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Q9D0L6 (BAMBI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Putative transmembrane protein NMA
Gene names
Name:Bambi
Synonyms:Nma
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negatively regulates TGF-beta signaling By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Developmental stage

Expressed at high levels during odontogenesis. Ref.1

Sequence similarities

Belongs to the BAMBI family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of catenin import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial to mesenchymal transition

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta receptor signaling pathway

Inferred from sequence alignment PubMed 11165491. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from sequence alignment PubMed 11165491. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 260234BMP and activin membrane-bound inhibitor homolog
PRO_0000020780

Regions

Topological domain27 – 152126Extracellular Potential
Transmembrane153 – 17321Helical; Potential
Topological domain174 – 26087Cytoplasmic Potential

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict261G → E in AAK60413. Ref.1
Sequence conflict116 – 1183SKS → PRG in AAK60413. Ref.1
Sequence conflict1381K → N in AAK60413. Ref.1
Sequence conflict1801N → I in AAK60413. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D0L6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3C27915AFA112693

FASTA26029,198
        10         20         30         40         50         60 
MDRHSSYFFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN 

        70         80         90        100        110        120 
TNSPLTHGCL DSLASTADIC RAKQAQNHSG PAMPTLECCH EDMCNYRGLH DVLSPSKSEA 

       130        140        150        160        170        180 
SGQGNRYQHD SSRNLITKMQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN 

       190        200        210        220        230        240 
KRLQDERQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQAELSNE 

       250        260 
KILSLVHWGM YSGHGKLEFI 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis."
Knight C., Simmons D., Gu T.T., Gluhak-Heinrich J., Pavlin D., Zeichner-David M., MacDougall M.
J. Dent. Res. 80:1895-1902(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Strain: Swiss Webster.
Tissue: Tooth.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF153440 mRNA. Translation: AAK60413.1.
AK011305 mRNA. Translation: BAB27531.1.
AK045192 mRNA. Translation: BAC32256.1.
AK164632 mRNA. Translation: BAE37852.1.
BC019378 mRNA. Translation: AAH19378.1.
RefSeqNP_080781.1. NM_026505.2.
UniGeneMm.284863.

3D structure databases

ProteinModelPortalQ9D0L6.
SMRQ9D0L6. Positions 27-115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9D0L6. 1 interaction.

PTM databases

PhosphoSiteQ9D0L6.

Proteomic databases

PRIDEQ9D0L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232.
GeneID68010.
KEGGmmu:68010.
UCSCuc008dyc.1. mouse.

Organism-specific databases

CTD25805.
MGIMGI:1915260. Bambi.

Phylogenomic databases

eggNOGNOG46186.
GeneTreeENSGT00390000014168.
HOGENOMHOG000095174.
HOVERGENHBG050659.
InParanoidQ9D0L6.
KOK10162.
OMAAKQAQNH.
OrthoDBEOG7CZK6Q.
PhylomeDBQ9D0L6.
TreeFamTF333466.

Gene expression databases

BgeeQ9D0L6.
GenevestigatorQ9D0L6.

Family and domain databases

InterProIPR009345. BMP/activin_membr-bound_inhib.
[Graphical view]
PANTHERPTHR15505. PTHR15505. 1 hit.
PfamPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFPIRSF037456. BAMBI. 1 hit.
ProtoNetSearch...

Other

ChiTaRSBAMBI. mouse.
NextBio326192.
PROQ9D0L6.
SOURCESearch...

Entry information

Entry nameBAMBI_MOUSE
AccessionPrimary (citable) accession number: Q9D0L6
Secondary accession number(s): Q3TP85, Q91XS6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot