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Q9CZY3

- UB2V1_MOUSE

UniProt

Q9CZY3 - UB2V1_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 variant 1

Gene

Ube2v1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation By similarity. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes By similarity.By similarity

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. protein binding Source: MGI
    3. ubiquitin conjugating enzyme binding Source: MGI
    4. ubiquitin-protein transferase activity Source: MGI

    GO - Biological processi

    1. error-free postreplication DNA repair Source: MGI
    2. protein K63-linked ubiquitination Source: UniProtKB

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198543. IRAK1 recruits IKK complex.
    REACT_198546. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_224208. Interleukin-1 signaling.
    REACT_225145. Downstream TCR signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 1
    Short name:
    UEV-1
    Alternative name(s):
    CROC-1
    Gene namesi
    Name:Ube2v1
    Synonyms:Croc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1913839. Ube2v1.

    Subcellular locationi

    Nucleus By similarity
    Note: Excluded from the nucleolus.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein complex Source: MGI
    3. UBC13-UEV1A complex Source: UniProtKB
    4. ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 147146Ubiquitin-conjugating enzyme E2 variant 1PRO_0000082601Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CZY3.
    PaxDbiQ9CZY3.
    PRIDEiQ9CZY3.

    PTM databases

    PhosphoSiteiQ9CZY3.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in heart, brain, liver, skeletal msucle, kidney and testis. Detected at lower levels in lung and spleen.1 Publication

    Gene expression databases

    BgeeiQ9CZY3.
    CleanExiMM_UBE2V1.
    GenevestigatoriQ9CZY3.

    Interactioni

    Subunit structurei

    Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211575. 3 interactions.
    IntActiQ9CZY3. 1 interaction.
    MINTiMINT-1869924.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZY3.
    SMRiQ9CZY3. Positions 8-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG239185.
    GeneTreeiENSGT00740000115534.
    HOGENOMiHOG000036561.
    HOVERGENiHBG054552.
    InParanoidiQ9CZY3.
    KOiK10704.
    OrthoDBiEOG77M8R5.
    PhylomeDBiQ9CZY3.
    TreeFamiTF316971.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CZY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG    50
    MIIGPPRTIY ENRIYSLKIE CGPKYPEAPP SVRFVTRVNM SGVSSSNGVV 100
    DPRATAVLAK WQNSHSIKVI LQELRRLMMS KENMKLPQPP EGQCYSN 147
    Length:147
    Mass (Da):16,355
    Last modified:June 1, 2001 - v1
    Checksum:iE66E83EEE9D08E92
    GO
    Isoform 2 (identifier: Q9CZY3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-99: Missing.

    Show »
    Length:105
    Mass (Da):11,725
    Checksum:iCCCF79601969C719
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591I → M in AAG22085. (PubMed:11406273)Curated
    Sequence conflicti66 – 661S → G in AAG22085. (PubMed:11406273)Curated
    Sequence conflicti78 – 781A → P in AAG22085. (PubMed:11406273)Curated
    Sequence conflicti100 – 1001V → M in AAG22085. (PubMed:11406273)Curated
    Sequence conflicti108 – 1081L → P in AAH19372. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei58 – 9942Missing in isoform 2. 1 PublicationVSP_011528Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012021 mRNA. Translation: BAB27978.1.
    AL589870 Genomic DNA. Translation: CAM13830.1.
    BC003449 mRNA. Translation: AAH03449.1.
    BC019372 mRNA. Translation: AAH19372.1.
    AF303829 mRNA. Translation: AAG22085.1.
    CCDSiCCDS17103.1. [Q9CZY3-1]
    RefSeqiNP_075719.1. NM_023230.2. [Q9CZY3-1]
    XP_006500078.1. XM_006500015.1. [Q9CZY3-2]
    UniGeneiMm.278783.
    Mm.360108.

    Genome annotation databases

    EnsembliENSMUST00000060645; ENSMUSP00000053109; ENSMUSG00000078923. [Q9CZY3-2]
    ENSMUST00000109207; ENSMUSP00000104830; ENSMUSG00000078923. [Q9CZY3-1]
    GeneIDi66589.
    KEGGimmu:66589.
    UCSCiuc008oaa.1. mouse. [Q9CZY3-1]
    uc008oab.1. mouse. [Q9CZY3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012021 mRNA. Translation: BAB27978.1 .
    AL589870 Genomic DNA. Translation: CAM13830.1 .
    BC003449 mRNA. Translation: AAH03449.1 .
    BC019372 mRNA. Translation: AAH19372.1 .
    AF303829 mRNA. Translation: AAG22085.1 .
    CCDSi CCDS17103.1. [Q9CZY3-1 ]
    RefSeqi NP_075719.1. NM_023230.2. [Q9CZY3-1 ]
    XP_006500078.1. XM_006500015.1. [Q9CZY3-2 ]
    UniGenei Mm.278783.
    Mm.360108.

    3D structure databases

    ProteinModelPortali Q9CZY3.
    SMRi Q9CZY3. Positions 8-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211575. 3 interactions.
    IntActi Q9CZY3. 1 interaction.
    MINTi MINT-1869924.

    PTM databases

    PhosphoSitei Q9CZY3.

    Proteomic databases

    MaxQBi Q9CZY3.
    PaxDbi Q9CZY3.
    PRIDEi Q9CZY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060645 ; ENSMUSP00000053109 ; ENSMUSG00000078923 . [Q9CZY3-2 ]
    ENSMUST00000109207 ; ENSMUSP00000104830 ; ENSMUSG00000078923 . [Q9CZY3-1 ]
    GeneIDi 66589.
    KEGGi mmu:66589.
    UCSCi uc008oaa.1. mouse. [Q9CZY3-1 ]
    uc008oab.1. mouse. [Q9CZY3-2 ]

    Organism-specific databases

    CTDi 7335.
    MGIi MGI:1913839. Ube2v1.

    Phylogenomic databases

    eggNOGi NOG239185.
    GeneTreei ENSGT00740000115534.
    HOGENOMi HOG000036561.
    HOVERGENi HBG054552.
    InParanoidi Q9CZY3.
    KOi K10704.
    OrthoDBi EOG77M8R5.
    PhylomeDBi Q9CZY3.
    TreeFami TF316971.

    Enzyme and pathway databases

    Reactomei REACT_198527. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
    REACT_198543. IRAK1 recruits IKK complex.
    REACT_198546. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_211125. NOD1/2 Signaling Pathway.
    REACT_224208. Interleukin-1 signaling.
    REACT_225145. Downstream TCR signaling.

    Miscellaneous databases

    NextBioi 322088.
    PROi Q9CZY3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZY3.
    CleanExi MM_UBE2V1.
    Genevestigatori Q9CZY3.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: NMRI.
      Tissue: Mammary tumor.
    4. "Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis."
      Franko J., Ashley C., Xiao W.
      Biochim. Biophys. Acta 1519:70-77(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-147 (ISOFORM 1), FUNCTION, INTERACTION WITH UBE2N, TISSUE SPECIFICITY.
    5. "Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex."
      Zhang M., Windheim M., Roe S.M., Peggie M., Cohen P., Prodromou C., Pearl L.H.
      Mol. Cell 20:525-538(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STUB1 AND UBE2N.

    Entry informationi

    Entry nameiUB2V1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZY3
    Secondary accession number(s): A2A467, Q8VEB5, Q9ERI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3