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Q9D0K1

- PEX13_MOUSE

UniProt

Q9D0K1 - PEX13_MOUSE

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Protein

Peroxisomal membrane protein PEX13

Gene

Pex13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity).By similarity

GO - Molecular functioni

  1. peroxisome targeting sequence binding Source: MGI

GO - Biological processi

  1. cerebral cortex cell migration Source: MGI
  2. fatty acid alpha-oxidation Source: MGI
  3. locomotory behavior Source: MGI
  4. microtubule-based peroxisome localization Source: MGI
  5. neuron migration Source: MGI
  6. protein import into peroxisome matrix, docking Source: MGI
  7. suckling behavior Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX13
Alternative name(s):
Peroxin-13
Gene namesi
Name:Pex13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919379. Pex13.

Subcellular locationi

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: Ensembl
  2. peroxisomal membrane Source: MGI
  3. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Peroxisomal membrane protein PEX13PRO_0000240662Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei356 – 3561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D0K1.
PaxDbiQ9D0K1.
PRIDEiQ9D0K1.

PTM databases

PhosphoSiteiQ9D0K1.

Expressioni

Gene expression databases

BgeeiQ9D0K1.
CleanExiMM_PEX13.
ExpressionAtlasiQ9D0K1. baseline and differential.
GenevestigatoriQ9D0K1.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Structurei

Secondary structure

1
405
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni269 – 2713
Beta strandi272 – 2743
Beta strandi279 – 2835
Beta strandi288 – 2925
Turni306 – 3083
Beta strandi316 – 3249
Beta strandi326 – 3283
Beta strandi333 – 3353
Turni343 – 3464

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WXUNMR-A267-346[»]
ProteinModelPortaliQ9D0K1.
SMRiQ9D0K1. Positions 264-347.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0K1.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 235235LumenalSequence AnalysisAdd
BLAST
Topological domaini257 – 405149CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini274 – 33865SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 6157Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the peroxin-13 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281515.
GeneTreeiENSGT00390000016883.
HOGENOMiHOG000231374.
HOVERGENiHBG053570.
InParanoidiQ9D0K1.
KOiK13344.
OMAiYRRLQWM.
OrthoDBiEOG7VX8W3.
PhylomeDBiQ9D0K1.
TreeFamiTF327117.

Family and domain databases

InterProiIPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF04088. Peroxin-13_N. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASQPPPPPK PWESRRIPGA GPGPGSGPGP TYQSADLGPT LLTRPGQPTL
60 70 80 90 100
TRVPPPILPR PSQQTGSNNV NTFRPAYSSF SSGYGAYGNS FYGSYSPYSY
110 120 130 140 150
GYNGLGFNRL RVDDLPPSRF VQQAEESSRG AFQSIESIVH AFASVSMMMD
160 170 180 190 200
ATFSAVYNSF RAVLDVANHF SRLKIHFTKV FSAFALVRTI RYLYRRLQWM
210 220 230 240 250
MGLRRGSENE DLWAESEGTV ACLSAEDQAT NSAKSWPIFL FFAVILGGPY
260 270 280 290 300
LIWKLLSTHN DEVTDNTNWA SGEDDHVVAR AEYDFVAVSD EEISFRAGDM
310 320 330 340 350
LNLALKEQQP KVRGWLLASL DGQTTGLIPA NYVKILGKRR GRKTIESSTM
360 370 380 390 400
LKQQQSFTNP TLIKGVTTTN PLDEQEAAFE SVFVETNKVS SAPDSTGKNG

