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Protein

Transmembrane protein 88

Gene

Tmem88

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity).By similarity

GO - Molecular functioni

  • PDZ domain binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 88
Gene namesi
Name:Tmem88
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914270. Tmem88.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002517081 – 159Transmembrane protein 88Add BLAST159

Proteomic databases

PaxDbiQ9D0N8.
PRIDEiQ9D0N8.

PTM databases

iPTMnetiQ9D0N8.
PhosphoSitePlusiQ9D0N8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045377.
CleanExiMM_TMEM88.
GenevisibleiQ9D0N8. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with DVL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dvl1P511412EBI-6136970,EBI-1538407

GO - Molecular functioni

  • PDZ domain binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

IntActiQ9D0N8. 1 interactor.
STRINGi10090.ENSMUSP00000055528.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM88 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZIZ. Eukaryota.
ENOG41121G3. LUCA.
GeneTreeiENSGT00510000047877.
HOGENOMiHOG000118356.
HOVERGENiHBG095158.
InParanoidiQ9D0N8.
OMAiLCHSKFL.
OrthoDBiEOG091G11O8.
PhylomeDBiQ9D0N8.
TreeFamiTF332743.

Family and domain databases

InterProiView protein in InterPro
IPR033355. TMEM88.
IPR033354. TMEM88A.
PANTHERiPTHR28628. PTHR28628. 1 hit.
PTHR28628:SF3. PTHR28628:SF3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D0N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVPGAQRP VLAGGPEPRD PLDCWACAVL VTAQNLLVAV FNLLLLALVL
60 70 80 90 100
GTILLPAVIM LGFGFLCHSQ FLRSQAPLCT SHLRDPGFTA LLVTGFLLLV
110 120 130 140 150
PLLVLALATY RRLCLRLRLA DCLVPYSRAL YRRRRIPQPK QIPVSPGSRS

VPTPGKVWV
Length:159
Mass (Da):17,358
Last modified:June 1, 2001 - v1
Checksum:i2988D626F2C13C36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64G → S in BAC32239 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045149 mRNA. Translation: BAC32239.1.
AK011240 mRNA. Translation: BAB27488.1.
AK161789 mRNA. Translation: BAE36575.1.
AL596125 Genomic DNA. Translation: CAI35995.1.
BC100316 mRNA. Translation: AAI00317.1.
BC120912 mRNA. Translation: AAI20913.1.
CCDSiCCDS24894.1.
RefSeqiNP_080191.3. NM_025915.4.
UniGeneiMm.390406.

Genome annotation databases

EnsembliENSMUST00000050140; ENSMUSP00000055528; ENSMUSG00000045377.
GeneIDi67020.
KEGGimmu:67020.
UCSCiuc007jqc.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTMM88_MOUSE
AccessioniPrimary (citable) accession number: Q9D0N8
Secondary accession number(s): Q497Z2, Q8BRC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families