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Protein

Probable dimethyladenosine transferase

Gene

Dimt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.By similarity

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N6-dimethyladenine(1779)/N6-dimethyladenine(1780) in 18S rRNA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei39S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei64S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei85S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei113S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei128S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dimethyladenosine transferase (EC:2.1.1.183By similarity)
Alternative name(s):
DIM1 dimethyladenosine transferase 1 homolog
DIM1 dimethyladenosine transferase 1-like
Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
Probable 18S rRNA dimethylase
Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
Name:Dimt1
Synonyms:Dimt1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913504 Dimt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001014671 – 313Probable dimethyladenosine transferaseAdd BLAST313

Proteomic databases

EPDiQ9D0D4
MaxQBiQ9D0D4
PaxDbiQ9D0D4
PeptideAtlasiQ9D0D4
PRIDEiQ9D0D4

PTM databases

iPTMnetiQ9D0D4
PhosphoSitePlusiQ9D0D4

Expressioni

Gene expression databases

BgeeiENSMUSG00000021692
GenevisibleiQ9D0D4 MM

Interactioni

Protein-protein interaction databases

BioGridi211329, 1 interactor
IntActiQ9D0D4, 1 interactor
MINTiQ9D0D4
STRINGi10090.ENSMUSP00000022203

Structurei

3D structure databases

ProteinModelPortaliQ9D0D4
SMRiQ9D0D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0820 Eukaryota
COG0030 LUCA
GeneTreeiENSGT00530000063389
HOGENOMiHOG000227963
HOVERGENiHBG031507
InParanoidiQ9D0D4
KOiK14191
OMAiKRFGQHW
OrthoDBiEOG091G0CD4
PhylomeDBiQ9D0D4
TreeFamiTF354255

Family and domain databases

InterProiView protein in InterPro
IPR001737 KsgA/Erm
IPR020596 rRNA_Ade_Mease_Trfase_CS
IPR020598 rRNA_Ade_methylase_Trfase_N
IPR011530 rRNA_adenine_dimethylase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11727 PTHR11727, 1 hit
PfamiView protein in Pfam
PF00398 RrnaAD, 1 hit
SMARTiView protein in SMART
SM00650 rADc, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00755 ksgA, 1 hit
PROSITEiView protein in PROSITE
PS01131 RRNA_A_DIMETH, 1 hit
PS51689 SAM_RNA_A_N6_MT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKAKSAASS RRRDRQEQRR ELKRAGGLMF NTGIGQHILK NPLIVNSIID
60 70 80 90 100
KAALRPTDVV LEVGPGTGNM TVKLLEKAKK VVACELDPRL VAELHKRVQG
110 120 130 140 150
TPLASKLQVL VGDVLKSDLP FFDACVANLP YQISSPFVFK LLLHRPFFRC
160 170 180 190 200
AILMFQREFA LRLVAKPGDK LYCRLSINTQ LLARVDHLMK VGKNNFRPPP
210 220 230 240 250
KVESSVVRIE PKNPPPPINF QEWDGLVRIT FVRKNKTLSA AFKSSAVQQL
260 270 280 290 300
LEKNYRIHCS VQNTVIPEDF SIADKIQQIL TSTGFSDKRA RSMDIDDFIR
310
LLHGFNAEGI HFS
Length:313
Mass (Da):35,274
Last modified:June 1, 2001 - v1
Checksum:iE968BE2ED0CC6E3E
GO

Sequence cautioni

The sequence BAC37166 differs from that shown. Introns retention.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011544 mRNA Translation: BAB27687.1
AK078186 mRNA Translation: BAC37166.1 Sequence problems.
AK161333 mRNA Translation: BAE36330.1
BC019799 mRNA Translation: AAH19799.1
CCDSiCCDS26758.1
RefSeqiNP_079723.1, NM_025447.4
UniGeneiMm.9563

Genome annotation databases

EnsembliENSMUST00000022203; ENSMUSP00000022203; ENSMUSG00000021692
GeneIDi66254
KEGGimmu:66254
UCSCiuc007rua.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDIM1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D4
Secondary accession number(s): Q3TTJ5, Q8BVH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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