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Protein

Nuclear protein MDM1

Gene

Mdm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of centriole replication Source: UniProtKB
  • photoreceptor cell maintenance Source: MGI
  • retina development in camera-type eye Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear protein MDM1
Alternative name(s):
Mdm4 transformed 3T3 cell double minute 1 protein
Mouse double minute 1
Gene namesi
Name:Mdm1
Synonyms:Mdm-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96951. Mdm1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: MGI
  • microtubule Source: UniProtKB-KW
  • non-motile cilium Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990601 – 708Nuclear protein MDM1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei284PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei315PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei556PhosphoserineCombined sources1
Modified residuei581PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D067.
PeptideAtlasiQ9D067.
PRIDEiQ9D067.

PTM databases

iPTMnetiQ9D067.
PhosphoSitePlusiQ9D067.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in the testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000020212.
CleanExiMM_MDM1.
ExpressionAtlasiQ9D067. baseline and differential.
GenevisibleiQ9D067. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127919.

Structurei

3D structure databases

ProteinModelPortaliQ9D067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili322 – 355Sequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 15ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilizationBy similarity7
Motifi193 – 199ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilizationBy similarity7
Motifi236 – 242ST]-E-Y-X(3)-F motif 3; required for efficient microtubule bindingBy similarity7
Motifi307 – 313ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilizationBy similarity7

Sequence similaritiesi

Belongs to the MDM1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410II1Y. Eukaryota.
ENOG410Y0E2. LUCA.
GeneTreeiENSGT00390000004106.
HOVERGENiHBG108124.
InParanoidiQ9D067.
KOiK17886.
PhylomeDBiQ9D067.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PANTHERiPTHR32078:SF1. PTHR32078:SF1. 1 hit.
PfamiPF15501. MDM1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms may exist.
Isoform 1 (identifier: Q9D067-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVRFKGLSE YQRNFLWKKS YLSESYNPSV GQKYSWAGLR SDQLGITKEP
60 70 80 90 100
GFISKRRVPY HDPQISKYLE WNGTVRKKDT LVPPEPQAFG TPKPQEAEQG
110 120 130 140 150
EDANQEAVLS LEASRVPKRT RSHSADSRAE GVSDTVEKHQ GVTRSHAPVS
160 170 180 190 200
ADVELRPSSK QPLSQSIDPR LDRHLRKKAG LAVVPTNNAL RNSEYQRQFV
210 220 230 240 250
WKTSKESAPV FASNQVFRNK SQIIPQFQGN TFTHETEYKR NFKGLTPVKE
260 270 280 290 300
PKSREYLKGN SSLEMLTPVK KADEPLDLEV DMASEDSDQS VKKPASWRHQ
310 320 330 340 350
RLGKVNSEYR AKFLSPAQYF YKAGAWTRVK ENLSNQVKEL REKAESYRKR
360 370 380 390 400
VQGTHFSRDH LNQIMSDSNC CWDVSSVTSS EGTVSSNIRA LDLAGDLTNH
410 420 430 440 450
RTPQKHPPTK LEERKVASGE QPLKNSTRRL EMPEPAASVR RKLAWDAEES
460 470 480 490 500
TKEDTQEEPR AEEDGREERG QDKQTCAVEL EKPDTQTPKA DRLTEGSETS
510 520 530 540 550
SVSSGKGGRL PTPRLRELGI QRTHHDLTTP AVGGAVLVSP SKVKPPGLEQ
560 570 580 590 600
RRRASSQDGL ETLKKDITKK GKPRPMSLLT SPAAGMKTVD PLPLREDCEA
610 620 630 640 650
NVLRFADTLP VSKILDRQPS TPGQLPPCAP PYCHPSSRIQ GRLRDPEFQH
660 670 680 690 700
NMGKPRTNNL QLHPHDAFND EDADRLSEIS ARSAVSSLRA FQTLARAQKR

KENFWGKP
Length:708
Mass (Da):79,689
Last modified:August 21, 2007 - v2
Checksum:iFF3BE0BA5167FB28
GO
Isoform 2 (identifier: Q9D067-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     607-607: D → EG
     652-672: MGKPRTNNLQLHPHDAFNDED → N

Show »
Length:689
Mass (Da):77,443
Checksum:i9D4E448C9D1A383D
GO
Isoform 3 (identifier: Q9D067-3) [UniParc]FASTAAdd to basket
Also known as: Mdm1a

The sequence of this isoform differs from the canonical sequence as follows:
     217-222: FRNKSQ → AQEMRF
     223-708: Missing.

