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Q9D011

- MPLKI_MOUSE

UniProt

Q9D011 - MPLKI_MOUSE

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Protein

M-phase-specific PLK1-interacting protein

Gene

Mplkip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.By similarity

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein homolog
Gene namesi
Name:Mplkip
Synonyms:Ttdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1913558. Mplkip.

Subcellular locationi

Nucleus. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. midbody Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178M-phase-specific PLK1-interacting proteinPRO_0000065675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei50 – 501PhosphothreonineBy similarity
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei119 – 1191PhosphothreonineBy similarity
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9D011.

PTM databases

PhosphoSiteiQ9D011.

Expressioni

Gene expression databases

BgeeiQ9D011.
CleanExiMM_2810021B07RIK.
ExpressionAtlasiQ9D011. baseline and differential.
GenevestigatoriQ9D011.

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45065.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ9D011.
OMAiHRPNFRP.
OrthoDBiEOG7BP84Z.
PhylomeDBiQ9D011.
TreeFamiTF335586.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP_like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D011-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT
60 70 80 90 100
PPCGPRARPY GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF
110 120 130 140 150
GYSPGQQQTY PQGSPRTSTP FGSGRGREKR MSNELESYFK PSMLEDPWAG
160 170
LEPVSVVDIS QQYSNTQTFT GKKGRYFS
Length:178
Mass (Da):19,060
Last modified:June 1, 2001 - v1
Checksum:i0DA799EDEB988986
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
CCDSiCCDS26253.1.
RefSeqiNP_079755.1. NM_025479.5.
UniGeneiMm.291109.
Mm.400463.

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneIDi66308.
KEGGimmu:66308.
UCSCiuc007poa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK011919 mRNA. Translation: BAB27916.1 .
AK030630 mRNA. Translation: BAC27054.1 .
CCDSi CCDS26253.1.
RefSeqi NP_079755.1. NM_025479.5.
UniGenei Mm.291109.
Mm.400463.

3D structure databases

ProteinModelPortali Q9D011.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D011.

Proteomic databases

PRIDEi Q9D011.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049744 ; ENSMUSP00000059154 ; ENSMUSG00000012429 .
GeneIDi 66308.
KEGGi mmu:66308.
UCSCi uc007poa.1. mouse.

Organism-specific databases

CTDi 136647.
MGIi MGI:1913558. Mplkip.

Phylogenomic databases

eggNOGi NOG45065.
GeneTreei ENSGT00390000002582.
HOGENOMi HOG000252982.
HOVERGENi HBG073319.
InParanoidi Q9D011.
OMAi HRPNFRP.
OrthoDBi EOG7BP84Z.
PhylomeDBi Q9D011.
TreeFami TF335586.

Miscellaneous databases

NextBioi 321269.
PROi Q9D011.
SOURCEi Search...

Gene expression databases

Bgeei Q9D011.
CleanExi MM_2810021B07RIK.
ExpressionAtlasi Q9D011. baseline and differential.
Genevestigatori Q9D011.

Family and domain databases

InterProi IPR028265. MPLKIP-like.
IPR026618. MPLKIP_like_vertebrate.
[Graphical view ]
PANTHERi PTHR22446. PTHR22446. 1 hit.
Pfami PF15502. MPLKIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Pituitary.

Entry informationi

Entry nameiMPLKI_MOUSE
AccessioniPrimary (citable) accession number: Q9D011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3