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Q9D0K1

- PEX13_MOUSE

UniProt

Q9D0K1 - PEX13_MOUSE

Protein

Peroxisomal membrane protein PEX13

Gene

Pex13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins By similarity.By similarity

    GO - Molecular functioni

    1. peroxisome targeting sequence binding Source: MGI

    GO - Biological processi

    1. cerebral cortex cell migration Source: MGI
    2. fatty acid alpha-oxidation Source: MGI
    3. locomotory behavior Source: MGI
    4. microtubule-based peroxisome localization Source: MGI
    5. neuron migration Source: MGI
    6. protein import into peroxisome matrix, docking Source: MGI
    7. suckling behavior Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PEX13
    Alternative name(s):
    Peroxin-13
    Gene namesi
    Name:Pex13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919379. Pex13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: Ensembl
    2. peroxisomal membrane Source: MGI
    3. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Peroxisomal membrane protein PEX13PRO_0000240662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei356 – 3561Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9D0K1.
    PRIDEiQ9D0K1.

    PTM databases

    PhosphoSiteiQ9D0K1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D0K1.
    BgeeiQ9D0K1.
    CleanExiMM_PEX13.
    GenevestigatoriQ9D0K1.

    Interactioni

    Subunit structurei

    Interacts with PEX19.By similarity

    Structurei

    Secondary structure

    1
    405
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni269 – 2713
    Beta strandi272 – 2743
    Beta strandi279 – 2835
    Beta strandi288 – 2925
    Turni306 – 3083
    Beta strandi316 – 3249
    Beta strandi326 – 3283
    Beta strandi333 – 3353
    Turni343 – 3464

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WXUNMR-A267-346[»]
    ProteinModelPortaliQ9D0K1.
    SMRiQ9D0K1. Positions 264-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9D0K1.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 235235LumenalSequence AnalysisAdd
    BLAST
    Topological domaini257 – 405149CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini274 – 33865SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 6157Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peroxin-13 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281515.
    GeneTreeiENSGT00390000016883.
    HOGENOMiHOG000231374.
    HOVERGENiHBG053570.
    InParanoidiQ9D0K1.
    KOiK13344.
    OMAiYRRLQWM.
    OrthoDBiEOG7VX8W3.
    PhylomeDBiQ9D0K1.
    TreeFamiTF327117.

    Family and domain databases

    InterProiIPR007223. Peroxin-13_N.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF04088. Peroxin-13_N. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D0K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQPPPPPK PWESRRIPGA GPGPGSGPGP TYQSADLGPT LLTRPGQPTL    50
    TRVPPPILPR PSQQTGSNNV NTFRPAYSSF SSGYGAYGNS FYGSYSPYSY 100
    GYNGLGFNRL RVDDLPPSRF VQQAEESSRG AFQSIESIVH AFASVSMMMD 150
    ATFSAVYNSF RAVLDVANHF SRLKIHFTKV FSAFALVRTI RYLYRRLQWM 200
    MGLRRGSENE DLWAESEGTV ACLSAEDQAT NSAKSWPIFL FFAVILGGPY 250
    LIWKLLSTHN DEVTDNTNWA SGEDDHVVAR AEYDFVAVSD EEISFRAGDM 300
    LNLALKEQQP KVRGWLLASL DGQTTGLIPA NYVKILGKRR GRKTIESSTM 350
    LKQQQSFTNP TLIKGVTTTN PLDEQEAAFE SVFVETNKVS SAPDSTGKNG 400
    DKQDL 405
    Length:405
    Mass (Da):44,610
    Last modified:June 1, 2001 - v1
    Checksum:i4ABF0463211AA466
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771F → C in CAC20705. 1 PublicationCurated
    Sequence conflicti200 – 2001M → K in BAC27635. (PubMed:16141072)Curated
    Sequence conflicti203 – 2031L → I in CAC20705. 1 PublicationCurated
    Sequence conflicti206 – 2061G → S in CAC20705. 1 PublicationCurated
    Sequence conflicti227 – 2271D → N in BAE31995. (PubMed:16141072)Curated
    Sequence conflicti239 – 2413FLF → ILS in CAC20705. 1 PublicationCurated
    Sequence conflicti291 – 2911E → G in BAE31995. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329877 mRNA. Translation: AAK15313.2.
    AJ304506 mRNA. Translation: CAC20705.1.
    AK011355 mRNA. Translation: BAB27563.1.
    AK029099 mRNA. Translation: BAC26296.1.
    AK029336 mRNA. Translation: BAC26402.1.
    AK031710 mRNA. Translation: BAC27526.1.
    AK031975 mRNA. Translation: BAC27635.1.
    AK032650 mRNA. Translation: BAC27971.1.
    AK153438 mRNA. Translation: BAE31995.1.
    AK169148 mRNA. Translation: BAE40927.1.
    BC023683 mRNA. Translation: AAH23683.1.
    CCDSiCCDS24478.1.
    RefSeqiNP_076140.2. NM_023651.4.
    UniGeneiMm.286622.
    Mm.29536.

