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Q9D0T2

- DUS12_MOUSE

UniProt

Q9D0T2 - DUS12_MOUSE

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Protein

Dual specificity protein phosphatase 12

Gene

Dusp12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. positive regulation of glucokinase activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 12 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase T-DSP4
Dual specificity phosphatase VH1
Gene namesi
Name:Dusp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1890614. Dusp12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Dual specificity protein phosphatase 12PRO_0000094819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D0T2.
PaxDbiQ9D0T2.
PRIDEiQ9D0T2.

PTM databases

PhosphoSiteiQ9D0T2.

Expressioni

Gene expression databases

BgeeiQ9D0T2.
CleanExiMM_DUSP12.
ExpressionAtlasiQ9D0T2. baseline and differential.
GenevestigatoriQ9D0T2.

Structurei

3D structure databases

ProteinModelPortaliQ9D0T2.
SMRiQ9D0T2. Positions 28-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 16175Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
HOVERGENiHBG051421.
InParanoidiQ9D0T2.
KOiK14819.
OMAiKITHILT.
PhylomeDBiQ9D0T2.
TreeFamiTF105123.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEAQGSNHG CERQAPTASP ASSAGHAVEV RPGLYLGGAA AVAEPGHLRE
60 70 80 90 100
AGITAVLTVD SEPAFPAGAG FEGLRSLFVP ALDKPETDLL SHLDRCVAFI
110 120 130 140 150
GQARSEGRAV LVHCHAGVSR SVAVVMAFIM KTDQLTFEKA YDILRTVKPE
160 170 180 190 200
AKVNEGFEWQ LKLYEAMGYE VDTSSAFYKQ YRLQKVTEKC PKLWNLPQEL
210 220 230 240 250
FAVDPTTISQ GLKDDILYKC RKCRRSLFRH SSILGHSEGS GPIAFAHKRT
260 270 280 290 300
APSSVLTTGS QAQCTSYFIE PVQWMESTLL GVMDGQLLCP KCSAKLGSFN
310 320 330
WYGEQCSCGR WITPAFQIHK NRVDEMKMLP VLGSQTKKL
Length:339
Mass (Da):37,159
Last modified:June 1, 2001 - v1
Checksum:iB6A254D319BEC98F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71S → T in AAG44739. (PubMed:11130991)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF280810 mRNA. Translation: AAK69508.1.
AF268196 mRNA. Translation: AAG44739.1.
AK004488 mRNA. Translation: BAB23328.1.
CCDSiCCDS15474.1.
RefSeqiNP_075662.2. NM_023173.2.
UniGeneiMm.34365.

Genome annotation databases

EnsembliENSMUST00000027970; ENSMUSP00000027970; ENSMUSG00000026659.
GeneIDi80915.
KEGGimmu:80915.
UCSCiuc007dml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF280810 mRNA. Translation: AAK69508.1 .
AF268196 mRNA. Translation: AAG44739.1 .
AK004488 mRNA. Translation: BAB23328.1 .
CCDSi CCDS15474.1.
RefSeqi NP_075662.2. NM_023173.2.
UniGenei Mm.34365.

3D structure databases

ProteinModelPortali Q9D0T2.
SMRi Q9D0T2. Positions 28-185.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D0T2.

Proteomic databases

MaxQBi Q9D0T2.
PaxDbi Q9D0T2.
PRIDEi Q9D0T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027970 ; ENSMUSP00000027970 ; ENSMUSG00000026659 .
GeneIDi 80915.
KEGGi mmu:80915.
UCSCi uc007dml.1. mouse.

Organism-specific databases

CTDi 11266.
MGIi MGI:1890614. Dusp12.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00740000115610.
HOGENOMi HOG000243638.
HOVERGENi HBG051421.
InParanoidi Q9D0T2.
KOi K14819.
OMAi KITHILT.
PhylomeDBi Q9D0T2.
TreeFami TF105123.

Miscellaneous databases

NextBioi 350298.
PROi Q9D0T2.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0T2.
CleanExi MM_DUSP12.
ExpressionAtlasi Q9D0T2. baseline and differential.
Genevestigatori Q9D0T2.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PIRSFi PIRSF000941. DUSP12. 1 hit.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of putative dual specificity phosphatase T-DSP4."
    Aoyama K., Matsuda T., Aoki N.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "mVH1, a dual-specificity phosphatase whose expression is cell cycle regulated."
    Zhang X.M., Dormady S.P., Chaung W., Basch R.S.
    Mamm. Genome 11:1154-1156(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiDUS12_MOUSE
AccessioniPrimary (citable) accession number: Q9D0T2
Secondary accession number(s): Q9EQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3