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Q9D0M1

- KPRA_MOUSE

UniProt

Q9D0M1 - KPRA_MOUSE

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Protein

Phosphoribosyl pyrophosphate synthase-associated protein 1

Gene

Prpsap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.By similarity

GO - Molecular functioni

  1. enzyme regulator activity Source: Ensembl
  2. magnesium ion binding Source: InterPro
  3. ribose phosphate diphosphokinase activity Source: InterPro

GO - Biological processi

  1. negative regulation of kinase activity Source: Ensembl
  2. nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Nucleotide biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl pyrophosphate synthase-associated protein 1
Short name:
PRPP synthase-associated protein 1
Alternative name(s):
39 kDa phosphoribosypyrophosphate synthase-associated protein
Short name:
PAP39
Gene namesi
Name:Prpsap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915013. Prpsap1.

Subcellular locationi

GO - Cellular componenti

  1. ribose phosphate diphosphokinase complex Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Phosphoribosyl pyrophosphate synthase-associated protein 1PRO_0000141080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei215 – 2151PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D0M1.
PaxDbiQ9D0M1.
PRIDEiQ9D0M1.

PTM databases

PhosphoSiteiQ9D0M1.

Expressioni

Gene expression databases

BgeeiQ9D0M1.
ExpressionAtlasiQ9D0M1. baseline and differential.
GenevestigatoriQ9D0M1.

Interactioni

Subunit structurei

Binds to PRPS1 and PRPS2.By similarity

Protein-protein interaction databases

BioGridi212425. 1 interaction.
DIPiDIP-59971N.
MINTiMINT-1857384.
STRINGi10090.ENSMUSP00000101999.

Structurei

3D structure databases

ProteinModelPortaliQ9D0M1.
SMRiQ9D0M1. Positions 7-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0462.
HOGENOMiHOG000210451.
HOVERGENiHBG001520.
InParanoidiQ9D0M1.

Family and domain databases

Gene3Di3.40.50.2020. 2 hits.
InterProiIPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 2 hits.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D0M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAARTGYRV FSANSTAACT ELAKRITERL GAELGKSVVY QETNGETRVE
60 70 80 90 100
IKESVRGQDI FIIQTIPRDV NTAVMELLIM AYALKTACAR NIIGVIPYFP
110 120 130 140 150
YSKQSKMRKR GSIVCKLLAS MLAKAGLTHI ITMDLHQKEI QGFFSFPVDN
160 170 180 190 200
LRASPFLLQY IQEEIPNYRN AVIVAKSPDA AKRAQSYAER LRLGLAVIHG
210 220 230 240 250
EAQCTELDMD DGRHSPPMVK NATVHPGLEL PLMMAKEKPP ITVVGDVGGR
260 270 280 290 300
IAIIVDDIID DVESFVAAAE ILKERGAYKI YVMATHGILS AEAPRLIEES
310 320 330 340 350
PIDEVVVTNT VPHELQKLQC PKIKTVDISL ILSEAIRRIH NGESMAYLFR

NITVDD
Length:356
Mass (Da):39,432
Last modified:June 1, 2001 - v1
Checksum:i0BCEA75BFE55401E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011290 mRNA. Translation: BAB27520.1.
BC029621 mRNA. Translation: AAH29621.1.
RefSeqiNP_080640.1. NM_026364.1.
UniGeneiMm.25125.

Genome annotation databases

GeneIDi67763.
KEGGimmu:67763.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011290 mRNA. Translation: BAB27520.1 .
BC029621 mRNA. Translation: AAH29621.1 .
RefSeqi NP_080640.1. NM_026364.1.
UniGenei Mm.25125.

3D structure databases

ProteinModelPortali Q9D0M1.
SMRi Q9D0M1. Positions 7-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212425. 1 interaction.
DIPi DIP-59971N.
MINTi MINT-1857384.
STRINGi 10090.ENSMUSP00000101999.

PTM databases

PhosphoSitei Q9D0M1.

Proteomic databases

MaxQBi Q9D0M1.
PaxDbi Q9D0M1.
PRIDEi Q9D0M1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 67763.
KEGGi mmu:67763.

Organism-specific databases

CTDi 5635.
MGIi MGI:1915013. Prpsap1.

Phylogenomic databases

eggNOGi COG0462.
HOGENOMi HOG000210451.
HOVERGENi HBG001520.
InParanoidi Q9D0M1.

Miscellaneous databases

ChiTaRSi Prpsap1. mouse.
NextBioi 325497.
PROi Q9D0M1.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0M1.
ExpressionAtlasi Q9D0M1. baseline and differential.
Genevestigatori Q9D0M1.

Family and domain databases

Gene3Di 3.40.50.2020. 2 hits.
InterProi IPR029099. Pribosyltran_N.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view ]
Pfami PF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 2 hits.
TIGRFAMsi TIGR01251. ribP_PPkin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKPRA_MOUSE
AccessioniPrimary (citable) accession number: Q9D0M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3