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Protein

Armadillo repeat-containing protein 10

Gene

Armc10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 10
Gene namesi
Name:Armc10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914461. Armc10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Armadillo repeat-containing protein 10PRO_0000297708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei48 – 481PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0L7.
MaxQBiQ9D0L7.
PaxDbiQ9D0L7.
PRIDEiQ9D0L7.

PTM databases

iPTMnetiQ9D0L7.
PhosphoSiteiQ9D0L7.
SwissPalmiQ9D0L7.

Expressioni

Gene expression databases

BgeeiQ9D0L7.
CleanExiMM_ARMC10.
ExpressionAtlasiQ9D0L7. baseline and differential.
GenevisibleiQ9D0L7. MM.

Interactioni

Subunit structurei

Interacts with the DNA-binding domain of p53/TP53.By similarity

Protein-protein interaction databases

IntActiQ9D0L7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9D0L7.
SMRiQ9D0L7. Positions 77-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 14343ARMAdd
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9D0L7.
OMAiLHGEECA.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ9D0L7.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGARDVGWV AAGLVLGAGA CYCIYRLTRG PRRGGRRLRP SRSAEDLTDG
60 70 80 90 100
SYDDILNAEQ LKKLLYLLES TDDPVITEKA LVTLGNNAAF STNQAIIREL
110 120 130 140 150
GGIPIVGNKI NSLNQSIKEK ALNALNNLSV NVENQTKIKI YVPQVCEDVF
160 170 180 190 200
ADPLNSAVQL AGLRLLTNMT VTNDYQHLLS GSVAGLFHLL LLGNGSTKVQ
210 220 230 240 250
VLKLLLNLSE NPAMTEGLLS VQVDSSFLSL YDGQVANEIL LRALTLFQNI
260 270 280 290 300
NNCLKVEGRL ANQIPFAKGS LFFLLYGEEC AQKMRALACH HDVDVKEKAL

AIKPKF
Length:306
Mass (Da):33,311
Last modified:June 1, 2001 - v1
Checksum:i127912DC336B4E04
GO
Isoform 2 (identifier: Q9D0L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-57: Missing.

Show »
Length:292
Mass (Da):31,788
Checksum:iFB67989CEFE9B0EE
GO

Sequence cautioni

The sequence BAB29775.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741P → T in BAB29775 (PubMed:16141072).Curated
Sequence conflicti191 – 1911L → P in BAB28526 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 5714Missing in isoform 2. 1 PublicationVSP_027363Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011303 mRNA. Translation: BAB27529.1.
AK012872 mRNA. Translation: BAB28526.1.
AK015272 mRNA. Translation: BAB29775.1. Frameshift.
BC038487 mRNA. Translation: AAH38487.1.
BC046281 mRNA. Translation: AAH46281.2.
BC058573 mRNA. Translation: AAH58573.1.
CCDSiCCDS19104.1. [Q9D0L7-1]
RefSeqiNP_080310.1. NM_026034.4. [Q9D0L7-1]
UniGeneiMm.260782.

Genome annotation databases

EnsembliENSMUST00000072896; ENSMUSP00000072669; ENSMUSG00000038525. [Q9D0L7-1]
ENSMUST00000148873; ENSMUSP00000120269; ENSMUSG00000038525. [Q9D0L7-2]
GeneIDi67211.
KEGGimmu:67211.
UCSCiuc008wos.1. mouse. [Q9D0L7-1]
uc008wot.1. mouse. [Q9D0L7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011303 mRNA. Translation: BAB27529.1.
AK012872 mRNA. Translation: BAB28526.1.
AK015272 mRNA. Translation: BAB29775.1. Frameshift.
BC038487 mRNA. Translation: AAH38487.1.
BC046281 mRNA. Translation: AAH46281.2.
BC058573 mRNA. Translation: AAH58573.1.
CCDSiCCDS19104.1. [Q9D0L7-1]
RefSeqiNP_080310.1. NM_026034.4. [Q9D0L7-1]
UniGeneiMm.260782.

3D structure databases

ProteinModelPortaliQ9D0L7.
SMRiQ9D0L7. Positions 77-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D0L7. 1 interaction.

PTM databases

iPTMnetiQ9D0L7.
PhosphoSiteiQ9D0L7.
SwissPalmiQ9D0L7.

Proteomic databases

EPDiQ9D0L7.
MaxQBiQ9D0L7.
PaxDbiQ9D0L7.
PRIDEiQ9D0L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072896; ENSMUSP00000072669; ENSMUSG00000038525. [Q9D0L7-1]
ENSMUST00000148873; ENSMUSP00000120269; ENSMUSG00000038525. [Q9D0L7-2]
GeneIDi67211.
KEGGimmu:67211.
UCSCiuc008wos.1. mouse. [Q9D0L7-1]
uc008wot.1. mouse. [Q9D0L7-2]

Organism-specific databases

CTDi83787.
MGIiMGI:1914461. Armc10.

Phylogenomic databases

eggNOGiENOG410IVCU. Eukaryota.
ENOG4112958. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG080349.
InParanoidiQ9D0L7.
OMAiLHGEECA.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ9D0L7.
TreeFamiTF335652.

Miscellaneous databases

PROiQ9D0L7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D0L7.
CleanExiMM_ARMC10.
ExpressionAtlasiQ9D0L7. baseline and differential.
GenevisibleiQ9D0L7. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N and FVB/N-3.
    Tissue: Colon and Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND THR-48, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiARM10_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L7
Secondary accession number(s): Q80ZY2, Q9CUN3, Q9CZ87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.