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Q9D0L4 (ADCK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized aarF domain-containing protein kinase 1

EC=2.7.11.-
Gene names
Name:Adck1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the protein kinase superfamily. ADCK protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9D0L4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9D0L4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 525508Uncharacterized aarF domain-containing protein kinase 1
PRO_0000252250

Regions

Domain148 – 477330Protein kinase
Nucleotide binding154 – 1629ATP By similarity

Sites

Active site3081Proton acceptor By similarity
Binding site1761ATP By similarity

Natural variations

Alternative sequence1 – 192192Missing in isoform 2.
VSP_020886

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 26947FCC43CDB967

FASTA52559,736
        10         20         30         40         50         60 
MARKALKLAS WTSVALAASG VYLYSNNYLD PNDFGAVRVG RAVATTAVIS YDYLTSLRSV 

        70         80         90        100        110        120 
PYGSEEYLQR RSQVHLRSAR RLFELCCANR GTFIKVGQHL GALDYLLPEE YTSTLKVLHS 

       130        140        150        160        170        180 
QAPQSSMQEV RQVIREDLGK EIHDLFLSFD DTPLGAASLA QVHKAVLHDG RTVAVKVQHP 

       190        200        210        220        230        240 
KVQAQSSKDI LLMEVLVLAV KQLFPDFEFM WLVDEAKKNL PLELDFLNEG RNAEKVAHML 

       250        260        270        280        290        300 
RHFDFLKVPQ IHWELSTKRV LLMEFVEGGQ VNDRAYMEKN QIDVNEISCH LGKMYSEMIF 

       310        320        330        340        350        360 
VNGFVHCDPH PGNVLVRKRP DTGKAEIVLL DHGLYQVLTE EFRLDYCHLW QSLIWTDMDG 

       370        380        390        400        410        420 
LKQYSQRLGA ADLYPLFACM LTARSWDSVK QGIGQAPVSA TEDSEIRNNA ACYLPEISQL 

       430        440        450        460        470        480 
LNHVPRQMLL ILKTNDLLRS IETTLGTRSS ASSFLNMSRC CIRALAEHKK RDAGSFFRRT 

       490        500        510        520 
QISFSEAFSL WQINLHELLL RVRALRLACW VSALLGWLTR APHRM 

« Hide

Isoform 2 [UniParc].

Checksum: 01171AB481D38B6B
Show »

FASTA33338,452

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK011310 mRNA. Translation: BAB27536.1.
AK050868 mRNA. Translation: BAC34439.1.
AK145987 mRNA. Translation: BAE26809.1.
AK154839 mRNA. Translation: BAE32867.1.
BC010539 mRNA. Translation: AAH10539.1.
RefSeqNP_001264225.1. NM_001277296.1.
NP_001264226.1. NM_001277297.1.
NP_082381.1. NM_028105.4.
UniGeneMm.181387.
Mm.333139.

3D structure databases

ProteinModelPortalQ9D0L4.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9D0L4.

Proteomic databases

PaxDbQ9D0L4.
PRIDEQ9D0L4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000101165; ENSMUSP00000098724; ENSMUSG00000021044. [Q9D0L4-1]
ENSMUST00000166940; ENSMUSP00000127254; ENSMUSG00000021044. [Q9D0L4-1]
GeneID72113.
KEGGmmu:72113.
UCSCuc007oju.1. mouse. [Q9D0L4-1]

Organism-specific databases

CTD57143.
MGIMGI:1919363. Adck1.

Phylogenomic databases

eggNOGCOG0661.
GeneTreeENSGT00550000074734.
HOGENOMHOG000240338.
HOVERGENHBG056527.
InParanoidQ9D0L4.
KOK08869.
OMAIWTDMKR.
OrthoDBEOG7RBZ82.
PhylomeDBQ9D0L4.
TreeFamTF314889.

Gene expression databases

BgeeQ9D0L4.
CleanExMM_ADCK1.
GenevestigatorQ9D0L4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR004147. UbiB_dom.
[Graphical view]
PfamPF03109. ABC1. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335472.
PROQ9D0L4.
SOURCESearch...

Entry information

Entry nameADCK1_MOUSE
AccessionPrimary (citable) accession number: Q9D0L4
Secondary accession number(s): Q3UKJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot