Q9CZX5 (PINX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PIN2/TERF1-interacting telomerase inhibitor 1

Alternative name(s):
67-11-3 protein
LPTS1
Liver-related putative tumor suppressor
Pin2-interacting protein X1
TRF1-interacting protein 1

Gene names

Name:	Pinx1
Synonyms:	Lpts

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor By similarity.
Subunit structure	Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA By similarity.
Subcellular location	Nucleus By similarity. Nucleus › nucleolus By similarity. Chromosome › telomere By similarity. Chromosome › centromere › kinetochore By similarity. Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE By similarity.
Domain	The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity By similarity. The TBM domain mediates interaction with TERF1 By similarity.
Sequence similarities	Belongs to the PINX1 family. Contains 1 G-patch domain.

Ontologies

Keywords
Cellular component	Centromere Chromosome Kinetochore Nucleus Telomere
Disease	Tumor suppressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitotic metaphase plate congression Inferred from electronic annotation. Source: Compara telomere maintenance via telomerase Inferred from direct assay Ref.1. Source: MGI
Cellular_component	chromosome, telomeric region Inferred from direct assay Ref.1. Source: MGI condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara nuclear chromosome Inferred from electronic annotation. Source: Compara nucleolus Inferred from direct assay Ref.1. Source: MGI spindle Inferred from electronic annotation. Source: Compara
Molecular_function	telomeric RNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	PIN2/TERF1-interacting telomerase inhibitor 1		PRO_0000058444
Regions
	Domain	26 – 72	47	G-patch
	Region	254 – 328	75	Telomerase inhibitory domain (TID)
	Motif	291 – 301	11	TBM
Experimental info
	Sequence conflict	40	1	S → A in BAC35998. Ref.3
	Sequence conflict	210 – 213	4	ETPV → HAPC in BAE43228. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9CZX5 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: 6B7147CED58D991A	FASTA	332	37,221
	10 20 30 40 50 60 MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ GATEHIKVKV 70 80 90 100 110 120 KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA DSSDKKEKKS FSLEEKSKIS 130 140 150 160 170 180 KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR RNKKLAQDGC SNSSADEVNT SLTTTTTTTS 190 200 210 220 230 240 AFTIQEYFAK RMAQLKNKPQ ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR 250 260 270 280 290 300 HKKKKRVEAE RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR 310 320 330 KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor." Zhou X.Z., Lu K.P. Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The expression of mouse LPTS1, a homolog of human tumor suppressor LPTS, in mouse liver." Liao C., Zhao M., Li T. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Stomach.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Schmidt T. Thesis (2001), University of Goettingen, Germany Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-332. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF421879 mRNA. Translation: AAL32445.1. AF321817 mRNA. Translation: AAL37221.1. AK011578 mRNA. No translation available. AK012057 mRNA. Translation: BAE43228.1. AK075840 mRNA. Translation: BAC35998.1. BC115636 mRNA. Translation: AAI15637.1. AJ344106 mRNA. Translation: CAC51439.1.
IPI	IPI00153088.
RefSeq	NP_082504.1. NM_028228.3.
UniGene	Mm.379214.
3D structure databases
ProteinModelPortal	Q9CZX5.
ModBase	Search...
PTM databases
PhosphoSite	Q9CZX5.
Proteomic databases
PRIDE	Q9CZX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
GeneID	72400.
KEGG	mmu:72400.
UCSC	uc007uhx.2. mouse.
Organism-specific databases
CTD	54984.
MGI	MGI:1919650. Pinx1.
Phylogenomic databases
eggNOG	NOG263032.
GeneTree	ENSGT00450000040279.
HOGENOM	HOG000035098.
HOVERGEN	HBG061365.
InParanoid	Q9CZX5.
KO	K11135.
OMA	HTEGKPE.
OrthoDB	EOG49079N.
Gene expression databases
Bgee	Q9CZX5.
CleanEx	MM_2610028A01RIK.
Genevestigator	Q9CZX5.
GermOnline	ENSMUSG00000021958. Mus musculus.
Family and domain databases
InterPro	IPR000467. G_patch_dom. [Graphical view]
Pfam	PF01585. G-patch. 1 hit. [Graphical view]
SMART	SM00443. G_patch. 1 hit. [Graphical view]
PROSITE	PS50174. G_PATCH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PINX1. mouse.
NextBio	336194.
SOURCE	Search...

Entry information

Entry name

PINX1_MOUSE

Accession

Primary (citable) accession number: Q9CZX5
Secondary accession number(s): Q14BS4 , Q3V450, Q8C6E5, Q91WZ9, Q9D0C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	June 20, 2002
Last modified:	April 3, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program