Q9D0K1 (PEX13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PEX13

Alternative name(s):
Peroxin-13

Gene names

Name:

Pex13

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins By similarity.
Subunit structure	Interacts with PEX19 By similarity.
Subcellular location	Peroxisome membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the peroxin-13 family. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane Peroxisome
Domain	SH3 domain Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cerebral cortex cell migration Inferred from mutant phenotype PubMed 12897163. Source: MGI fatty acid alpha-oxidation Inferred from mutant phenotype PubMed 12897163. Source: MGI locomotory behavior Inferred from mutant phenotype PubMed 12897163. Source: MGI microtubule-based peroxisome localization Inferred from mutant phenotype PubMed 16449325. Source: MGI neuron migration Inferred from mutant phenotype PubMed 12897163. Source: MGI protein import into peroxisome matrix, docking Inferred from mutant phenotype PubMed 12897163. Source: MGI suckling behavior Inferred from mutant phenotype PubMed 12897163. Source: MGI
Cellular_component	integral to peroxisomal membrane Inferred from electronic annotation. Source: Compara peroxisomal membrane Inferred from direct assay PubMed 16449325. Source: MGI
Molecular_function	peroxisome targeting sequence binding Traceable author statement Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 405

405

Peroxisomal membrane protein PEX13

PRO_0000240662

Regions

Topological domain

1 – 235

235

Lumenal Potential

Transmembrane

236 – 256

21

Helical; Potential

Topological domain

257 – 405

149

Cytoplasmic Potential

Domain

274 – 338

65

SH3

Compositional bias

5 – 61

57

Pro-rich

Experimental info

Sequence conflict

177

1

F → C in CAC20705. Ref.2

Sequence conflict

200

1

M → K in BAC27635. Ref.3

Sequence conflict

203

1

L → I in CAC20705. Ref.2

Sequence conflict

206

1

G → S in CAC20705. Ref.2

Sequence conflict

227

1

D → N in BAE31995. Ref.3

Sequence conflict

239 – 241

3

FLF → ILS in CAC20705. Ref.2

Sequence conflict

291

1

E → G in BAE31995. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

405

Helix Strand Turn

Details...

Turn

269 – 271

3

Beta strand

272 – 274

3

Beta strand

279 – 283

5

Beta strand

288 – 292

5

Turn

306 – 308

3

Beta strand

316 – 324

9

Beta strand

326 – 328

3

Beta strand

333 – 335

3

Turn

343 – 346

4

Sequences

	Sequence		Length	Mass (Da)
	Q9D0K1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 4ABF0463211AA466	FASTA	405	44,610
	10 20 30 40 50 60 MASQPPPPPK PWESRRIPGA GPGPGSGPGP TYQSADLGPT LLTRPGQPTL TRVPPPILPR 70 80 90 100 110 120 PSQQTGSNNV NTFRPAYSSF SSGYGAYGNS FYGSYSPYSY GYNGLGFNRL RVDDLPPSRF 130 140 150 160 170 180 VQQAEESSRG AFQSIESIVH AFASVSMMMD ATFSAVYNSF RAVLDVANHF SRLKIHFTKV 190 200 210 220 230 240 FSAFALVRTI RYLYRRLQWM MGLRRGSENE DLWAESEGTV ACLSAEDQAT NSAKSWPIFL 250 260 270 280 290 300 FFAVILGGPY LIWKLLSTHN DEVTDNTNWA SGEDDHVVAR AEYDFVAVSD EEISFRAGDM 310 320 330 340 350 360 LNLALKEQQP KVRGWLLASL DGQTTGLIPA NYVKILGKRR GRKTIESSTM LKQQQSFTNP 370 380 390 400 TLIKGVTTTN PLDEQEAAFE SVFVETNKVS SAPDSTGKNG DKQDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes." Bjoerkman J., Gould S.J., Crane D.I. Genomics 79:162-168(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ.
[2]	"Cloning of mouse peroxins." Van Veldhoven P.P. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Amnion, Cerebellum, Embryo and Testis.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[5]	"Solution structure of the SH3 domain of mouse peroxisomal biogenesis factor 13." RIKEN structural genomics initiative (RSGI) Submitted (JAN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 267-347.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF329877 mRNA. Translation: AAK15313.2.
AJ304506 mRNA. Translation: CAC20705.1.
AK011355 mRNA. Translation: BAB27563.1.
AK029099 mRNA. Translation: BAC26296.1.
AK029336 mRNA. Translation: BAC26402.1.
AK031710 mRNA. Translation: BAC27526.1.
AK031975 mRNA. Translation: BAC27635.1.
AK032650 mRNA. Translation: BAC27971.1.
AK153438 mRNA. Translation: BAE31995.1.
AK169148 mRNA. Translation: BAE40927.1.
BC023683 mRNA. Translation: AAH23683.1.

IPI

IPI00461329.

RefSeq

NP_076140.2. NM_023651.4.
XP_003945941.1. XM_003945892.1.

UniGene

Mm.286622.
Mm.29536.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WXU	NMR	-	A	267-347	[»]

ProteinModelPortal

Q9D0K1.

SMR

Q9D0K1. Positions 264-347.

ModBase

Search...

PTM databases

PhosphoSite

Q9D0K1.

Proteomic databases

PaxDb

Q9D0K1.

PRIDE

Q9D0K1.

Protocols and materials databases

DNASU

72129.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000020523; ENSMUSP00000020523; ENSMUSG00000020283.

GeneID

101056392.
72129.

KEGG

mmu:101056392.
mmu:72129.

Organism-specific databases

CTD

5194.

MGI

MGI:1919379. Pex13.

Phylogenomic databases

eggNOG

NOG281515.

GeneTree

ENSGT00390000016883.

HOGENOM

HOG000231374.

HOVERGEN

HBG053570.

InParanoid

Q9D0K1.

KO

K13344.

OMA

YRRLQWM.

OrthoDB

EOG4VMFG3.

Gene expression databases

ArrayExpress

Q9D0K1.

Bgee

Q9D0K1.

CleanEx

MM_PEX13.

Genevestigator

Q9D0K1.

GermOnline

ENSMUSG00000020283. Mus musculus.

Family and domain databases

InterPro

IPR007223. Peroxin-13_N.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF04088. Peroxin-13_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]

PRINTS

PR00452. SH3DOMAIN.

SMART

SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.

PROSITE

PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9D0K1.

NextBio

335514.

SOURCE

Search...

Entry information

Entry name

PEX13_MOUSE

Accession

Primary (citable) accession number: Q9D0K1
Secondary accession number(s): Q3U5T1 , Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program