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Q9D0D5

- T2EA_MOUSE

UniProt

Q9D0D5 - T2EA_MOUSE

Protein

General transcription factor IIE subunit 1

Gene

Gtf2e1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription initiation from RNA polymerase II promoter Source: InterPro

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIE subunit 1
    Alternative name(s):
    General transcription factor IIE 56 kDa subunit
    Transcription initiation factor IIE subunit alpha
    Short name:
    TFIIE-alpha
    Gene namesi
    Name:Gtf2e1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1921447. Gtf2e1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 440439General transcription factor IIE subunit 1PRO_0000211223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei67 – 671N6-acetyllysineBy similarity
    Modified residuei268 – 2681PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9D0D5.
    PaxDbiQ9D0D5.
    PRIDEiQ9D0D5.

    PTM databases

    PhosphoSiteiQ9D0D5.

    Expressioni

    Gene expression databases

    BgeeiQ9D0D5.
    GenevestigatoriQ9D0D5.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 By similarity. Interacts with ATF7IP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi216568. 12 interactions.
    IntActiQ9D0D5. 1 interaction.
    MINTiMINT-4136705.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D0D5.
    SMRiQ9D0D5. Positions 113-174, 395-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 10491HTH TFE/IIEalpha-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi380 – 39415Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIE alpha subunit family.Curated
    Contains 1 HTH TFE/IIEalpha-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri129 – 15729C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1675.
    GeneTreeiENSGT00390000016696.
    HOGENOMiHOG000007666.
    HOVERGENiHBG008614.
    InParanoidiQ9D0D5.
    KOiK03136.
    OMAiQEDHRAS.
    OrthoDBiEOG7NGQBK.
    PhylomeDBiQ9D0D5.
    TreeFamiTF313429.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR017919. TFIIE/TFIIEa_HTH.
    IPR002853. TFIIE_asu.
    IPR021600. TFIIE_asu_C.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF11521. TFIIE-A_C-term. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00531. TFIIE. 1 hit.
    [Graphical view]
    PROSITEiPS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D0D5-1 [UniParc]FASTAAdd to Basket

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    MADPDVLTEV PAALKRLAKY VIRGFYGIEH VLALDILIRN PCVKEEDMLE    50
    LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV 100
    NVVKYKLDHM RRRIETDERN STNRASFKCP VCCSTFTDLE ANQLFDPMTG 150
    TFRCTFCHTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA 200
    YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT NKGPSYEDLY 250
    TQNVVINMDD QDDVHRPSLE GKAAKERPIW LRESTVQGAY SSEEMKEGGI 300
    DVDTFQEREE ARAGPDDNEE VMRALLIHEK KTSSVTAGSV GAAAPVTAAN 350
    GSDSESETSE SDDDSPPRPA AAAPPHHHRD EDEEDEEFEE VADDPIVMVA 400
    GCPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE 440
    Length:440
    Mass (Da):49,593
    Last modified:June 1, 2001 - v1
    Checksum:i0587E4DFE6FA0442
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011543 mRNA. Translation: BAB27686.1.
    AK031528 mRNA. Translation: BAC27436.1.
    AK154283 mRNA. Translation: BAE32487.1.
    BC056966 mRNA. Translation: AAH56966.1.
    CCDSiCCDS28160.1.
    RefSeqiNP_083088.1. NM_028812.3.
    XP_006522722.1. XM_006522659.1.
    UniGeneiMm.287795.

    Genome annotation databases

    EnsembliENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828.
    GeneIDi74197.
    KEGGimmu:74197.
    UCSCiuc007zeb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011543 mRNA. Translation: BAB27686.1 .
    AK031528 mRNA. Translation: BAC27436.1 .
    AK154283 mRNA. Translation: BAE32487.1 .
    BC056966 mRNA. Translation: AAH56966.1 .
    CCDSi CCDS28160.1.
    RefSeqi NP_083088.1. NM_028812.3.
    XP_006522722.1. XM_006522659.1.
    UniGenei Mm.287795.

    3D structure databases

    ProteinModelPortali Q9D0D5.
    SMRi Q9D0D5. Positions 113-174, 395-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216568. 12 interactions.
    IntActi Q9D0D5. 1 interaction.
    MINTi MINT-4136705.

    PTM databases

    PhosphoSitei Q9D0D5.

    Proteomic databases

    MaxQBi Q9D0D5.
    PaxDbi Q9D0D5.
    PRIDEi Q9D0D5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023525 ; ENSMUSP00000023525 ; ENSMUSG00000022828 .
    GeneIDi 74197.
    KEGGi mmu:74197.
    UCSCi uc007zeb.1. mouse.

    Organism-specific databases

    CTDi 2960.
    MGIi MGI:1921447. Gtf2e1.

    Phylogenomic databases

    eggNOGi COG1675.
    GeneTreei ENSGT00390000016696.
    HOGENOMi HOG000007666.
    HOVERGENi HBG008614.
    InParanoidi Q9D0D5.
    KOi K03136.
    OMAi QEDHRAS.
    OrthoDBi EOG7NGQBK.
    PhylomeDBi Q9D0D5.
    TreeFami TF313429.

    Miscellaneous databases

    NextBioi 340074.
    PROi Q9D0D5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D0D5.
    Genevestigatori Q9D0D5.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR017919. TFIIE/TFIIEa_HTH.
    IPR002853. TFIIE_asu.
    IPR021600. TFIIE_asu_C.
    IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF11521. TFIIE-A_C-term. 1 hit.
    PF02002. TFIIE_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00531. TFIIE. 1 hit.
    [Graphical view ]
    PROSITEi PS51344. HTH_TFE_IIE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiT2EA_MOUSE
    AccessioniPrimary (citable) accession number: Q9D0D5
    Secondary accession number(s): Q544T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3