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Protein

Mitochondrial pyruvate carrier 2

Gene

Mpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

GO - Biological processi

  • mitochondrial acetyl-CoA biosynthetic process from pyruvate Source: MGI
  • mitochondrial pyruvate transmembrane transport Source: MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Gene namesi
Name:Mpc2
Synonyms:Brp44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917706. Mpc2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei73 – 90HelicalSequence analysisAdd BLAST18
Transmembranei93 – 115HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002127941 – 127Mitochondrial pyruvate carrier 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D023.
MaxQBiQ9D023.
PaxDbiQ9D023.
PeptideAtlasiQ9D023.
PRIDEiQ9D023.

PTM databases

iPTMnetiQ9D023.
PhosphoSitePlusiQ9D023.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026568.
CleanExiMM_BRP44.
ExpressionAtlasiQ9D023. baseline and differential.
GenevisibleiQ9D023. MM.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.1 Publication

Protein-protein interaction databases

BioGridi214064. 2 interactors.
IntActiQ9D023. 3 interactors.
MINTiMINT-1846500.
STRINGi10090.ENSMUSP00000027853.

Structurei

3D structure databases

ProteinModelPortaliQ9D023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1589. Eukaryota.
ENOG4111UER. LUCA.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiQ9D023.
OMAiSQLYRIW.
OrthoDBiEOG091G0XXH.
PhylomeDBiQ9D023.
TreeFamiTF300066.

Family and domain databases

InterProiView protein in InterPro
IPR005336. MPC.
PfamiView protein in Pfam
PF03650. MPC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGARGLR ATYHRLMDKV ELLLPKKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSTVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGSAGASQ LFRIWRYNQE LKSKGIQ
Length:127
Mass (Da):14,286
Last modified:June 1, 2001 - v1
Checksum:iBE8AEC9DF74405A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002233 mRNA. Translation: BAC24983.1.
AK011889 mRNA. Translation: BAB27898.1.
AK151522 mRNA. Translation: BAE30471.1.
BC018324 mRNA. Translation: AAH18324.1.
CCDSiCCDS15442.1.
RefSeqiNP_081706.1. NM_027430.2.
UniGeneiMm.195625.
Mm.450001.

Genome annotation databases

EnsembliENSMUST00000027853; ENSMUSP00000027853; ENSMUSG00000026568.
GeneIDi70456.
KEGGimmu:70456.
UCSCiuc007djd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D023
Secondary accession number(s): Q3UA44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families