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Q9D0L4

- ADCK1_MOUSE

UniProt

Q9D0L4 - ADCK1_MOUSE

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Protein
Uncharacterized aarF domain-containing protein kinase 1
Gene
Adck1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei176 – 1761ATP By similarity
Active sitei308 – 3081Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi154 – 1629ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:Adck1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1919363. Adck1.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 525508Uncharacterized aarF domain-containing protein kinase 1
PRO_0000252250Add
BLAST

Proteomic databases

MaxQBiQ9D0L4.
PaxDbiQ9D0L4.
PRIDEiQ9D0L4.

PTM databases

PhosphoSiteiQ9D0L4.

Expressioni

Gene expression databases

BgeeiQ9D0L4.
CleanExiMM_ADCK1.
GenevestigatoriQ9D0L4.

Structurei

3D structure databases

ProteinModelPortaliQ9D0L4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 477330Protein kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0661.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ9D0L4.
KOiK08869.
OMAiIWTDMKR.
OrthoDBiEOG7RBZ82.
PhylomeDBiQ9D0L4.
TreeFamiTF314889.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D0L4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARKALKLAS WTSVALAASG VYLYSNNYLD PNDFGAVRVG RAVATTAVIS    50
YDYLTSLRSV PYGSEEYLQR RSQVHLRSAR RLFELCCANR GTFIKVGQHL 100
GALDYLLPEE YTSTLKVLHS QAPQSSMQEV RQVIREDLGK EIHDLFLSFD 150
DTPLGAASLA QVHKAVLHDG RTVAVKVQHP KVQAQSSKDI LLMEVLVLAV 200
KQLFPDFEFM WLVDEAKKNL PLELDFLNEG RNAEKVAHML RHFDFLKVPQ 250
IHWELSTKRV LLMEFVEGGQ VNDRAYMEKN QIDVNEISCH LGKMYSEMIF 300
VNGFVHCDPH PGNVLVRKRP DTGKAEIVLL DHGLYQVLTE EFRLDYCHLW 350
QSLIWTDMDG LKQYSQRLGA ADLYPLFACM LTARSWDSVK QGIGQAPVSA 400
TEDSEIRNNA ACYLPEISQL LNHVPRQMLL ILKTNDLLRS IETTLGTRSS 450
ASSFLNMSRC CIRALAEHKK RDAGSFFRRT QISFSEAFSL WQINLHELLL 500
RVRALRLACW VSALLGWLTR APHRM 525
Length:525
Mass (Da):59,736
Last modified:June 1, 2001 - v1
Checksum:i26947FCC43CDB967
GO
Isoform 2 (identifier: Q9D0L4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):38,452
Checksum:i01171AB481D38B6B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 192192Missing in isoform 2.
VSP_020886Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011310 mRNA. Translation: BAB27536.1.
AK050868 mRNA. Translation: BAC34439.1.
AK145987 mRNA. Translation: BAE26809.1.
AK154839 mRNA. Translation: BAE32867.1.
BC010539 mRNA. Translation: AAH10539.1.
CCDSiCCDS26087.1. [Q9D0L4-1]
RefSeqiNP_001264225.1. NM_001277296.1. [Q9D0L4-1]
NP_001264226.1. NM_001277297.1. [Q9D0L4-1]
NP_082381.1. NM_028105.4. [Q9D0L4-1]
UniGeneiMm.181387.
Mm.333139.

Genome annotation databases

EnsembliENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044. [Q9D0L4-1]
ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044. [Q9D0L4-1]
GeneIDi72113.
KEGGimmu:72113.
UCSCiuc007oju.1. mouse. [Q9D0L4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011310 mRNA. Translation: BAB27536.1 .
AK050868 mRNA. Translation: BAC34439.1 .
AK145987 mRNA. Translation: BAE26809.1 .
AK154839 mRNA. Translation: BAE32867.1 .
BC010539 mRNA. Translation: AAH10539.1 .
CCDSi CCDS26087.1. [Q9D0L4-1 ]
RefSeqi NP_001264225.1. NM_001277296.1. [Q9D0L4-1 ]
NP_001264226.1. NM_001277297.1. [Q9D0L4-1 ]
NP_082381.1. NM_028105.4. [Q9D0L4-1 ]
UniGenei Mm.181387.
Mm.333139.

3D structure databases

ProteinModelPortali Q9D0L4.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D0L4.

Proteomic databases

MaxQBi Q9D0L4.
PaxDbi Q9D0L4.
PRIDEi Q9D0L4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101165 ; ENSMUSP00000098724 ; ENSMUSG00000021044 . [Q9D0L4-1 ]
ENSMUST00000166940 ; ENSMUSP00000127254 ; ENSMUSG00000021044 . [Q9D0L4-1 ]
GeneIDi 72113.
KEGGi mmu:72113.
UCSCi uc007oju.1. mouse. [Q9D0L4-1 ]

Organism-specific databases

CTDi 57143.
MGIi MGI:1919363. Adck1.

Phylogenomic databases

eggNOGi COG0661.
GeneTreei ENSGT00550000074734.
HOGENOMi HOG000240338.
HOVERGENi HBG056527.
InParanoidi Q9D0L4.
KOi K08869.
OMAi IWTDMKR.
OrthoDBi EOG7RBZ82.
PhylomeDBi Q9D0L4.
TreeFami TF314889.

Miscellaneous databases

NextBioi 335472.
PROi Q9D0L4.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0L4.
CleanExi MM_ADCK1.
Genevestigatori Q9D0L4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR004147. UbiB_dom.
[Graphical view ]
Pfami PF03109. ABC1. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiADCK1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L4
Secondary accession number(s): Q3UKJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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