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Protein

Pygopus homolog 1

Gene

Pygo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri338 – 396PHD-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • kidney development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • post-embryonic development Source: MGI
  • protein localization to nucleus Source: MGI
  • spermatid development Source: MGI
  • spermatid nucleus differentiation Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 1
Gene namesi
Name:Pygo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919385 Pygo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971221 – 417Pygopus homolog 1Add BLAST417

Proteomic databases

PaxDbiQ9D0P5
PRIDEiQ9D0P5

PTM databases

iPTMnetiQ9D0P5
PhosphoSitePlusiQ9D0P5

Expressioni

Gene expression databases

BgeeiENSMUSG00000034910
CleanExiMM_PYGO1
ExpressionAtlasiQ9D0P5 baseline and differential
GenevisibleiQ9D0P5 MM

Interactioni

Subunit structurei

Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ebd1Q9W0N93EBI-8607760,EBI-141287From Drosophila melanogaster.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215174, 6 interactors
IntActiQ9D0P5, 3 interactors
MINTiQ9D0P5
STRINGi10090.ENSMUSP00000044368

Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni342 – 344Combined sources3
Beta strandi354 – 356Combined sources3
Turni358 – 361Combined sources4
Beta strandi364 – 366Combined sources3
Helixi367 – 370Combined sources4
Helixi374 – 382Combined sources9
Beta strandi386 – 388Combined sources3
Helixi391 – 394Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DX8X-ray2.70A/B330-396[»]
2YYRX-ray2.50A/B330-396[»]
ProteinModelPortaliQ9D0P5
SMRiQ9D0P5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0P5

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni339 – 386Interaction with H3K4me2By similarityAdd BLAST48
Regioni371 – 389Interaction with BCL9By similarityAdd BLAST19

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 41Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 135Pro-richAdd BLAST86
Compositional biasi153 – 305Asn-richAdd BLAST153

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri338 – 396PHD-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IDYF Eukaryota
ENOG4111FFC LUCA
GeneTreeiENSGT00530000063948
HOGENOMiHOG000001580
HOVERGENiHBG053774
InParanoidiQ9D0P5
OMAiPVYPCGI
OrthoDBiEOG091G0KKH
PhylomeDBiQ9D0P5
TreeFamiTF333020

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQDKEPI ALKRVRGGDS GLDGLGGPNI QLGSPDKKKR KANTQGSSFP
60 70 80 90 100
PLSEYAPPPN PNSDHLVAAN PFDDSYNTIS YKPLPSSNPY LGPGYPGFGG
110 120 130 140 150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP
160 170 180 190 200
HDNSNFGNPP YNNVLTQDIN MPGQHFRQGS AENFSQIPPQ NVGQVSNPDL
210 220 230 240 250
ASNFAPGNNS NFTSPLETNH SFIPPPNAFG QAKAPLPKQD FTQGATKTPN
260 270 280 290 300
QNSSTHPPHL NMEDPVNQSN VELKNVNRNN VVQENSRSGS AEATNNHANG
310 320 330 340 350
TQNKPRQPRG AADLCTPDKS RKFSLLPSRH GHSSSDPVYP CGICTNEVND
360 370 380 390 400
DQDAILCEAS CQKWFHRICT GMTETAYGLL TAEASAVWGC DTCMADKDVQ
410
LMRTREAFGP PAVGGDA
Length:417
Mass (Da):45,090
Last modified:June 1, 2001 - v1
Checksum:i614023BD83221F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011208 mRNA Translation: BAB27468.1
CCDSiCCDS23332.1
RefSeqiNP_082392.1, NM_028116.2
UniGeneiMm.273605

Genome annotation databases

EnsembliENSMUST00000038489; ENSMUSP00000044368; ENSMUSG00000034910
GeneIDi72135
KEGGimmu:72135
UCSCiuc009qqi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPYGO1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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