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Protein

Syntaxin-17

Gene

Stx17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-171 Publication
Gene namesi
Name:Stx17Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914977 Stx17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 227CytoplasmicSequence analysisAdd BLAST226
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 253LumenalSequence analysis5
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 301CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102292 – 301Syntaxin-17Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei41N6-acetyllysineBy similarity1
Modified residuei156Phosphotyrosine; by ABL1By similarity1
Modified residuei288PhosphoserineCombined sources1

Post-translational modificationi

Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity). Phosphorylated at Tyr-156 probably by ABL1 (PubMed:23006999).By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0I4
MaxQBiQ9D0I4
PaxDbiQ9D0I4
PeptideAtlasiQ9D0I4
PRIDEiQ9D0I4

PTM databases

iPTMnetiQ9D0I4
PhosphoSitePlusiQ9D0I4

Expressioni

Gene expression databases

BgeeiENSMUSG00000061455
CleanExiMM_STX17
ExpressionAtlasiQ9D0I4 baseline and differential
GenevisibleiQ9D0I4 MM

Interactioni

Subunit structurei

Forms a SNARE complex composed of VAMP8, SNAP29 and STX17 involved in fusion of autophagosome with lysosome (By similarity). May interact with VTI1B (By similarity). Probably interacts with BET1, SCFD1 and SEC22B (By similarity). Interacts with PTPN2 and ABL1; involved in STX17 phosphorylation (By similarity). Interacts with COPB1 (By similarity). Interacts with TMED9 and TMED10; the interaction is direct (By similarity). Interacts with VAMP7 (PubMed:23217709).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D0I4, 2 interactors
STRINGi10090.ENSMUSP00000068087

Structurei

3D structure databases

ProteinModelPortaliQ9D0I4
SMRiQ9D0I4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 223t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni228 – 274Necessary and sufficient for localization to autophagosomeBy similarityAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 128Sequence analysisAdd BLAST80

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi298 – 301Endoplasmic reticulum retention signalSequence analysis4

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00390000013283
HOGENOMiHOG000006905
HOVERGENiHBG055257
InParanoidiQ9D0I4
KOiK08491
OMAiFNVAIPH
OrthoDBiEOG091G127M
PhylomeDBiQ9D0I4
TreeFamiTF323947

Family and domain databases

InterProiView protein in InterPro
IPR010989 SNARE
IPR028676 STX17
IPR006012 Syntaxin/epimorphin_CS
IPR000727 T_SNARE_dom
PANTHERiPTHR19957:SF139 PTHR19957:SF139, 1 hit
SMARTiView protein in SMART
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDEEKVKL RRLEPAIQKF TKIVIPTDLE RLRKHQINIE KYQRCRIWDK
60 70 80 90 100
LHEEHINAGR TVQQLRSNIR EMEKLCLKVH KDDLVLLKRM IDPVKEAAAT
110 120 130 140 150
ATAEFLQLHL ESVEELKKQV NDEELLQPSL TRSTTVDGVL HTGEAEAASQ
160 170 180 190 200
SLTQIYALPE IPQDQNAAES WETLEADLIE LSHLVTDMSL LVSSQQEKID
210 220 230 240 250
SIADHVNSAA VNVEEGTKNL QKAAKYKLAA LPVAGALIGG VVGGPIGLLA
260 270 280 290 300
GFKVAGIAAA LGGGVLGFTG GKLIQRRKQK MMEKLTSSCP DLPSQSDKKR

S
Length:301
Mass (Da):33,221
Last modified:June 1, 2001 - v1
Checksum:i3715C8D747FF7FF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294S → G in BAB31255 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011400 mRNA Translation: BAB27592.1
AK018526 mRNA Translation: BAB31255.1
AK034718 mRNA Translation: BAC28806.1
AK154503 mRNA Translation: BAE32634.1
AL683893 Genomic DNA No translation available.
BC028639 mRNA Translation: AAH28639.1
CCDSiCCDS18164.1
RefSeqiNP_080619.2, NM_026343.2
XP_006538271.1, XM_006538208.1
UniGeneiMm.171334

Genome annotation databases

EnsembliENSMUST00000064765; ENSMUSP00000068087; ENSMUSG00000061455
ENSMUST00000107720; ENSMUSP00000103348; ENSMUSG00000061455
GeneIDi67727
KEGGimmu:67727
UCSCiuc008sux.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSTX17_MOUSE
AccessioniPrimary (citable) accession number: Q9D0I4
Secondary accession number(s): B1AVI3, Q9D330
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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