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Q9D081

- ALG14_MOUSE

UniProt

Q9D081 - ALG14_MOUSE

Protein

UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Gene

Alg14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER By similarity.By similarity

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylglucosamine transferase subunit ALG14 homolog
    Gene namesi
    Name:Alg14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1914039. Alg14.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217UDP-N-acetylglucosamine transferase subunit ALG14 homologPRO_0000265117Add
    BLAST

    Proteomic databases

    PaxDbiQ9D081.
    PRIDEiQ9D081.

    PTM databases

    PhosphoSiteiQ9D081.

    Expressioni

    Gene expression databases

    BgeeiQ9D081.
    GenevestigatoriQ9D081.

    Interactioni

    Subunit structurei

    Heterodimer with ALG13 to form a functional enzyme.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D081.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33LumenalSequence Analysis
    Topological domaini27 – 217191CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALG14 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0707.
    GeneTreeiENSGT00390000002579.
    HOGENOMiHOG000182099.
    HOVERGENiHBG059605.
    InParanoidiQ9D081.
    KOiK07441.
    OMAiHQIPRSR.
    OrthoDBiEOG7SN8DK.
    PhylomeDBiQ9D081.
    TreeFamiTF105628.

    Family and domain databases

    InterProiIPR013969. Oligosacch_biosynth_Alg14.
    [Graphical view]
    PANTHERiPTHR12154. PTHR12154. 1 hit.
    PfamiPF08660. Alg14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D081-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSILILAAT AAGLVILLFQ RLWTVLGPHH VTPRESLRLL IVAGSGGHTT    50
    EILRLVGSLS NAYSPRHYVI AESDEMSAKK IHSLEELSRA QNDSTTEYPK 100
    YHLHRIPRSR EVRQSWLSSV FTTFYSMWFS FPLVLRIKPD LVLCNGPGTC 150
    VPICVSALLL GILGVKKVII VYVESICRVE TLSLSGKILR HLSDYFIVQW 200
    PTLKEKYPKS VYLGRIV 217
    Length:217
    Mass (Da):24,429
    Last modified:June 1, 2001 - v1
    Checksum:i471268EC8AF6BF15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011733 mRNA. Translation: BAB27807.1.
    AK017354 mRNA. Translation: BAC25513.1.
    BC002278 mRNA. Translation: AAH02278.1.
    CCDSiCCDS17801.1.
    RefSeqiNP_077140.1. NM_024178.2.
    UniGeneiMm.269881.

    Genome annotation databases

    EnsembliENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887.
    GeneIDi66789.
    KEGGimmu:66789.
    UCSCiuc008rdx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011733 mRNA. Translation: BAB27807.1 .
    AK017354 mRNA. Translation: BAC25513.1 .
    BC002278 mRNA. Translation: AAH02278.1 .
    CCDSi CCDS17801.1.
    RefSeqi NP_077140.1. NM_024178.2.
    UniGenei Mm.269881.

    3D structure databases

    ProteinModelPortali Q9D081.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q9D081.

    Proteomic databases

    PaxDbi Q9D081.
    PRIDEi Q9D081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039442 ; ENSMUSP00000038387 ; ENSMUSG00000039887 .
    GeneIDi 66789.
    KEGGi mmu:66789.
    UCSCi uc008rdx.1. mouse.

    Organism-specific databases

    CTDi 199857.
    MGIi MGI:1914039. Alg14.

    Phylogenomic databases

    eggNOGi COG0707.
    GeneTreei ENSGT00390000002579.
    HOGENOMi HOG000182099.
    HOVERGENi HBG059605.
    InParanoidi Q9D081.
    KOi K07441.
    OMAi HQIPRSR.
    OrthoDBi EOG7SN8DK.
    PhylomeDBi Q9D081.
    TreeFami TF105628.

    Miscellaneous databases

    NextBioi 322659.
    PROi Q9D081.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D081.
    Genevestigatori Q9D081.

    Family and domain databases

    InterProi IPR013969. Oligosacch_biosynth_Alg14.
    [Graphical view ]
    PANTHERi PTHR12154. PTHR12154. 1 hit.
    Pfami PF08660. Alg14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiALG14_MOUSE
    AccessioniPrimary (citable) accession number: Q9D081
    Secondary accession number(s): Q8CEP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3