Reviewed,
UniProtKB/Swiss-Prot Q9CZW4 (ACSL3_MOUSE)
Last modified
October 13, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Long-chain-fatty-acid--CoA ligase 3 EC=6.2.1.3 Alternative name(s): Long-chain acyl-CoA synthetase 3 Short name=LACS 3 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 720 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 has mainly an anabolic role in energy metabolism By similarity. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) By similarity. Mediates hepatic lipogenesis By similarity. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates By similarity. |
| Catalytic activity | ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Cofactor | Magnesium By similarity. |
| Subcellular location | Mitochondrion outer membrane; Single-pass type III membrane protein By similarity. Peroxisome membrane; Single-pass type III membrane protein By similarity. Microsome membrane; Single-pass type III membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity. |
| Induction | High expression in ob/ob mice (obese) and mice fed at high sucrose diet. Ref.2 |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 720 | 720 | Long-chain-fatty-acid--CoA ligase 3 | PRO_0000193108 | |||||
Regions | |||||||||
| Transmembrane | 21 – 41 | 21 | Signal-anchor for type III membrane protein Potential | ||||||
| Topological domain | 42 – 720 | 679 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 593 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 683 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 688 | 1 | Phosphothreonine By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo. |
| [2] | "Suppression of long chain acyl-CoA synthetase 3 (ACSL3) decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity." Bu S.Y., Mashek M.T., Mashek D.G. J. Biol. Chem. 0:0-0(2009) [PubMed: 19737935] [Abstract] Cited for: INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK012088 mRNA. Translation: BAB28022.1. | |
| IPI | IPI00169772. |
| RefSeq | NP_001028778.2. |
| UniGene | Mm.276016 Mm.427252 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9CZW4. |
PTM databases | |
| PhosphoSite | Q9CZW4. |
Proteomic databases | |
| PRIDE | Q9CZW4. |
Genome annotation databases | |
| Ensembl | ENSMUST00000012393; ENSMUSP00000012393; ENSMUSG00000032883; Mus musculus. [Genome view] ENSMUST00000035779; ENSMUSP00000045291; ENSMUSG00000032883; Mus musculus. [Genome view] ENSMUST00000113521; ENSMUSP00000109149; ENSMUSG00000032883; Mus musculus. [Genome view] |
| GeneID | 74205. |
| KEGG | mmu:74205. |
| UCSC | uc007bqp.1. mouse. |
Organism-specific databases | |
| MGI | MGI:1921455. Acsl3. |
Phylogenomic databases | |
| HOVERGEN | Q9CZW4. |
Enzyme and pathway databases | |
| BRENDA | 6.2.1.3. 244. |
Gene expression databases | |
| ArrayExpress | Q9CZW4. |
| Bgee | Q9CZW4. |
| Genevestigator | Q9CZW4. |
| GermOnline | ENSMUSG00000032883. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 340106. |
| SOURCE | Search... |
Entry information
| Entry name | ACSL3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9CZW4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


