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Protein

Arpin

Gene

Arpin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Arpin
Alternative name(s):
Arp2/3 inhibition protein
Gene namesi
Name:Arpin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917670. Arpin.

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002442661 – 226ArpinAdd BLAST226

Proteomic databases

MaxQBiQ9D0A3.
PaxDbiQ9D0A3.
PeptideAtlasiQ9D0A3.
PRIDEiQ9D0A3.

PTM databases

iPTMnetiQ9D0A3.
PhosphoSitePlusiQ9D0A3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039043.
CleanExiMM_2610034B18RIK.
GenevisibleiQ9D0A3. MM.

Interactioni

Subunit structurei

Associates with the Arp2/3 complex. Interacts with ARPC2; enhanced by activated RAC1. Interacts with ARPC5; the interaction is dependent on RAC1.1 Publication

Protein-protein interaction databases

DIPiDIP-60588N.
IntActiQ9D0A3. 2 interactors.
MINTiMINT-4126368.
STRINGi10090.ENSMUSP00000049440.

Structurei

3D structure databases

ProteinModelPortaliQ9D0A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 226Necessary and sufficient fopr interaction with ARPC2By similarityAdd BLAST16

Domaini

The acidic C-terminus is necessary and sufficient to inhibit ARP2/3 complex activity.By similarity

Sequence similaritiesi

Belongs to the Arpin family.Curated

Phylogenomic databases

eggNOGiENOG410IGMB. Eukaryota.
ENOG4111JJD. LUCA.
GeneTreeiENSGT00530000064251.
HOGENOMiHOG000111854.
HOVERGENiHBG054275.
InParanoidiQ9D0A3.
OMAiTDKIMAN.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ9D0A3.

Family and domain databases

InterProiView protein in InterPro
IPR018889. Arpin.
PANTHERiPTHR31199. PTHR31199. 1 hit.
PfamiView protein in Pfam
PF10574. UPF0552. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D0A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRIYQDSAL RNKAVQSARL PGTWDPATHQ GGNGILLEGE LVDVSRHSIL
60 70 80 90 100
DAHGRKERYY VLYIQPSCIH RRKFDPKGNE IEPNFSATRK VNTGFLMSSY
110 120 130 140 150
KVEAKGDTDR LTLEALKSLV NKPQLLELTE SLTPDQAVAF WMPESEMEVM
160 170 180 190 200
ELELGTGVRL KTRGDGPFID SLAKLELGTV TKCNFAGDGK TGASWTDNIM
210 220
AQKSSERNTA EIREQGDGAE DEEWDD
Length:226
Mass (Da):25,193
Last modified:June 1, 2001 - v1
Checksum:i31D7F805E7581345
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49I → V in BAE33545 (PubMed:16141072).Curated1
Sequence conflicti85F → L in BAC30326 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011654 mRNA. Translation: BAB27760.1.
AK039350 mRNA. Translation: BAC30326.1.
AK051261 mRNA. Translation: BAC34579.1.
AK156013 mRNA. Translation: BAE33545.1.
BC031379 mRNA. Translation: AAH31379.1.
CCDSiCCDS21390.1.
RefSeqiNP_081696.1. NM_027420.4.
UniGeneiMm.34266.

Genome annotation databases

EnsembliENSMUST00000048731; ENSMUSP00000049440; ENSMUSG00000039043.
GeneIDi70420.
KEGGimmu:70420.
UCSCiuc009hzh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiARPIN_MOUSE
AccessioniPrimary (citable) accession number: Q9D0A3
Secondary accession number(s): Q3U1F3, Q8CA84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families