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Q9D0F3

- LMAN1_MOUSE

UniProt

Q9D0F3 - LMAN1_MOUSE

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Protein

Protein ERGIC-53

Gene

Lman1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961CarbohydratePROSITE-ProRule annotation
Binding sitei129 – 1291CarbohydratePROSITE-ProRule annotation
Metal bindingi160 – 1601CalciumPROSITE-ProRule annotation
Metal bindingi162 – 1621Calcium; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi164 – 1641CalciumPROSITE-ProRule annotation
Binding sitei164 – 1641CarbohydratePROSITE-ProRule annotation
Binding sitei186 – 1861CarbohydratePROSITE-ProRule annotation
Metal bindingi189 – 1891CalciumPROSITE-ProRule annotation
Sitei508 – 5081Required for ER exportBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. endoplasmic reticulum organization Source: MGI
  2. ER to Golgi vesicle-mediated transport Source: MGI
  3. Golgi organization Source: Ensembl
  4. positive regulation of organelle organization Source: Ensembl
  5. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_206143. Transport to the Golgi and subsequent modification.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ERGIC-53
Alternative name(s):
ER-Golgi intermediate compartment 53 kDa protein
Lectin mannose-binding 1
p58
Gene namesi
Name:Lman1
Synonyms:Ergic53
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1917611. Lman1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
  3. ER to Golgi transport vesicle Source: MGI
  4. extracellular vesicular exosome Source: Ensembl
  5. Golgi apparatus Source: MGI
  6. integral component of membrane Source: UniProtKB-KW
  7. sarcomere Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 517487Protein ERGIC-53PRO_0000017661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi198 ↔ 238PROSITE-ProRule annotation
Disulfide bondi473 – 473InterchainPROSITE-ProRule annotation
Disulfide bondi482 – 482InterchainPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9D0F3.
PaxDbiQ9D0F3.
PRIDEiQ9D0F3.

PTM databases

PhosphoSiteiQ9D0F3.

Expressioni

Gene expression databases

BgeeiQ9D0F3.
CleanExiMM_LMAN1.
ExpressionAtlasiQ9D0F3. baseline and differential.
GenevestigatoriQ9D0F3.

Interactioni

Subunit structurei

Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D0F3. 6 interactions.
MINTiMINT-1858436.

Structurei

3D structure databases

ProteinModelPortaliQ9D0F3.
SMRiQ9D0F3. Positions 43-277.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 484454LumenalSequence AnalysisAdd
BLAST
Topological domaini506 – 51712CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei485 – 50521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 275224L-type lectin-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni259 – 2613Carbohydrate bindingPROSITE-ProRule annotation

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi516 – 5172ER export motifBy similarity

Domaini

The FF ER export motif at the C-terminus is not sufficient to support endoplasmic reticulum exit, and needs assistance of Gln-508 for proper recognition of COPII coat components.By similarity

Sequence similaritiesi

Contains 1 L-type lectin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG292314.
GeneTreeiENSGT00530000062977.
HOVERGENiHBG052332.
InParanoidiQ9D0F3.
KOiK10080.
OMAiGTVPFWA.
OrthoDBiEOG7QC7VR.
PhylomeDBiQ9D0F3.
TreeFamiTF313311.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR005052. Lectin_leg.
[Graphical view]
PANTHERiPTHR12223. PTHR12223. 1 hit.
PfamiPF03388. Lectin_leg-like. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51328. L_LECTIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0F3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVSRRRVPQ AGARSFFCAL LLSFSQFTGS DGTGGDAAAP GAAGTQAELP
60 70 80 90 100
HRRFEYKYSF KGPHLVQSDG TVPFWAHAGN AIPSADQIRI APSLKSQRGS
110 120 130 140 150
VWTKAKAAFE NWEVEVTFRV TGRGRIGADG LAIWYTENQG LDGPVFGSAD
160 170 180 190 200
TWNGVGIFFD SFDNDGKKNN PAIVVIGNNG QINYDHQNDG ATQALASCQR
210 220 230 240 250
DFRNKPYPVR AKITYYQKTL TVMINNGFTP DKNDYEFCAK VENMVIPTQG
260 270 280 290 300
HFGISAATGG LADDHDVLSF LTFQLTEPGK EPPTAEKDIS EKEKEKYQEE
310 320 330 340 350
FEHFQQELDK KKEEFQKGHP DLQGQPADDI FESIGDRELR QVFEGQNRIH
360 370 380 390 400
LEIKQLNRQL DMILDEQRRY VSSLTEEISR RGAGTPGQPG QVSQQELDTV
410 420 430 440 450
VKSQQEILRQ VNEVKNSMSE TVRLVSGIQH PGSAGVYETT QHFMDIKEHL
460 470 480 490 500
HVVKRDIDSL AQRSMPSNEK PKCPDLPPFP SCLSTIHFVI FVVVQTVLFV
510
GYIMYRTQQE AAAKKFF
Length:517
Mass (Da):57,789
Last modified:June 1, 2001 - v1
Checksum:iBA9FCFDEBCC5656D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011495 mRNA. Translation: BAB27655.1.
BC057165 mRNA. Translation: AAH57165.1.
CCDSiCCDS29313.1.
RefSeqiNP_001165533.1. NM_001172062.1.
NP_081676.1. NM_027400.3.
UniGeneiMm.290857.
Mm.449042.

Genome annotation databases

EnsembliENSMUST00000048260; ENSMUSP00000040140; ENSMUSG00000041891.
ENSMUST00000120461; ENSMUSP00000113326; ENSMUSG00000041891.
GeneIDi70361.
KEGGimmu:70361.
UCSCiuc008ffn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011495 mRNA. Translation: BAB27655.1 .
BC057165 mRNA. Translation: AAH57165.1 .
CCDSi CCDS29313.1.
RefSeqi NP_001165533.1. NM_001172062.1.
NP_081676.1. NM_027400.3.
UniGenei Mm.290857.
Mm.449042.

3D structure databases

ProteinModelPortali Q9D0F3.
SMRi Q9D0F3. Positions 43-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9D0F3. 6 interactions.
MINTi MINT-1858436.

PTM databases

PhosphoSitei Q9D0F3.

Proteomic databases

MaxQBi Q9D0F3.
PaxDbi Q9D0F3.
PRIDEi Q9D0F3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048260 ; ENSMUSP00000040140 ; ENSMUSG00000041891 .
ENSMUST00000120461 ; ENSMUSP00000113326 ; ENSMUSG00000041891 .
GeneIDi 70361.
KEGGi mmu:70361.
UCSCi uc008ffn.2. mouse.

Organism-specific databases

CTDi 3998.
MGIi MGI:1917611. Lman1.

Phylogenomic databases

eggNOGi NOG292314.
GeneTreei ENSGT00530000062977.
HOVERGENi HBG052332.
InParanoidi Q9D0F3.
KOi K10080.
OMAi GTVPFWA.
OrthoDBi EOG7QC7VR.
PhylomeDBi Q9D0F3.
TreeFami TF313311.

Enzyme and pathway databases

Reactomei REACT_206143. Transport to the Golgi and subsequent modification.

Miscellaneous databases

NextBioi 331450.
PROi Q9D0F3.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0F3.
CleanExi MM_LMAN1.
ExpressionAtlasi Q9D0F3. baseline and differential.
Genevestigatori Q9D0F3.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR005052. Lectin_leg.
[Graphical view ]
PANTHERi PTHR12223. PTHR12223. 1 hit.
Pfami PF03388. Lectin_leg-like. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51328. L_LECTIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiLMAN1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3