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Protein

GTPase Era, mitochondrial

Gene

Eral1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 127GTPSequence analysis8
Nucleotide bindingi167 – 171GTPSequence analysis5
Nucleotide bindingi236 – 239GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase Era, mitochondrial
Short name:
M-ERA
Alternative name(s):
Conserved ERA-like GTPase
Short name:
CEGA
ERA-W
ERA-like protein 1
Gene namesi
Name:Eral1
Synonyms:Mera
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1889295. Eral1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000018008221 – 437GTPase Era, mitochondrialAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZU4.
MaxQBiQ9CZU4.
PaxDbiQ9CZU4.
PeptideAtlasiQ9CZU4.
PRIDEiQ9CZU4.

PTM databases

PhosphoSitePlusiQ9CZU4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020832.
CleanExiMM_ERAL1.
GenevisibleiQ9CZU4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021183.

Structurei

3D structure databases

ProteinModelPortaliQ9CZU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 330Era-type GAdd BLAST219
Domaini360 – 437KH type-2Add BLAST78

Sequence similaritiesi

Contains 1 KH type-2 domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1423. Eukaryota.
COG1159. LUCA.
GeneTreeiENSGT00390000013800.
HOGENOMiHOG000245598.
HOVERGENiHBG051495.
InParanoidiQ9CZU4.
OMAiVITEQFE.
OrthoDBiEOG091G0BPI.
PhylomeDBiQ9CZU4.
TreeFamiTF321650.

Family and domain databases

CDDicd04163. Era. 1 hit.
Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00367. GTPase_Era. 1 hit.
InterProiIPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51713. G_ERA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRRYCAG LVRALLGARQ VGSHAGREWL APPGCLLGNQ ARCVSCVVGS
60 70 80 90 100
TFSGPLLASA SSRYGQDSAL DRILGFSQPD SSLVPSVPAV SVHRDEQNLL
110 120 130 140 150
LVHTPDMPEN PRVLRVVLLG APNAGKSTLS NQLLGRKVFP VSKKVHTTRC
160 170 180 190 200
QALGVITEKE TQVILLDTPG IISPVKQKRH HLERSLLEDP WTSMESADLV
210 220 230 240 250
VVLVDVSDKW TRSRLNPQVL QCLTKFSQVP SILVLNKVDC LKQKSVLLEL
260 270 280 290 300
TAALTEGVVN GKKLNIKQAL RSRSSTHCPG PETEGPNAHS VRNPQRIGWP
310 320 330 340 350
YFQEIFMLSA LNNKDVNTLK QYLLTQAQPG PWEFHSGVLT SQTPEEICAN
360 370 380 390 400
KIREKLLEYL PEEVPYGVQQ KTVIWEEGPS GELVIQQNLL VPKESHVRIL
410 420 430
IGQKGLLISQ IAQEVGRDLM DIFHCDVLIR LSVKLLK
Length:437
Mass (Da):48,187
Last modified:June 1, 2001 - v1
Checksum:iD6118FD53DC9A7E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154G → W in BAB56113 (PubMed:11733036).Curated1
Sequence conflicti407L → S in AAH68271 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049389 mRNA. Translation: BAB56113.1.
AK012155 mRNA. Translation: BAB28065.1.
AL669840 Genomic DNA. Translation: CAI25706.1.
BC019728 mRNA. Translation: AAH19728.1.
BC068271 mRNA. Translation: AAH68271.1.
CCDSiCCDS48856.1.
RefSeqiNP_071708.2. NM_022313.2.
UniGeneiMm.21096.

Genome annotation databases

EnsembliENSMUST00000021183; ENSMUSP00000021183; ENSMUSG00000020832.
GeneIDi57837.
KEGGimmu:57837.
UCSCiuc007kia.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049389 mRNA. Translation: BAB56113.1.
AK012155 mRNA. Translation: BAB28065.1.
AL669840 Genomic DNA. Translation: CAI25706.1.
BC019728 mRNA. Translation: AAH19728.1.
BC068271 mRNA. Translation: AAH68271.1.
CCDSiCCDS48856.1.
RefSeqiNP_071708.2. NM_022313.2.
UniGeneiMm.21096.

3D structure databases

ProteinModelPortaliQ9CZU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021183.

PTM databases

PhosphoSitePlusiQ9CZU4.

Proteomic databases

EPDiQ9CZU4.
MaxQBiQ9CZU4.
PaxDbiQ9CZU4.
PeptideAtlasiQ9CZU4.
PRIDEiQ9CZU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021183; ENSMUSP00000021183; ENSMUSG00000020832.
GeneIDi57837.
KEGGimmu:57837.
UCSCiuc007kia.2. mouse.

Organism-specific databases

CTDi26284.
MGIiMGI:1889295. Eral1.

Phylogenomic databases

eggNOGiKOG1423. Eukaryota.
COG1159. LUCA.
GeneTreeiENSGT00390000013800.
HOGENOMiHOG000245598.
HOVERGENiHBG051495.
InParanoidiQ9CZU4.
OMAiVITEQFE.
OrthoDBiEOG091G0BPI.
PhylomeDBiQ9CZU4.
TreeFamiTF321650.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ9CZU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020832.
CleanExiMM_ERAL1.
GenevisibleiQ9CZU4. MM.

Family and domain databases

CDDicd04163. Era. 1 hit.
Gene3Di3.30.300.20. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00367. GTPase_Era. 1 hit.
InterProiIPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
PfamiPF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51713. G_ERA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERAL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZU4
Secondary accession number(s): Q6NV78, Q8VE60, Q925U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.