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Protein

Zinc finger BED domain-containing protein 3

Gene

Zbed3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 9563BED-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of protein phosphorylation Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of protein targeting to mitochondrion Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • protein stabilization Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 3
Alternative name(s):
Axin-interacting protein
Gene namesi
Name:Zbed3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1919364. Zbed3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi111 – 1111S → A: Decreases the interaction with AXIN1, GSK3B-mediated beta-catenin phosphorylation, cytoplasmic beta-catenin accumulation and Wnt-mediated transcription activation. 1 Publication
Mutagenesisi113 – 1131T → A: Decreases the interaction with AXIN1, GSK3B-mediated beta-catenin phosphorylation, cytoplasmic beta-catenin accumulation and Wnt-mediated transcription activation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Zinc finger BED domain-containing protein 3PRO_0000421257Add
BLAST

Post-translational modificationi

Dual phosphorylation on serine and tyrosine residues of the cytoplasmic PPPSP motif by GSK3 and CK1 may be required for AXIN1-binding.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D0L1.
PaxDbiQ9D0L1.

2D gel databases

REPRODUCTION-2DPAGEQ9D0L1.

PTM databases

iPTMnetiQ9D0L1.
PhosphoSiteiQ9D0L1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041995.
GenevisibleiQ9D0L1. MM.

Interactioni

Subunit structurei

Interacts (via PPPSP motif) with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.1 Publication

Protein-protein interaction databases

BioGridi215161. 2 interactions.
IntActiQ9D0L1. 2 interactions.
STRINGi10090.ENSMUSP00000044774.

Structurei

3D structure databases

ProteinModelPortaliQ9D0L1.
SMRiQ9D0L1. Positions 37-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili132 – 18554Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi103 – 11311PPPSP motifAdd
BLAST

Sequence similaritiesi

Contains 1 BED-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 9563BED-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXJY. Eukaryota.
ENOG41115R7. LUCA.
GeneTreeiENSGT00390000013530.
HOVERGENiHBG063677.
InParanoidiQ9D0L1.
OMAiAAPEGDW.
OrthoDBiEOG091G0JGE.
PhylomeDBiQ9D0L1.
TreeFamiTF338048.

Family and domain databases

InterProiIPR033546. ZBED3.
IPR003656. Znf_BED.
[Graphical view]
PANTHERiPTHR35827:SF2. PTHR35827:SF2. 1 hit.
SMARTiSM00614. ZnF_BED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSKKPLKIT MEDSRRLNDP AEQGGLCPAP VGPSYSEAWG YFHLDPAQPR
60 70 80 90 100
HRMMSAWATC RLCGLQVGGL PNFQMWTRAL CQHLSDVHLP ELKKSAAPSS
110 120 130 140 150
PTTMPCPPPP SPTMAAEGDW ARLLEQMGEL AMRGSQRELE LERREAALMQ
160 170 180 190 200
AELELERKRQ ALKQEAQSVE QERHQLQVER EALSKWIKKQ SPGAQVPEPP
210 220
SPLPLLPKED PDIHDNNSDN DMVTKVLL
Length:228
Mass (Da):25,609
Last modified:June 1, 2001 - v1
Checksum:i1CB44DD084B895A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011319 mRNA. Translation: BAB27542.1.
AK135692 mRNA. Translation: BAE22613.1.
AK135797 mRNA. Translation: BAE22666.1.
AK162256 mRNA. Translation: BAE36818.1.
AK163367 mRNA. Translation: BAE37318.1.
AC133188 Genomic DNA. No translation available.
CH466567 Genomic DNA. Translation: EDL00907.1.
CH466567 Genomic DNA. Translation: EDL00908.1.
CH466567 Genomic DNA. Translation: EDL00909.1.
BC016263 mRNA. Translation: AAH16263.1.
BC085478 mRNA. Translation: AAH85478.1.
CCDSiCCDS26696.1.
RefSeqiNP_001289467.1. NM_001302538.1.
NP_001289468.1. NM_001302539.1.
NP_082382.1. NM_028106.3.
UniGeneiMm.3774.

Genome annotation databases

EnsembliENSMUST00000045909; ENSMUSP00000044774; ENSMUSG00000041995.
GeneIDi72114.
KEGGimmu:72114.
UCSCiuc007rmg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011319 mRNA. Translation: BAB27542.1.
AK135692 mRNA. Translation: BAE22613.1.
AK135797 mRNA. Translation: BAE22666.1.
AK162256 mRNA. Translation: BAE36818.1.
AK163367 mRNA. Translation: BAE37318.1.
AC133188 Genomic DNA. No translation available.
CH466567 Genomic DNA. Translation: EDL00907.1.
CH466567 Genomic DNA. Translation: EDL00908.1.
CH466567 Genomic DNA. Translation: EDL00909.1.
BC016263 mRNA. Translation: AAH16263.1.
BC085478 mRNA. Translation: AAH85478.1.
CCDSiCCDS26696.1.
RefSeqiNP_001289467.1. NM_001302538.1.
NP_001289468.1. NM_001302539.1.
NP_082382.1. NM_028106.3.
UniGeneiMm.3774.

3D structure databases

ProteinModelPortaliQ9D0L1.
SMRiQ9D0L1. Positions 37-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215161. 2 interactions.
IntActiQ9D0L1. 2 interactions.
STRINGi10090.ENSMUSP00000044774.

PTM databases

iPTMnetiQ9D0L1.
PhosphoSiteiQ9D0L1.

2D gel databases

REPRODUCTION-2DPAGEQ9D0L1.

Proteomic databases

MaxQBiQ9D0L1.
PaxDbiQ9D0L1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045909; ENSMUSP00000044774; ENSMUSG00000041995.
GeneIDi72114.
KEGGimmu:72114.
UCSCiuc007rmg.2. mouse.

Organism-specific databases

CTDi84327.
MGIiMGI:1919364. Zbed3.

Phylogenomic databases

eggNOGiENOG410IXJY. Eukaryota.
ENOG41115R7. LUCA.
GeneTreeiENSGT00390000013530.
HOVERGENiHBG063677.
InParanoidiQ9D0L1.
OMAiAAPEGDW.
OrthoDBiEOG091G0JGE.
PhylomeDBiQ9D0L1.
TreeFamiTF338048.

Miscellaneous databases

ChiTaRSiZbed3. mouse.
PROiQ9D0L1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041995.
GenevisibleiQ9D0L1. MM.

Family and domain databases

InterProiIPR033546. ZBED3.
IPR003656. Znf_BED.
[Graphical view]
PANTHERiPTHR35827:SF2. PTHR35827:SF2. 1 hit.
SMARTiSM00614. ZnF_BED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBED3_MOUSE
AccessioniPrimary (citable) accession number: Q9D0L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.