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Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene

Pinx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity).By similarity

GO - Molecular functioni

  1. telomeric RNA binding Source: MGI

GO - Biological processi

  1. mitotic metaphase plate congression Source: MGI
  2. telomere maintenance via telomerase Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PIN2/TERF1-interacting telomerase inhibitor 1
Alternative name(s):
67-11-3 protein
LPTS1
Liver-related putative tumor suppressor
Pin2-interacting protein X1
TRF1-interacting protein 1
Gene namesi
Name:Pinx1
Synonyms:Lpts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1919650. Pinx1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus By similarity. Chromosometelomere By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE (By similarity).By similarity

GO - Cellular componenti

  1. chromosome, telomeric region Source: MGI
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. cytoplasm Source: MGI
  4. intracellular membrane-bounded organelle Source: MGI
  5. kinetochore Source: MGI
  6. mitochondrion Source: MGI
  7. nuclear chromosome Source: MGI
  8. nucleolus Source: MGI
  9. nucleoplasm Source: MGI
  10. nucleus Source: MGI
  11. spindle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus, Telomere

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332PIN2/TERF1-interacting telomerase inhibitor 1PRO_0000058444Add
BLAST

Proteomic databases

MaxQBiQ9CZX5.
PRIDEiQ9CZX5.

PTM databases

PhosphoSiteiQ9CZX5.

Expressioni

Gene expression databases

BgeeiQ9CZX5.
CleanExiMM_2610028A01RIK.
GenevestigatoriQ9CZX5.

Interactioni

Subunit structurei

Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CZX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7247G-patchPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 32875Telomerase inhibitory domain (TID)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi291 – 30111TBMAdd
BLAST

Domaini

The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity.By similarity
The TBM domain mediates interaction with TERF1.By similarity

Sequence similaritiesi

Belongs to the PINX1 family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG263032.
GeneTreeiENSGT00450000040279.
HOGENOMiHOG000035098.
HOVERGENiHBG061365.
InParanoidiQ9CZX5.
KOiK11135.
OMAiPKAKRHT.
OrthoDBiEOG789CCG.
PhylomeDBiQ9CZX5.
TreeFamiTF321918.

Family and domain databases

InterProiIPR000467. G_patch_dom.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ
60 70 80 90 100
GATEHIKVKV KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA
110 120 130 140 150
DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR
160 170 180 190 200
RNKKLAQDGC SNSSADEVNT SLTTTTTTTS AFTIQEYFAK RMAQLKNKPQ
210 220 230 240 250
ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR HKKKKRVEAE
260 270 280 290 300
RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR
310 320 330
KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR
Length:332
Mass (Da):37,221
Last modified:June 20, 2002 - v2
Checksum:i6B7147CED58D991A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401S → A in BAC35998 (PubMed:16141072).Curated
Sequence conflicti210 – 2134ETPV → HAPC in BAE43228 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421879 mRNA. Translation: AAL32445.1.
AF321817 mRNA. Translation: AAL37221.1.
AK011578 mRNA. No translation available.
AK012057 mRNA. Translation: BAE43228.1.
AK075840 mRNA. Translation: BAC35998.1.
BC115636 mRNA. Translation: AAI15637.1.
AJ344106 mRNA. Translation: CAC51439.1.
CCDSiCCDS27205.1.
RefSeqiNP_082504.1. NM_028228.3.
UniGeneiMm.379214.

Genome annotation databases

EnsembliENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
GeneIDi72400.
KEGGimmu:72400.
UCSCiuc007uhx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421879 mRNA. Translation: AAL32445.1.
AF321817 mRNA. Translation: AAL37221.1.
AK011578 mRNA. No translation available.
AK012057 mRNA. Translation: BAE43228.1.
AK075840 mRNA. Translation: BAC35998.1.
BC115636 mRNA. Translation: AAI15637.1.
AJ344106 mRNA. Translation: CAC51439.1.
CCDSiCCDS27205.1.
RefSeqiNP_082504.1. NM_028228.3.
UniGeneiMm.379214.

3D structure databases

ProteinModelPortaliQ9CZX5.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9CZX5.

Proteomic databases

MaxQBiQ9CZX5.
PRIDEiQ9CZX5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
GeneIDi72400.
KEGGimmu:72400.
UCSCiuc007uhx.2. mouse.

Organism-specific databases

CTDi54984.
MGIiMGI:1919650. Pinx1.

Phylogenomic databases

eggNOGiNOG263032.
GeneTreeiENSGT00450000040279.
HOGENOMiHOG000035098.
HOVERGENiHBG061365.
InParanoidiQ9CZX5.
KOiK11135.
OMAiPKAKRHT.
OrthoDBiEOG789CCG.
PhylomeDBiQ9CZX5.
TreeFamiTF321918.

Miscellaneous databases

ChiTaRSiPinx1. mouse.
NextBioi336194.
PROiQ9CZX5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZX5.
CleanExiMM_2610028A01RIK.
GenevestigatoriQ9CZX5.

Family and domain databases

InterProiIPR000467. G_patch_dom.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."
    Zhou X.Z., Lu K.P.
    Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The expression of mouse LPTS1, a homolog of human tumor suppressor LPTS, in mouse liver."
    Liao C., Zhao M., Li T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Schmidt T.
    Thesis (2001), University of Goettingen, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-332.
    Tissue: Embryo.

Entry informationi

Entry nameiPINX1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX5
Secondary accession number(s): Q14BS4
, Q3V450, Q8C6E5, Q91WZ9, Q9D0C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: March 4, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.