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Protein

M-phase-specific PLK1-interacting protein

Gene

Mplkip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.By similarity

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein homolog
Gene namesi
Name:Mplkip
Synonyms:Ttdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913558. Mplkip.

Subcellular locationi

Nucleus. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. Golgi apparatus Source: MGI
  4. midbody Source: UniProtKB
  5. nucleoplasm Source: MGI
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178M-phase-specific PLK1-interacting proteinPRO_0000065675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei50 – 501PhosphothreonineBy similarity
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei119 – 1191PhosphothreonineBy similarity
Modified residuei123 – 1231PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9D011.

PTM databases

PhosphoSiteiQ9D011.

Expressioni

Gene expression databases

BgeeiQ9D011.
CleanExiMM_2810021B07RIK.
ExpressionAtlasiQ9D011. baseline and differential.
GenevestigatoriQ9D011.

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45065.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ9D011.
OMAiSYSKSPA.
OrthoDBiEOG7BP84Z.
PhylomeDBiQ9D011.
TreeFamiTF335586.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP_like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT
60 70 80 90 100
PPCGPRARPY GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF
110 120 130 140 150
GYSPGQQQTY PQGSPRTSTP FGSGRGREKR MSNELESYFK PSMLEDPWAG
160 170
LEPVSVVDIS QQYSNTQTFT GKKGRYFS
Length:178
Mass (Da):19,060
Last modified:June 1, 2001 - v1
Checksum:i0DA799EDEB988986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
CCDSiCCDS26253.1.
RefSeqiNP_079755.1. NM_025479.5.
UniGeneiMm.291109.
Mm.400463.

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneIDi66308.
KEGGimmu:66308.
UCSCiuc007poa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
CCDSiCCDS26253.1.
RefSeqiNP_079755.1. NM_025479.5.
UniGeneiMm.291109.
Mm.400463.

3D structure databases

ProteinModelPortaliQ9D011.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9D011.

Proteomic databases

PRIDEiQ9D011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneIDi66308.
KEGGimmu:66308.
UCSCiuc007poa.1. mouse.

Organism-specific databases

CTDi136647.
MGIiMGI:1913558. Mplkip.

Phylogenomic databases

eggNOGiNOG45065.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ9D011.
OMAiSYSKSPA.
OrthoDBiEOG7BP84Z.
PhylomeDBiQ9D011.
TreeFamiTF335586.

Miscellaneous databases

NextBioi321269.
PROiQ9D011.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D011.
CleanExiMM_2810021B07RIK.
ExpressionAtlasiQ9D011. baseline and differential.
GenevestigatoriQ9D011.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP_like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Pituitary.

Entry informationi

Entry nameiMPLKI_MOUSE
AccessioniPrimary (citable) accession number: Q9D011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.