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Protein

Peroxisomal membrane protein PEX13

Gene

Pex13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity).By similarity

GO - Molecular functioni

  • peroxisome targeting sequence binding Source: MGI

GO - Biological processi

  • cerebral cortex cell migration Source: MGI
  • fatty acid alpha-oxidation Source: MGI
  • locomotory behavior Source: MGI
  • microtubule-based peroxisome localization Source: MGI
  • neuron migration Source: MGI
  • protein import into peroxisome matrix, docking Source: MGI
  • suckling behavior Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PEX13
Alternative name(s):
Peroxin-13
Gene namesi
Name:Pex13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919379. Pex13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 235LumenalSequence analysisAdd BLAST235
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 405CytoplasmicSequence analysisAdd BLAST149

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406621 – 405Peroxisomal membrane protein PEX13Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei356PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D0K1.
MaxQBiQ9D0K1.
PaxDbiQ9D0K1.
PeptideAtlasiQ9D0K1.
PRIDEiQ9D0K1.

PTM databases

iPTMnetiQ9D0K1.
PhosphoSitePlusiQ9D0K1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020283.
CleanExiMM_PEX13.
ExpressionAtlasiQ9D0K1. baseline and differential.
GenevisibleiQ9D0K1. MM.

Interactioni

Subunit structurei

Interacts with PEX19.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020523.

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni269 – 271Combined sources3
Beta strandi272 – 274Combined sources3
Beta strandi279 – 283Combined sources5
Beta strandi288 – 292Combined sources5
Turni306 – 308Combined sources3
Beta strandi316 – 324Combined sources9
Beta strandi326 – 328Combined sources3
Beta strandi333 – 335Combined sources3
Turni343 – 346Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WXUNMR-A267-346[»]
ProteinModelPortaliQ9D0K1.
SMRiQ9D0K1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D0K1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 338SH3PROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 61Pro-richAdd BLAST57

Sequence similaritiesi

Belongs to the peroxin-13 family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3875. Eukaryota.
ENOG410XRU7. LUCA.
GeneTreeiENSGT00390000016883.
HOGENOMiHOG000231374.
HOVERGENiHBG053570.
InParanoidiQ9D0K1.
KOiK13344.
OMAiDSTFFAL.
OrthoDBiEOG091G0LMX.
PhylomeDBiQ9D0K1.
TreeFamiTF327117.

Family and domain databases

InterProiView protein in InterPro
IPR007223. Peroxin-13_N.
IPR035463. Pex13.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PANTHERiPTHR19332. PTHR19332. 1 hit.
PfamiView protein in Pfam
PF04088. Peroxin-13_N. 1 hit.
PF14604. SH3_9. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D0K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQPPPPPK PWESRRIPGA GPGPGSGPGP TYQSADLGPT LLTRPGQPTL
60 70 80 90 100
TRVPPPILPR PSQQTGSNNV NTFRPAYSSF SSGYGAYGNS FYGSYSPYSY
110 120 130 140 150
GYNGLGFNRL RVDDLPPSRF VQQAEESSRG AFQSIESIVH AFASVSMMMD
160 170 180 190 200
ATFSAVYNSF RAVLDVANHF SRLKIHFTKV FSAFALVRTI RYLYRRLQWM
210 220 230 240 250
MGLRRGSENE DLWAESEGTV ACLSAEDQAT NSAKSWPIFL FFAVILGGPY
260 270 280 290 300
LIWKLLSTHN DEVTDNTNWA SGEDDHVVAR AEYDFVAVSD EEISFRAGDM
310 320 330 340 350
LNLALKEQQP KVRGWLLASL DGQTTGLIPA NYVKILGKRR GRKTIESSTM
360 370 380 390 400
LKQQQSFTNP TLIKGVTTTN PLDEQEAAFE SVFVETNKVS SAPDSTGKNG

DKQDL
Length:405
Mass (Da):44,610
Last modified:June 1, 2001 - v1
Checksum:i4ABF0463211AA466
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177F → C in CAC20705 (Ref. 2) Curated1
Sequence conflicti200M → K in BAC27635 (PubMed:16141072).Curated1
Sequence conflicti203L → I in CAC20705 (Ref. 2) Curated1
Sequence conflicti206G → S in CAC20705 (Ref. 2) Curated1
Sequence conflicti227D → N in BAE31995 (PubMed:16141072).Curated1
Sequence conflicti239 – 241FLF → ILS in CAC20705 (Ref. 2) Curated3
Sequence conflicti291E → G in BAE31995 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329877 mRNA. Translation: AAK15313.2.
AJ304506 mRNA. Translation: CAC20705.1.
AK011355 mRNA. Translation: BAB27563.1.
AK029099 mRNA. Translation: BAC26296.1.
AK029336 mRNA. Translation: BAC26402.1.
AK031710 mRNA. Translation: BAC27526.1.
AK031975 mRNA. Translation: BAC27635.1.
AK032650 mRNA. Translation: BAC27971.1.
AK153438 mRNA. Translation: BAE31995.1.
AK169148 mRNA. Translation: BAE40927.1.
BC023683 mRNA. Translation: AAH23683.1.
CCDSiCCDS24478.1.
RefSeqiNP_076140.2. NM_023651.4.
UniGeneiMm.286622.
Mm.29536.

Genome annotation databases

EnsembliENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283.
GeneIDi72129.
KEGGimmu:72129.
UCSCiuc007ifj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPEX13_MOUSE
AccessioniPrimary (citable) accession number: Q9D0K1
Secondary accession number(s): Q3U5T1
, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families