Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial pyruvate carrier 2

Gene

Mpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of pyruvate into mitochondria.1 Publication

GO - Biological processi

  • mitochondrial acetyl-CoA biosynthetic process from pyruvate Source: MGI
  • mitochondrial pyruvate transmembrane transport Source: MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial pyruvate carrier 2
Alternative name(s):
Brain protein 44
Gene namesi
Name:Mpc2
Synonyms:Brp44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917706. Mpc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei73 – 90HelicalSequence analysisAdd BLAST18
Transmembranei93 – 115HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002127941 – 127Mitochondrial pyruvate carrier 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D023.
MaxQBiQ9D023.
PaxDbiQ9D023.
PeptideAtlasiQ9D023.
PRIDEiQ9D023.

PTM databases

iPTMnetiQ9D023.
PhosphoSitePlusiQ9D023.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026568.
CleanExiMM_BRP44.
ExpressionAtlasiQ9D023. baseline and differential.
GenevisibleiQ9D023. MM.

Interactioni

Subunit structurei

The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.1 Publication

Protein-protein interaction databases

BioGridi214064. 1 interactor.
IntActiQ9D023. 3 interactors.
MINTiMINT-1846500.
STRINGi10090.ENSMUSP00000027853.

Structurei

3D structure databases

ProteinModelPortaliQ9D023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1589. Eukaryota.
ENOG4111UER. LUCA.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiQ9D023.
OMAiASYHRIL.
OrthoDBiEOG091G0XXH.
PhylomeDBiQ9D023.
TreeFamiTF300066.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGARGLR ATYHRLMDKV ELLLPKKLRP LYNHPAGPRT VFFWAPIMKW
60 70 80 90 100
GLVCAGLADM ARPAEKLSTA QSTVLMATGF IWSRYSLVII PKNWSLFAVN
110 120
FFVGSAGASQ LFRIWRYNQE LKSKGIQ
Length:127
Mass (Da):14,286
Last modified:June 1, 2001 - v1
Checksum:iBE8AEC9DF74405A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002233 mRNA. Translation: BAC24983.1.
AK011889 mRNA. Translation: BAB27898.1.
AK151522 mRNA. Translation: BAE30471.1.
BC018324 mRNA. Translation: AAH18324.1.
CCDSiCCDS15442.1.
RefSeqiNP_081706.1. NM_027430.2.
UniGeneiMm.195625.
Mm.450001.

Genome annotation databases

EnsembliENSMUST00000027853; ENSMUSP00000027853; ENSMUSG00000026568.
GeneIDi70456.
KEGGimmu:70456.
UCSCiuc007djd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002233 mRNA. Translation: BAC24983.1.
AK011889 mRNA. Translation: BAB27898.1.
AK151522 mRNA. Translation: BAE30471.1.
BC018324 mRNA. Translation: AAH18324.1.
CCDSiCCDS15442.1.
RefSeqiNP_081706.1. NM_027430.2.
UniGeneiMm.195625.
Mm.450001.

3D structure databases

ProteinModelPortaliQ9D023.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214064. 1 interactor.
IntActiQ9D023. 3 interactors.
MINTiMINT-1846500.
STRINGi10090.ENSMUSP00000027853.

PTM databases

iPTMnetiQ9D023.
PhosphoSitePlusiQ9D023.

Proteomic databases

EPDiQ9D023.
MaxQBiQ9D023.
PaxDbiQ9D023.
PeptideAtlasiQ9D023.
PRIDEiQ9D023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027853; ENSMUSP00000027853; ENSMUSG00000026568.
GeneIDi70456.
KEGGimmu:70456.
UCSCiuc007djd.1. mouse.

Organism-specific databases

CTDi25874.
MGIiMGI:1917706. Mpc2.

Phylogenomic databases

eggNOGiKOG1589. Eukaryota.
ENOG4111UER. LUCA.
GeneTreeiENSGT00510000047120.
HOGENOMiHOG000188910.
HOVERGENiHBG023934.
InParanoidiQ9D023.
OMAiASYHRIL.
OrthoDBiEOG091G0XXH.
PhylomeDBiQ9D023.
TreeFamiTF300066.

Miscellaneous databases

PROiQ9D023.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026568.
CleanExiMM_BRP44.
ExpressionAtlasiQ9D023. baseline and differential.
GenevisibleiQ9D023. MM.

Family and domain databases

InterProiIPR005336. MPC.
[Graphical view]
PfamiPF03650. MPC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D023
Secondary accession number(s): Q3UA44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.