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Protein

Heterogeneous nuclear ribonucleoprotein M

Gene

Hnrnpm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein M
Short name:
hnRNP M
Gene namesi
Name:Hnrnpm
Synonyms:Hnrpm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1926465. Hnrnpm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000818652 – 729Heterogeneous nuclear ribonucleoprotein MAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei29PhosphoserineBy similarity1
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei85PhosphoserineBy similarity1
Modified residuei133N6-acetyllysineCombined sources1
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei203PhosphoserineBy similarity1
Modified residuei276N6-acetyllysineBy similarity1
Modified residuei364PhosphoserineBy similarity1
Modified residuei376PhosphoserineBy similarity1
Cross-linki387Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei396PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei451PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1
Modified residuei480PhosphoserineBy similarity1
Modified residuei495Omega-N-methylarginineBy similarity1
Modified residuei527PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei632PhosphoserineBy similarity1
Modified residuei636PhosphoserineBy similarity1
Modified residuei664PhosphothreonineBy similarity1
Modified residuei671N6-acetyllysineCombined sources1
Cross-linki684Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei697N6-acetyllysine; alternateCombined sources1
Cross-linki697Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki697Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei700PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9D0E1.
PeptideAtlasiQ9D0E1.
PRIDEiQ9D0E1.

PTM databases

iPTMnetiQ9D0E1.
PhosphoSitePlusiQ9D0E1.
SwissPalmiQ9D0E1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000059208.
ExpressionAtlasiQ9D0E1. baseline and differential.
GenevisibleiQ9D0E1. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218411. 8 interactors.
IntActiQ9D0E1. 8 interactors.
MINTiMINT-1868359.
STRINGi10090.ENSMUSP00000120115.

Structurei

3D structure databases

ProteinModelPortaliQ9D0E1.
SMRiQ9D0E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 148RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini203 – 280RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati399 – 40416
Repeati406 – 41126
Repeati414 – 41936
Repeati425 – 43046
Repeati432 – 43756
Repeati439 – 44466
Repeati445 – 45076
Repeati452 – 45786
Repeati460 – 46596
Repeati467 – 472106
Repeati474 – 479116
Repeati481 – 486126
Repeati492 – 497136
Repeati499 – 504146
Repeati506 – 511156
Repeati513 – 518166
Repeati520 – 525176
Repeati527 – 532186
Repeati539 – 544196
Repeati546 – 551206
Repeati553 – 558216
Repeati561 – 566226
Repeati566 – 571236
Repeati574 – 579246
Repeati579 – 584256
Repeati587 – 592266
Repeati602 – 607276
Domaini652 – 728RRM 3PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni399 – 60727 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]Add BLAST209

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi389 – 395Poly-Gly7

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4212. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00410000025635.
HOGENOMiHOG000231932.
HOVERGENiHBG054880.
InParanoidiQ9D0E1.
KOiK12887.
OMAiGMNKMGG.
OrthoDBiEOG091G0E2C.
PhylomeDBiQ9D0E1.
TreeFamiTF313406.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR024667. HnRNP_M.
IPR024666. HnRNP_M_PY-NLS.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23003:SF6. PTHR23003:SF6. 3 hits.
PfamiPF11532. HnRNP_M. 1 hit.
PF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D0E1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGVEAAAE VAATEPKMEE ESGAPCVPSG NGAPGPKGEE RPTQNEKRKE
60 70 80 90 100
KNIKRGGNRF EPYSNPTKRY RAFITNIPFD VKWQSLKDLV KEKVGEVTYV
110 120 130 140 150
ELLMDAEGKS RGCAVVEFKM EESMKKAAEV LNKHSLSGRP LKVKEDPDGE
160 170 180 190 200
HARRAMQKVM ATTGGMGMGP GGPGMINIPP SILNNPNIPN EIIHALQAGR
210 220 230 240 250
LGSTVFVANL DYKVGWKKLK EVFSMAGVVV RADILEDKDG KSRGIGIVTF
260 270 280 290 300
EQSIEAVQAI SMFNGQLLFD RPMHVKMDER ALPKGDFFPP ERPQQLPHGL
310 320 330 340 350
GGIGMGLGPG GQPIDANHLS KGIGMGNLGP AGMGMEGIGF GINKIGGMEG
360 370 380 390 400
PFGGGMENMG RFGSGMNMGR INEILSNALK RGEIIAKQGG GGAGGSVPGI
410 420 430 440 450
ERMGPGIDRI SGAGMERMGA GLGHGMDRVG SEIERMGLVM DRMGSVERMG
460 470 480 490 500
SSIERMGPLG LDHMASSIER MGQTMERIGS GVERMGAGMG FGLERMAAPI
510 520 530 540 550
DRVGQTIERM GSGVERMGPA IERMGLSMDR MVPTGMGASL ERMGPVMDRM
560 570 580 590 600
ATGLERMGAN NLERMGLERM GANSLERMGL ERMGANSLER MGPAMGPALG
610 620 630 640 650
AGIERMGLAM GGAGGASFDR AIEMERGNFG GSFAGSFGGA GGHAPGVARK
660 670 680 690 700
ACQIFVRNLP FDFTWKMLKD KFNECGHVLY ADIKMENGKS KGCGVVKFES
710 720
PEVAERACRM MNGMKLSGRE IDVRIDRNA
Length:729
Mass (Da):77,649
Last modified:January 23, 2007 - v3
Checksum:iD42650B419362D6B
GO
Isoform 2 (identifier: Q9D0E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-197: Missing.

