Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

Adck1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176ATPPROSITE-ProRule annotation1
Active sitei308Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 162ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:Adck1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919363 Adck1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025225018 – 525Uncharacterized aarF domain-containing protein kinase 1Add BLAST508

Proteomic databases

PaxDbiQ9D0L4
PeptideAtlasiQ9D0L4
PRIDEiQ9D0L4

PTM databases

PhosphoSitePlusiQ9D0L4

Expressioni

Gene expression databases

BgeeiENSMUSG00000021044
CleanExiMM_ADCK1
GenevisibleiQ9D0L4 MM

Interactioni

Protein-protein interaction databases

BioGridi2151601 interactor.
STRINGi10090.ENSMUSP00000098724

Structurei

3D structure databases

ProteinModelPortaliQ9D0L4
SMRiQ9D0L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 477Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1235 Eukaryota
COG0661 LUCA
GeneTreeiENSGT00550000074734
HOGENOMiHOG000240338
HOVERGENiHBG056527
InParanoidiQ9D0L4
KOiK08869
OMAiPYVKGNS
OrthoDBiEOG091G06EF
PhylomeDBiQ9D0L4
TreeFamiTF314889

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR004147 UbiB_dom
PfamiView protein in Pfam
PF03109 ABC1, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0L4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKALKLAS WTSVALAASG VYLYSNNYLD PNDFGAVRVG RAVATTAVIS
60 70 80 90 100
YDYLTSLRSV PYGSEEYLQR RSQVHLRSAR RLFELCCANR GTFIKVGQHL
110 120 130 140 150
GALDYLLPEE YTSTLKVLHS QAPQSSMQEV RQVIREDLGK EIHDLFLSFD
160 170 180 190 200
DTPLGAASLA QVHKAVLHDG RTVAVKVQHP KVQAQSSKDI LLMEVLVLAV
210 220 230 240 250
KQLFPDFEFM WLVDEAKKNL PLELDFLNEG RNAEKVAHML RHFDFLKVPQ
260 270 280 290 300
IHWELSTKRV LLMEFVEGGQ VNDRAYMEKN QIDVNEISCH LGKMYSEMIF
310 320 330 340 350
VNGFVHCDPH PGNVLVRKRP DTGKAEIVLL DHGLYQVLTE EFRLDYCHLW
360 370 380 390 400
QSLIWTDMDG LKQYSQRLGA ADLYPLFACM LTARSWDSVK QGIGQAPVSA
410 420 430 440 450
TEDSEIRNNA ACYLPEISQL LNHVPRQMLL ILKTNDLLRS IETTLGTRSS
460 470 480 490 500
ASSFLNMSRC CIRALAEHKK RDAGSFFRRT QISFSEAFSL WQINLHELLL
510 520
RVRALRLACW VSALLGWLTR APHRM
Length:525
Mass (Da):59,736
Last modified:June 1, 2001 - v1
Checksum:i26947FCC43CDB967
GO
Isoform 2 (identifier: Q9D0L4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,452
Checksum:i01171AB481D38B6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0208861 – 192Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011310 mRNA Translation: BAB27536.1
AK050868 mRNA Translation: BAC34439.1
AK145987 mRNA Translation: BAE26809.1
AK154839 mRNA Translation: BAE32867.1
BC010539 mRNA Translation: AAH10539.1
CCDSiCCDS26087.1 [Q9D0L4-1]
RefSeqiNP_001264225.1, NM_001277296.1 [Q9D0L4-1]
NP_001264226.1, NM_001277297.1 [Q9D0L4-1]
NP_082381.1, NM_028105.4 [Q9D0L4-1]
UniGeneiMm.181387
Mm.333139

Genome annotation databases

EnsembliENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044 [Q9D0L4-1]
ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044 [Q9D0L4-1]
ENSMUST00000222695; ENSMUSP00000152821; ENSMUSG00000021044 [Q9D0L4-1]
GeneIDi72113
KEGGimmu:72113
UCSCiuc007oju.2 mouse [Q9D0L4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADCK1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L4
Secondary accession number(s): Q3UKJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome