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Q9CZX5 (PINX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PIN2/TERF1-interacting telomerase inhibitor 1
Alternative name(s):
67-11-3 protein
LPTS1
Liver-related putative tumor suppressor
Pin2-interacting protein X1
TRF1-interacting protein 1
Gene names
Name:Pinx1
Synonyms:Lpts
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor By similarity.

Subunit structure

Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA By similarity.

Subcellular location

Nucleus By similarity. Nucleusnucleolus By similarity. Chromosometelomere By similarity. Chromosomecentromerekinetochore By similarity. Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE By similarity.

Domain

The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity By similarity.

The TBM domain mediates interaction with TERF1 By similarity.

Sequence similarities

Belongs to the PINX1 family.

Contains 1 G-patch domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332PIN2/TERF1-interacting telomerase inhibitor 1
PRO_0000058444

Regions

Domain26 – 7247G-patch
Region254 – 32875Telomerase inhibitory domain (TID)
Motif291 – 30111TBM

Experimental info

Sequence conflict401S → A in BAC35998. Ref.3
Sequence conflict210 – 2134ETPV → HAPC in BAE43228. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9CZX5 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: 6B7147CED58D991A

FASTA33237,221
        10         20         30         40         50         60 
MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ GATEHIKVKV 

        70         80         90        100        110        120 
KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA DSSDKKEKKS FSLEEKSKIS 

       130        140        150        160        170        180 
KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR RNKKLAQDGC SNSSADEVNT SLTTTTTTTS 

       190        200        210        220        230        240 
AFTIQEYFAK RMAQLKNKPQ ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR 

       250        260        270        280        290        300 
HKKKKRVEAE RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR 

       310        320        330 
KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR 

« Hide

References

« Hide 'large scale' references
[1]"The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."
Zhou X.Z., Lu K.P.
Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The expression of mouse LPTS1, a homolog of human tumor suppressor LPTS, in mouse liver."
Liao C., Zhao M., Li T.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Stomach.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Schmidt T.
Thesis (2001), University of Goettingen, Germany
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-332.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF421879 mRNA. Translation: AAL32445.1.
AF321817 mRNA. Translation: AAL37221.1.
AK011578 mRNA. No translation available.
AK012057 mRNA. Translation: BAE43228.1.
AK075840 mRNA. Translation: BAC35998.1.
BC115636 mRNA. Translation: AAI15637.1.
AJ344106 mRNA. Translation: CAC51439.1.
RefSeqNP_082504.1. NM_028228.3.
UniGeneMm.379214.

3D structure databases

ProteinModelPortalQ9CZX5.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CZX5.

Proteomic databases

PRIDEQ9CZX5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
GeneID72400.
KEGGmmu:72400.
UCSCuc007uhx.2. mouse.

Organism-specific databases

CTD54984.
MGIMGI:1919650. Pinx1.

Phylogenomic databases

eggNOGNOG263032.
GeneTreeENSGT00450000040279.
HOGENOMHOG000035098.
HOVERGENHBG061365.
InParanoidQ9CZX5.
KOK11135.
OMAEDCVWPP.
OrthoDBEOG789CCG.
PhylomeDBQ9CZX5.
TreeFamTF321918.

Gene expression databases

BgeeQ9CZX5.
CleanExMM_2610028A01RIK.
GenevestigatorQ9CZX5.

Family and domain databases

InterProIPR000467. G_patch_dom.
[Graphical view]
PfamPF01585. G-patch. 1 hit.
[Graphical view]
SMARTSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPINX1. mouse.
NextBio336194.
PROQ9CZX5.
SOURCESearch...

Entry information

Entry namePINX1_MOUSE
AccessionPrimary (citable) accession number: Q9CZX5
Secondary accession number(s): Q14BS4 expand/collapse secondary AC list , Q3V450, Q8C6E5, Q91WZ9, Q9D0C2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot