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Protein

Pygopus homolog 1

Gene

Pygo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri338 – 39659PHD-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • kidney development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • post-embryonic development Source: MGI
  • protein localization to nucleus Source: MGI
  • spermatid development Source: MGI
  • spermatid nucleus differentiation Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 1
Gene namesi
Name:Pygo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1919385. Pygo1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Pygopus homolog 1PRO_0000097122Add
BLAST

Proteomic databases

MaxQBiQ9D0P5.
PaxDbiQ9D0P5.
PRIDEiQ9D0P5.

PTM databases

iPTMnetiQ9D0P5.
PhosphoSiteiQ9D0P5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034910.
CleanExiMM_PYGO1.
ExpressionAtlasiQ9D0P5. baseline and differential.
GenevisibleiQ9D0P5. MM.

Interactioni

Subunit structurei

Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Found in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ebd1Q9W0N93EBI-8607760,EBI-141287From a different organism.

Protein-protein interaction databases

BioGridi215174. 6 interactions.
IntActiQ9D0P5. 3 interactions.
MINTiMINT-8177753.
STRINGi10090.ENSMUSP00000044368.

Structurei

Secondary structure

1
417
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni342 – 3443Combined sources
Beta strandi354 – 3563Combined sources
Turni358 – 3614Combined sources
Beta strandi364 – 3663Combined sources
Helixi367 – 3704Combined sources
Helixi374 – 3829Combined sources
Beta strandi386 – 3883Combined sources
Helixi391 – 3944Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DX8X-ray2.70A/B330-396[»]
2YYRX-ray2.50A/B330-396[»]
ProteinModelPortaliQ9D0P5.
SMRiQ9D0P5. Positions 339-395.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0P5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 38648Interaction with H3K4me2By similarityAdd
BLAST
Regioni371 – 38919Interaction with BCL9By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 417Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 13586Pro-richAdd
BLAST
Compositional biasi153 – 305153Asn-richAdd
BLAST

Sequence similaritiesi

Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri338 – 39659PHD-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IDYF. Eukaryota.
ENOG4111FFC. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9D0P5.
OMAiSAVWGCD.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9D0P5.
TreeFamiTF333020.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEQDKEPI ALKRVRGGDS GLDGLGGPNI QLGSPDKKKR KANTQGSSFP
60 70 80 90 100
PLSEYAPPPN PNSDHLVAAN PFDDSYNTIS YKPLPSSNPY LGPGYPGFGG
110 120 130 140 150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP
160 170 180 190 200
HDNSNFGNPP YNNVLTQDIN MPGQHFRQGS AENFSQIPPQ NVGQVSNPDL
210 220 230 240 250
ASNFAPGNNS NFTSPLETNH SFIPPPNAFG QAKAPLPKQD FTQGATKTPN
260 270 280 290 300
QNSSTHPPHL NMEDPVNQSN VELKNVNRNN VVQENSRSGS AEATNNHANG
310 320 330 340 350
TQNKPRQPRG AADLCTPDKS RKFSLLPSRH GHSSSDPVYP CGICTNEVND
360 370 380 390 400
DQDAILCEAS CQKWFHRICT GMTETAYGLL TAEASAVWGC DTCMADKDVQ
410
LMRTREAFGP PAVGGDA
Length:417
Mass (Da):45,090
Last modified:June 1, 2001 - v1
Checksum:i614023BD83221F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011208 mRNA. Translation: BAB27468.1.
CCDSiCCDS23332.1.
RefSeqiNP_082392.1. NM_028116.2.
UniGeneiMm.273605.

Genome annotation databases

EnsembliENSMUST00000038489; ENSMUSP00000044368; ENSMUSG00000034910.
GeneIDi72135.
KEGGimmu:72135.
UCSCiuc009qqi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011208 mRNA. Translation: BAB27468.1.
CCDSiCCDS23332.1.
RefSeqiNP_082392.1. NM_028116.2.
UniGeneiMm.273605.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DX8X-ray2.70A/B330-396[»]
2YYRX-ray2.50A/B330-396[»]
ProteinModelPortaliQ9D0P5.
SMRiQ9D0P5. Positions 339-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215174. 6 interactions.
IntActiQ9D0P5. 3 interactions.
MINTiMINT-8177753.
STRINGi10090.ENSMUSP00000044368.

PTM databases

iPTMnetiQ9D0P5.
PhosphoSiteiQ9D0P5.

Proteomic databases

MaxQBiQ9D0P5.
PaxDbiQ9D0P5.
PRIDEiQ9D0P5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038489; ENSMUSP00000044368; ENSMUSG00000034910.
GeneIDi72135.
KEGGimmu:72135.
UCSCiuc009qqi.1. mouse.

Organism-specific databases

CTDi26108.
MGIiMGI:1919385. Pygo1.

Phylogenomic databases

eggNOGiENOG410IDYF. Eukaryota.
ENOG4111FFC. LUCA.
GeneTreeiENSGT00530000063948.
HOGENOMiHOG000001580.
HOVERGENiHBG053774.
InParanoidiQ9D0P5.
OMAiSAVWGCD.
OrthoDBiEOG091G0KKH.
PhylomeDBiQ9D0P5.
TreeFamiTF333020.

Enzyme and pathway databases

ReactomeiR-MMU-201722. Formation of the beta-catenin:TCF transactivating complex.
R-MMU-3769402. Deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

EvolutionaryTraceiQ9D0P5.
PROiQ9D0P5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034910.
CleanExiMM_PYGO1.
ExpressionAtlasiQ9D0P5. baseline and differential.
GenevisibleiQ9D0P5. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPYGO1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.