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UniProtKB - Q9D091 (Q9D091_MOUSE)

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Protein
Submitted name:

GTPase NRas

Gene

Nras

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1169092. Activation of RAS in B cells.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1433557. Signaling by SCF-KIT.
R-MMU-171007. p38MAPK events.
R-MMU-179812. GRB2 events in EGFR signaling.
R-MMU-180336. SHC1 events in EGFR signaling.
R-MMU-186763. Downstream signal transduction.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-210993. Tie2 Signaling.
R-MMU-2179392. EGFR Transactivation by Gastrin.
R-MMU-2424491. DAP12 signaling.
R-MMU-2871796. FCERI mediated MAPK activation.
R-MMU-375165. NCAM signaling for neurite out-growth.
R-MMU-5218921. VEGFR2 mediated cell proliferation.
R-MMU-5621575. CD209 (DC-SIGN) signaling.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-5673000. RAF activation.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-5674135. MAP2K and MAPK activation.
R-MMU-5675221. Negative regulation of MAPK pathway.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
R-MMU-8851805. MET activates RAS signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase NRasImported
Submitted name:
Neuroblastoma ras oncogeneImported
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:NrasImported
ORF Names:mCG_6411Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:97376. Nras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000027852.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOVERGENiHBG009351.
KOiK07828.
OMAiTIEXEQI.
OrthoDBiEOG091G0UAU.
TreeFamiTF312796.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51421. RAS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET 
        60         70         80         90        100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI 
       110        120        130        140        150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ 
       160        170        180 
GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPCVLM
Length:189
Mass (Da):21,243
Last modified:June 1, 2001 - v1
Checksum:i688D33F6815B1EC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163297 Genomic DNA. No translation available.
BC051443 mRNA. Translation: AAH51443.1.
BC058755 mRNA. Translation: AAH58755.1.
AK011704 mRNA. Translation: BAB27790.1.
CH466608 Genomic DNA. Translation: EDL07604.1.
RefSeqiNP_035067.2. NM_010937.2.
XP_006501183.1. XM_006501120.3.
XP_006501184.1. XM_006501121.3.
XP_006501185.1. XM_006501122.1.
XP_006501186.1. XM_006501123.1.
UniGeneiMm.400954.

Genome annotation databases

EnsembliENSMUST00000029445; ENSMUSP00000029445; ENSMUSG00000027852.
ENSMUST00000196355; ENSMUSP00000142438; ENSMUSG00000027852.
ENSMUST00000200069; ENSMUSP00000143391; ENSMUSG00000027852.
GeneIDi18176.
KEGGimmu:18176.
UCSCiuc008qsm.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9D091_MOUSE
AccessioniPrimary (citable) accession number: Q9D091
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported