Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

General transcription factor IIE subunit 1

Gene

Gtf2e1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 157C4-typeSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 1
Alternative name(s):
General transcription factor IIE 56 kDa subunit
Transcription initiation factor IIE subunit alpha
Short name:
TFIIE-alpha
Gene namesi
Name:Gtf2e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921447. Gtf2e1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002112232 – 440General transcription factor IIE subunit 1Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei67N6-acetyllysineBy similarity1
Modified residuei268PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D0D5.
MaxQBiQ9D0D5.
PaxDbiQ9D0D5.
PeptideAtlasiQ9D0D5.
PRIDEiQ9D0D5.

PTM databases

iPTMnetiQ9D0D5.
PhosphoSitePlusiQ9D0D5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022828.
GenevisibleiQ9D0D5. MM.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 (By similarity). Interacts with ATF7IP (By similarity).By similarity

Protein-protein interaction databases

BioGridi216568. 13 interactors.
IntActiQ9D0D5. 1 interactor.
MINTiMINT-4136705.
STRINGi10090.ENSMUSP00000023525.

Structurei

3D structure databases

ProteinModelPortaliQ9D0D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 104HTH TFE/IIEalpha-typePROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi380 – 394Asp/Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the TFIIE alpha subunit family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri129 – 157C4-typeSequence analysisAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2593. Eukaryota.
COG1675. LUCA.
GeneTreeiENSGT00390000016696.
HOGENOMiHOG000007666.
HOVERGENiHBG008614.
InParanoidiQ9D0D5.
KOiK03136.
OMAiEFRCTYC.
OrthoDBiEOG091G0D8N.
PhylomeDBiQ9D0D5.
TreeFamiTF313429.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR011991. WHTH_DNA-bd_dom.
IPR013137. Znf_TFIIB.
PfamiView protein in Pfam
PF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
SMARTiView protein in SMART
SM00531. TFIIE. 1 hit.
PROSITEiView protein in PROSITE
PS51344. HTH_TFE_IIE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPDVLTEV PAALKRLAKY VIRGFYGIEH VLALDILIRN PCVKEEDMLE
60 70 80 90 100
LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV
110 120 130 140 150
NVVKYKLDHM RRRIETDERN STNRASFKCP VCCSTFTDLE ANQLFDPMTG
160 170 180 190 200
TFRCTFCHTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA
210 220 230 240 250
YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT NKGPSYEDLY
260 270 280 290 300
TQNVVINMDD QDDVHRPSLE GKAAKERPIW LRESTVQGAY SSEEMKEGGI
310 320 330 340 350
DVDTFQEREE ARAGPDDNEE VMRALLIHEK KTSSVTAGSV GAAAPVTAAN
360 370 380 390 400
GSDSESETSE SDDDSPPRPA AAAPPHHHRD EDEEDEEFEE VADDPIVMVA
410 420 430 440
GCPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE
Length:440
Mass (Da):49,593
Last modified:June 1, 2001 - v1
Checksum:i0587E4DFE6FA0442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011543 mRNA. Translation: BAB27686.1.
AK031528 mRNA. Translation: BAC27436.1.
AK154283 mRNA. Translation: BAE32487.1.
BC056966 mRNA. Translation: AAH56966.1.
CCDSiCCDS28160.1.
RefSeqiNP_083088.1. NM_028812.3.
XP_006522722.1. XM_006522659.3.
UniGeneiMm.287795.

Genome annotation databases

EnsembliENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828.
GeneIDi74197.
KEGGimmu:74197.
UCSCiuc007zeb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiT2EA_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D5
Secondary accession number(s): Q544T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families