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Q9D0D5 (T2EA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIE subunit 1
Alternative name(s):
General transcription factor IIE 56 kDa subunit
Transcription initiation factor IIE subunit alpha
Short name=TFIIE-alpha
Gene names
Name:Gtf2e1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Subunit structure

Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80 By similarity. Interacts with ATF7IP By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the TFIIE alpha subunit family.

Contains 1 HTH TFE/IIEalpha-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 440439General transcription factor IIE subunit 1
PRO_0000211223

Regions

Domain14 – 10491HTH TFE/IIEalpha-type
Zinc finger129 – 15729C4-type Potential
Compositional bias380 – 39415Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue671N6-acetyllysine By similarity
Modified residue2681Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9D0D5 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0587E4DFE6FA0442

FASTA44049,593
        10         20         30         40         50         60 
MADPDVLTEV PAALKRLAKY VIRGFYGIEH VLALDILIRN PCVKEEDMLE LLKFDRKQLR 

        70         80         90        100        110        120 
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERN 

       130        140        150        160        170        180 
STNRASFKCP VCCSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF 

       190        200        210        220        230        240 
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDR AATAAGAAGL AGGHHREAWT 

       250        260        270        280        290        300 
NKGPSYEDLY TQNVVINMDD QDDVHRPSLE GKAAKERPIW LRESTVQGAY SSEEMKEGGI 

       310        320        330        340        350        360 
DVDTFQEREE ARAGPDDNEE VMRALLIHEK KTSSVTAGSV GAAAPVTAAN GSDSESETSE 

       370        380        390        400        410        420 
SDDDSPPRPA AAAPPHHHRD EDEEDEEFEE VADDPIVMVA GCPFSYSEVS QRPELVAQMT 

       430        440 
PEEKEAYIAM GQRMFEDLFE 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK011543 mRNA. Translation: BAB27686.1.
AK031528 mRNA. Translation: BAC27436.1.
AK154283 mRNA. Translation: BAE32487.1.
BC056966 mRNA. Translation: AAH56966.1.
CCDSCCDS28160.1.
RefSeqNP_083088.1. NM_028812.3.
XP_006522722.1. XM_006522659.1.
UniGeneMm.287795.

3D structure databases

ProteinModelPortalQ9D0D5.
SMRQ9D0D5. Positions 113-174, 395-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid216568. 12 interactions.
IntActQ9D0D5. 1 interaction.
MINTMINT-4136705.

PTM databases

PhosphoSiteQ9D0D5.

Proteomic databases

MaxQBQ9D0D5.
PaxDbQ9D0D5.
PRIDEQ9D0D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023525; ENSMUSP00000023525; ENSMUSG00000022828.
GeneID74197.
KEGGmmu:74197.
UCSCuc007zeb.1. mouse.

Organism-specific databases

CTD2960.
MGIMGI:1921447. Gtf2e1.

Phylogenomic databases

eggNOGCOG1675.
GeneTreeENSGT00390000016696.
HOGENOMHOG000007666.
HOVERGENHBG008614.
InParanoidQ9D0D5.
KOK03136.
OMAQEDHRAS.
OrthoDBEOG7NGQBK.
PhylomeDBQ9D0D5.
TreeFamTF313429.

Gene expression databases

BgeeQ9D0D5.
GenevestigatorQ9D0D5.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR017919. TFIIE/TFIIEa_HTH.
IPR002853. TFIIE_asu.
IPR021600. TFIIE_asu_C.
IPR024550. TFIIEa/SarR/Rpc3_HTH_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR013137. Znf_TFIIB.
[Graphical view]
PfamPF08271. TF_Zn_Ribbon. 1 hit.
PF11521. TFIIE-A_C-term. 1 hit.
PF02002. TFIIE_alpha. 1 hit.
[Graphical view]
SMARTSM00531. TFIIE. 1 hit.
[Graphical view]
PROSITEPS51344. HTH_TFE_IIE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio340074.
PROQ9D0D5.
SOURCESearch...

Entry information

Entry nameT2EA_MOUSE
AccessionPrimary (citable) accession number: Q9D0D5
Secondary accession number(s): Q544T0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot