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Protein

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Gene

Pip4p2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (EC:3.1.3.78)
Short name:
Type 2 PtdIns-4,5-P2 4-Ptase
Alternative name(s):
PtdIns-4,5-P2 4-Ptase II
Transmembrane protein 55A
Gene namesi
Name:Pip4p2
Synonyms:Tmem55a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919769 Tmem55a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352291 – 257Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphataseAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphothreonineCombined sources1
Modified residuei33PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZX7
MaxQBiQ9CZX7
PaxDbiQ9CZX7
PeptideAtlasiQ9CZX7
PRIDEiQ9CZX7

PTM databases

iPTMnetiQ9CZX7
PhosphoSitePlusiQ9CZX7
SwissPalmiQ9CZX7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028221
CleanExiMM_TMEM55A
GenevisibleiQ9CZX7 MM

Interactioni

Protein-protein interaction databases

BioGridi215414, 5 interactors
IntActiQ9CZX7, 6 interactors
MINTiQ9CZX7
STRINGi10090.ENSMUSP00000029875

Structurei

3D structure databases

ProteinModelPortaliQ9CZX7
SMRiQ9CZX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 113CX5R motif7

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4684 Eukaryota
ENOG410XSVD LUCA
GeneTreeiENSGT00390000003680
HOGENOMiHOG000231722
HOVERGENiHBG080409
InParanoidiQ9CZX7
KOiK13084
OMAiMVIPEEQ
OrthoDBiEOG091G0HQD
PhylomeDBiQ9CZX7
TreeFamiTF316367

Family and domain databases

InterProiView protein in InterPro
IPR019178 PtdIns-P2-Ptase
PANTHERiPTHR21014 PTHR21014, 1 hit
PfamiView protein in Pfam
PF09788 Tmemb_55A, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADGVDERS PLLSASHSGN VTPTAPPYLQ ESSPRAELPP PYTAIASPGT
60 70 80 90 100
SGIPVINCRV CQSLINLDGK LHQHVVKCTV CNEATPIKTP PTGKKYVRCP
110 120 130 140 150
CNCLLICKDT SRRIGCPRPN CRRIINLGPV MLISEEQPAQ PALPIQPEGT
160 170 180 190 200
RVVCGHCGNT FLWMELRFNT LAKCPHCKKI SSVGSALPRR RCCAYVTIGM
210 220 230 240 250
ICIFIAVGLT VGTQDFSRRF HATYVSWAIA YLLGLICLIR ACYWGAIRVS

YPEHGFA
Length:257
Mass (Da):28,038
Last modified:June 1, 2001 - v1
Checksum:i0330A735DBCEC243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012054 mRNA Translation: BAB27995.1
AK033845 mRNA Translation: BAC28493.1
AK049213 mRNA Translation: BAC33613.1
BC021435 mRNA Translation: AAH21435.1
CCDSiCCDS17981.1
RefSeqiNP_082540.1, NM_028264.4
UniGeneiMm.279158

Genome annotation databases

EnsembliENSMUST00000029875; ENSMUSP00000029875; ENSMUSG00000028221
GeneIDi72519
KEGGimmu:72519
UCSCiuc008sbg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPP4P2_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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