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Q9CZU4

- ERAL1_MOUSE

UniProt

Q9CZU4 - ERAL1_MOUSE

Protein

GTPase Era, mitochondrial

Gene

Eral1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi120 – 1278GTPSequence Analysis
    Nucleotide bindingi167 – 1715GTPSequence Analysis
    Nucleotide bindingi236 – 2394GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. ribosomal small subunit binding Source: UniProtKB
    3. rRNA binding Source: UniProtKB

    GO - Biological processi

    1. ribosomal small subunit assembly Source: UniProtKB

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding, RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase Era, mitochondrial
    Short name:
    M-ERA
    Alternative name(s):
    Conserved ERA-like GTPase
    Short name:
    CEGA
    ERA-W
    ERA-like protein 1
    Gene namesi
    Name:Eral1
    Synonyms:Mera
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1889295. Eral1.

    Subcellular locationi

    Mitochondrion matrix By similarity. Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity
    Note: Localizes on the matrix side on the mitochondrial inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrial matrix Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2020MitochondrionSequence AnalysisAdd
    BLAST
    Chaini21 – 437417GTPase Era, mitochondrialPRO_0000180082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei173 – 1731PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9CZU4.

    PTM databases

    PhosphoSiteiQ9CZU4.

    Expressioni

    Gene expression databases

    BgeeiQ9CZU4.
    CleanExiMM_ERAL1.
    GenevestigatoriQ9CZU4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZU4.
    SMRiQ9CZU4. Positions 112-436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 330219Era-type GAdd
    BLAST
    Domaini360 – 43778KH type-2Add
    BLAST

    Sequence similaritiesi

    Contains 1 KH type-2 domain.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1159.
    GeneTreeiENSGT00390000013800.
    HOGENOMiHOG000245598.
    HOVERGENiHBG051495.
    InParanoidiQ8VE60.
    OMAiHDNAQIV.
    OrthoDBiEOG7XWPNP.
    PhylomeDBiQ9CZU4.
    TreeFamiTF321650.

    Family and domain databases

    Gene3Di3.30.300.20. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00367. GTPase_Era.
    InterProiIPR005662. GTP-bd_Era.
    IPR006073. GTP_binding_domain.
    IPR015946. KH_dom-like_a/b.
    IPR009019. KH_prok-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view]
    PfamiPF01926. MMR_HSR1. 1 hit.
    [Graphical view]
    PRINTSiPR00326. GTP1OBG.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF54814. SSF54814. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51713. G_ERA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CZU4-1 [UniParc]FASTAAdd to Basket

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    MAAPRRYCAG LVRALLGARQ VGSHAGREWL APPGCLLGNQ ARCVSCVVGS    50
    TFSGPLLASA SSRYGQDSAL DRILGFSQPD SSLVPSVPAV SVHRDEQNLL 100
    LVHTPDMPEN PRVLRVVLLG APNAGKSTLS NQLLGRKVFP VSKKVHTTRC 150
    QALGVITEKE TQVILLDTPG IISPVKQKRH HLERSLLEDP WTSMESADLV 200
    VVLVDVSDKW TRSRLNPQVL QCLTKFSQVP SILVLNKVDC LKQKSVLLEL 250
    TAALTEGVVN GKKLNIKQAL RSRSSTHCPG PETEGPNAHS VRNPQRIGWP 300
    YFQEIFMLSA LNNKDVNTLK QYLLTQAQPG PWEFHSGVLT SQTPEEICAN 350
    KIREKLLEYL PEEVPYGVQQ KTVIWEEGPS GELVIQQNLL VPKESHVRIL 400
    IGQKGLLISQ IAQEVGRDLM DIFHCDVLIR LSVKLLK 437
    Length:437
    Mass (Da):48,187
    Last modified:June 1, 2001 - v1
    Checksum:iD6118FD53DC9A7E1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541G → W in BAB56113. (PubMed:11733036)Curated
    Sequence conflicti407 – 4071L → S in AAH68271. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049389 mRNA. Translation: BAB56113.1.
    AK012155 mRNA. Translation: BAB28065.1.
    AL669840 Genomic DNA. Translation: CAI25706.1.
    BC019728 mRNA. Translation: AAH19728.1.
    BC068271 mRNA. Translation: AAH68271.1.
    CCDSiCCDS48856.1.
    RefSeqiNP_071708.2. NM_022313.2.
    UniGeneiMm.21096.

    Genome annotation databases

    EnsembliENSMUST00000021183; ENSMUSP00000021183; ENSMUSG00000020832.
    GeneIDi57837.
    KEGGimmu:57837.
    UCSCiuc007kia.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049389 mRNA. Translation: BAB56113.1 .
    AK012155 mRNA. Translation: BAB28065.1 .
    AL669840 Genomic DNA. Translation: CAI25706.1 .
    BC019728 mRNA. Translation: AAH19728.1 .
    BC068271 mRNA. Translation: AAH68271.1 .
    CCDSi CCDS48856.1.
    RefSeqi NP_071708.2. NM_022313.2.
    UniGenei Mm.21096.

    3D structure databases

    ProteinModelPortali Q9CZU4.
    SMRi Q9CZU4. Positions 112-436.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CZU4.

    Proteomic databases

    PRIDEi Q9CZU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021183 ; ENSMUSP00000021183 ; ENSMUSG00000020832 .
    GeneIDi 57837.
    KEGGi mmu:57837.
    UCSCi uc007kia.2. mouse.

    Organism-specific databases

    CTDi 26284.
    MGIi MGI:1889295. Eral1.

    Phylogenomic databases

    eggNOGi COG1159.
    GeneTreei ENSGT00390000013800.
    HOGENOMi HOG000245598.
    HOVERGENi HBG051495.
    InParanoidi Q8VE60.
    OMAi HDNAQIV.
    OrthoDBi EOG7XWPNP.
    PhylomeDBi Q9CZU4.
    TreeFami TF321650.

    Miscellaneous databases

    NextBioi 314014.
    PROi Q9CZU4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZU4.
    CleanExi MM_ERAL1.
    Genevestigatori Q9CZU4.

    Family and domain databases

    Gene3Di 3.30.300.20. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00367. GTPase_Era.
    InterProi IPR005662. GTP-bd_Era.
    IPR006073. GTP_binding_domain.
    IPR015946. KH_dom-like_a/b.
    IPR009019. KH_prok-type.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    [Graphical view ]
    Pfami PF01926. MMR_HSR1. 1 hit.
    [Graphical view ]
    PRINTSi PR00326. GTP1OBG.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF54814. SSF54814. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51713. G_ERA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity."
      Akiyama T., Gohda J., Shibata S., Nomura Y., Azuma S., Ohmori Y., Sugano S., Arai H., Yamamoto T., Inoue J.
      Genes Cells 6:987-1001(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129/Sv X 129SvCp and Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiERAL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZU4
    Secondary accession number(s): Q6NV78, Q8VE60, Q925U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3