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Protein

Ubiquitin-conjugating enzyme E2 variant 1

Gene

Ube2v1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 1
Short name:
UEV-1
Alternative name(s):
CROC-1
Gene namesi
Name:Ube2v1
Synonyms:Croc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913839 Ube2v1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000826012 – 147Ubiquitin-conjugating enzyme E2 variant 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CZY3
PaxDbiQ9CZY3
PeptideAtlasiQ9CZY3
PRIDEiQ9CZY3

PTM databases

iPTMnetiQ9CZY3
PhosphoSitePlusiQ9CZY3

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in heart, brain, liver, skeletal msucle, kidney and testis. Detected at lower levels in lung and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000078923
CleanExiMM_UBE2V1
ExpressionAtlasiQ9CZY3 baseline and differential
GenevisibleiQ9CZY3 MM

Interactioni

Subunit structurei

Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6 (By similarity).By similarity

GO - Molecular functioni

  • ubiquitin conjugating enzyme binding Source: MGI
  • ubiquitin protein ligase binding Source: GO_Central

Protein-protein interaction databases

BioGridi211575, 6 interactors
IntActiQ9CZY3, 1 interactor
STRINGi10090.ENSMUSP00000104830

Structurei

3D structure databases

ProteinModelPortaliQ9CZY3
SMRiQ9CZY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3011 Eukaryota
ENOG410XRWR LUCA
GeneTreeiENSGT00740000115534
HOGENOMiHOG000036561
HOVERGENiHBG054552
InParanoidiQ9CZY3
KOiK10704
PhylomeDBiQ9CZY3
TreeFamiTF316971

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG
60 70 80 90 100
MIIGPPRTIY ENRIYSLKIE CGPKYPEAPP SVRFVTRVNM SGVSSSNGVV
110 120 130 140
DPRATAVLAK WQNSHSIKVI LQELRRLMMS KENMKLPQPP EGQCYSN
Length:147
Mass (Da):16,355
Last modified:June 1, 2001 - v1
Checksum:iE66E83EEE9D08E92
GO
Isoform 2 (identifier: Q9CZY3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-99: Missing.

Show »
Length:105
Mass (Da):11,725
Checksum:iCCCF79601969C719
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59I → M in AAG22085 (PubMed:11406273).Curated1
Sequence conflicti66S → G in AAG22085 (PubMed:11406273).Curated1
Sequence conflicti78A → P in AAG22085 (PubMed:11406273).Curated1
Sequence conflicti100V → M in AAG22085 (PubMed:11406273).Curated1
Sequence conflicti108L → P in AAH19372 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01152858 – 99Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012021 mRNA Translation: BAB27978.1
AL589870 Genomic DNA No translation available.
BC003449 mRNA Translation: AAH03449.1
BC019372 mRNA Translation: AAH19372.1
AF303829 mRNA Translation: AAG22085.1
CCDSiCCDS17103.1 [Q9CZY3-1]
CCDS79869.1 [Q9CZY3-2]
RefSeqiNP_001298075.1, NM_001311146.1 [Q9CZY3-2]
NP_075719.1, NM_023230.2 [Q9CZY3-1]
UniGeneiMm.278783
Mm.360108

Genome annotation databases

EnsembliENSMUST00000060645; ENSMUSP00000053109; ENSMUSG00000078923 [Q9CZY3-2]
ENSMUST00000109207; ENSMUSP00000104830; ENSMUSG00000078923 [Q9CZY3-1]
GeneIDi66589
KEGGimmu:66589
UCSCiuc008oaa.1 mouse [Q9CZY3-1]
uc008oab.1 mouse [Q9CZY3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUB2V1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZY3
Secondary accession number(s): A2A467, Q8VEB5, Q9ERI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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