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Protein

Coiled-coil domain-containing protein 47

Gene

Ccdc47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • poly(A) RNA binding Source: MGI

GO - Biological processi

  • calcium ion homeostasis Source: MGI
  • endoplasmic reticulum organization Source: MGI
  • ER-associated ubiquitin-dependent protein catabolic process Source: MGI
  • ER overload response Source: MGI
  • osteoblast differentiation Source: MGI
  • post-embryonic development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 47
Alternative name(s):
Adipocyte-specific protein 4
Gene namesi
Name:Ccdc47
Synonyms:Asp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1914413. Ccdc47.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • rough endoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023579921 – 483Coiled-coil domain-containing protein 47Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9D024.
PaxDbiQ9D024.
PeptideAtlasiQ9D024.
PRIDEiQ9D024.

PTM databases

iPTMnetiQ9D024.
PhosphoSitePlusiQ9D024.
SwissPalmiQ9D024.

Expressioni

Gene expression databases

BgeeiENSMUSG00000078622.
CleanExiMM_CCDC47.
ExpressionAtlasiQ9D024. baseline and differential.
GenevisibleiQ9D024. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D024. 3 interactors.
MINTiMINT-4122411.
STRINGi10090.ENSMUSP00000002043.

Structurei

3D structure databases

ProteinModelPortaliQ9D024.
SMRiQ9D024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili450 – 483Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2357. Eukaryota.
ENOG410XREM. LUCA.
GeneTreeiENSGT00390000013997.
HOGENOMiHOG000007179.
HOVERGENiHBG081033.
InParanoidiQ9D024.
OMAiIDQKVEP.
OrthoDBiEOG091G0ERU.
PhylomeDBiQ9D024.
TreeFamiTF314902.

Family and domain databases

InterProiIPR012879. DUF1682.
[Graphical view]
PANTHERiPTHR12883. PTHR12883. 1 hit.
PfamiPF07946. DUF1682. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D024-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAFYAFCVV LLVFGSVSEA KFDDFEDEED IVEYDDNDFA EFEDVMEDSV
60 70 80 90 100
TESPQRVIST EDDEDEATVE LEGQDESQEG DFEDADTQEG DTESEPYDDE
110 120 130 140 150
EFEGYEDKPD TSSNKNKDPI TIVDVPAHLQ NSWESYYLEI LMVTGLLAYI
160 170 180 190 200
MNYIIGKNKN SRLAQAWFNS HRELLESNFT LVGDDGTNKE ATSTGKLNQE
210 220 230 240 250
NEHIYNLWCS GRVCCEGMLI QLRFLKRQDL LNVLARMMRP VSDQVQIKVT
260 270 280 290 300
MNDEDMDTYV FAVGTRKALL RLQKEMQDLS EFCSDKPKSG AKYGLPDSLA
310 320 330 340 350
ILSEMGEVTE GMMDTKMVHF LTHYADKIES VHFSDQFSGP KIMQEEGQPL
360 370 380 390 400
KLPDTKRTLL FTFNVPGSGN TYPKDMESLL PLMNMVIYSI DKAKKFRLNR
410 420 430 440 450
EGKQKADKNR ARVEENFLKL THVQRQEAAQ SRREEKKRAE KERIMNEEDP
460 470 480
EKQRRLEEAA LRREQKKLEK KQMKMKQIKV KAM
Length:483
Mass (Da):55,844
Last modified:May 16, 2006 - v2
Checksum:iDDD4DDFE644D65E9
GO
Isoform 2 (identifier: Q9D024-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-483: EAALRREQKKLEKKQMKMKQIKVKAM → VRHSEARLLGSASLLCGFMF

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):54,865
Checksum:i56C30747478FE3BB
GO
Isoform 3 (identifier: Q9D024-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,846
Checksum:i44ED19BF0E62EE61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111T → A in BAB27896 (PubMed:16141072).Curated1
Sequence conflicti111T → A in BAE36760 (PubMed:16141072).Curated1
Sequence conflicti145G → S in BAC37406 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184791 – 316Missing in isoform 3. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_018480458 – 483EAALR…KVKAM → VRHSEARLLGSASLLCGFMF in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040489 mRNA. Translation: BAB68502.1.
AK011882 mRNA. Translation: BAB27896.1.
AK078812 mRNA. Translation: BAC37406.1.
AK132273 mRNA. Translation: BAE21073.1.
AK162160 mRNA. Translation: BAE36760.1.
AL596331 Genomic DNA. Translation: CAM27020.1.
CCDSiCCDS25551.1. [Q9D024-1]
RefSeqiNP_080285.2. NM_026009.2. [Q9D024-1]
UniGeneiMm.22109.

Genome annotation databases

EnsembliENSMUST00000002043; ENSMUSP00000002043; ENSMUSG00000078622. [Q9D024-1]
ENSMUST00000106865; ENSMUSP00000102478; ENSMUSG00000078622. [Q9D024-3]
GeneIDi67163.
KEGGimmu:67163.
UCSCiuc007lyi.1. mouse. [Q9D024-1]
uc007lyj.1. mouse. [Q9D024-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040489 mRNA. Translation: BAB68502.1.
AK011882 mRNA. Translation: BAB27896.1.
AK078812 mRNA. Translation: BAC37406.1.
AK132273 mRNA. Translation: BAE21073.1.
AK162160 mRNA. Translation: BAE36760.1.
AL596331 Genomic DNA. Translation: CAM27020.1.
CCDSiCCDS25551.1. [Q9D024-1]
RefSeqiNP_080285.2. NM_026009.2. [Q9D024-1]
UniGeneiMm.22109.

3D structure databases

ProteinModelPortaliQ9D024.
SMRiQ9D024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D024. 3 interactors.
MINTiMINT-4122411.
STRINGi10090.ENSMUSP00000002043.

PTM databases

iPTMnetiQ9D024.
PhosphoSitePlusiQ9D024.
SwissPalmiQ9D024.

Proteomic databases

EPDiQ9D024.
PaxDbiQ9D024.
PeptideAtlasiQ9D024.
PRIDEiQ9D024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002043; ENSMUSP00000002043; ENSMUSG00000078622. [Q9D024-1]
ENSMUST00000106865; ENSMUSP00000102478; ENSMUSG00000078622. [Q9D024-3]
GeneIDi67163.
KEGGimmu:67163.
UCSCiuc007lyi.1. mouse. [Q9D024-1]
uc007lyj.1. mouse. [Q9D024-2]

Organism-specific databases

CTDi57003.
MGIiMGI:1914413. Ccdc47.

Phylogenomic databases

eggNOGiKOG2357. Eukaryota.
ENOG410XREM. LUCA.
GeneTreeiENSGT00390000013997.
HOGENOMiHOG000007179.
HOVERGENiHBG081033.
InParanoidiQ9D024.
OMAiIDQKVEP.
OrthoDBiEOG091G0ERU.
PhylomeDBiQ9D024.
TreeFamiTF314902.

Miscellaneous databases

PROiQ9D024.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078622.
CleanExiMM_CCDC47.
ExpressionAtlasiQ9D024. baseline and differential.
GenevisibleiQ9D024. MM.

Family and domain databases

InterProiIPR012879. DUF1682.
[Graphical view]
PANTHERiPTHR12883. PTHR12883. 1 hit.
PfamiPF07946. DUF1682. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD47_MOUSE
AccessioniPrimary (citable) accession number: Q9D024
Secondary accession number(s): B1AR94
, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.