Show »
Length:222
Mass (Da):25,148
Checksum:iB55D376B9CE19200
GO
Isoform 4 (identifier: Q9D067-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-215: Missing.

Show »
Length:663
Mass (Da):74,551
Checksum:i8F44EC266D3F2C6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40R → K in BAB27830 (PubMed:16141072).Curated1
Sequence conflicti438S → L in AAA39511 (PubMed:3182840).Curated1
Sequence conflicti442K → E in BAB23566 (PubMed:16141072).Curated1
Sequence conflicti456Q → P in BAB23566 (PubMed:16141072).Curated1
Sequence conflicti472D → G in AAA39511 (PubMed:3182840).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027548171 – 215Missing in isoform 4. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_027549217 – 222FRNKSQ → AQEMRF in isoform 3. 1 Publication6
Alternative sequenceiVSP_027550223 – 708Missing in isoform 3. 1 PublicationAdd BLAST486
Alternative sequenceiVSP_027551607D → EG in isoform 2. 1 Publication1
Alternative sequenceiVSP_027552652 – 672MGKPR…FNDED → N in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20823 mRNA. Translation: AAA39511.1.
M20824 mRNA. Translation: AAA39512.1.
AK004789 mRNA. Translation: BAB23566.1.
AK011769 mRNA. Translation: BAB27830.1.
CCDSiCCDS36069.1. [Q9D067-1]
PIRiA31794.
B31794.
RefSeqiNP_001156376.1. NM_001162904.1.
NP_001156377.1. NM_001162905.1.
NP_034915.2. NM_010785.2.
NP_683724.2. NM_148922.3. [Q9D067-1]
UniGeneiMm.101191.
Mm.442618.

Genome annotation databases

EnsembliENSMUST00000020437; ENSMUSP00000020437; ENSMUSG00000020212. [Q9D067-1]
GeneIDi17245.
KEGGimmu:17245.
UCSCiuc007hds.2. mouse. [Q9D067-3]
uc007hdt.2. mouse. [Q9D067-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20823 mRNA. Translation: AAA39511.1.
M20824 mRNA. Translation: AAA39512.1.
AK004789 mRNA. Translation: BAB23566.1.
AK011769 mRNA. Translation: BAB27830.1.
CCDSiCCDS36069.1. [Q9D067-1]
PIRiA31794.
B31794.
RefSeqiNP_001156376.1. NM_001162904.1.
NP_001156377.1. NM_001162905.1.
NP_034915.2. NM_010785.2.
NP_683724.2. NM_148922.3. [Q9D067-1]
UniGeneiMm.101191.
Mm.442618.

3D structure databases

ProteinModelPortaliQ9D067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127919.

PTM databases

iPTMnetiQ9D067.
PhosphoSitePlusiQ9D067.

Proteomic databases

PaxDbiQ9D067.
PeptideAtlasiQ9D067.
PRIDEiQ9D067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020437; ENSMUSP00000020437; ENSMUSG00000020212. [Q9D067-1]
GeneIDi17245.
KEGGimmu:17245.
UCSCiuc007hds.2. mouse. [Q9D067-3]
uc007hdt.2. mouse. [Q9D067-1]

Organism-specific databases

CTDi56890.
MGIiMGI:96951. Mdm1.

Phylogenomic databases

eggNOGiENOG410II1Y. Eukaryota.
ENOG410Y0E2. LUCA.
GeneTreeiENSGT00390000004106.
HOVERGENiHBG108124.
InParanoidiQ9D067.
KOiK17886.
PhylomeDBiQ9D067.

Miscellaneous databases

PROiQ9D067.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020212.
CleanExiMM_MDM1.
ExpressionAtlasiQ9D067. baseline and differential.
GenevisibleiQ9D067. MM.

Family and domain databases

InterProiIPR029136. MDM1.
[Graphical view]
PANTHERiPTHR32078:SF1. PTHR32078:SF1. 1 hit.
PfamiPF15501. MDM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDM1_MOUSE
AccessioniPrimary (citable) accession number: Q9D067
Secondary accession number(s): Q61841, Q61842, Q9DBR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.