Q9CZX8 (RS19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S19

Gene names

Name:

Rps19

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for pre-rRNA processing and maturation of 40S ribosomal subunits By similarity.
Subunit structure	Interacts with RPS19BP1. Ref.4
Sequence similarities	Belongs to the ribosomal protein S19e family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	erythrocyte differentiation Inferred from sequence or structural similarity. Source: HGNC gas transport Inferred from electronic annotation. Source: Compara rRNA processing Inferred from electronic annotation. Source: Compara ribosomal small subunit biogenesis Inferred from electronic annotation. Source: Compara translation Inferred from electronic annotation. Source: InterPro
Cellular_component	cytosolic small ribosomal subunit Inferred from sequence or structural similarity. Source: HGNC nucleolus Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 145	144	40S ribosomal protein S19		PRO_0000153811
Amino acid modifications
	Modified residue	23	1	N6-acetyllysine By similarity
	Modified residue	111	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CZX8 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 180032B887FA6E41	FASTA	145	16,085
	10 20 30 40 50 60 MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST 70 80 90 100 110 120 ARHLYLRGGA GVGSMTKIYG GRQRNGVRPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG 130 140 RKLTPQGQRD LDRIAGQVAA ANKKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RPS19 gene in Mus musculus and Drosophila melanogaster, and conserved features among 40 different species." Willig T.-N.D., Peters L.L., Parra M.K., Tchernia G., Mohandas N. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney and Mammary gland.
[4]	"A novel nucleolar protein interacts with ribosomal protein S19." Maeda N., Toku S., Kenmochi N., Tanaka T. Biochem. Biophys. Res. Commun. 339:41-46(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RPS19BP1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF216207 Genomic DNA. Translation: AAF65683.1. AK013524 mRNA. Translation: BAB28898.1. AK018725 mRNA. Translation: BAB31370.1. AK028244 mRNA. Translation: BAC25836.1. BC034506 mRNA. Translation: AAH34506.1. BC086938 mRNA. Translation: AAH86938.1.
IPI	IPI00113241.
RefSeq	NP_075622.1. NM_023133.1.
UniGene	Mm.300281. Mm.445088.
3D structure databases
ProteinModelPortal	Q9CZX8.
SMR	Q9CZX8. Positions 5-138.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9CZX8. 2 interactions.
STRING	10090.ENSMUSP00000098160.
PTM databases
PhosphoSite	Q9CZX8.
Proteomic databases
PaxDb	Q9CZX8.
PRIDE	Q9CZX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000108429; ENSMUSP00000104067; ENSMUSG00000040952. ENSMUST00000108430; ENSMUSP00000104068; ENSMUSG00000040952.
GeneID	20085.
KEGG	mmu:20085.
UCSC	uc009fqq.1. mouse.
Organism-specific databases
CTD	6223.
MGI	MGI:1333780. Rps19.
Phylogenomic databases
eggNOG	COG2238.
GeneTree	ENSGT00390000013102.
HOGENOM	HOG000230649.
HOVERGEN	HBG000240.
KO	K02966.
OrthoDB	EOG4PC9TC.
Gene expression databases
ArrayExpress	Q9CZX8.
Bgee	Q9CZX8.
CleanEx	MM_RPS19.
Genevestigator	Q9CZX8.
GermOnline	ENSMUSG00000040952. Mus musculus.
Family and domain databases
InterPro	IPR001266. Ribosomal_S19e. IPR018277. Ribosomal_S19e_CS. [Graphical view]
PANTHER	PTHR11710. PTHR11710. 1 hit.
Pfam	PF01090. Ribosomal_S19e. 1 hit. [Graphical view]
ProDom	PD003854. Ribosomal_S19e. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00628. RIBOSOMAL_S19E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	297579.
SOURCE	Search...

Entry information

Entry name

RS19_MOUSE

Accession

Primary (citable) accession number: Q9CZX8
Secondary accession number(s): Q5M9J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program