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Q9D0L4

- ADCK1_MOUSE

UniProt

Q9D0L4 - ADCK1_MOUSE

Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

Adck1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei176 – 1761ATPPROSITE-ProRule annotation
    Active sitei308 – 3081Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi154 – 1629ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
    Gene namesi
    Name:Adck1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1919363. Adck1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 525508Uncharacterized aarF domain-containing protein kinase 1PRO_0000252250Add
    BLAST

    Proteomic databases

    MaxQBiQ9D0L4.
    PaxDbiQ9D0L4.
    PRIDEiQ9D0L4.

    PTM databases

    PhosphoSiteiQ9D0L4.

    Expressioni

    Gene expression databases

    BgeeiQ9D0L4.
    CleanExiMM_ADCK1.
    GenevestigatoriQ9D0L4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D0L4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini148 – 477330Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0661.
    GeneTreeiENSGT00550000074734.
    HOGENOMiHOG000240338.
    HOVERGENiHBG056527.
    InParanoidiQ9D0L4.
    KOiK08869.
    OMAiIWTDMKR.
    OrthoDBiEOG7RBZ82.
    PhylomeDBiQ9D0L4.
    TreeFamiTF314889.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR004147. UbiB_dom.
    [Graphical view]
    PfamiPF03109. ABC1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D0L4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARKALKLAS WTSVALAASG VYLYSNNYLD PNDFGAVRVG RAVATTAVIS    50
    YDYLTSLRSV PYGSEEYLQR RSQVHLRSAR RLFELCCANR GTFIKVGQHL 100
    GALDYLLPEE YTSTLKVLHS QAPQSSMQEV RQVIREDLGK EIHDLFLSFD 150
    DTPLGAASLA QVHKAVLHDG RTVAVKVQHP KVQAQSSKDI LLMEVLVLAV 200
    KQLFPDFEFM WLVDEAKKNL PLELDFLNEG RNAEKVAHML RHFDFLKVPQ 250
    IHWELSTKRV LLMEFVEGGQ VNDRAYMEKN QIDVNEISCH LGKMYSEMIF 300
    VNGFVHCDPH PGNVLVRKRP DTGKAEIVLL DHGLYQVLTE EFRLDYCHLW 350
    QSLIWTDMDG LKQYSQRLGA ADLYPLFACM LTARSWDSVK QGIGQAPVSA 400
    TEDSEIRNNA ACYLPEISQL LNHVPRQMLL ILKTNDLLRS IETTLGTRSS 450
    ASSFLNMSRC CIRALAEHKK RDAGSFFRRT QISFSEAFSL WQINLHELLL 500
    RVRALRLACW VSALLGWLTR APHRM 525
    Length:525
    Mass (Da):59,736
    Last modified:June 1, 2001 - v1
    Checksum:i26947FCC43CDB967
    GO
    Isoform 2 (identifier: Q9D0L4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-192: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:333
    Mass (Da):38,452
    Checksum:i01171AB481D38B6B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 192192Missing in isoform 2. 1 PublicationVSP_020886Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011310 mRNA. Translation: BAB27536.1.
    AK050868 mRNA. Translation: BAC34439.1.
    AK145987 mRNA. Translation: BAE26809.1.
    AK154839 mRNA. Translation: BAE32867.1.
    BC010539 mRNA. Translation: AAH10539.1.
    CCDSiCCDS26087.1. [Q9D0L4-1]
    RefSeqiNP_001264225.1. NM_001277296.1. [Q9D0L4-1]
    NP_001264226.1. NM_001277297.1. [Q9D0L4-1]
    NP_082381.1. NM_028105.4. [Q9D0L4-1]
    UniGeneiMm.181387.
    Mm.333139.

    Genome annotation databases

    EnsembliENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044. [Q9D0L4-1]
    ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044. [Q9D0L4-1]
    GeneIDi72113.
    KEGGimmu:72113.
    UCSCiuc007oju.1. mouse. [Q9D0L4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011310 mRNA. Translation: BAB27536.1 .
    AK050868 mRNA. Translation: BAC34439.1 .
    AK145987 mRNA. Translation: BAE26809.1 .
    AK154839 mRNA. Translation: BAE32867.1 .
    BC010539 mRNA. Translation: AAH10539.1 .
    CCDSi CCDS26087.1. [Q9D0L4-1 ]
    RefSeqi NP_001264225.1. NM_001277296.1. [Q9D0L4-1 ]
    NP_001264226.1. NM_001277297.1. [Q9D0L4-1 ]
    NP_082381.1. NM_028105.4. [Q9D0L4-1 ]
    UniGenei Mm.181387.
    Mm.333139.

    3D structure databases

    ProteinModelPortali Q9D0L4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D0L4.

    Proteomic databases

    MaxQBi Q9D0L4.
    PaxDbi Q9D0L4.
    PRIDEi Q9D0L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101165 ; ENSMUSP00000098724 ; ENSMUSG00000021044 . [Q9D0L4-1 ]
    ENSMUST00000166940 ; ENSMUSP00000127254 ; ENSMUSG00000021044 . [Q9D0L4-1 ]
    GeneIDi 72113.
    KEGGi mmu:72113.
    UCSCi uc007oju.1. mouse. [Q9D0L4-1 ]

    Organism-specific databases

    CTDi 57143.
    MGIi MGI:1919363. Adck1.

    Phylogenomic databases

    eggNOGi COG0661.
    GeneTreei ENSGT00550000074734.
    HOGENOMi HOG000240338.
    HOVERGENi HBG056527.
    InParanoidi Q9D0L4.
    KOi K08869.
    OMAi IWTDMKR.
    OrthoDBi EOG7RBZ82.
    PhylomeDBi Q9D0L4.
    TreeFami TF314889.

    Miscellaneous databases

    NextBioi 335472.
    PROi Q9D0L4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D0L4.
    CleanExi MM_ADCK1.
    Genevestigatori Q9D0L4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR004147. UbiB_dom.
    [Graphical view ]
    Pfami PF03109. ABC1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiADCK1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D0L4
    Secondary accession number(s): Q3UKJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3