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Protein

NHP2-like protein 1

Gene

Snu13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
NHP2-like protein 1
Alternative name(s):
Fertilization antigen 1
Short name:
FA-1
High mobility group-like nuclear protein 2 homolog 1
Sperm-specific antigen 1
U4/U6.U5 small nuclear ribonucleoprotein SNU13By similarity
U4/U6.U5 tri-snRNP 15.5 kDa protein
Cleaved into the following chain:
Gene namesi
Name:Snu13By similarity
Synonyms:Nhp2l1Imported, Ssfa1
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 15, Chromosome 9

Organism-specific databases

MGIiMGI:893586. Nhp2l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128NHP2-like protein 1PRO_0000136779Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 128127NHP2-like protein 1, N-terminally processedPRO_0000423262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in NHP2-like protein 1, N-terminally processedBy similarity
Modified residuei21 – 211N6-acetyllysineCombined sources
Modified residuei122 – 1221PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0T1.
MaxQBiQ9D0T1.
PaxDbiQ9D0T1.
PeptideAtlasiQ9D0T1.
PRIDEiQ9D0T1.
TopDownProteomicsiQ9D0T1.

PTM databases

iPTMnetiQ9D0T1.
PhosphoSiteiQ9D0T1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063480.
ExpressionAtlasiQ9D0T1. baseline.
GenevisibleiQ9D0T1. MM.

Interactioni

Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts with RAD17 and PRPF31 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203509. 47 interactions.
IntActiQ9D0T1. 52 interactions.
MINTiMINT-1853862.
STRINGi10090.ENSMUSP00000130867.

Structurei

3D structure databases

ProteinModelPortaliQ9D0T1.
SMRiQ9D0T1. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7Ae family.Curated

Phylogenomic databases

eggNOGiKOG3387. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00550000074840.
HOGENOMiHOG000055226.
HOVERGENiHBG000328.
InParanoidiQ9D0T1.
KOiK12845.
OMAiAIDKLMV.
OrthoDBiEOG091G0YVI.
PhylomeDBiQ9D0T1.
TreeFamiTF300184.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI
60 70 80 90 100
SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI
110 120
ACSVTIKEGS QLKQQIQSIQ QSIERLLV
Length:128
Mass (Da):14,174
Last modified:January 23, 2007 - v4
Checksum:i78849EBB497089ED
GO

Sequence cautioni

The sequence AAC53177 differs from that shown. Reason: Frameshift at positions 11, 54, 70, 93 and 128. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91K → R in BAB23329 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95114 mRNA. Translation: AAC53177.1. Frameshift.
AK004489 mRNA. Translation: BAB23329.1.
AK134943 mRNA. Translation: BAE22349.1.
AK145608 mRNA. Translation: BAE26537.1.
AK168930 mRNA. Translation: BAE40743.1.
AK169103 mRNA. Translation: BAE40885.1.
BC026755 mRNA. Translation: AAH26755.1.
BC054450 mRNA. Translation: AAH54450.1.
BC083315 mRNA. Translation: AAH83315.1.
CCDSiCCDS37154.1.
PIRiT10105.
RefSeqiNP_035612.2. NM_011482.4.
XP_003689233.1. XM_003689185.4.
UniGeneiMm.299312.

Genome annotation databases

EnsembliENSMUST00000080622; ENSMUSP00000091840; ENSMUSG00000063480.
ENSMUST00000165252; ENSMUSP00000130867; ENSMUSG00000063543.
GeneIDi100862468.
20826.
KEGGimmu:100862468.
mmu:20826.
UCSCiuc007wya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95114 mRNA. Translation: AAC53177.1. Frameshift.
AK004489 mRNA. Translation: BAB23329.1.
AK134943 mRNA. Translation: BAE22349.1.
AK145608 mRNA. Translation: BAE26537.1.
AK168930 mRNA. Translation: BAE40743.1.
AK169103 mRNA. Translation: BAE40885.1.
BC026755 mRNA. Translation: AAH26755.1.
BC054450 mRNA. Translation: AAH54450.1.
BC083315 mRNA. Translation: AAH83315.1.
CCDSiCCDS37154.1.
PIRiT10105.
RefSeqiNP_035612.2. NM_011482.4.
XP_003689233.1. XM_003689185.4.
UniGeneiMm.299312.

3D structure databases

ProteinModelPortaliQ9D0T1.
SMRiQ9D0T1. Positions 3-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203509. 47 interactions.
IntActiQ9D0T1. 52 interactions.
MINTiMINT-1853862.
STRINGi10090.ENSMUSP00000130867.

PTM databases

iPTMnetiQ9D0T1.
PhosphoSiteiQ9D0T1.

Proteomic databases

EPDiQ9D0T1.
MaxQBiQ9D0T1.
PaxDbiQ9D0T1.
PeptideAtlasiQ9D0T1.
PRIDEiQ9D0T1.
TopDownProteomicsiQ9D0T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080622; ENSMUSP00000091840; ENSMUSG00000063480.
ENSMUST00000165252; ENSMUSP00000130867; ENSMUSG00000063543.
GeneIDi100862468.
20826.
KEGGimmu:100862468.
mmu:20826.
UCSCiuc007wya.1. mouse.

Organism-specific databases

CTDi20826.
MGIiMGI:893586. Nhp2l1.

Phylogenomic databases

eggNOGiKOG3387. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00550000074840.
HOGENOMiHOG000055226.
HOVERGENiHBG000328.
InParanoidiQ9D0T1.
KOiK12845.
OMAiAIDKLMV.
OrthoDBiEOG091G0YVI.
PhylomeDBiQ9D0T1.
TreeFamiTF300184.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiNhp2l1. mouse.
PROiQ9D0T1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063480.
ExpressionAtlasiQ9D0T1. baseline.
GenevisibleiQ9D0T1. MM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNH2L1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0T1
Secondary accession number(s): O08754, Q3UY64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.