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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

Bambi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates TGF-beta signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_294789. Downregulation of TGF-beta receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homolog
Alternative name(s):
Putative transmembrane protein NMA
Gene namesi
Name:Bambi
Synonyms:Nma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1915260. Bambi.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 152126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Topological domaini174 – 26087CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 260234BMP and activin membrane-bound inhibitor homologPRO_0000020780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9D0L6.

PTM databases

PhosphoSiteiQ9D0L6.

Expressioni

Developmental stagei

Expressed at high levels during odontogenesis.1 Publication

Gene expression databases

BgeeiQ9D0L6.
GenevestigatoriQ9D0L6.

Interactioni

Protein-protein interaction databases

IntActiQ9D0L6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9D0L6.
SMRiQ9D0L6. Positions 27-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BAMBI family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46186.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ9D0L6.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ9D0L6.
TreeFamiTF333466.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRHSSYFFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN TNSPLTHGCL DSLASTADIC RAKQAQNHSG PAMPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLSPSKSEA SGQGNRYQHD SSRNLITKMQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDERQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQAELSNE KILSLVHWGM
260
YSGHGKLEFI
Length:260
Mass (Da):29,198
Last modified:June 1, 2001 - v1
Checksum:i3C27915AFA112693
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261G → E in AAK60413 (PubMed:11706948).Curated
Sequence conflicti116 – 1183SKS → PRG in AAK60413 (PubMed:11706948).Curated
Sequence conflicti138 – 1381K → N in AAK60413 (PubMed:11706948).Curated
Sequence conflicti180 – 1801N → I in AAK60413 (PubMed:11706948).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153440 mRNA. Translation: AAK60413.1.
AK011305 mRNA. Translation: BAB27531.1.
AK045192 mRNA. Translation: BAC32256.1.
AK164632 mRNA. Translation: BAE37852.1.
BC019378 mRNA. Translation: AAH19378.1.
CCDSiCCDS29034.1.
RefSeqiNP_080781.1. NM_026505.2.
UniGeneiMm.284863.

Genome annotation databases

EnsembliENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232.
GeneIDi68010.
KEGGimmu:68010.
UCSCiuc008dyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153440 mRNA. Translation: AAK60413.1.
AK011305 mRNA. Translation: BAB27531.1.
AK045192 mRNA. Translation: BAC32256.1.
AK164632 mRNA. Translation: BAE37852.1.
BC019378 mRNA. Translation: AAH19378.1.
CCDSiCCDS29034.1.
RefSeqiNP_080781.1. NM_026505.2.
UniGeneiMm.284863.

3D structure databases

ProteinModelPortaliQ9D0L6.
SMRiQ9D0L6. Positions 27-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D0L6. 1 interaction.

PTM databases

PhosphoSiteiQ9D0L6.

Proteomic databases

PRIDEiQ9D0L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232.
GeneIDi68010.
KEGGimmu:68010.
UCSCiuc008dyc.1. mouse.

Organism-specific databases

CTDi25805.
MGIiMGI:1915260. Bambi.

Phylogenomic databases

eggNOGiNOG46186.
GeneTreeiENSGT00390000014168.
HOGENOMiHOG000095174.
HOVERGENiHBG050659.
InParanoidiQ9D0L6.
KOiK10162.
OMAiAKQAQNH.
OrthoDBiEOG7CZK6Q.
PhylomeDBiQ9D0L6.
TreeFamiTF333466.

Enzyme and pathway databases

ReactomeiREACT_294789. Downregulation of TGF-beta receptor signaling.

Miscellaneous databases

ChiTaRSiBambi. mouse.
NextBioi326192.
PROiQ9D0L6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D0L6.
GenevestigatoriQ9D0L6.

Family and domain databases

InterProiIPR009345. BAMBI.
[Graphical view]
PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
PfamiPF06211. BAMBI. 1 hit.
[Graphical view]
PIRSFiPIRSF037456. BAMBI. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis."
    Knight C., Simmons D., Gu T.T., Gluhak-Heinrich J., Pavlin D., Zeichner-David M., MacDougall M.
    J. Dent. Res. 80:1895-1902(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Strain: Swiss Webster.
    Tissue: Tooth.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBAMBI_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L6
Secondary accession number(s): Q3TP85, Q91XS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.