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Q9CZX5

- PINX1_MOUSE

UniProt

Q9CZX5 - PINX1_MOUSE

Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene

Pinx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. telomeric RNA binding Source: Ensembl

    GO - Biological processi

    1. mitotic metaphase plate congression Source: Ensembl
    2. telomere maintenance via telomerase Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PIN2/TERF1-interacting telomerase inhibitor 1
    Alternative name(s):
    67-11-3 protein
    LPTS1
    Liver-related putative tumor suppressor
    Pin2-interacting protein X1
    TRF1-interacting protein 1
    Gene namesi
    Name:Pinx1
    Synonyms:Lpts
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1919650. Pinx1.

    Subcellular locationi

    Nucleus By similarity. Nucleusnucleolus By similarity. Chromosometelomere By similarity. Chromosomecentromerekinetochore By similarity
    Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE By similarity.By similarity

    GO - Cellular componenti

    1. chromosome, telomeric region Source: MGI
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. mitochondrion Source: Ensembl
    4. nuclear chromosome Source: Ensembl
    5. nucleolus Source: MGI
    6. spindle Source: Ensembl

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus, Telomere

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332PIN2/TERF1-interacting telomerase inhibitor 1PRO_0000058444Add
    BLAST

    Proteomic databases

    PRIDEiQ9CZX5.

    PTM databases

    PhosphoSiteiQ9CZX5.

    Expressioni

    Gene expression databases

    BgeeiQ9CZX5.
    CleanExiMM_2610028A01RIK.
    GenevestigatoriQ9CZX5.

    Interactioni

    Subunit structurei

    Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7247G-patchPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 32875Telomerase inhibitory domain (TID)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi291 – 30111TBMAdd
    BLAST

    Domaini

    The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity.By similarity
    The TBM domain mediates interaction with TERF1.By similarity

    Sequence similaritiesi

    Belongs to the PINX1 family.Curated
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG263032.
    GeneTreeiENSGT00450000040279.
    HOGENOMiHOG000035098.
    HOVERGENiHBG061365.
    InParanoidiQ9CZX5.
    KOiK11135.
    OMAiEDCVWPP.
    OrthoDBiEOG789CCG.
    PhylomeDBiQ9CZX5.
    TreeFamiTF321918.

    Family and domain databases

    InterProiIPR000467. G_patch_dom.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    [Graphical view]
    PROSITEiPS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CZX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ    50
    GATEHIKVKV KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA 100
    DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR 150
    RNKKLAQDGC SNSSADEVNT SLTTTTTTTS AFTIQEYFAK RMAQLKNKPQ 200
    ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR HKKKKRVEAE 250
    RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR 300
    KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR 332
    Length:332
    Mass (Da):37,221
    Last modified:June 20, 2002 - v2
    Checksum:i6B7147CED58D991A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401S → A in BAC35998. (PubMed:16141072)Curated
    Sequence conflicti210 – 2134ETPV → HAPC in BAE43228. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421879 mRNA. Translation: AAL32445.1.
    AF321817 mRNA. Translation: AAL37221.1.
    AK011578 mRNA. No translation available.
    AK012057 mRNA. Translation: BAE43228.1.
    AK075840 mRNA. Translation: BAC35998.1.
    BC115636 mRNA. Translation: AAI15637.1.
    AJ344106 mRNA. Translation: CAC51439.1.
    CCDSiCCDS27205.1.
    RefSeqiNP_082504.1. NM_028228.3.
    UniGeneiMm.379214.

    Genome annotation databases

    EnsembliENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
    GeneIDi72400.
    KEGGimmu:72400.
    UCSCiuc007uhx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF421879 mRNA. Translation: AAL32445.1 .
    AF321817 mRNA. Translation: AAL37221.1 .
    AK011578 mRNA. No translation available.
    AK012057 mRNA. Translation: BAE43228.1 .
    AK075840 mRNA. Translation: BAC35998.1 .
    BC115636 mRNA. Translation: AAI15637.1 .
    AJ344106 mRNA. Translation: CAC51439.1 .
    CCDSi CCDS27205.1.
    RefSeqi NP_082504.1. NM_028228.3.
    UniGenei Mm.379214.

    3D structure databases

    ProteinModelPortali Q9CZX5.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CZX5.

    Proteomic databases

    PRIDEi Q9CZX5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022528 ; ENSMUSP00000022528 ; ENSMUSG00000021958 .
    GeneIDi 72400.
    KEGGi mmu:72400.
    UCSCi uc007uhx.2. mouse.

    Organism-specific databases

    CTDi 54984.
    MGIi MGI:1919650. Pinx1.

    Phylogenomic databases

    eggNOGi NOG263032.
    GeneTreei ENSGT00450000040279.
    HOGENOMi HOG000035098.
    HOVERGENi HBG061365.
    InParanoidi Q9CZX5.
    KOi K11135.
    OMAi EDCVWPP.
    OrthoDBi EOG789CCG.
    PhylomeDBi Q9CZX5.
    TreeFami TF321918.

    Miscellaneous databases

    ChiTaRSi PINX1. mouse.
    NextBioi 336194.
    PROi Q9CZX5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZX5.
    CleanExi MM_2610028A01RIK.
    Genevestigatori Q9CZX5.

    Family and domain databases

    InterProi IPR000467. G_patch_dom.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    [Graphical view ]
    PROSITEi PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."
      Zhou X.Z., Lu K.P.
      Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The expression of mouse LPTS1, a homolog of human tumor suppressor LPTS, in mouse liver."
      Liao C., Zhao M., Li T.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Stomach.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Schmidt T.
      Thesis (2001), University of Goettingen, Germany
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-332.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPINX1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZX5
    Secondary accession number(s): Q14BS4
    , Q3V450, Q8C6E5, Q91WZ9, Q9D0C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3