Show »
Length:690
Mass (Da):73,741
Checksum:iC72B1AE0C8A5DE4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357E → G in AAH05758 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011933159 – 197Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011521 mRNA. Translation: BAB27675.1.
BC005758 mRNA. Translation: AAH05758.1.
BC065172 mRNA. Translation: AAH65172.1.
CCDSiCCDS37570.1. [Q9D0E1-1]
CCDS50068.1. [Q9D0E1-2]
RefSeqiNP_001103383.1. NM_001109913.1. [Q9D0E1-2]
NP_084080.1. NM_029804.3. [Q9D0E1-1]
UniGeneiMm.311439.

Genome annotation databases

EnsembliENSMUST00000087582; ENSMUSP00000084864; ENSMUSG00000059208. [Q9D0E1-2]
ENSMUST00000148178; ENSMUSP00000120115; ENSMUSG00000059208. [Q9D0E1-1]
GeneIDi76936.
KEGGimmu:76936.
UCSCiuc008bze.2. mouse. [Q9D0E1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011521 mRNA. Translation: BAB27675.1.
BC005758 mRNA. Translation: AAH05758.1.
BC065172 mRNA. Translation: AAH65172.1.
CCDSiCCDS37570.1. [Q9D0E1-1]
CCDS50068.1. [Q9D0E1-2]
RefSeqiNP_001103383.1. NM_001109913.1. [Q9D0E1-2]
NP_084080.1. NM_029804.3. [Q9D0E1-1]
UniGeneiMm.311439.

3D structure databases

ProteinModelPortaliQ9D0E1.
SMRiQ9D0E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218411. 8 interactors.
IntActiQ9D0E1. 8 interactors.
MINTiMINT-1868359.
STRINGi10090.ENSMUSP00000120115.

PTM databases

iPTMnetiQ9D0E1.
PhosphoSitePlusiQ9D0E1.
SwissPalmiQ9D0E1.

Proteomic databases

PaxDbiQ9D0E1.
PeptideAtlasiQ9D0E1.
PRIDEiQ9D0E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087582; ENSMUSP00000084864; ENSMUSG00000059208. [Q9D0E1-2]
ENSMUST00000148178; ENSMUSP00000120115; ENSMUSG00000059208. [Q9D0E1-1]
GeneIDi76936.
KEGGimmu:76936.
UCSCiuc008bze.2. mouse. [Q9D0E1-1]

Organism-specific databases

CTDi4670.
MGIiMGI:1926465. Hnrnpm.

Phylogenomic databases

eggNOGiKOG4212. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00410000025635.
HOGENOMiHOG000231932.
HOVERGENiHBG054880.
InParanoidiQ9D0E1.
KOiK12887.
OMAiGMNKMGG.
OrthoDBiEOG091G0E2C.
PhylomeDBiQ9D0E1.
TreeFamiTF313406.

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiHnrnpm. mouse.
PROiQ9D0E1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059208.
ExpressionAtlasiQ9D0E1. baseline and differential.
GenevisibleiQ9D0E1. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR024667. HnRNP_M.
IPR024666. HnRNP_M_PY-NLS.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR23003:SF6. PTHR23003:SF6. 3 hits.
PfamiPF11532. HnRNP_M. 1 hit.
PF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRPM_MOUSE
AccessioniPrimary (citable) accession number: Q9D0E1
Secondary accession number(s): Q6P1B2, Q99JQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.