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Protein

Probable ATP-dependent RNA helicase DDX56

Gene

Ddx56

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 58ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX56 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent 61 kDa nucleolar RNA helicase
DEAD box protein 56
Gene namesi
Name:Ddx56
Synonyms:D11Ertd619e, Noh61
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277172. Ddx56.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550591 – 546Probable ATP-dependent RNA helicase DDX56Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei141PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0R4.
MaxQBiQ9D0R4.
PaxDbiQ9D0R4.
PRIDEiQ9D0R4.

PTM databases

iPTMnetiQ9D0R4.
PhosphoSitePlusiQ9D0R4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000004393.
CleanExiMM_DDX56.
ExpressionAtlasiQ9D0R4. baseline and differential.
GenevisibleiQ9D0R4. MM.

Interactioni

Subunit structurei

May form homooligomeric complexes.

Protein-protein interaction databases

BioGridi206632. 3 interactors.
CORUMiQ9D0R4.
IntActiQ9D0R4. 1 interactor.
STRINGi10090.ENSMUSP00000004507.

Structurei

3D structure databases

ProteinModelPortaliQ9D0R4.
SMRiQ9D0R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 218Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST181
Domaini230 – 424Helicase C-terminalPROSITE-ProRule annotationAdd BLAST195

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 35Q motifAdd BLAST29
Motifi166 – 169DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0346. Eukaryota.
ENOG410XR15. LUCA.
GeneTreeiENSGT00550000074946.
HOGENOMiHOG000253015.
HOVERGENiHBG051334.
InParanoidiQ9D0R4.
KOiK14810.
OMAiRYRMEDA.
OrthoDBiEOG091G04UR.
PhylomeDBiQ9D0R4.
TreeFamiTF300620.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D0R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDQEALGFE HMGLDPRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR
60 70 80 90 100
ARTGSGKTAA YAIPMLQSLL HKKATGPVME QAVRGLVLVP TKELARQAQA
110 120 130 140 150
MIQQLAAYCA RDVRVANVSA AEDSASQRAV LMEKPDVVVG TPSRVLSHLQ
160 170 180 190 200
QNTLKLRDSL ELLVVDEADL LFSFGFEDEL KSLLCHLPRI YQAFLMSATF
210 220 230 240 250
NEDVQTLKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET EEDKFLLLYA
260 270 280 290 300
LLKLSLIRGK ALLFVNTLER GYRLRLFLEQ FSIPSCVLNG ELPLRSRCHI
310 320 330 340 350
ISQFNQGLYD CVIATDAEIL GPQVKGKRRG RGSKGNKASD PESGVARGID
360 370 380 390 400
FHHVSAVLNF DLPPTAEAYV HRAGRTARAN NPGIVLTFVL PAEQPFLGKI
410 420 430 440 450
EDLLSGEGEA PILLPYQFQM EEIESFRYRC RDAMRSVTKQ AIREARLKEI
460 470 480 490 500
KEELLHSEKL KTYFEDNPRD LQLLRHDLPL HPAVVKPHLG HVPDYLVPAA
510 520 530 540
LRGLVHPRKK RRKVPFSRKA KKVKAQNPLR DFKHRGKKPK PAAKPS
Length:546
Mass (Da):61,212
Last modified:June 1, 2001 - v1
Checksum:i3C19F7354C29F9A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011136 mRNA. Translation: BAB27426.1.
AK077514 mRNA. Translation: BAC36839.1.
BC018291 mRNA. Translation: AAH18291.1.
CCDSiCCDS24414.1.
RefSeqiNP_080814.1. NM_026538.3.
UniGeneiMm.29810.

Genome annotation databases

EnsembliENSMUST00000004507; ENSMUSP00000004507; ENSMUSG00000004393.
GeneIDi52513.
KEGGimmu:52513.
UCSCiuc007hyc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiDDX56_MOUSE
AccessioniPrimary (citable) accession number: Q9D0R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families