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Q9D032

- SSBP3_MOUSE

UniProt

Q9D032 - SSBP3_MOUSE

Protein

Single-stranded DNA-binding protein 3

Gene

Ssbp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. single-stranded DNA binding Source: MGI

    GO - Biological processi

    1. head development Source: UniProtKB
    2. head morphogenesis Source: UniProtKB
    3. hematopoietic progenitor cell differentiation Source: MGI
    4. midbrain-hindbrain boundary initiation Source: UniProtKB
    5. positive regulation of anterior head development Source: UniProtKB
    6. positive regulation of cell proliferation Source: UniProtKB
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    9. prechordal plate formation Source: UniProtKB
    10. protein complex assembly Source: UniProtKB
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Single-stranded DNA-binding protein 3
    Alternative name(s):
    Lck-associated signal transducer
    Sequence-specific single-stranded-DNA-binding protein
    Gene namesi
    Name:Ssbp3
    Synonyms:Last, Ssdp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1919725. Ssbp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Single-stranded DNA-binding protein 3PRO_0000123829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei347 – 3471Phosphoserine1 Publication
    Modified residuei352 – 3521PhosphoserineBy similarity
    Modified residuei360 – 3601Phosphothreonine1 Publication
    Modified residuei381 – 3811PhosphoserineBy similarity
    Modified residuei387 – 3871PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9D032.
    PaxDbiQ9D032.
    PRIDEiQ9D032.

    PTM databases

    PhosphoSiteiQ9D032.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D032.
    BgeeiQ9D032.
    CleanExiMM_SSBP3.
    GenevestigatoriQ9D032.

    Interactioni

    Protein-protein interaction databases

    BioGridi215389. 27 interactions.
    DIPiDIP-42843N.
    IntActiQ9D032. 1 interaction.
    MINTiMINT-2568056.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D032.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 4833LisHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi98 – 319222Pro-richAdd
    BLAST
    Compositional biasi158 – 369212Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245801.
    GeneTreeiENSGT00390000009187.
    HOGENOMiHOG000037785.
    HOVERGENiHBG068487.
    InParanoidiQ9D032.
    OMAiHNPNSMM.
    OrthoDBiEOG7V4B0F.
    PhylomeDBiQ9D032.
    TreeFamiTF318961.

    Family and domain databases

    InterProiIPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view]
    PRINTSiPR01743. SSDNABINDING.
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D032-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI    50
    TLGEPPGFLH SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP 100
    VLGNIPPNDG MPGGPIPPGF FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP 150
    FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL LPNSMDPTRQ QGHPNMGGSM 200
    QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG PGAGRPWPNP 250
    NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP 300
    VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN 350
    ISGISNPPGT PRDDGELGGN FLHSFQNDNY SPSMTMSV 388
    Length:388
    Mass (Da):40,421
    Last modified:January 16, 2004 - v2
    Checksum:iDBBB169D4EE10536
    GO
    Isoform 2 (identifier: Q9D032-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-148: Missing.

    Show »
    Length:361
    Mass (Da):37,697
    Checksum:iCECDA59F18EFC0B2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431A → D in AAG43403. 1 PublicationCurated
    Sequence conflicti243 – 2431A → V in BAB27882. (PubMed:16141072)Curated
    Sequence conflicti335 – 3351L → V in AAG43403. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei122 – 14827Missing in isoform 2. 4 PublicationsVSP_006262Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170906 mRNA. Translation: AAG43403.1.
    AF500117 mRNA. Translation: AAM22102.1.
    AY167987 mRNA. Translation: AAN87333.1.
    AK011853 mRNA. Translation: BAB27882.1.
    BC003430 mRNA. Translation: AAH03430.1.
    CCDSiCCDS18427.1. [Q9D032-1]
    CCDS18428.1. [Q9D032-2]
    RefSeqiNP_076161.2. NM_023672.2. [Q9D032-1]
    NP_940840.1. NM_198438.1. [Q9D032-2]
    UniGeneiMm.195635.
    Mm.474861.

    Genome annotation databases

    EnsembliENSMUST00000030367; ENSMUSP00000030367; ENSMUSG00000061887. [Q9D032-1]
    ENSMUST00000072753; ENSMUSP00000072536; ENSMUSG00000061887. [Q9D032-2]
    GeneIDi72475.
    KEGGimmu:72475.
    UCSCiuc008tyx.1. mouse. [Q9D032-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF170906 mRNA. Translation: AAG43403.1 .
    AF500117 mRNA. Translation: AAM22102.1 .
    AY167987 mRNA. Translation: AAN87333.1 .
    AK011853 mRNA. Translation: BAB27882.1 .
    BC003430 mRNA. Translation: AAH03430.1 .
    CCDSi CCDS18427.1. [Q9D032-1 ]
    CCDS18428.1. [Q9D032-2 ]
    RefSeqi NP_076161.2. NM_023672.2. [Q9D032-1 ]
    NP_940840.1. NM_198438.1. [Q9D032-2 ]
    UniGenei Mm.195635.
    Mm.474861.

    3D structure databases

    ProteinModelPortali Q9D032.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 215389. 27 interactions.
    DIPi DIP-42843N.
    IntActi Q9D032. 1 interaction.
    MINTi MINT-2568056.

    PTM databases

    PhosphoSitei Q9D032.

    Proteomic databases

    MaxQBi Q9D032.
    PaxDbi Q9D032.
    PRIDEi Q9D032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030367 ; ENSMUSP00000030367 ; ENSMUSG00000061887 . [Q9D032-1 ]
    ENSMUST00000072753 ; ENSMUSP00000072536 ; ENSMUSG00000061887 . [Q9D032-2 ]
    GeneIDi 72475.
    KEGGi mmu:72475.
    UCSCi uc008tyx.1. mouse. [Q9D032-1 ]

    Organism-specific databases

    CTDi 23648.
    MGIi MGI:1919725. Ssbp3.

    Phylogenomic databases

    eggNOGi NOG245801.
    GeneTreei ENSGT00390000009187.
    HOGENOMi HOG000037785.
    HOVERGENi HBG068487.
    InParanoidi Q9D032.
    OMAi HNPNSMM.
    OrthoDBi EOG7V4B0F.
    PhylomeDBi Q9D032.
    TreeFami TF318961.

    Miscellaneous databases

    ChiTaRSi SSBP3. mouse.
    NextBioi 336302.
    PROi Q9D032.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D032.
    Bgeei Q9D032.
    CleanExi MM_SSBP3.
    Genevestigatori Q9D032.

    Family and domain databases

    InterProi IPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view ]
    PRINTSi PR01743. SSDNABINDING.
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LAST, a novel protein binding to the SH2 domain of Lck/Src, mediates signaling events of the Src-type tyrosine kinase."
      Park C., Choi Y.B., Park D., Hur E.M., Yun Y.D.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: T-cell lymphoma.
    2. "SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain."
      Bayarsaihan D.
      Biochim. Biophys. Acta 1599:152-155(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo."
      van Meyel D.J., Thomas J.B., Agulnick A.D.
      Development 130:1915-1925(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C3H.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND THR-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSSBP3_MOUSE
    AccessioniPrimary (citable) accession number: Q9D032
    Secondary accession number(s): Q99LC6, Q9EQP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3