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Protein

NHP2-like protein 1

Gene

Snu13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.By similarity

GO - Molecular functioni

  • ATPase binding Source: MGI
  • box C/D snoRNA binding Source: CAFA
  • U3 snoRNA binding Source: MGI
  • U4atac snRNA binding Source: UniProtKB
  • U4 snRNA binding Source: MGI

GO - Biological processi

  • box C/D snoRNP assembly Source: CAFA
  • maturation of LSU-rRNA Source: GO_Central
  • maturation of SSU-rRNA Source: GO_Central
  • mRNA splicing, via spliceosome Source: UniProtKB
  • single fertilization Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
NHP2-like protein 1
Alternative name(s):
Fertilization antigen 11 Publication
Short name:
FA-1
High mobility group-like nuclear protein 2 homolog 1
Sperm-specific antigen 1
U4/U6.U5 small nuclear ribonucleoprotein SNU13By similarity
U4/U6.U5 tri-snRNP 15.5 kDa protein
Cleaved into the following chain:
Gene namesi
Name:Snu13By similarity
Synonyms:Nhp2l1Imported, Ssfa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:893586 Snu13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367791 – 128NHP2-like protein 1Add BLAST128
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004232622 – 128NHP2-like protein 1, N-terminally processedAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in NHP2-like protein 1, N-terminally processedBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei122PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0T1
MaxQBiQ9D0T1
PaxDbiQ9D0T1
PeptideAtlasiQ9D0T1
PRIDEiQ9D0T1
TopDownProteomicsiQ9D0T1

PTM databases

iPTMnetiQ9D0T1
PhosphoSitePlusiQ9D0T1
SwissPalmiQ9D0T1

Expressioni

Gene expression databases

BgeeiENSMUSG00000063480
ExpressionAtlasiQ9D0T1 baseline and differential
GenevisibleiQ9D0T1 MM

Interactioni

Subunit structurei

Identified in the spliceosome B complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31. The complex formed by SNU13 and PRPF31 binds U4 snRNA. The complex formed by SNU13 and PRPF31 binds also U4atac snRNA, a characteristic component of specific, less abundant spliceosomal complexes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei61Interaction with U4 snRNA and U4atac snRNABy similarity1
Sitei86Interaction with U4 snRNA and U4atac snRNABy similarity1

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203509, 48 interactors
IntActiQ9D0T1, 52 interactors
MINTiQ9D0T1
STRINGi10090.ENSMUSP00000130867

Structurei

3D structure databases

ProteinModelPortaliQ9D0T1
SMRiQ9D0T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 48Interaction with U4 snRNA and U4atac snRNABy similarityAdd BLAST13
Regioni96 – 128Important for U4 snRNA-bindingBy similarityAdd BLAST33

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3387 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00550000074840
HOGENOMiHOG000055226
HOVERGENiHBG000328
InParanoidiQ9D0T1
KOiK12845
OMAiKPFYVRF
OrthoDBiEOG091G0YVI
PhylomeDBiQ9D0T1
TreeFamiTF300184

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR002415 H/ACA_rnp_Nhp2_euk
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00883 NUCLEARHMG
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI
60 70 80 90 100
SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI
110 120
ACSVTIKEGS QLKQQIQSIQ QSIERLLV
Length:128
Mass (Da):14,174
Last modified:January 23, 2007 - v4
Checksum:i78849EBB497089ED
GO

Sequence cautioni

The sequence AAC53177 differs from that shown. Reason: Frameshift at positions 11, 54, 70, 93 and 128.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9K → R in BAB23329 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95114 mRNA Translation: AAC53177.1 Frameshift.
AK004489 mRNA Translation: BAB23329.1
AK134943 mRNA Translation: BAE22349.1
AK145608 mRNA Translation: BAE26537.1
AK168930 mRNA Translation: BAE40743.1
AK169103 mRNA Translation: BAE40885.1
BC026755 mRNA Translation: AAH26755.1
BC054450 mRNA Translation: AAH54450.1
BC083315 mRNA Translation: AAH83315.1
CCDSiCCDS37154.1
PIRiT10105
RefSeqiNP_035612.2, NM_011482.4
XP_003689233.1, XM_003689185.5
UniGeneiMm.299312

Genome annotation databases

EnsembliENSMUST00000080622; ENSMUSP00000091840; ENSMUSG00000063480
GeneIDi100862468
20826
KEGGimmu:100862468
mmu:20826
UCSCiuc007wya.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNH2L1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0T1
Secondary accession number(s): O08754, Q3UY64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 142 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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