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Protein

TBC1 domain family member 7

Gene

Tbc1d7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.1 Publication

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: UniProtKB
  • negative regulation of cilium assembly Source: MGI
  • negative regulation of TOR signaling Source: UniProtKB
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of protein ubiquitination Source: UniProtKB
  • response to growth factor Source: MGI

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-8854214. TBC/RABGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 7
Gene namesi
Name:Tbc1d7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914296. Tbc1d7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080321 – 293TBC1 domain family member 7Add BLAST293

Proteomic databases

PaxDbiQ9D0K0.
PRIDEiQ9D0K0.

PTM databases

PhosphoSitePlusiQ9D0K0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021368.
CleanExiMM_TBC1D7.
GenevisibleiQ9D0K0. MM.

Interactioni

Subunit structurei

Component of the TSC-TBC complex (also named Rhebulator complex), composed of the TSC1-TSC2 heterodimer and TBC1D7. Interacts with TSC1 (via C-terminal half of the coiled-coil domain).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211900. 10 interactors.
IntActiQ9D0K0. 9 interactors.
STRINGi10090.ENSMUSP00000021797.

Structurei

3D structure databases

ProteinModelPortaliQ9D0K0.
SMRiQ9D0K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 231Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

eggNOGiENOG410IHB4. Eukaryota.
ENOG410YME8. LUCA.
GeneTreeiENSGT00390000009122.
HOGENOMiHOG000007897.
HOVERGENiHBG055235.
InParanoidiQ9D0K0.
KOiK20396.
OMAiLQRVWDK.
OrthoDBiEOG091G0I5H.
PhylomeDBiQ9D0K0.
TreeFamiTF323655.

Family and domain databases

InterProiView protein in InterPro
IPR000195. Rab-GTPase-TBC_dom.
IPR035969. Rab-GTPase_TBC_sf.
PfamiView protein in Pfam
PF00566. RabGAP-TBC. 1 hit.
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiView protein in PROSITE
PS50086. TBC_RABGAP. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTDDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLDIE KLCTFSQRFP
60 70 80 90 100
LPSMYRALVW KALLGILPPH HDTHSQVMAY RKDQYHDILH ALTVVRFISD
110 120 130 140 150
ATPQAEVYLR MYQLESGKLP RSPSFPLEPE DEVFLAIAKA MEEMVEDSVD
160 170 180 190 200
CYWISRCFVK QLNNKYRDAL PQLPKAFEQY LNLEDSRLLS HLKTCSAVSK
210 220 230 240 250
LPYDLWFQRC FAGCLPESSL QRVWDKVVSG SCKILVFVAV EILLTFKIKV
260 270 280 290
MALNSAEKIT KFLENIPQDS SDAIVSKAID LWHKHCGTPV HSA
Length:293
Mass (Da):33,826
Last modified:June 1, 2001 - v1
Checksum:iD71D019F574BDA89
GO
Isoform 2 (identifier: Q9D0K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-265: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):29,646
Checksum:iF3505904366763F4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044187228 – 265Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011356 mRNA. Translation: BAB27564.1.
AK156543 mRNA. Translation: BAE33751.1.
CH466546 Genomic DNA. Translation: EDL40988.1.
CH466546 Genomic DNA. Translation: EDL40989.1.
BC125307 mRNA. Translation: AAI25308.1.
BC125309 mRNA. Translation: AAI25310.1.
BC145156 mRNA. Translation: AAI45157.1.
BC145157 mRNA. Translation: AAI45158.1.
CCDSiCCDS26476.1. [Q9D0K0-1]
RefSeqiNP_001239568.1. NM_001252639.1. [Q9D0K0-1]
NP_001239569.1. NM_001252640.1. [Q9D0K0-2]
NP_080211.1. NM_025935.3. [Q9D0K0-1]
UniGeneiMm.269213.
Mm.489645.

Genome annotation databases

EnsembliENSMUST00000021797; ENSMUSP00000021797; ENSMUSG00000021368. [Q9D0K0-1]
ENSMUST00000179852; ENSMUSP00000137280; ENSMUSG00000021368. [Q9D0K0-1]
ENSMUST00000220787; ENSMUSP00000152358; ENSMUSG00000021368. [Q9D0K0-2]
GeneIDi67046.
KEGGimmu:67046.
UCSCiuc007qfu.2. mouse. [Q9D0K0-1]
uc011yyt.2. mouse. [Q9D0K0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTBCD7_MOUSE
AccessioniPrimary (citable) accession number: Q9D0K0
Secondary accession number(s): B7ZNC1, Q05AE0, Q3U0V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot