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Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene

Pinx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PIN2/TERF1-interacting telomerase inhibitor 1
Alternative name(s):
67-11-3 protein
LPTS1
Liver-related putative tumor suppressor
Pin2-interacting protein X1
TRF1-interacting protein 1
Gene namesi
Name:Pinx1
Synonyms:Lpts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1919650 Pinx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus, Telomere

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584441 – 332PIN2/TERF1-interacting telomerase inhibitor 1Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei277PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZX5
MaxQBiQ9CZX5
PaxDbiQ9CZX5
PeptideAtlasiQ9CZX5
PRIDEiQ9CZX5

PTM databases

iPTMnetiQ9CZX5
PhosphoSitePlusiQ9CZX5

Expressioni

Gene expression databases

BgeeiENSMUSG00000021958
CleanExiMM_2610028A01RIK
GenevisibleiQ9CZX5 MM

Interactioni

Subunit structurei

Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022528

Structurei

3D structure databases

ProteinModelPortaliQ9CZX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 72G-patchPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni254 – 328Telomerase inhibitory domain (TID)Add BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi291 – 301TBMAdd BLAST11

Domaini

The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity.By similarity
The TBM domain mediates interaction with TERF1.By similarity

Sequence similaritiesi

Belongs to the PINX1 family.Curated

Phylogenomic databases

eggNOGiKOG2809 Eukaryota
ENOG4111IXK LUCA
GeneTreeiENSGT00450000040279
HOGENOMiHOG000035098
HOVERGENiHBG061365
InParanoidiQ9CZX5
KOiK11135
OMAiLNEIFMI
OrthoDBiEOG091G0SES
PhylomeDBiQ9CZX5
TreeFamiTF321918

Family and domain databases

InterProiView protein in InterPro
IPR000467 G_patch_dom
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ
60 70 80 90 100
GATEHIKVKV KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA
110 120 130 140 150
DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR
160 170 180 190 200
RNKKLAQDGC SNSSADEVNT SLTTTTTTTS AFTIQEYFAK RMAQLKNKPQ
210 220 230 240 250
ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR HKKKKRVEAE
260 270 280 290 300
RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR
310 320 330
KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR
Length:332
Mass (Da):37,221
Last modified:June 20, 2002 - v2
Checksum:i6B7147CED58D991A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40S → A in BAC35998 (PubMed:16141072).Curated1
Sequence conflicti210 – 213ETPV → HAPC in BAE43228 (PubMed:16141072).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF421879 mRNA Translation: AAL32445.1
AF321817 mRNA Translation: AAL37221.1
AK011578 mRNA No translation available.
AK012057 mRNA Translation: BAE43228.1
AK075840 mRNA Translation: BAC35998.1
BC115636 mRNA Translation: AAI15637.1
AJ344106 mRNA Translation: CAC51439.1
CCDSiCCDS27205.1
RefSeqiNP_082504.1, NM_028228.3
UniGeneiMm.379214

Genome annotation databases

EnsembliENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958
GeneIDi72400
KEGGimmu:72400
UCSCiuc007uhx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPINX1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX5
Secondary accession number(s): Q14BS4
, Q3V450, Q8C6E5, Q91WZ9, Q9D0C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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