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Protein

Cytochrome c1, heme protein, mitochondrial

Gene

Cyc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211Heme (covalent)
Binding sitei124 – 1241Heme (covalent)
Metal bindingi125 – 1251Iron (heme axial ligand)
Metal bindingi244 – 2441Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4
Complex III subunit IV
Cytochrome b-c1 complex subunit 4
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit
Short name:
Cytochrome c-1
Gene namesi
Name:Cyc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913695. Cyc1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei292 – 30615Helical; Note=Anchors to the membraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8484MitochondrionBy similarityAdd
BLAST
Chaini85 – 325241Cytochrome c1, heme protein, mitochondrialPRO_0000006555Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Proteomic databases

MaxQBiQ9D0M3.
PaxDbiQ9D0M3.
PeptideAtlasiQ9D0M3.
PRIDEiQ9D0M3.
TopDownProteomicsiQ9D0M3-1. [Q9D0M3-1]

PTM databases

iPTMnetiQ9D0M3.
PhosphoSiteiQ9D0M3.
SwissPalmiQ9D0M3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022551.
CleanExiMM_CYC1.
GenevisibleiQ9D0M3. MM.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Protein-protein interaction databases

BioGridi211479. 1 interaction.
IntActiQ9D0M3. 14 interactions.
MINTiMINT-1860602.
STRINGi10090.ENSMUSP00000023210.

Structurei

3D structure databases

ProteinModelPortaliQ9D0M3.
SMRiQ9D0M3. Positions 85-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 209102Cytochrome cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c family.Curated
Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
GeneTreeiENSGT00390000012445.
HOGENOMiHOG000003867.
HOVERGENiHBG001239.
InParanoidiQ9D0M3.
KOiK00413.
OMAiKMLLMMG.
OrthoDBiEOG091G0FT2.
PhylomeDBiQ9D0M3.
TreeFamiTF314799.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0M3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAASLRR TVLGPRGVGL PGASAPGLLG GARSRQLPLR TPQAVSLSSK
60 70 80 90 100
SGPSRGRKVM LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG
110 120 130 140 150
LLSSLDHTSI RRGFQVYKQV CSSCHSMDYV AYRHLVGVCY TEEEAKALAE
160 170 180 190 200
EVEVQDGPND DGEMFMRPGK LSDYFPKPYP NPEAARAANN GALPPDLSYI
210 220 230 240 250
VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ AIGMAPPIYT
260 270 280 290 300
EVLEYDDGTP ATMSQVAKDV ATFLRWASEP EHDHRKRMGL KMLLMMGLLL
310 320
PLTYAMKRHK WSVLKSRKLA YRPPK
Length:325
Mass (Da):35,328
Last modified:June 1, 2001 - v1
Checksum:i5F7DD8B78677E9BF
GO
Isoform 2 (identifier: Q9D0M3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:266
Mass (Da):29,498
Checksum:iA01018037C1561B5
GO

Sequence cautioni

The sequence AAH82790 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441A → R in BAB22380 (PubMed:16141072).Curated
Sequence conflicti318 – 3181K → R in BAB22380 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 2. 2 PublicationsVSP_025056Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002815 mRNA. Translation: BAB22380.1.
AK011288 mRNA. Translation: BAB27518.1.
AK151299 mRNA. Translation: BAE30282.1.
AK170272 mRNA. Translation: BAE41677.1.
BC005620 mRNA. Translation: AAH05620.1.
BC082790 mRNA. Translation: AAH82790.1. Different initiation.
CCDSiCCDS27567.1. [Q9D0M3-1]
RefSeqiNP_079843.1. NM_025567.2. [Q9D0M3-1]
UniGeneiMm.29196.

Genome annotation databases

EnsembliENSMUST00000023210; ENSMUSP00000023210; ENSMUSG00000022551. [Q9D0M3-1]
GeneIDi66445.
KEGGimmu:66445.
UCSCiuc007wjs.1. mouse. [Q9D0M3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002815 mRNA. Translation: BAB22380.1.
AK011288 mRNA. Translation: BAB27518.1.
AK151299 mRNA. Translation: BAE30282.1.
AK170272 mRNA. Translation: BAE41677.1.
BC005620 mRNA. Translation: AAH05620.1.
BC082790 mRNA. Translation: AAH82790.1. Different initiation.
CCDSiCCDS27567.1. [Q9D0M3-1]
RefSeqiNP_079843.1. NM_025567.2. [Q9D0M3-1]
UniGeneiMm.29196.

3D structure databases

ProteinModelPortaliQ9D0M3.
SMRiQ9D0M3. Positions 85-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211479. 1 interaction.
IntActiQ9D0M3. 14 interactions.
MINTiMINT-1860602.
STRINGi10090.ENSMUSP00000023210.

PTM databases

iPTMnetiQ9D0M3.
PhosphoSiteiQ9D0M3.
SwissPalmiQ9D0M3.

Proteomic databases

MaxQBiQ9D0M3.
PaxDbiQ9D0M3.
PeptideAtlasiQ9D0M3.
PRIDEiQ9D0M3.
TopDownProteomicsiQ9D0M3-1. [Q9D0M3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023210; ENSMUSP00000023210; ENSMUSG00000022551. [Q9D0M3-1]
GeneIDi66445.
KEGGimmu:66445.
UCSCiuc007wjs.1. mouse. [Q9D0M3-1]

Organism-specific databases

CTDi1537.
MGIiMGI:1913695. Cyc1.

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
GeneTreeiENSGT00390000012445.
HOGENOMiHOG000003867.
HOVERGENiHBG001239.
InParanoidiQ9D0M3.
KOiK00413.
OMAiKMLLMMG.
OrthoDBiEOG091G0FT2.
PhylomeDBiQ9D0M3.
TreeFamiTF314799.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.

Miscellaneous databases

PROiQ9D0M3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022551.
CleanExiMM_CYC1.
GenevisibleiQ9D0M3. MM.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0M3
Secondary accession number(s): Q3TDC5
, Q3UAN2, Q63ZW4, Q9DCG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.