Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

M-phase-specific PLK1-interacting protein

Gene

Mplkip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein homolog
Gene namesi
Name:Mplkip
Synonyms:Ttdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913558. Mplkip.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656751 – 178M-phase-specific PLK1-interacting proteinAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36Asymmetric dimethylarginineCombined sources1
Modified residuei39PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei50PhosphothreonineBy similarity1
Modified residuei56Omega-N-methylarginineBy similarity1
Modified residuei58Asymmetric dimethylarginineCombined sources1
Modified residuei67Asymmetric dimethylarginineCombined sources1
Modified residuei76Asymmetric dimethylarginineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei116Omega-N-methylarginineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei123PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated during mitosis in the cell cycle probably by CDK1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9D011.
PRIDEiQ9D011.

PTM databases

iPTMnetiQ9D011.
PhosphoSitePlusiQ9D011.

Expressioni

Gene expression databases

BgeeiENSMUSG00000012429.
CleanExiMM_2810021B07RIK.
ExpressionAtlasiQ9D011. baseline and differential.
GenevisibleiQ9D011. MM.

Interactioni

Subunit structurei

Interacts with PLK1; phosphorylation-dependent.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059154.

Structurei

3D structure databases

ProteinModelPortaliQ9D011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0XS. Eukaryota.
ENOG4111V2F. LUCA.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ9D011.
OMAiHRPNFRP.
OrthoDBiEOG091G13KW.
PhylomeDBiQ9D011.
TreeFamiTF335586.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP-like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT
60 70 80 90 100
PPCGPRARPY GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF
110 120 130 140 150
GYSPGQQQTY PQGSPRTSTP FGSGRGREKR MSNELESYFK PSMLEDPWAG
160 170
LEPVSVVDIS QQYSNTQTFT GKKGRYFS
Length:178
Mass (Da):19,060
Last modified:June 1, 2001 - v1
Checksum:i0DA799EDEB988986
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
CCDSiCCDS26253.1.
RefSeqiNP_079755.1. NM_025479.5.
UniGeneiMm.291109.
Mm.400463.

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneIDi66308.
KEGGimmu:66308.
UCSCiuc007poa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
CCDSiCCDS26253.1.
RefSeqiNP_079755.1. NM_025479.5.
UniGeneiMm.291109.
Mm.400463.

3D structure databases

ProteinModelPortaliQ9D011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059154.

PTM databases

iPTMnetiQ9D011.
PhosphoSitePlusiQ9D011.

Proteomic databases

PaxDbiQ9D011.
PRIDEiQ9D011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneIDi66308.
KEGGimmu:66308.
UCSCiuc007poa.1. mouse.

Organism-specific databases

CTDi136647.
MGIiMGI:1913558. Mplkip.

Phylogenomic databases

eggNOGiENOG410J0XS. Eukaryota.
ENOG4111V2F. LUCA.
GeneTreeiENSGT00390000002582.
HOGENOMiHOG000252982.
HOVERGENiHBG073319.
InParanoidiQ9D011.
OMAiHRPNFRP.
OrthoDBiEOG091G13KW.
PhylomeDBiQ9D011.
TreeFamiTF335586.

Miscellaneous databases

PROiQ9D011.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012429.
CleanExiMM_2810021B07RIK.
ExpressionAtlasiQ9D011. baseline and differential.
GenevisibleiQ9D011. MM.

Family and domain databases

InterProiIPR028265. MPLKIP-like.
IPR026618. MPLKIP-like_vertebrate.
[Graphical view]
PANTHERiPTHR22446. PTHR22446. 1 hit.
PfamiPF15502. MPLKIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPLKI_MOUSE
AccessioniPrimary (citable) accession number: Q9D011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.