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Protein

Histidine triad nucleotide-binding protein 2, mitochondrial

Gene

Hint2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Purine nucleotide phosphoramidateBy similarity
Active sitei149 – 1491Tele-AMP-histidine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812Purine nucleotide phosphoramidateBy similarity
Nucleotide bindingi142 – 1443Purine nucleotide phosphoramidateBy similarity
Nucleotide bindingi149 – 1513Purine nucleotide phosphoramidateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Apoptosis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine triad nucleotide-binding protein 2, mitochondrial (EC:3.-.-.-)
Short name:
HINT-2
Alternative name(s):
HINT-3
Gene namesi
Name:Hint2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916167. Hint2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
  • nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717MitochondrionSequence analysisAdd
BLAST
Chaini18 – 163146Histidine triad nucleotide-binding protein 2, mitochondrialPRO_0000109787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-succinyllysineCombined sources
Modified residuei119 – 1191N6-acetyllysineCombined sources
Modified residuei128 – 1281N6-acetyllysine; alternateCombined sources
Modified residuei128 – 1281N6-succinyllysine; alternateCombined sources
Modified residuei139 – 1391N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D0S9.
MaxQBiQ9D0S9.
PaxDbiQ9D0S9.
PRIDEiQ9D0S9.

PTM databases

iPTMnetiQ9D0S9.
PhosphoSiteiQ9D0S9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028470.
CleanExiMM_HINT2.
ExpressionAtlasiQ9D0S9. baseline and differential.
GenevisibleiQ9D0S9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D0S9. 3 interactions.
MINTiMINT-1605434.
STRINGi10090.ENSMUSP00000030192.

Structurei

3D structure databases

ProteinModelPortaliQ9D0S9.
SMRiQ9D0S9. Positions 63-163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 163109HITPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi147 – 1515Histidine triad motif

Sequence similaritiesi

Belongs to the HINT family.Curated
Contains 1 HIT domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3275. Eukaryota.
COG0537. LUCA.
GeneTreeiENSGT00510000046448.
HOGENOMiHOG000061064.
HOVERGENiHBG051906.
InParanoidiQ9D0S9.
OMAiNVAKQES.
OrthoDBiEOG091G1001.
PhylomeDBiQ9D0S9.
TreeFamiTF314862.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR23089. PTHR23089. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
PRINTSiPR00332. HISTRIAD.
SUPFAMiSSF54197. SSF54197. 1 hit.
PROSITEiPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLLAVG LRAARRTLAA AGARGAQVRG NAGVSDGSEV AKAQKAAPGG
60 70 80 90 100
ASPTIFSRIL DRSLPADILY EDQQCLVFRD VAPQAPVHFL VIPRKPIPRI
110 120 130 140 150
SQAEEDDQQL LGHLLLVAKK IAQAQGLKDG YRLVVNDGKM GAQSVYHLHI
160
HVLGGRQLQW PPG
Length:163
Mass (Da):17,320
Last modified:June 1, 2001 - v1
Checksum:i1FD421AF2AD3E448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356874 mRNA. Translation: AAM00220.1.
AY040765 Genomic DNA. Translation: AAK94774.1.
AK004497 mRNA. Translation: BAB23334.1.
CCDSiCCDS18106.1.
RefSeqiNP_081147.1. NM_026871.1.
UniGeneiMm.25285.

Genome annotation databases

EnsembliENSMUST00000030192; ENSMUSP00000030192; ENSMUSG00000028470.
GeneIDi68917.
KEGGimmu:68917.
UCSCiuc008sqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356874 mRNA. Translation: AAM00220.1.
AY040765 Genomic DNA. Translation: AAK94774.1.
AK004497 mRNA. Translation: BAB23334.1.
CCDSiCCDS18106.1.
RefSeqiNP_081147.1. NM_026871.1.
UniGeneiMm.25285.

3D structure databases

ProteinModelPortaliQ9D0S9.
SMRiQ9D0S9. Positions 63-163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D0S9. 3 interactions.
MINTiMINT-1605434.
STRINGi10090.ENSMUSP00000030192.

PTM databases

iPTMnetiQ9D0S9.
PhosphoSiteiQ9D0S9.

Proteomic databases

EPDiQ9D0S9.
MaxQBiQ9D0S9.
PaxDbiQ9D0S9.
PRIDEiQ9D0S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030192; ENSMUSP00000030192; ENSMUSG00000028470.
GeneIDi68917.
KEGGimmu:68917.
UCSCiuc008sqs.1. mouse.

Organism-specific databases

CTDi84681.
MGIiMGI:1916167. Hint2.

Phylogenomic databases

eggNOGiKOG3275. Eukaryota.
COG0537. LUCA.
GeneTreeiENSGT00510000046448.
HOGENOMiHOG000061064.
HOVERGENiHBG051906.
InParanoidiQ9D0S9.
OMAiNVAKQES.
OrthoDBiEOG091G1001.
PhylomeDBiQ9D0S9.
TreeFamiTF314862.

Miscellaneous databases

PROiQ9D0S9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028470.
CleanExiMM_HINT2.
ExpressionAtlasiQ9D0S9. baseline and differential.
GenevisibleiQ9D0S9. MM.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR019808. Histidine_triad_CS.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR23089. PTHR23089. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
PRINTSiPR00332. HISTRIAD.
SUPFAMiSSF54197. SSF54197. 1 hit.
PROSITEiPS00892. HIT_1. 1 hit.
PS51084. HIT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHINT2_MOUSE
AccessioniPrimary (citable) accession number: Q9D0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.