homolog
Gene namesi
Name:Maf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916127 Maf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002139741 – 258Repressor of RNA polymerase III transcription MAF1 homologAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1 and SUMO2)By similarity
Modified residuei60Phosphoserine; by MTORBy similarity1
Modified residuei64PhosphothreonineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei68Phosphoserine; by MTORBy similarity1
Modified residuei70PhosphoserineBy similarity1
Modified residuei75Phosphoserine; by MTORBy similarity1
Modified residuei212PhosphothreonineBy similarity1
Modified residuei214PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function (By similarity).By similarity
Sumoylated with SUMO1 and SUMO2, mainly on Lys-35. Desumoylated by SENP1. SUMOylation promotes the ability of MAF1 to repress transcription and suppress colony formation (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9D0U6
MaxQBiQ9D0U6
PaxDbiQ9D0U6
PRIDEiQ9D0U6

PTM databases

iPTMnetiQ9D0U6
PhosphoSitePlusiQ9D0U6

Expressioni

Gene expression databases

BgeeiENSMUSG00000022553
CleanExiMM_MAF1
ExpressionAtlasiQ9D0U6 baseline and differential
GenevisibleiQ9D0U6 MM

Interactioni

Subunit structurei

Interacts with BRF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023212

Structurei

3D structure databases

ProteinModelPortaliQ9D0U6
SMRiQ9D0U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAF1 family.Curated

Phylogenomic databases

eggNOGiKOG3104 Eukaryota
COG5046 LUCA
GeneTreeiENSGT00390000006896
HOGENOMiHOG000185242
HOVERGENiHBG052395
InParanoidiQ9D0U6
OMAiGEDGCLW
OrthoDBiEOG091G0JHN
PhylomeDBiQ9D0U6
TreeFamiTF315149

Family and domain databases

Gene3Di3.40.1000.50, 2 hits
InterProiView protein in InterPro
IPR015257 Maf1
IPR038564 Maf1_sf
PANTHERiPTHR22504 PTHR22504, 1 hit
PfamiView protein in Pfam
PF09174 Maf1, 1 hit
PIRSFiPIRSF037240 RNA_polIII_Trep_MAF1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLENSSFE AINSQLTVET GDAHIIGRIE SYSCKMAGDD KHMFKQFCQE
60 70 80 90 100
GQPHVLEALS PPQTSGLSPS RLSKSQGGED ESPLSDKCSR KTLFYLIATL
110 120 130 140 150
NESFRPDYDF STARSHEFSR EPSLRWVVNA VNCSLFSAVR EDFKALKPQL
160 170 180 190 200
WNAVDEEICL AECDIYSYNP DLDSDPFGED GSLWSFNYFF YNKRLKRIVF
210 220 230 240 250
FSCRSISGST YTPSEAGNAL DLELGAEEAD EESGGGGGEG RAEETSTMEE

DRVPVICM
Length:258
Mass (Da):28,780
Last modified:June 1, 2001 - v1
Checksum:i5CE8AE117604B27F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79E → D in AAH16260 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004406 mRNA Translation: BAB23294.1
AK042913 mRNA Translation: BAC31403.1
AK154047 mRNA Translation: BAE32337.1
BC016260 mRNA Translation: AAH16260.1
CCDSiCCDS27568.1
RefSeqiNP_001158079.1, NM_001164607.1
NP_001158080.1, NM_001164608.1
NP_081135.3, NM_026859.3
UniGeneiMm.289680

Genome annotation databases

EnsembliENSMUST00000023212; ENSMUSP00000023212; ENSMUSG00000022553
ENSMUST00000160853; ENSMUSP00000124893; ENSMUSG00000022553
ENSMUST00000161527; ENSMUSP00000125387; ENSMUSG00000022553
GeneIDi68877
KEGGimmu:68877
UCSCiuc007wjw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMAF1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0U6
Secondary accession number(s): Q3U4U3, Q91W84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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