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Q9D011 (MPLKI_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
M-phase-specific PLK1-interacting protein
Alternative name(s):
TTD non-photosensitive 1 protein homolog
Gene names
Name:Mplkip
Synonyms:Ttdn1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis By similarity.

Subunit structure

Interacts with PLK1; phosphorylation-dependent By similarity.

Subcellular location

Nucleus. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

Post-translational modification

Phosphorylated during mitosis in the cell cycle probably by CDK1 By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178M-phase-specific PLK1-interacting protein
PRO_0000065675

Amino acid modifications

Modified residue461Phosphoserine By similarity
Modified residue501Phosphothreonine By similarity
Modified residue791Phosphoserine By similarity
Modified residue811Phosphoserine By similarity
Modified residue921Phosphoserine By similarity
Modified residue1031Phosphoserine By similarity
Modified residue1191Phosphothreonine By similarity
Modified residue1231Phosphoserine By similarity
Modified residue1321Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9D011 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 0DA799EDEB988986

FASTA17819,060
        10         20         30         40         50         60 
MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT PPCGPRARPY 

        70         80         90        100        110        120 
GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF GYSPGQQQTY PQGSPRTSTP 

       130        140        150        160        170 
FGSGRGREKR MSNELESYFK PSMLEDPWAG LEPVSVVDIS QQYSNTQTFT GKKGRYFS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK011919 mRNA. Translation: BAB27916.1.
AK030630 mRNA. Translation: BAC27054.1.
RefSeqNP_079755.1. NM_025479.5.
UniGeneMm.291109.
Mm.400463.

3D structure databases

ProteinModelPortalQ9D011.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9D011.

Proteomic databases

PRIDEQ9D011.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
GeneID66308.
KEGGmmu:66308.
UCSCuc007poa.1. mouse.

Organism-specific databases

CTD136647.
MGIMGI:1913558. Mplkip.

Phylogenomic databases

eggNOGNOG45065.
GeneTreeENSGT00390000002582.
HOGENOMHOG000252982.
HOVERGENHBG073319.
InParanoidQ9D011.
OMASYSKSPA.
OrthoDBEOG7BP84Z.
PhylomeDBQ9D011.
TreeFamTF335586.

Gene expression databases

ArrayExpressQ9D011.
BgeeQ9D011.
CleanExMM_2810021B07RIK.
GenevestigatorQ9D011.

Family and domain databases

InterProIPR026618. MPLKIP.
IPR028265. MPLKIP-like.
[Graphical view]
PANTHERPTHR22446. PTHR22446. 1 hit.
PfamPF15502. MPLKIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio321269.
PROQ9D011.
SOURCESearch...

Entry information

Entry nameMPLKI_MOUSE
AccessionPrimary (citable) accession number: Q9D011
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot