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Protein

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Gene

Tmem55a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (EC:3.1.3.78)
Short name:
Type 2 PtdIns-4,5-P2 4-Ptase
Alternative name(s):
PtdIns-4,5-P2 4-Ptase II
Transmembrane protein 55A
Gene namesi
Name:Tmem55a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919769. Tmem55a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatasePRO_0000235229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphothreonineCombined sources
Modified residuei33 – 331PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZX7.
MaxQBiQ9CZX7.
PaxDbiQ9CZX7.
PRIDEiQ9CZX7.

PTM databases

iPTMnetiQ9CZX7.
PhosphoSiteiQ9CZX7.
SwissPalmiQ9CZX7.

Expressioni

Gene expression databases

BgeeiQ9CZX7.
CleanExiMM_TMEM55A.
GenevisibleiQ9CZX7. MM.

Interactioni

Protein-protein interaction databases

BioGridi215414. 5 interactions.
IntActiQ9CZX7. 6 interactions.
MINTiMINT-4126302.
STRINGi10090.ENSMUSP00000029875.

Structurei

3D structure databases

ProteinModelPortaliQ9CZX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 1137CX5R motif

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4684. Eukaryota.
ENOG410XSVD. LUCA.
GeneTreeiENSGT00390000003680.
HOGENOMiHOG000231722.
HOVERGENiHBG080409.
InParanoidiQ9CZX7.
KOiK13084.
OMAiGMYFLYV.
OrthoDBiEOG7DZ8KH.
PhylomeDBiQ9CZX7.
TreeFamiTF316367.

Family and domain databases

InterProiIPR019178. PtdIns-P2-Ptase.
[Graphical view]
PANTHERiPTHR21014. PTHR21014. 1 hit.
PfamiPF09788. Tmemb_55A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADGVDERS PLLSASHSGN VTPTAPPYLQ ESSPRAELPP PYTAIASPGT
60 70 80 90 100
SGIPVINCRV CQSLINLDGK LHQHVVKCTV CNEATPIKTP PTGKKYVRCP
110 120 130 140 150
CNCLLICKDT SRRIGCPRPN CRRIINLGPV MLISEEQPAQ PALPIQPEGT
160 170 180 190 200
RVVCGHCGNT FLWMELRFNT LAKCPHCKKI SSVGSALPRR RCCAYVTIGM
210 220 230 240 250
ICIFIAVGLT VGTQDFSRRF HATYVSWAIA YLLGLICLIR ACYWGAIRVS

YPEHGFA
Length:257
Mass (Da):28,038
Last modified:June 1, 2001 - v1
Checksum:i0330A735DBCEC243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012054 mRNA. Translation: BAB27995.1.
AK033845 mRNA. Translation: BAC28493.1.
AK049213 mRNA. Translation: BAC33613.1.
BC021435 mRNA. Translation: AAH21435.1.
CCDSiCCDS17981.1.
RefSeqiNP_082540.1. NM_028264.4.
UniGeneiMm.279158.

Genome annotation databases

EnsembliENSMUST00000029875; ENSMUSP00000029875; ENSMUSG00000028221.
GeneIDi72519.
KEGGimmu:72519.
UCSCiuc008sbg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012054 mRNA. Translation: BAB27995.1.
AK033845 mRNA. Translation: BAC28493.1.
AK049213 mRNA. Translation: BAC33613.1.
BC021435 mRNA. Translation: AAH21435.1.
CCDSiCCDS17981.1.
RefSeqiNP_082540.1. NM_028264.4.
UniGeneiMm.279158.

3D structure databases

ProteinModelPortaliQ9CZX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215414. 5 interactions.
IntActiQ9CZX7. 6 interactions.
MINTiMINT-4126302.
STRINGi10090.ENSMUSP00000029875.

PTM databases

iPTMnetiQ9CZX7.
PhosphoSiteiQ9CZX7.
SwissPalmiQ9CZX7.

Proteomic databases

EPDiQ9CZX7.
MaxQBiQ9CZX7.
PaxDbiQ9CZX7.
PRIDEiQ9CZX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029875; ENSMUSP00000029875; ENSMUSG00000028221.
GeneIDi72519.
KEGGimmu:72519.
UCSCiuc008sbg.1. mouse.

Organism-specific databases

CTDi55529.
MGIiMGI:1919769. Tmem55a.

Phylogenomic databases

eggNOGiKOG4684. Eukaryota.
ENOG410XSVD. LUCA.
GeneTreeiENSGT00390000003680.
HOGENOMiHOG000231722.
HOVERGENiHBG080409.
InParanoidiQ9CZX7.
KOiK13084.
OMAiGMYFLYV.
OrthoDBiEOG7DZ8KH.
PhylomeDBiQ9CZX7.
TreeFamiTF316367.

Miscellaneous databases

PROiQ9CZX7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZX7.
CleanExiMM_TMEM55A.
GenevisibleiQ9CZX7. MM.

Family and domain databases

InterProiIPR019178. PtdIns-P2-Ptase.
[Graphical view]
PANTHERiPTHR21014. PTHR21014. 1 hit.
PfamiPF09788. Tmemb_55A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Epididymis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-22 AND SER-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTM55A_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.