DKQDL
Length:405
Mass (Da):44,610
Last modified:June 1, 2001 - v1
Checksum:i4ABF0463211AA466
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771F → C in CAC20705. 1 PublicationCurated
Sequence conflicti200 – 2001M → K in BAC27635. (PubMed:16141072)Curated
Sequence conflicti203 – 2031L → I in CAC20705. 1 PublicationCurated
Sequence conflicti206 – 2061G → S in CAC20705. 1 PublicationCurated
Sequence conflicti227 – 2271D → N in BAE31995. (PubMed:16141072)Curated
Sequence conflicti239 – 2413FLF → ILS in CAC20705. 1 PublicationCurated
Sequence conflicti291 – 2911E → G in BAE31995. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329877 mRNA. Translation: AAK15313.2.
AJ304506 mRNA. Translation: CAC20705.1.
AK011355 mRNA. Translation: BAB27563.1.
AK029099 mRNA. Translation: BAC26296.1.
AK029336 mRNA. Translation: BAC26402.1.
AK031710 mRNA. Translation: BAC27526.1.
AK031975 mRNA. Translation: BAC27635.1.
AK032650 mRNA. Translation: BAC27971.1.
AK153438 mRNA. Translation: BAE31995.1.
AK169148 mRNA. Translation: BAE40927.1.
BC023683 mRNA. Translation: AAH23683.1.
CCDSiCCDS24478.1.
RefSeqiNP_076140.2. NM_023651.4.
UniGeneiMm.286622.
Mm.29536.

Genome annotation databases

EnsembliENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283.
GeneIDi72129.
KEGGimmu:72129.
UCSCiuc007ifj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF329877 mRNA. Translation: AAK15313.2 .
AJ304506 mRNA. Translation: CAC20705.1 .
AK011355 mRNA. Translation: BAB27563.1 .
AK029099 mRNA. Translation: BAC26296.1 .
AK029336 mRNA. Translation: BAC26402.1 .
AK031710 mRNA. Translation: BAC27526.1 .
AK031975 mRNA. Translation: BAC27635.1 .
AK032650 mRNA. Translation: BAC27971.1 .
AK153438 mRNA. Translation: BAE31995.1 .
AK169148 mRNA. Translation: BAE40927.1 .
BC023683 mRNA. Translation: AAH23683.1 .
CCDSi CCDS24478.1.
RefSeqi NP_076140.2. NM_023651.4.
UniGenei Mm.286622.
Mm.29536.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WXU NMR - A 267-346 [» ]
ProteinModelPortali Q9D0K1.
SMRi Q9D0K1. Positions 264-347.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D0K1.

Proteomic databases

MaxQBi Q9D0K1.
PaxDbi Q9D0K1.
PRIDEi Q9D0K1.

Protocols and materials databases

DNASUi 72129.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020523 ; ENSMUSP00000020523 ; ENSMUSG00000020283 .
GeneIDi 72129.
KEGGi mmu:72129.
UCSCi uc007ifj.1. mouse.

Organism-specific databases

CTDi 5194.
MGIi MGI:1919379. Pex13.

Phylogenomic databases

eggNOGi NOG281515.
GeneTreei ENSGT00390000016883.
HOGENOMi HOG000231374.
HOVERGENi HBG053570.
InParanoidi Q9D0K1.
KOi K13344.
OMAi YRRLQWM.
OrthoDBi EOG7VX8W3.
PhylomeDBi Q9D0K1.
TreeFami TF327117.

Miscellaneous databases

EvolutionaryTracei Q9D0K1.
NextBioi 335514.
PROi Q9D0K1.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0K1.
CleanExi MM_PEX13.
ExpressionAtlasi Q9D0K1. baseline and differential.
Genevestigatori Q9D0K1.

Family and domain databases

InterProi IPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF04088. Peroxin-13_N. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes."
    Bjoerkman J., Gould S.J., Crane D.I.
    Genomics 79:162-168(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  2. "Cloning of mouse peroxins."
    Van Veldhoven P.P.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Cerebellum, Embryo and Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Solution structure of the SH3 domain of mouse peroxisomal biogenesis factor 13."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JAN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 267-347.

Entry informationi

Entry nameiPEX13_MOUSE
AccessioniPrimary (citable) accession number: Q9D0K1
Secondary accession number(s): Q3U5T1
, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3