SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9D0D5

- T2EA_MOUSE

UniProt

Q9D0D5 - T2EA_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
General transcription factor IIE subunit 1
Gene
Gtf2e1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 15729C4-type Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription initiation from RNA polymerase II promoter Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIE subunit 1
Alternative name(s):
General transcription factor IIE 56 kDa subunit
Transcription initiation factor IIE subunit alpha
Short name:
TFIIE-alpha
Gene namesi
Name:Gtf2e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1921447. Gtf2e1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 440439General transcription factor IIE subunit 1
PRO_0000211223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei67 – 671N6-acetyllysine By similarity
Modified residuei268 – 2681Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D0D5.
PaxDbiQ9D0D5.
PRIDEiQ9D0D5.

PTM databases

PhosphoSiteiQ9D0D5.

Expressioni

Gene expression databases

BgeeiQ9D0D5.
GenevestigatoriQ9D0D5.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 By similarity. Interacts with ATF7IP By similarity.

Protein-protein interaction databases

BioGridi216568. 12 interactions.
IntActiQ9D0D5. 1 interaction.
MINTiMINT-4136705.

Structurei

3D structure databases

ProteinModelPortaliQ9D0D5.
SMRiQ9D0D5. Positions 113-174, 395-440.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10491HTH TFE/IIEalpha-type
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi380 – 39415Asp/Glu-rich (acidic)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1675.
GeneTreeiENSGT00390000016696.
HOGENOMiHOG000007666.
HOVERGENiHBG008614.
InParanoidiQ9D0D5.
KOiK03136.
OMAiQEDHRAS.
OrthoDBiEOG7NGQBK.
PhylomeDBiQ9D0D5.
TreeFamiTF313429.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view]
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view]
SMARTiSM00531. TFIIE. 1 hit.
[Graphical view]
PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0D5-1 [UniParc]FASTAAdd to Basket

« Hide

MADPDVLTEV PAALKRLAKY VIRGFYGIEH VLALDILIRN PCVKEEDMLE    50
LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV 100
NVVKYKLDHM RRRIETDERN STNRASFKCP VCCSTFTDLE ANQLFDPMTG 150
TFRCTFCHTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA 200
YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT NKGPSYEDLY 250
TQNVVINMDD QDDVHRPSLE GKAAKERPIW LRESTVQGAY SSEEMKEGGI 300
DVDTFQEREE ARAGPDDNEE VMRALLIHEK KTSSVTAGSV GAAAPVTAAN 350
GSDSESETSE SDDDSPPRPA AAAPPHHHRD EDEEDEEFEE VADDPIVMVA 400
GCPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE 440
Length:440
Mass (Da):49,593
Last modified:June 1, 2001 - v1
Checksum:i0587E4DFE6FA0442
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011543 mRNA. Translation: BAB27686.1.
AK031528 mRNA. Translation: BAC27436.1.
AK154283 mRNA. Translation: BAE32487.1.
BC056966 mRNA. Translation: AAH56966.1.
CCDSiCCDS28160.1.
RefSeqiNP_083088.1. NM_028812.3.
XP_006522722.1. XM_006522659.1.
UniGeneiMm.287795.

Genome annotation databases

EnsembliENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828.
GeneIDi74197.
KEGGimmu:74197.
UCSCiuc007zeb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011543 mRNA. Translation: BAB27686.1 .
AK031528 mRNA. Translation: BAC27436.1 .
AK154283 mRNA. Translation: BAE32487.1 .
BC056966 mRNA. Translation: AAH56966.1 .
CCDSi CCDS28160.1.
RefSeqi NP_083088.1. NM_028812.3.
XP_006522722.1. XM_006522659.1.
UniGenei Mm.287795.

3D structure databases

ProteinModelPortali Q9D0D5.
SMRi Q9D0D5. Positions 113-174, 395-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 216568. 12 interactions.
IntActi Q9D0D5. 1 interaction.
MINTi MINT-4136705.

PTM databases

PhosphoSitei Q9D0D5.

Proteomic databases

MaxQBi Q9D0D5.
PaxDbi Q9D0D5.
PRIDEi Q9D0D5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023525 ; ENSMUSP00000023525 ; ENSMUSG00000022828 .
GeneIDi 74197.
KEGGi mmu:74197.
UCSCi uc007zeb.1. mouse.

Organism-specific databases

CTDi 2960.
MGIi MGI:1921447. Gtf2e1.

Phylogenomic databases

eggNOGi COG1675.
GeneTreei ENSGT00390000016696.
HOGENOMi HOG000007666.
HOVERGENi HBG008614.
InParanoidi Q9D0D5.
KOi K03136.
OMAi QEDHRAS.
OrthoDBi EOG7NGQBK.
PhylomeDBi Q9D0D5.
TreeFami TF313429.

Miscellaneous databases

NextBioi 340074.
PROi Q9D0D5.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0D5.
Genevestigatori Q9D0D5.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view ]
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view ]
SMARTi SM00531. TFIIE. 1 hit.
[Graphical view ]
PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiT2EA_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D5
Secondary accession number(s): Q544T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi