Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9D0L6

- BAMBI_MOUSE

UniProt

Q9D0L6 - BAMBI_MOUSE

Protein

BMP and activin membrane-bound inhibitor homolog

Gene

Bambi

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Negatively regulates TGF-beta signaling.By similarity

    GO - Biological processi

    1. cell migration Source: Ensembl
    2. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    3. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    4. positive regulation of catenin import into nucleus Source: Ensembl
    5. positive regulation of cell proliferation Source: Ensembl
    6. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    7. positive regulation of protein binding Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: Ensembl
    9. regulation of cell shape Source: Ensembl
    10. transforming growth factor beta receptor signaling pathway Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_215733. Downregulation of TGF-beta receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BMP and activin membrane-bound inhibitor homolog
    Alternative name(s):
    Putative transmembrane protein NMA
    Gene namesi
    Name:Bambi
    Synonyms:Nma
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1915260. Bambi.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 260234BMP and activin membrane-bound inhibitor homologPRO_0000020780Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9D0L6.

    PTM databases

    PhosphoSiteiQ9D0L6.

    Expressioni

    Developmental stagei

    Expressed at high levels during odontogenesis.1 Publication

    Gene expression databases

    BgeeiQ9D0L6.
    GenevestigatoriQ9D0L6.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9D0L6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D0L6.
    SMRiQ9D0L6. Positions 27-115.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 152126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 26087CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BAMBI family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46186.
    GeneTreeiENSGT00390000014168.
    HOGENOMiHOG000095174.
    HOVERGENiHBG050659.
    InParanoidiQ9D0L6.
    KOiK10162.
    OMAiREVIKTH.
    OrthoDBiEOG7CZK6Q.
    PhylomeDBiQ9D0L6.
    TreeFamiTF333466.

    Family and domain databases

    InterProiIPR009345. BAMBI.
    [Graphical view]
    PANTHERiPTHR15505:SF0. PTHR15505:SF0. 1 hit.
    PfamiPF06211. BAMBI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037456. BAMBI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D0L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRHSSYFFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA    50
    CFSRLLDPQN TNSPLTHGCL DSLASTADIC RAKQAQNHSG PAMPTLECCH 100
    EDMCNYRGLH DVLSPSKSEA SGQGNRYQHD SSRNLITKMQ ELTSSKELWF 150
    RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDERQQM LSRLHYSFHG 200
    HHSKKGQVAK LDLECMVPVS GQENCCLTCD KMRQAELSNE KILSLVHWGM 250
    YSGHGKLEFI 260
    Length:260
    Mass (Da):29,198
    Last modified:June 1, 2001 - v1
    Checksum:i3C27915AFA112693
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261G → E in AAK60413. (PubMed:11706948)Curated
    Sequence conflicti116 – 1183SKS → PRG in AAK60413. (PubMed:11706948)Curated
    Sequence conflicti138 – 1381K → N in AAK60413. (PubMed:11706948)Curated
    Sequence conflicti180 – 1801N → I in AAK60413. (PubMed:11706948)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153440 mRNA. Translation: AAK60413.1.
    AK011305 mRNA. Translation: BAB27531.1.
    AK045192 mRNA. Translation: BAC32256.1.
    AK164632 mRNA. Translation: BAE37852.1.
    BC019378 mRNA. Translation: AAH19378.1.
    CCDSiCCDS29034.1.
    RefSeqiNP_080781.1. NM_026505.2.
    UniGeneiMm.284863.

    Genome annotation databases

    EnsembliENSMUST00000025075; ENSMUSP00000025075; ENSMUSG00000024232.
    GeneIDi68010.
    KEGGimmu:68010.
    UCSCiuc008dyc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153440 mRNA. Translation: AAK60413.1 .
    AK011305 mRNA. Translation: BAB27531.1 .
    AK045192 mRNA. Translation: BAC32256.1 .
    AK164632 mRNA. Translation: BAE37852.1 .
    BC019378 mRNA. Translation: AAH19378.1 .
    CCDSi CCDS29034.1.
    RefSeqi NP_080781.1. NM_026505.2.
    UniGenei Mm.284863.

    3D structure databases

    ProteinModelPortali Q9D0L6.
    SMRi Q9D0L6. Positions 27-115.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D0L6. 1 interaction.

    PTM databases

    PhosphoSitei Q9D0L6.

    Proteomic databases

    PRIDEi Q9D0L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025075 ; ENSMUSP00000025075 ; ENSMUSG00000024232 .
    GeneIDi 68010.
    KEGGi mmu:68010.
    UCSCi uc008dyc.1. mouse.

    Organism-specific databases

    CTDi 25805.
    MGIi MGI:1915260. Bambi.

    Phylogenomic databases

    eggNOGi NOG46186.
    GeneTreei ENSGT00390000014168.
    HOGENOMi HOG000095174.
    HOVERGENi HBG050659.
    InParanoidi Q9D0L6.
    KOi K10162.
    OMAi REVIKTH.
    OrthoDBi EOG7CZK6Q.
    PhylomeDBi Q9D0L6.
    TreeFami TF333466.

    Enzyme and pathway databases

    Reactomei REACT_215733. Downregulation of TGF-beta receptor signaling.

    Miscellaneous databases

    ChiTaRSi BAMBI. mouse.
    NextBioi 326192.
    PROi Q9D0L6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D0L6.
    Genevestigatori Q9D0L6.

    Family and domain databases

    InterProi IPR009345. BAMBI.
    [Graphical view ]
    PANTHERi PTHR15505:SF0. PTHR15505:SF0. 1 hit.
    Pfami PF06211. BAMBI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037456. BAMBI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis."
      Knight C., Simmons D., Gu T.T., Gluhak-Heinrich J., Pavlin D., Zeichner-David M., MacDougall M.
      J. Dent. Res. 80:1895-1902(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Strain: Swiss Webster.
      Tissue: Tooth.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiBAMBI_MOUSE
    AccessioniPrimary (citable) accession number: Q9D0L6
    Secondary accession number(s): Q3TP85, Q91XS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3