    Genome annotation databases

    EnsembliENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283.
    GeneIDi72129.
    KEGGimmu:72129.
    UCSCiuc007ifj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF329877 mRNA. Translation: AAK15313.2 .
    AJ304506 mRNA. Translation: CAC20705.1 .
    AK011355 mRNA. Translation: BAB27563.1 .
    AK029099 mRNA. Translation: BAC26296.1 .
    AK029336 mRNA. Translation: BAC26402.1 .
    AK031710 mRNA. Translation: BAC27526.1 .
    AK031975 mRNA. Translation: BAC27635.1 .
    AK032650 mRNA. Translation: BAC27971.1 .
    AK153438 mRNA. Translation: BAE31995.1 .
    AK169148 mRNA. Translation: BAE40927.1 .
    BC023683 mRNA. Translation: AAH23683.1 .
    CCDSi CCDS24478.1.
    RefSeqi NP_076140.2. NM_023651.4.
    UniGenei Mm.286622.
    Mm.29536.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WXU NMR - A 267-346 [» ]
    ProteinModelPortali Q9D0K1.
    SMRi Q9D0K1. Positions 264-347.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D0K1.

    Proteomic databases

    PaxDbi Q9D0K1.
    PRIDEi Q9D0K1.

    Protocols and materials databases

    DNASUi 72129.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020523 ; ENSMUSP00000020523 ; ENSMUSG00000020283 .
    GeneIDi 72129.
    KEGGi mmu:72129.
    UCSCi uc007ifj.1. mouse.

    Organism-specific databases

    CTDi 5194.
    MGIi MGI:1919379. Pex13.

    Phylogenomic databases

    eggNOGi NOG281515.
    GeneTreei ENSGT00390000016883.
    HOGENOMi HOG000231374.
    HOVERGENi HBG053570.
    InParanoidi Q9D0K1.
    KOi K13344.
    OMAi YRRLQWM.
    OrthoDBi EOG7VX8W3.
    PhylomeDBi Q9D0K1.
    TreeFami TF327117.

    Miscellaneous databases

    EvolutionaryTracei Q9D0K1.
    NextBioi 335514.
    PROi Q9D0K1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D0K1.
    Bgeei Q9D0K1.
    CleanExi MM_PEX13.
    Genevestigatori Q9D0K1.

    Family and domain databases

    InterProi IPR007223. Peroxin-13_N.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF04088. Peroxin-13_N. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes."
      Bjoerkman J., Gould S.J., Crane D.I.
      Genomics 79:162-168(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    2. "Cloning of mouse peroxins."
      Van Veldhoven P.P.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Cerebellum, Embryo and Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Solution structure of the SH3 domain of mouse peroxisomal biogenesis factor 13."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JAN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 267-347.

    Entry informationi

    Entry nameiPEX13_MOUSE
    AccessioniPrimary (citable) accession number: Q9D0K1
    Secondary accession number(s): Q3U5T1
    , Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3