Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9D0P5 (PYGO1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pygopus homolog 1
Gene names
Name:Pygo1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in signal transduction through the Wnt pathway By similarity.

Subunit structure

Binds to BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1 By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 PHD-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Pygopus homolog 1
PRO_0000097122

Regions

Zinc finger338 – 39659PHD-type
Motif35 – 417Nuclear localization signal Potential
Compositional bias50 – 13586Pro-rich
Compositional bias153 – 305153Asn-rich

Secondary structure

1 ................ 417
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9D0P5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 614023BD83221F86

FASTA41745,090
        10         20         30         40         50         60 
MSAEQDKEPI ALKRVRGGDS GLDGLGGPNI QLGSPDKKKR KANTQGSSFP PLSEYAPPPN 

        70         80         90        100        110        120 
PNSDHLVAAN PFDDSYNTIS YKPLPSSNPY LGPGYPGFGG YSTFRMPPHV PPRMSSPYCG 

       130        140        150        160        170        180 
PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP HDNSNFGNPP YNNVLTQDIN MPGQHFRQGS 

       190        200        210        220        230        240 
AENFSQIPPQ NVGQVSNPDL ASNFAPGNNS NFTSPLETNH SFIPPPNAFG QAKAPLPKQD 

       250        260        270        280        290        300 
FTQGATKTPN QNSSTHPPHL NMEDPVNQSN VELKNVNRNN VVQENSRSGS AEATNNHANG 

       310        320        330        340        350        360 
TQNKPRQPRG AADLCTPDKS RKFSLLPSRH GHSSSDPVYP CGICTNEVND DQDAILCEAS 

       370        380        390        400        410 
CQKWFHRICT GMTETAYGLL TAEASAVWGC DTCMADKDVQ LMRTREAFGP PAVGGDA

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK011208 mRNA. Translation: BAB27468.1.
IPIIPI00132827.
RefSeqNP_082392.1. NM_028116.2.
UniGeneMm.273605.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DX8X-ray2.70A/B330-396[»]
2YYRX-ray2.50A/B330-396[»]
ProteinModelPortalQ9D0P5.
SMRQ9D0P5. Positions 339-395.
ModBaseSearch...

PTM databases

PhosphoSiteQ9D0P5.

Proteomic databases

PRIDEQ9D0P5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038489; ENSMUSP00000044368; ENSMUSG00000034910.
GeneID72135.
KEGGmmu:72135.

Organism-specific databases

CTD26108.
MGIMGI:1919385. Pygo1.

Phylogenomic databases

eggNOGNOG72798.
GeneTreeENSGT00530000063948.
HOGENOMHOG000001580.
HOVERGENHBG053774.
InParanoidQ9D0P5.
OMASAVWGCD.
OrthoDBEOG43BMP0.

Gene expression databases

ArrayExpressQ9D0P5.
BgeeQ9D0P5.
CleanExMM_PYGO1.
GenevestigatorQ9D0P5.
GermOnlineENSMUSG00000034910. Mus musculus.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9D0P5.
NextBio335528.
SOURCESearch...

Entry information

Entry namePYGO1_MOUSE
AccessionPrimary (citable) accession number: Q9D0P5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents