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Protein

Mitochondrial import receptor subunit TOM70

Gene

Tomm70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70By similarity
Gene namesi
Name:Tomm70By similarity
Synonyms:D16Wsu109e, Tomm70a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:106295. Tomm70a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 41Mitochondrial intermembraneSequence analysisAdd BLAST40
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 611CytoplasmicSequence analysisAdd BLAST549

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001063372 – 611Mitochondrial import receptor subunit TOM70Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei74Omega-N-methylarginineBy similarity1
Modified residuei94PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei105PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei188N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9CZW5.
MaxQBiQ9CZW5.
PaxDbiQ9CZW5.
PRIDEiQ9CZW5.

PTM databases

iPTMnetiQ9CZW5.
PhosphoSitePlusiQ9CZW5.
SwissPalmiQ9CZW5.

Expressioni

Tissue specificityi

Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication

Gene expression databases

BgeeiENSMUSG00000022752.
GenevisibleiQ9CZW5. MM.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rgs13Q8K44312EBI-642469,EBI-645999

Protein-protein interaction databases

BioGridi205817. 2 interactors.
IntActiQ9CZW5. 5 interactors.
MINTiMINT-4111674.
STRINGi10090.ENSMUSP00000129186.

Structurei

3D structure databases

ProteinModelPortaliQ9CZW5.
SMRiQ9CZW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati117 – 150TPR 1Add BLAST34
Repeati156 – 189TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34
Repeati332 – 365TPR 4Add BLAST34
Repeati370 – 403TPR 5Add BLAST34
Repeati404 – 437TPR 6Add BLAST34
Repeati445 – 478TPR 7Add BLAST34
Repeati479 – 512TPR 8Add BLAST34
Repeati514 – 547TPR 9Add BLAST34
Repeati548 – 581TPR 10Add BLAST34

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00860000133798.
HOVERGENiHBG062335.
InParanoidiQ9CZW5.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG091G0CYZ.
TreeFamiTF106203.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKPIEAA MAAAAAPGSG NGVGGGGGTA GPGSGAGTLP RWHVALAIGA
60 70 80 90 100
PLLLGAGAMY LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG
110 120 130 140 150
HHDGSGDSLE MSSLDRAQAA KNKGNKYFKA GKYEQAIQCY TEAISLCPTE
160 170 180 190 200
KNVDLSTFYQ NRAAAFEQLQ KWKEVAQDCT KAVELNPKYV KALFRRAKAH
210 220 230 240 250
EKLDNKKECL EDVTAVCILE GFQNEQSMLL ADKVLKLLGK ENAKEKYKNR
260 270 280 290 300
EPLMPSPQFI KSYFSSFTDD IISQPMLKGE KSDEDKDKEG EALEVKENSG
310 320 330 340 350
YLKAKQYMEE ENYDKIISEC SKEIDAQGKY MAEALLLRAT FYLLIGSANA
360 370 380 390 400
AKPDLDKVIS LKEANVKLRA NALIKRGTMC MQQQQPMLST QDFNMAAEID
410 420 430 440 450
PMNSDVYHHR GQLKILLDLV EEAVADFDAC IRLRPKFALA QAQKCFALYR
460 470 480 490 500
QAYTANNSSQ VQAAMKGFEE IIKKFPRCAE GYALYAQALT DQQQFGKADE
510 520 530 540 550
MYDKCIDLEP DNATTYVHKG LLQLQWKQDL DKGLELISKA IEIDNKCDFA
560 570 580 590 600
YETMGTIEVQ RGNMEKAIDM FNKAINLAKS EMEMAHLYSL CDAAHAQTEV
610
AKKYGLKPPT L
Length:611
Mass (Da):67,590
Last modified:July 27, 2011 - v2
Checksum:i5103C658D8BF9C53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116R → S in BAB28018 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA. Translation: BAB28018.1.
AK083586 mRNA. Translation: BAC38960.1.
AK145458 mRNA. Translation: BAE26448.1.
AK150429 mRNA. Translation: BAE29552.1.
BC057096 mRNA. Translation: AAH57096.1.
BC139420 mRNA. Translation: AAI39421.1.
BC139421 mRNA. Translation: AAI39422.1.
CCDSiCCDS28227.1.
RefSeqiNP_613065.2. NM_138599.5.
UniGeneiMm.196933.
Mm.213292.

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752.
GeneIDi28185.
KEGGimmu:28185.
UCSCiuc007zmz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA. Translation: BAB28018.1.
AK083586 mRNA. Translation: BAC38960.1.
AK145458 mRNA. Translation: BAE26448.1.
AK150429 mRNA. Translation: BAE29552.1.
BC057096 mRNA. Translation: AAH57096.1.
BC139420 mRNA. Translation: AAI39421.1.
BC139421 mRNA. Translation: AAI39422.1.
CCDSiCCDS28227.1.
RefSeqiNP_613065.2. NM_138599.5.
UniGeneiMm.196933.
Mm.213292.

3D structure databases

ProteinModelPortaliQ9CZW5.
SMRiQ9CZW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205817. 2 interactors.
IntActiQ9CZW5. 5 interactors.
MINTiMINT-4111674.
STRINGi10090.ENSMUSP00000129186.

PTM databases

iPTMnetiQ9CZW5.
PhosphoSitePlusiQ9CZW5.
SwissPalmiQ9CZW5.

Proteomic databases

EPDiQ9CZW5.
MaxQBiQ9CZW5.
PaxDbiQ9CZW5.
PRIDEiQ9CZW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752.
GeneIDi28185.
KEGGimmu:28185.
UCSCiuc007zmz.1. mouse.

Organism-specific databases

CTDi28185.
MGIiMGI:106295. Tomm70a.

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00860000133798.
HOVERGENiHBG062335.
InParanoidiQ9CZW5.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG091G0CYZ.
TreeFamiTF106203.

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

ChiTaRSiTomm70a. mouse.
PROiQ9CZW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022752.
GenevisibleiQ9CZW5. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM70_MOUSE
AccessioniPrimary (citable) accession number: Q9CZW5
Secondary accession number(s): Q8BNI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.