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Q9D011

- MPLKI_MOUSE

UniProt

Q9D011 - MPLKI_MOUSE

Protein

M-phase-specific PLK1-interacting protein

Gene

Mplkip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    M-phase-specific PLK1-interacting protein
    Alternative name(s):
    TTD non-photosensitive 1 protein homolog
    Gene namesi
    Name:Mplkip
    Synonyms:Ttdn1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1913558. Mplkip.

    Subcellular locationi

    Nucleus. Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. midbody Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178M-phase-specific PLK1-interacting proteinPRO_0000065675Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461PhosphoserineBy similarity
    Modified residuei50 – 501PhosphothreonineBy similarity
    Modified residuei79 – 791PhosphoserineBy similarity
    Modified residuei81 – 811PhosphoserineBy similarity
    Modified residuei92 – 921PhosphoserineBy similarity
    Modified residuei103 – 1031PhosphoserineBy similarity
    Modified residuei119 – 1191PhosphothreonineBy similarity
    Modified residuei123 – 1231PhosphoserineBy similarity
    Modified residuei132 – 1321PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated during mitosis in the cell cycle probably by CDK1.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9D011.

    PTM databases

    PhosphoSiteiQ9D011.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D011.
    BgeeiQ9D011.
    CleanExiMM_2810021B07RIK.
    GenevestigatoriQ9D011.

    Interactioni

    Subunit structurei

    Interacts with PLK1; phosphorylation-dependent.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D011.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45065.
    GeneTreeiENSGT00390000002582.
    HOGENOMiHOG000252982.
    HOVERGENiHBG073319.
    InParanoidiQ9D011.
    OMAiHRPNFRP.
    OrthoDBiEOG7BP84Z.
    PhylomeDBiQ9D011.
    TreeFamiTF335586.

    Family and domain databases

    InterProiIPR028265. MPLKIP-like.
    IPR026618. MPLKIP_like_vertebrate.
    [Graphical view]
    PANTHERiPTHR22446. PTHR22446. 1 hit.
    PfamiPF15502. MPLKIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRPNFRPPT PPYPSPGIGG WGGGNNFRGA LGGGPRPPSP RDGYGSPHHT    50
    PPCGPRARPY GSSQSPRHGG NFSGARFGSP SPGGYPGSYS RSPAGSQHQF 100
    GYSPGQQQTY PQGSPRTSTP FGSGRGREKR MSNELESYFK PSMLEDPWAG 150
    LEPVSVVDIS QQYSNTQTFT GKKGRYFS 178
    Length:178
    Mass (Da):19,060
    Last modified:June 1, 2001 - v1
    Checksum:i0DA799EDEB988986
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011919 mRNA. Translation: BAB27916.1.
    AK030630 mRNA. Translation: BAC27054.1.
    CCDSiCCDS26253.1.
    RefSeqiNP_079755.1. NM_025479.5.
    UniGeneiMm.291109.
    Mm.400463.

    Genome annotation databases

    EnsembliENSMUST00000049744; ENSMUSP00000059154; ENSMUSG00000012429.
    GeneIDi66308.
    KEGGimmu:66308.
    UCSCiuc007poa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011919 mRNA. Translation: BAB27916.1 .
    AK030630 mRNA. Translation: BAC27054.1 .
    CCDSi CCDS26253.1.
    RefSeqi NP_079755.1. NM_025479.5.
    UniGenei Mm.291109.
    Mm.400463.

    3D structure databases

    ProteinModelPortali Q9D011.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D011.

    Proteomic databases

    PRIDEi Q9D011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049744 ; ENSMUSP00000059154 ; ENSMUSG00000012429 .
    GeneIDi 66308.
    KEGGi mmu:66308.
    UCSCi uc007poa.1. mouse.

    Organism-specific databases

    CTDi 136647.
    MGIi MGI:1913558. Mplkip.

    Phylogenomic databases

    eggNOGi NOG45065.
    GeneTreei ENSGT00390000002582.
    HOGENOMi HOG000252982.
    HOVERGENi HBG073319.
    InParanoidi Q9D011.
    OMAi HRPNFRP.
    OrthoDBi EOG7BP84Z.
    PhylomeDBi Q9D011.
    TreeFami TF335586.

    Miscellaneous databases

    NextBioi 321269.
    PROi Q9D011.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D011.
    Bgeei Q9D011.
    CleanExi MM_2810021B07RIK.
    Genevestigatori Q9D011.

    Family and domain databases

    InterProi IPR028265. MPLKIP-like.
    IPR026618. MPLKIP_like_vertebrate.
    [Graphical view ]
    PANTHERi PTHR22446. PTHR22446. 1 hit.
    Pfami PF15502. MPLKIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Pituitary.

    Entry informationi

    Entry nameiMPLKI_MOUSE
    AccessioniPrimary (citable) accession number: Q9D011
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3