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Q9D081

- ALG14_MOUSE

UniProt

Q9D081 - ALG14_MOUSE

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Protein

UDP-N-acetylglucosamine transferase subunit ALG14 homolog

Gene

Alg14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).By similarity

Enzyme and pathway databases

ReactomeiREACT_262413. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG14 homolog
Gene namesi
Name:Alg14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1914039. Alg14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalSequence Analysis
Transmembranei4 – 2623HelicalSequence AnalysisAdd
BLAST
Topological domaini27 – 217191CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217UDP-N-acetylglucosamine transferase subunit ALG14 homologPRO_0000265117Add
BLAST

Proteomic databases

MaxQBiQ9D081.
PaxDbiQ9D081.
PRIDEiQ9D081.

PTM databases

PhosphoSiteiQ9D081.

Expressioni

Gene expression databases

BgeeiQ9D081.
GenevestigatoriQ9D081.

Interactioni

Subunit structurei

Heterodimer with ALG13 to form a functional enzyme.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0707.
GeneTreeiENSGT00390000002579.
HOGENOMiHOG000182099.
HOVERGENiHBG059605.
InParanoidiQ9D081.
KOiK07441.
OMAiHQIPRSR.
OrthoDBiEOG7SN8DK.
PhylomeDBiQ9D081.
TreeFamiTF105628.

Family and domain databases

InterProiIPR013969. Oligosacch_biosynth_Alg14.
[Graphical view]
PANTHERiPTHR12154. PTHR12154. 1 hit.
PfamiPF08660. Alg14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D081-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSILILAAT AAGLVILLFQ RLWTVLGPHH VTPRESLRLL IVAGSGGHTT
60 70 80 90 100
EILRLVGSLS NAYSPRHYVI AESDEMSAKK IHSLEELSRA QNDSTTEYPK
110 120 130 140 150
YHLHRIPRSR EVRQSWLSSV FTTFYSMWFS FPLVLRIKPD LVLCNGPGTC
160 170 180 190 200
VPICVSALLL GILGVKKVII VYVESICRVE TLSLSGKILR HLSDYFIVQW
210
PTLKEKYPKS VYLGRIV
Length:217
Mass (Da):24,429
Last modified:June 1, 2001 - v1
Checksum:i471268EC8AF6BF15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011733 mRNA. Translation: BAB27807.1.
AK017354 mRNA. Translation: BAC25513.1.
BC002278 mRNA. Translation: AAH02278.1.
CCDSiCCDS17801.1.
RefSeqiNP_077140.1. NM_024178.2.
UniGeneiMm.269881.

Genome annotation databases

EnsembliENSMUST00000039442; ENSMUSP00000038387; ENSMUSG00000039887.
GeneIDi66789.
KEGGimmu:66789.
UCSCiuc008rdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011733 mRNA. Translation: BAB27807.1 .
AK017354 mRNA. Translation: BAC25513.1 .
BC002278 mRNA. Translation: AAH02278.1 .
CCDSi CCDS17801.1.
RefSeqi NP_077140.1. NM_024178.2.
UniGenei Mm.269881.

3D structure databases

ProteinModelPortali Q9D081.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q9D081.

Proteomic databases

MaxQBi Q9D081.
PaxDbi Q9D081.
PRIDEi Q9D081.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039442 ; ENSMUSP00000038387 ; ENSMUSG00000039887 .
GeneIDi 66789.
KEGGi mmu:66789.
UCSCi uc008rdx.1. mouse.

Organism-specific databases

CTDi 199857.
MGIi MGI:1914039. Alg14.

Phylogenomic databases

eggNOGi COG0707.
GeneTreei ENSGT00390000002579.
HOGENOMi HOG000182099.
HOVERGENi HBG059605.
InParanoidi Q9D081.
KOi K07441.
OMAi HQIPRSR.
OrthoDBi EOG7SN8DK.
PhylomeDBi Q9D081.
TreeFami TF105628.

Enzyme and pathway databases

Reactomei REACT_262413. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Miscellaneous databases

NextBioi 322659.
PROi Q9D081.
SOURCEi Search...

Gene expression databases

Bgeei Q9D081.
Genevestigatori Q9D081.

Family and domain databases

InterProi IPR013969. Oligosacch_biosynth_Alg14.
[Graphical view ]
PANTHERi PTHR12154. PTHR12154. 1 hit.
Pfami PF08660. Alg14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiALG14_MOUSE
AccessioniPrimary (citable) accession number: Q9D081
Secondary accession number(s): Q8CEP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3