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Protein

F-box/LRR-repeat protein 20

Gene

Fbxl20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • behavioral fear response Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 20
Alternative name(s):
F-box and leucine-rich repeat protein 20
F-box/LRR-repeat protein 2-like
Gene namesi
Name:Fbxl20
Synonyms:Fbl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919444 Fbxl20

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Altered electrophysiological synaptic activity, with increased frequency of miniature excitatory postsynaptic currents.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198711 – 436F-box/LRR-repeat protein 20Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei417PhosphothreonineCombined sources1
Modified residuei421PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CZV8
PeptideAtlasiQ9CZV8
PRIDEiQ9CZV8

PTM databases

iPTMnetiQ9CZV8
PhosphoSitePlusiQ9CZV8
SwissPalmiQ9CZV8

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000020883
CleanExiMM_FBXL20
ExpressionAtlasiQ9CZV8 baseline and differential
GenevisibleiQ9CZV8 MM

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Rims1Q99NE54EBI-1551033,EBI-775541

Protein-protein interaction databases

BioGridi215210, 4 interactors
CORUMiQ9CZV8
IntActiQ9CZV8, 5 interactors
STRINGi10090.ENSMUSP00000099432

Structurei

3D structure databases

ProteinModelPortaliQ9CZV8
SMRiQ9CZV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 68F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati74 – 100LRR 1Add BLAST27
Repeati101 – 126LRR 2Add BLAST26
Repeati127 – 152LRR 3Add BLAST26
Repeati153 – 178LRR 4Add BLAST26
Repeati179 – 204LRR 5Add BLAST26
Repeati205 – 230LRR 6Add BLAST26
Repeati231 – 256LRR 7Add BLAST26
Repeati257 – 282LRR 8Add BLAST26
Repeati283 – 308LRR 9Add BLAST26
Repeati309 – 334LRR 10Add BLAST26
Repeati335 – 363LRR 11Add BLAST29
Repeati364 – 388LRR 12Add BLAST25
Repeati389 – 414LRR 13Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4341 Eukaryota
ENOG410XQ54 LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000230659
HOVERGENiHBG051586
InParanoidiQ9CZV8
KOiK10268
OMAiDLYDCQN
OrthoDBiEOG091G060Y
PhylomeDBiQ9CZV8
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 4 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 12 hits
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ
60 70 80 90 100
VSRAWNVLAL DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG
110 120 130 140 150
CLGVGDNALR TFAQNCRNIE VLSLNGCTKT TDATCTSLSK FCSKLRHLDL
160 170 180 190 200
ASCTSITNMS LKALSEGCPL LEQLNISWCD QVTKDGIQAL VRGCGGLKAL
210 220 230 240 250
FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI TICRGCHKLQ
260 270 280 290 300
SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
310 320 330 340 350
LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA
360 370 380 390 400
CAHDQLEVIE LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL
410 420 430
RTHLPNIKVH AYFAPVTPPP SVGGSRQRFC RCCIIL
Length:436
Mass (Da):48,396
Last modified:February 5, 2008 - v3
Checksum:i3218F38C02EA1BCE
GO
Isoform 2 (identifier: Q9CZV8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Note: No experimental confirmation available.
Show »
Length:422
Mass (Da):46,719
Checksum:iD6E65241BB8191EB
GO
Isoform 3 (identifier: Q9CZV8-3) [UniParc]FASTAAdd to basket
Also known as: Scrapper

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MRRDVNGVTKSRFE → MAPSRDRLLHFGFKAT

Show »
Length:438
Mass (Da):48,548
Checksum:i305466A743427E36
GO

Sequence cautioni

The sequence BAC29349 differs from that shown. Intron retention.Curated
The sequence BAD90157 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40L → P in BAB28039 (PubMed:16141072).Curated1
Sequence conflicti379 – 381HSL → PSF in BAB28039 (PubMed:16141072).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383541 – 14Missing in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0307701 – 14MRRDV…KSRFE → MAPSRDRLLHFGFKAT in isoform 3. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF649694 mRNA Translation: ABU95014.1
AK012109 mRNA Translation: BAB28039.1
AK036217 mRNA Translation: BAC29349.1 Sequence problems.
AK144786 mRNA Translation: BAE26066.1
AK220232 mRNA Translation: BAD90157.1 Different initiation.
AL591205, AL591209 Genomic DNA Translation: CAM21260.1
AL591209, AL591205 Genomic DNA Translation: CAM20406.1
CCDSiCCDS25339.1 [Q9CZV8-1]
RefSeqiNP_082425.1, NM_028149.1 [Q9CZV8-1]
XP_006534361.1, XM_006534298.3 [Q9CZV8-3]
XP_006534362.1, XM_006534299.3 [Q9CZV8-4]
UniGeneiMm.218350

Genome annotation databases

EnsembliENSMUST00000103143; ENSMUSP00000099432; ENSMUSG00000020883 [Q9CZV8-1]
GeneIDi72194
KEGGimmu:72194
UCSCiuc007lfm.1 mouse [Q9CZV8-1]
uc009vah.1 mouse [Q9CZV8-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFXL20_MOUSE
AccessioniPrimary (citable) accession number: Q9CZV8
Secondary accession number(s): A7YE80
, Q3UMN2, Q571F7, Q8BZ95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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