Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable dimethyladenosine transferase

Gene

Dimt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.By similarity

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei39 – 391S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei64 – 641S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei85 – 851S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei113 – 1131S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei128 – 1281S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dimethyladenosine transferase (EC:2.1.1.183)
Alternative name(s):
DIM1 dimethyladenosine transferase 1 homolog
DIM1 dimethyladenosine transferase 1-like
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Probable 18S rRNA dimethylase
Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
Name:Dimt1
Synonyms:Dimt1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913504. Dimt1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Probable dimethyladenosine transferasePRO_0000101467Add
BLAST

Proteomic databases

EPDiQ9D0D4.
MaxQBiQ9D0D4.
PaxDbiQ9D0D4.
PRIDEiQ9D0D4.

PTM databases

iPTMnetiQ9D0D4.
PhosphoSiteiQ9D0D4.

Expressioni

Gene expression databases

BgeeiQ9D0D4.
GenevisibleiQ9D0D4. MM.

Interactioni

Protein-protein interaction databases

BioGridi211329. 2 interactions.
IntActiQ9D0D4. 1 interaction.
MINTiMINT-4093119.
STRINGi10090.ENSMUSP00000022203.

Structurei

3D structure databases

ProteinModelPortaliQ9D0D4.
SMRiQ9D0D4. Positions 36-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
HOGENOMiHOG000227963.
HOVERGENiHBG031507.
InParanoidiQ9D0D4.
KOiK14191.
OMAiIMLGDFM.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ9D0D4.
TreeFamiTF354255.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAKSAASS RRRDRQEQRR ELKRAGGLMF NTGIGQHILK NPLIVNSIID
60 70 80 90 100
KAALRPTDVV LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG
110 120 130 140 150
TPLASKLQVL VGDVLKSDLP FFDACVANLP YQISSPFVFK LLLHRPFFRC
160 170 180 190 200
AILMFQREFA LRLVAKPGDK LYCRLSINTQ LLARVDHLMK VGKNNFRPPP
210 220 230 240 250
KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA AFKSSAVQQL
260 270 280 290 300
LEKNYRIHCS VQNTVIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR
310
LLHGFNAEGI HFS
Length:313
Mass (Da):35,274
Last modified:June 1, 2001 - v1
Checksum:iE968BE2ED0CC6E3E
GO

Sequence cautioni

The sequence BAC37166.1 differs from that shown.Introns retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011544 mRNA. Translation: BAB27687.1.
AK078186 mRNA. Translation: BAC37166.1. Sequence problems.
AK161333 mRNA. Translation: BAE36330.1.
BC019799 mRNA. Translation: AAH19799.1.
CCDSiCCDS26758.1.
RefSeqiNP_079723.1. NM_025447.4.
UniGeneiMm.9563.

Genome annotation databases

EnsembliENSMUST00000022203; ENSMUSP00000022203; ENSMUSG00000021692.
GeneIDi66254.
KEGGimmu:66254.
UCSCiuc007rua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011544 mRNA. Translation: BAB27687.1.
AK078186 mRNA. Translation: BAC37166.1. Sequence problems.
AK161333 mRNA. Translation: BAE36330.1.
BC019799 mRNA. Translation: AAH19799.1.
CCDSiCCDS26758.1.
RefSeqiNP_079723.1. NM_025447.4.
UniGeneiMm.9563.

3D structure databases

ProteinModelPortaliQ9D0D4.
SMRiQ9D0D4. Positions 36-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211329. 2 interactions.
IntActiQ9D0D4. 1 interaction.
MINTiMINT-4093119.
STRINGi10090.ENSMUSP00000022203.

PTM databases

iPTMnetiQ9D0D4.
PhosphoSiteiQ9D0D4.

Proteomic databases

EPDiQ9D0D4.
MaxQBiQ9D0D4.
PaxDbiQ9D0D4.
PRIDEiQ9D0D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022203; ENSMUSP00000022203; ENSMUSG00000021692.
GeneIDi66254.
KEGGimmu:66254.
UCSCiuc007rua.2. mouse.

Organism-specific databases

CTDi27292.
MGIiMGI:1913504. Dimt1.

Phylogenomic databases

eggNOGiKOG0820. Eukaryota.
COG0030. LUCA.
GeneTreeiENSGT00530000063389.
HOGENOMiHOG000227963.
HOVERGENiHBG031507.
InParanoidiQ9D0D4.
KOiK14191.
OMAiIMLGDFM.
OrthoDBiEOG7RZ5QG.
PhylomeDBiQ9D0D4.
TreeFamiTF354255.

Miscellaneous databases

NextBioi321099.
PROiQ9D0D4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D0D4.
GenevisibleiQ9D0D4. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001737. KsgA/Erm.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
PS51689. SAM_RNA_A_N6_MT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiDIM1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D4
Secondary accession number(s): Q3TTJ5, Q8BVH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.