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Protein

Uncharacterized aarF domain-containing protein kinase 1

Gene

Adck1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei176ATPPROSITE-ProRule annotation1
Active sitei308Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 162ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized aarF domain-containing protein kinase 1 (EC:2.7.11.-)
Gene namesi
Name:Adck1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919363. Adck1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000025225018 – 525Uncharacterized aarF domain-containing protein kinase 1Add BLAST508

Proteomic databases

PaxDbiQ9D0L4.
PeptideAtlasiQ9D0L4.
PRIDEiQ9D0L4.

PTM databases

PhosphoSitePlusiQ9D0L4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021044.
CleanExiMM_ADCK1.
GenevisibleiQ9D0L4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098724.

Structurei

3D structure databases

ProteinModelPortaliQ9D0L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 477Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1235. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ9D0L4.
KOiK08869.
OMAiKSQVHLR.
OrthoDBiEOG091G06EF.
PhylomeDBiQ9D0L4.
TreeFamiTF314889.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0L4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARKALKLAS WTSVALAASG VYLYSNNYLD PNDFGAVRVG RAVATTAVIS
60 70 80 90 100
YDYLTSLRSV PYGSEEYLQR RSQVHLRSAR RLFELCCANR GTFIKVGQHL
110 120 130 140 150
GALDYLLPEE YTSTLKVLHS QAPQSSMQEV RQVIREDLGK EIHDLFLSFD
160 170 180 190 200
DTPLGAASLA QVHKAVLHDG RTVAVKVQHP KVQAQSSKDI LLMEVLVLAV
210 220 230 240 250
KQLFPDFEFM WLVDEAKKNL PLELDFLNEG RNAEKVAHML RHFDFLKVPQ
260 270 280 290 300
IHWELSTKRV LLMEFVEGGQ VNDRAYMEKN QIDVNEISCH LGKMYSEMIF
310 320 330 340 350
VNGFVHCDPH PGNVLVRKRP DTGKAEIVLL DHGLYQVLTE EFRLDYCHLW
360 370 380 390 400
QSLIWTDMDG LKQYSQRLGA ADLYPLFACM LTARSWDSVK QGIGQAPVSA
410 420 430 440 450
TEDSEIRNNA ACYLPEISQL LNHVPRQMLL ILKTNDLLRS IETTLGTRSS
460 470 480 490 500
ASSFLNMSRC CIRALAEHKK RDAGSFFRRT QISFSEAFSL WQINLHELLL
510 520
RVRALRLACW VSALLGWLTR APHRM
Length:525
Mass (Da):59,736
Last modified:June 1, 2001 - v1
Checksum:i26947FCC43CDB967
GO
Isoform 2 (identifier: Q9D0L4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Note: No experimental confirmation available.
Show »
Length:333
Mass (Da):38,452
Checksum:i01171AB481D38B6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0208861 – 192Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011310 mRNA. Translation: BAB27536.1.
AK050868 mRNA. Translation: BAC34439.1.
AK145987 mRNA. Translation: BAE26809.1.
AK154839 mRNA. Translation: BAE32867.1.
BC010539 mRNA. Translation: AAH10539.1.
CCDSiCCDS26087.1. [Q9D0L4-1]
RefSeqiNP_001264225.1. NM_001277296.1. [Q9D0L4-1]
NP_001264226.1. NM_001277297.1. [Q9D0L4-1]
NP_082381.1. NM_028105.4. [Q9D0L4-1]
UniGeneiMm.181387.
Mm.333139.

Genome annotation databases

EnsembliENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044. [Q9D0L4-1]
ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044. [Q9D0L4-1]
GeneIDi72113.
KEGGimmu:72113.
UCSCiuc007oju.2. mouse. [Q9D0L4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011310 mRNA. Translation: BAB27536.1.
AK050868 mRNA. Translation: BAC34439.1.
AK145987 mRNA. Translation: BAE26809.1.
AK154839 mRNA. Translation: BAE32867.1.
BC010539 mRNA. Translation: AAH10539.1.
CCDSiCCDS26087.1. [Q9D0L4-1]
RefSeqiNP_001264225.1. NM_001277296.1. [Q9D0L4-1]
NP_001264226.1. NM_001277297.1. [Q9D0L4-1]
NP_082381.1. NM_028105.4. [Q9D0L4-1]
UniGeneiMm.181387.
Mm.333139.

3D structure databases

ProteinModelPortaliQ9D0L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098724.

PTM databases

PhosphoSitePlusiQ9D0L4.

Proteomic databases

PaxDbiQ9D0L4.
PeptideAtlasiQ9D0L4.
PRIDEiQ9D0L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044. [Q9D0L4-1]
ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044. [Q9D0L4-1]
GeneIDi72113.
KEGGimmu:72113.
UCSCiuc007oju.2. mouse. [Q9D0L4-1]

Organism-specific databases

CTDi57143.
MGIiMGI:1919363. Adck1.

Phylogenomic databases

eggNOGiKOG1235. Eukaryota.
COG0661. LUCA.
GeneTreeiENSGT00550000074734.
HOGENOMiHOG000240338.
HOVERGENiHBG056527.
InParanoidiQ9D0L4.
KOiK08869.
OMAiKSQVHLR.
OrthoDBiEOG091G06EF.
PhylomeDBiQ9D0L4.
TreeFamiTF314889.

Miscellaneous databases

PROiQ9D0L4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021044.
CleanExiMM_ADCK1.
GenevisibleiQ9D0L4. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamiPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADCK1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L4
Secondary accession number(s): Q3UKJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.