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Protein

Parathymosin

Gene

Ptms

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Parathymosin
Gene namesi
Name:Ptms
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916452. Ptms.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 101100ParathymosinPRO_0000191633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei5 – 51PhosphoserineCombined sources
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei15 – 151N6-acetyllysineCombined sources
Modified residuei52 – 521PhosphothreonineBy similarity
Modified residuei91 – 911N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0J8.
MaxQBiQ9D0J8.
PaxDbiQ9D0J8.
PeptideAtlasiQ9D0J8.
PRIDEiQ9D0J8.
TopDownProteomicsiQ9D0J8.

PTM databases

iPTMnetiQ9D0J8.
PhosphoSiteiQ9D0J8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030122.
CleanExiMM_PTMS.
GenevisibleiQ9D0J8. MM.

Interactioni

Protein-protein interaction databases

BioGridi213291. 1 interaction.
IntActiQ9D0J8. 1 interaction.
STRINGi10090.ENSMUSP00000032216.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 9055Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J7IP. Eukaryota.
ENOG4111CKZ. LUCA.
GeneTreeiENSGT00730000111656.
HOGENOMiHOG000115773.
InParanoidiQ9D0J8.
OMAiVEEPRSC.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKSVEAAA ELSAKDLKEK KDKVEEKAGR KERKKEVVEE EENGAEEEEE
60 70 80 90 100
ETAEDGEDDD EGDEEDEEEE EEDEGPVRKR TAEEEDEADP KRQKTENGAS

A
Length:101
Mass (Da):11,430
Last modified:January 23, 2007 - v3
Checksum:i5AF9F2A1541A67D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011360 mRNA. Translation: BAB27568.1.
BC052699 mRNA. Translation: AAH52699.1.
CCDSiCCDS39630.1.
RefSeqiNP_081264.1. NM_026988.2.
UniGeneiMm.142187.

Genome annotation databases

EnsembliENSMUST00000032216; ENSMUSP00000032216; ENSMUSG00000030122.
GeneIDi69202.
KEGGimmu:69202.
UCSCiuc009dsm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011360 mRNA. Translation: BAB27568.1.
BC052699 mRNA. Translation: AAH52699.1.
CCDSiCCDS39630.1.
RefSeqiNP_081264.1. NM_026988.2.
UniGeneiMm.142187.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213291. 1 interaction.
IntActiQ9D0J8. 1 interaction.
STRINGi10090.ENSMUSP00000032216.

PTM databases

iPTMnetiQ9D0J8.
PhosphoSiteiQ9D0J8.

Proteomic databases

EPDiQ9D0J8.
MaxQBiQ9D0J8.
PaxDbiQ9D0J8.
PeptideAtlasiQ9D0J8.
PRIDEiQ9D0J8.
TopDownProteomicsiQ9D0J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032216; ENSMUSP00000032216; ENSMUSG00000030122.
GeneIDi69202.
KEGGimmu:69202.
UCSCiuc009dsm.2. mouse.

Organism-specific databases

CTDi5763.
MGIiMGI:1916452. Ptms.

Phylogenomic databases

eggNOGiENOG410J7IP. Eukaryota.
ENOG4111CKZ. LUCA.
GeneTreeiENSGT00730000111656.
HOGENOMiHOG000115773.
InParanoidiQ9D0J8.
OMAiVEEPRSC.

Miscellaneous databases

ChiTaRSiPtms. mouse.
PROiQ9D0J8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030122.
CleanExiMM_PTMS.
GenevisibleiQ9D0J8. MM.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTMS_MOUSE
AccessioniPrimary (citable) accession number: Q9D0J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.