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Q9D0T2

- DUS12_MOUSE

UniProt

Q9D0T2 - DUS12_MOUSE

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Protein
Dual specificity protein phosphatase 12
Gene
Dusp12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
  3. protein tyrosine/serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. positive regulation of glucokinase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 12 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase T-DSP4
Dual specificity phosphatase VH1
Gene namesi
Name:Dusp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1890614. Dusp12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Dual specificity protein phosphatase 12
PRO_0000094819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9D0T2.
PRIDEiQ9D0T2.

PTM databases

PhosphoSiteiQ9D0T2.

Expressioni

Gene expression databases

ArrayExpressiQ9D0T2.
BgeeiQ9D0T2.
CleanExiMM_DUSP12.
GenevestigatoriQ9D0T2.

Structurei

3D structure databases

ProteinModelPortaliQ9D0T2.
SMRiQ9D0T2. Positions 28-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 16175Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
HOVERGENiHBG051421.
InParanoidiQ9D0T2.
KOiK14819.
OMAiKITHILT.
PhylomeDBiQ9D0T2.
TreeFamiTF105123.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0T2-1 [UniParc]FASTAAdd to Basket

« Hide

MLEAQGSNHG CERQAPTASP ASSAGHAVEV RPGLYLGGAA AVAEPGHLRE    50
AGITAVLTVD SEPAFPAGAG FEGLRSLFVP ALDKPETDLL SHLDRCVAFI 100
GQARSEGRAV LVHCHAGVSR SVAVVMAFIM KTDQLTFEKA YDILRTVKPE 150
AKVNEGFEWQ LKLYEAMGYE VDTSSAFYKQ YRLQKVTEKC PKLWNLPQEL 200
FAVDPTTISQ GLKDDILYKC RKCRRSLFRH SSILGHSEGS GPIAFAHKRT 250
APSSVLTTGS QAQCTSYFIE PVQWMESTLL GVMDGQLLCP KCSAKLGSFN 300
WYGEQCSCGR WITPAFQIHK NRVDEMKMLP VLGSQTKKL 339
Length:339
Mass (Da):37,159
Last modified:June 1, 2001 - v1
Checksum:iB6A254D319BEC98F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → T in AAG44739. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF280810 mRNA. Translation: AAK69508.1.
AF268196 mRNA. Translation: AAG44739.1.
AK004488 mRNA. Translation: BAB23328.1.
CCDSiCCDS15474.1.
RefSeqiNP_075662.2. NM_023173.2.
UniGeneiMm.34365.

Genome annotation databases

EnsembliENSMUST00000027970; ENSMUSP00000027970; ENSMUSG00000026659.
GeneIDi80915.
KEGGimmu:80915.
UCSCiuc007dml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF280810 mRNA. Translation: AAK69508.1 .
AF268196 mRNA. Translation: AAG44739.1 .
AK004488 mRNA. Translation: BAB23328.1 .
CCDSi CCDS15474.1.
RefSeqi NP_075662.2. NM_023173.2.
UniGenei Mm.34365.

3D structure databases

ProteinModelPortali Q9D0T2.
SMRi Q9D0T2. Positions 28-185.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D0T2.

Proteomic databases

PaxDbi Q9D0T2.
PRIDEi Q9D0T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027970 ; ENSMUSP00000027970 ; ENSMUSG00000026659 .
GeneIDi 80915.
KEGGi mmu:80915.
UCSCi uc007dml.1. mouse.

Organism-specific databases

CTDi 11266.
MGIi MGI:1890614. Dusp12.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00740000115610.
HOGENOMi HOG000243638.
HOVERGENi HBG051421.
InParanoidi Q9D0T2.
KOi K14819.
OMAi KITHILT.
PhylomeDBi Q9D0T2.
TreeFami TF105123.

Miscellaneous databases

NextBioi 350298.
PROi Q9D0T2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9D0T2.
Bgeei Q9D0T2.
CleanExi MM_DUSP12.
Genevestigatori Q9D0T2.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PIRSFi PIRSF000941. DUSP12. 1 hit.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of putative dual specificity phosphatase T-DSP4."
    Aoyama K., Matsuda T., Aoki N.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "mVH1, a dual-specificity phosphatase whose expression is cell cycle regulated."
    Zhang X.M., Dormady S.P., Chaung W., Basch R.S.
    Mamm. Genome 11:1154-1156(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiDUS12_MOUSE
AccessioniPrimary (citable) accession number: Q9D0T2
Secondary accession number(s): Q9EQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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