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Protein

Mitochondrial import receptor subunit TOM70

Gene

Tomm70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor that accelerates the import of all mitochondrial precursor proteins.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM70
Alternative name(s):
Mitochondrial precursor proteins import receptor
Translocase of outer membrane 70 kDa subunit
Translocase of outer mitochondrial membrane protein 70By similarity
Gene namesi
Name:Tomm70By similarity
Synonyms:D16Wsu109e, Tomm70a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:106295. Tomm70a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4140Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 611549CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 611610Mitochondrial import receptor subunit TOM70PRO_0000106337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei99 – 991PhosphoserineCombined sources
Modified residuei105 – 1051PhosphoserineBy similarity
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei188 – 1881N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CZW5.
MaxQBiQ9CZW5.
PaxDbiQ9CZW5.
PRIDEiQ9CZW5.

PTM databases

iPTMnetiQ9CZW5.
PhosphoSiteiQ9CZW5.
SwissPalmiQ9CZW5.

Expressioni

Tissue specificityi

Expressed in the base region of the oxyntic and pyloric mucosae.1 Publication

Gene expression databases

BgeeiQ9CZW5.
GenevisibleiQ9CZW5. MM.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rgs13Q8K44312EBI-642469,EBI-645999

Protein-protein interaction databases

BioGridi205817. 2 interactions.
IntActiQ9CZW5. 5 interactions.
MINTiMINT-4111674.
STRINGi10090.ENSMUSP00000129186.

Structurei

3D structure databases

ProteinModelPortaliQ9CZW5.
SMRiQ9CZW5. Positions 113-589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati117 – 15034TPR 1Add
BLAST
Repeati156 – 18934TPR 2Add
BLAST
Repeati297 – 33034TPR 3Add
BLAST
Repeati332 – 36534TPR 4Add
BLAST
Repeati370 – 40334TPR 5Add
BLAST
Repeati404 – 43734TPR 6Add
BLAST
Repeati445 – 47834TPR 7Add
BLAST
Repeati479 – 51234TPR 8Add
BLAST
Repeati514 – 54734TPR 9Add
BLAST
Repeati548 – 58134TPR 10Add
BLAST

Sequence similaritiesi

Belongs to the Tom70 family.Curated
Contains 10 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00840000129775.
HOVERGENiHBG062335.
InParanoidiQ9CZW5.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG7DVD9R.
TreeFamiTF106203.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKPIEAA MAAAAAPGSG NGVGGGGGTA GPGSGAGTLP RWHVALAIGA
60 70 80 90 100
PLLLGAGAMY LWSRRRRRRE AGGRGDASGL KRNSERKTPE GRASPALGSG
110 120 130 140 150
HHDGSGDSLE MSSLDRAQAA KNKGNKYFKA GKYEQAIQCY TEAISLCPTE
160 170 180 190 200
KNVDLSTFYQ NRAAAFEQLQ KWKEVAQDCT KAVELNPKYV KALFRRAKAH
210 220 230 240 250
EKLDNKKECL EDVTAVCILE GFQNEQSMLL ADKVLKLLGK ENAKEKYKNR
260 270 280 290 300
EPLMPSPQFI KSYFSSFTDD IISQPMLKGE KSDEDKDKEG EALEVKENSG
310 320 330 340 350
YLKAKQYMEE ENYDKIISEC SKEIDAQGKY MAEALLLRAT FYLLIGSANA
360 370 380 390 400
AKPDLDKVIS LKEANVKLRA NALIKRGTMC MQQQQPMLST QDFNMAAEID
410 420 430 440 450
PMNSDVYHHR GQLKILLDLV EEAVADFDAC IRLRPKFALA QAQKCFALYR
460 470 480 490 500
QAYTANNSSQ VQAAMKGFEE IIKKFPRCAE GYALYAQALT DQQQFGKADE
510 520 530 540 550
MYDKCIDLEP DNATTYVHKG LLQLQWKQDL DKGLELISKA IEIDNKCDFA
560 570 580 590 600
YETMGTIEVQ RGNMEKAIDM FNKAINLAKS EMEMAHLYSL CDAAHAQTEV
610
AKKYGLKPPT L
Length:611
Mass (Da):67,590
Last modified:July 27, 2011 - v2
Checksum:i5103C658D8BF9C53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161R → S in BAB28018 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA. Translation: BAB28018.1.
AK083586 mRNA. Translation: BAC38960.1.
AK145458 mRNA. Translation: BAE26448.1.
AK150429 mRNA. Translation: BAE29552.1.
BC057096 mRNA. Translation: AAH57096.1.
BC139420 mRNA. Translation: AAI39421.1.
BC139421 mRNA. Translation: AAI39422.1.
CCDSiCCDS28227.1.
RefSeqiNP_613065.2. NM_138599.5.
UniGeneiMm.196933.
Mm.213292.

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752.
GeneIDi28185.
KEGGimmu:28185.
UCSCiuc007zmz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012084 mRNA. Translation: BAB28018.1.
AK083586 mRNA. Translation: BAC38960.1.
AK145458 mRNA. Translation: BAE26448.1.
AK150429 mRNA. Translation: BAE29552.1.
BC057096 mRNA. Translation: AAH57096.1.
BC139420 mRNA. Translation: AAI39421.1.
BC139421 mRNA. Translation: AAI39422.1.
CCDSiCCDS28227.1.
RefSeqiNP_613065.2. NM_138599.5.
UniGeneiMm.196933.
Mm.213292.

3D structure databases

ProteinModelPortaliQ9CZW5.
SMRiQ9CZW5. Positions 113-589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205817. 2 interactions.
IntActiQ9CZW5. 5 interactions.
MINTiMINT-4111674.
STRINGi10090.ENSMUSP00000129186.

PTM databases

iPTMnetiQ9CZW5.
PhosphoSiteiQ9CZW5.
SwissPalmiQ9CZW5.

Proteomic databases

EPDiQ9CZW5.
MaxQBiQ9CZW5.
PaxDbiQ9CZW5.
PRIDEiQ9CZW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166897; ENSMUSP00000129186; ENSMUSG00000022752.
GeneIDi28185.
KEGGimmu:28185.
UCSCiuc007zmz.1. mouse.

Organism-specific databases

CTDi28185.
MGIiMGI:106295. Tomm70a.

Phylogenomic databases

eggNOGiKOG0547. Eukaryota.
ENOG410YVNZ. LUCA.
GeneTreeiENSGT00840000129775.
HOVERGENiHBG062335.
InParanoidiQ9CZW5.
KOiK17768.
OMAiKWTEVAQ.
OrthoDBiEOG7DVD9R.
TreeFamiTF106203.

Enzyme and pathway databases

ReactomeiR-MMU-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

ChiTaRSiTomm70a. mouse.
PROiQ9CZW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZW5.
GenevisibleiQ9CZW5. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 10 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 163-171; 330-357; 451-466 AND 520-527, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP."
    Hata S., Koyama S., Kawahara H., Doi N., Maeda T., Toyama-Sorimachi N., Abe K., Suzuki K., Sorimachi H.
    J. Biol. Chem. 281:11214-11224(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAPN8, TISSUE SPECIFICITY.
  5. "Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS."
    Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.
    Mol. Cell. Proteomics 6:669-676(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94; SER-99 AND SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTOM70_MOUSE
AccessioniPrimary (citable) accession number: Q9CZW5
Secondary accession number(s): Q8BNI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.