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Q9D0D3

- PAPD1_MOUSE

UniProt

Q9D0D3 - PAPD1_MOUSE

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Protein

Poly(A) RNA polymerase, mitochondrial

Gene
Mtpap, Papd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA By similarity.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Magnesium or manganese; catalytic Reviewed prediction
Metal bindingi248 – 2481Magnesium or manganese; catalytic Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1093ATP Reviewed prediction
Nucleotide bindingi244 – 2452ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. manganese ion binding Source: UniProtKB
  4. polynucleotide adenylyltransferase activity Source: UniProtKB
  5. RNA binding Source: UniProtKB-KW
  6. UTP binding Source: UniProtKB

GO - Biological processi

  1. histone mRNA catabolic process Source: UniProtKB
  2. mRNA polyadenylation Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) RNA polymerase, mitochondrial (EC:2.7.7.19)
Short name:
PAP
Alternative name(s):
PAP-associated domain-containing protein 1
Polynucleotide adenylyltransferase
Gene namesi
Name:Mtpap
Synonyms:Papd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1914690. Mtpap.

Subcellular locationi

Cytoplasm By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. mitochondrion Source: MGI
  3. nucleus Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion Reviewed predictionAdd
BLAST
Chaini38 – 585548Poly(A) RNA polymerase, mitochondrialPRO_0000250690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9D0D3.
PaxDbiQ9D0D3.
PRIDEiQ9D0D3.

PTM databases

PhosphoSiteiQ9D0D3.

Expressioni

Gene expression databases

BgeeiQ9D0D3.
CleanExiMM_PAPD1.
GenevestigatoriQ9D0D3.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025077.

Structurei

3D structure databases

ProteinModelPortaliQ9D0D3.
SMRiQ9D0D3. Positions 62-535.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini441 – 48646PAP-associatedAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5260.
GeneTreeiENSGT00550000074490.
HOGENOMiHOG000115438.
HOVERGENiHBG082104.
InParanoidiQ9D0D3.
KOiK18060.
OMAiDAEDKCI.
OrthoDBiEOG7353WD.
PhylomeDBiQ9D0D3.
TreeFamiTF354308.

Family and domain databases

InterProiIPR002058. PAP_assoc.
[Graphical view]
PfamiPF03828. PAP_assoc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D0D3-1 [UniParc]FASTAAdd to Basket

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MAARGVGLLT RLPVCSQRRN RIPRSISRLL SCPGTIAASI GSEEQSSVVA    50
ETGIEDKTLQ KKFSEVQKER REQAQRTVLI HCPNNINEKK FLKYLSQHGP 100
VNNHFFYESF GLFAVVEFCQ KDSIKSLQNG THTPTQSTEA AIPFKSRFLN 150
LRLKNPSSQV SGQPFVQTTN QSPPSSKKLF ELLSYAESIE EQLNTLLKAF 200
QLTEENIRLR HLTCSLIEDI AAAYFPSCVI RPFGSSVNTF GKLGCDLDMF 250
LDLDETGKLD VHKNTGNFFM EFQVKNVPSE RIATQKILSV IGECLDNFGP 300
GCVGVQKILN ARCPLVRFSH QGSGFQCDLT ANNSIALKSS ELLYIYGSLD 350
SRVRALVFSV RCWARAHSLT SSIPGAWITN FSLTVMVIFF LQRRSPPILP 400
TLDSLKSIAD AEDRCILEGN NCTFVQDVNK IQPSGNTETL ELLIKEFFEY 450
FGNFAFNKNS INIRQGREQN KPDSSPLYIQ NPFETSLNIS KNVSQSQLQK 500
FVELARDSAW ILEQEDKNQP FSSSRQPWGL AALLLPPGSG HTSLSRKKKK 550
KPMSEKVKGL LASIKSNSPD SSTDTSGKRT ISTQA 585
Length:585
Mass (Da):65,229
Last modified:June 1, 2001 - v1
Checksum:i33DB6AC61A080B82
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741A → S in BAE22572. 1 Publication
Sequence conflicti190 – 1901E → G in BAC36396. 1 Publication
Sequence conflicti249 – 2491M → T in BAE22572. 1 Publication
Sequence conflicti578 – 5781K → E in BAC36396. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011546 mRNA. Translation: BAB27689.1.
AK076565 mRNA. Translation: BAC36396.1.
AK135537 mRNA. Translation: BAE22572.1.
BC057643 mRNA. Translation: AAH57643.1.
CCDSiCCDS37718.1.
RefSeqiNP_080433.1. NM_026157.2.
UniGeneiMm.49826.

Genome annotation databases

EnsembliENSMUST00000025077; ENSMUSP00000025077; ENSMUSG00000024234.
GeneIDi67440.
KEGGimmu:67440.
UCSCiuc008dyi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011546 mRNA. Translation: BAB27689.1 .
AK076565 mRNA. Translation: BAC36396.1 .
AK135537 mRNA. Translation: BAE22572.1 .
BC057643 mRNA. Translation: AAH57643.1 .
CCDSi CCDS37718.1.
RefSeqi NP_080433.1. NM_026157.2.
UniGenei Mm.49826.

3D structure databases

ProteinModelPortali Q9D0D3.
SMRi Q9D0D3. Positions 62-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025077.

PTM databases

PhosphoSitei Q9D0D3.

Proteomic databases

MaxQBi Q9D0D3.
PaxDbi Q9D0D3.
PRIDEi Q9D0D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025077 ; ENSMUSP00000025077 ; ENSMUSG00000024234 .
GeneIDi 67440.
KEGGi mmu:67440.
UCSCi uc008dyi.1. mouse.

Organism-specific databases

CTDi 55149.
MGIi MGI:1914690. Mtpap.

Phylogenomic databases

eggNOGi COG5260.
GeneTreei ENSGT00550000074490.
HOGENOMi HOG000115438.
HOVERGENi HBG082104.
InParanoidi Q9D0D3.
KOi K18060.
OMAi DAEDKCI.
OrthoDBi EOG7353WD.
PhylomeDBi Q9D0D3.
TreeFami TF354308.

Miscellaneous databases

NextBioi 324570.
PROi Q9D0D3.
SOURCEi Search...

Gene expression databases

Bgeei Q9D0D3.
CleanExi MM_PAPD1.
Genevestigatori Q9D0D3.

Family and domain databases

InterProi IPR002058. PAP_assoc.
[Graphical view ]
Pfami PF03828. PAP_assoc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Muellerian duct and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPAPD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D0D3
Secondary accession number(s): Q3UXJ1, Q8C651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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