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Q9CZX5

- PINX1_MOUSE

UniProt

Q9CZX5 - PINX1_MOUSE

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Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene
Pinx1, Lpts
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. telomeric RNA binding Source: Ensembl

GO - Biological processi

  1. mitotic metaphase plate congression Source: Ensembl
  2. telomere maintenance via telomerase Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PIN2/TERF1-interacting telomerase inhibitor 1
Alternative name(s):
67-11-3 protein
LPTS1
Liver-related putative tumor suppressor
Pin2-interacting protein X1
TRF1-interacting protein 1
Gene namesi
Name:Pinx1
Synonyms:Lpts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1919650. Pinx1.

Subcellular locationi

Nucleus By similarity. Nucleusnucleolus By similarity. Chromosometelomere By similarity. Chromosomecentromerekinetochore By similarity
Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE By similarity.

GO - Cellular componenti

  1. chromosome, telomeric region Source: MGI
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. mitochondrion Source: Ensembl
  4. nuclear chromosome Source: Ensembl
  5. nucleolus Source: MGI
  6. spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus, Telomere

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332PIN2/TERF1-interacting telomerase inhibitor 1PRO_0000058444Add
BLAST

Proteomic databases

PRIDEiQ9CZX5.

PTM databases

PhosphoSiteiQ9CZX5.

Expressioni

Gene expression databases

BgeeiQ9CZX5.
CleanExiMM_2610028A01RIK.
GenevestigatoriQ9CZX5.

Interactioni

Subunit structurei

Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9CZX5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7247G-patchAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni254 – 32875Telomerase inhibitory domain (TID)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi291 – 30111TBMAdd
BLAST

Domaini

The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibits its activity By similarity.
The TBM domain mediates interaction with TERF1 By similarity.

Sequence similaritiesi

Belongs to the PINX1 family.
Contains 1 G-patch domain.

Phylogenomic databases

eggNOGiNOG263032.
GeneTreeiENSGT00450000040279.
HOGENOMiHOG000035098.
HOVERGENiHBG061365.
InParanoidiQ9CZX5.
KOiK11135.
OMAiEDCVWPP.
OrthoDBiEOG789CCG.
PhylomeDBiQ9CZX5.
TreeFamiTF321918.

Family and domain databases

InterProiIPR000467. G_patch_dom.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZX5-1 [UniParc]FASTAAdd to Basket

« Hide

MSMLAERRRK QKWTVDPRNT AWSNDDSKFG QKMLEKMGWS KGKGLGAQEQ    50
GATEHIKVKV KNNHLGLGAT NNNEDNWIAH QDDFNQLLAA LNTCHGQETA 100
DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSE TDLDCIFGKR 150
RNKKLAQDGC SNSSADEVNT SLTTTTTTTS AFTIQEYFAK RMAQLKNKPQ 200
ASAPGSDLSE TPVERKKGKK KNKEAADTDV ENSPQHKAKR HKKKKRVEAE 250
RGPVAKKRDR AELQPGGPSE DECSDASVEA AEDCVQTPDI QDDVPKPKKR 300
KAKKKLQRPE GVEIDATLDR APVKKKKKKV SR 332
Length:332
Mass (Da):37,221
Last modified:June 20, 2002 - v2
Checksum:i6B7147CED58D991A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401S → A in BAC35998. 1 Publication
Sequence conflicti210 – 2134ETPV → HAPC in BAE43228. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF421879 mRNA. Translation: AAL32445.1.
AF321817 mRNA. Translation: AAL37221.1.
AK011578 mRNA. No translation available.
AK012057 mRNA. Translation: BAE43228.1.
AK075840 mRNA. Translation: BAC35998.1.
BC115636 mRNA. Translation: AAI15637.1.
AJ344106 mRNA. Translation: CAC51439.1.
CCDSiCCDS27205.1.
RefSeqiNP_082504.1. NM_028228.3.
UniGeneiMm.379214.

Genome annotation databases

EnsembliENSMUST00000022528; ENSMUSP00000022528; ENSMUSG00000021958.
GeneIDi72400.
KEGGimmu:72400.
UCSCiuc007uhx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF421879 mRNA. Translation: AAL32445.1 .
AF321817 mRNA. Translation: AAL37221.1 .
AK011578 mRNA. No translation available.
AK012057 mRNA. Translation: BAE43228.1 .
AK075840 mRNA. Translation: BAC35998.1 .
BC115636 mRNA. Translation: AAI15637.1 .
AJ344106 mRNA. Translation: CAC51439.1 .
CCDSi CCDS27205.1.
RefSeqi NP_082504.1. NM_028228.3.
UniGenei Mm.379214.

3D structure databases

ProteinModelPortali Q9CZX5.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CZX5.

Proteomic databases

PRIDEi Q9CZX5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022528 ; ENSMUSP00000022528 ; ENSMUSG00000021958 .
GeneIDi 72400.
KEGGi mmu:72400.
UCSCi uc007uhx.2. mouse.

Organism-specific databases

CTDi 54984.
MGIi MGI:1919650. Pinx1.

Phylogenomic databases

eggNOGi NOG263032.
GeneTreei ENSGT00450000040279.
HOGENOMi HOG000035098.
HOVERGENi HBG061365.
InParanoidi Q9CZX5.
KOi K11135.
OMAi EDCVWPP.
OrthoDBi EOG789CCG.
PhylomeDBi Q9CZX5.
TreeFami TF321918.

Miscellaneous databases

ChiTaRSi PINX1. mouse.
NextBioi 336194.
PROi Q9CZX5.
SOURCEi Search...

Gene expression databases

Bgeei Q9CZX5.
CleanExi MM_2610028A01RIK.
Genevestigatori Q9CZX5.

Family and domain databases

InterProi IPR000467. G_patch_dom.
[Graphical view ]
Pfami PF01585. G-patch. 1 hit.
[Graphical view ]
SMARTi SM00443. G_patch. 1 hit.
[Graphical view ]
PROSITEi PS50174. G_PATCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."
    Zhou X.Z., Lu K.P.
    Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The expression of mouse LPTS1, a homolog of human tumor suppressor LPTS, in mouse liver."
    Liao C., Zhao M., Li T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Schmidt T.
    Thesis (2001), University of Goettingen, Germany
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-332.
    Tissue: Embryo.

Entry informationi

Entry nameiPINX1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZX5
Secondary accession number(s): Q14BS4
, Q3V450, Q8C6E5, Q91WZ9, Q9D0C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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