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Protein

Superkiller viralicidic activity 2-like 2

Gene

Skiv2l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi159 – 166ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

mRNA processing, mRNA splicing, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Superkiller viralicidic activity 2-like 2 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent helicase SKIV2L2
TRAMP-like complex helicase
Gene namesi
Name:Skiv2l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1919448. Skiv2l2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001020952 – 1040Superkiller viralicidic activity 2-like 2Add BLAST1039

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Modified residuei49N6-acetyllysineBy similarity1
Modified residuei76N6-acetyllysineCombined sources1
Cross-linki682Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CZU3.
MaxQBiQ9CZU3.
PaxDbiQ9CZU3.
PeptideAtlasiQ9CZU3.
PRIDEiQ9CZU3.

PTM databases

iPTMnetiQ9CZU3.
PhosphoSitePlusiQ9CZU3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016018.
GenevisibleiQ9CZU3. MM.

Interactioni

Subunit structurei

Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex. Interacts with NVL in an ATP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi215213. 4 interactors.
IntActiQ9CZU3. 3 interactors.
MINTiMINT-4126258.
STRINGi10090.ENSMUSP00000022281.

Structurei

3D structure databases

ProteinModelPortaliQ9CZU3.
SMRiQ9CZU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 302Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST157
Domaini403 – 575Helicase C-terminalPROSITE-ProRule annotationAdd BLAST173

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi250 – 253DEIH box4

Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0948. Eukaryota.
COG4581. LUCA.
GeneTreeiENSGT00820000127042.
HOGENOMiHOG000163047.
HOVERGENiHBG104255.
InParanoidiQ9CZU3.
KOiK12598.
OMAiDKGKWKG.
OrthoDBiEOG091G01TA.
PhylomeDBiQ9CZU3.
TreeFamiTF300597.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR025696. rRNA_proc-arch_dom.
IPR016438. Ski2.
IPR012961. Ski2_C.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08148. DSHCT. 1 hit.
PF00271. Helicase_C. 1 hit.
PF13234. rRNA_proc-arch. 1 hit.
[Graphical view]
PIRSFiPIRSF005198. Antiviral_helicase_SKI2. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM01142. DSHCT. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAFGDELF SVFEDDSTSA AGAKKDKEKE KWKGPPGSAD KAGKRLDTKL
60 70 80 90 100
QSESASGGKN KRDLDVEGTD EPIFGKKPRI EDSINEDLSL ADLMPRVKVQ
110 120 130 140 150
SVETVEGCTH EVALPADEDY IPLKPRVGKA AKEYPFILDA FQREAIQCVD
160 170 180 190 200
NNQSVLVSAH TSAGKTVCAE YAIALALREK QRVIFTSPIK ALSNQKYREM
210 220 230 240 250
YEEFQDVGLM TGDVTINPTA SCLVMTTEIL RSMLYRGSEV MREVAWVIFD
260 270 280 290 300
EIHYMRDSER GVVWEETIIL LPDNVHYVFL SATIPNARQF AEWICHLHKQ
310 320 330 340 350
PCHVIYTDYR PTPLQHYIFP AGGDGLHLVV DENGDFREDN FNTAMQVLRD
360 370 380 390 400
AGDLAKGDQK GRKGGTKGPS NVFKIVKMIM ERNFQPVIIF SFSKKDCEAY
410 420 430 440 450
ALQMTKLDFN TDEEKKMVEE VFNNAIDCLS DEDKKLPQVE HVLPLLKRGI
460 470 480 490 500
GIHHGGLLPI LKETIEILFS EGLIKALFAT ETFAMGINMP ARTVLFTNAR
510 520 530 540 550
KYDGKDFRWI SSGEYIQMSG RAGRRGMDDR GIVILMVDEK MSPTIGKQLL
560 570 580 590 600
KGSADPLNSA FHLTYNMVLN LLRVEEINPE YMLEKSFYQF QHYRAIPGVV
610 620 630 640 650
EKVKNSEEQY NKIVIPNEEN VVIYYKIRQQ LAKLGKEIEE YIHKPKYCLP
660 670 680 690 700
FLQPGRLVKV KNEGDDFGWG VVVNFSKKSN VKPNSGELDP LYVVEVLLRC
710 720 730 740 750
SKESLKNSAT EAAKPAKPDE KGEMQVVPVL VHLLSAISTV RLYIPKDLRP
760 770 780 790 800
VDNRQSVLKS IQEVQRRFPD GVPLLDPIDD MGIQDQGLKK VIQKVEAFEH
810 820 830 840 850
RMYSHPLHND PNLETVYTLC ERKAQIALDI KSAKRELKKA RTVLQMDELK
860 870 880 890 900
CRKRVLRRLG FATSSDVIEM KGRVACEISS ADELLLTEMM FNGLFNDLSS
910 920 930 940 950
EQATALLSCF VFQENSSEMP KLTEQLAGPL RQMQECAKRI AKVSAEAKLE
960 970 980 990 1000
IDEETYLSSF KPHLMDVVYT WATGATFAHI CKMTDVFEGS IIRCMRRLEE
1010 1020 1030 1040
LLRQMCQAAK AIGNTELENK FAEGITKIKR DIVFAASLYL
Length:1,040
Mass (Da):117,636
Last modified:June 1, 2001 - v1
Checksum:i76C1243DB5C27F65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012158 mRNA. Translation: BAB28066.1.
BC029230 mRNA. Translation: AAH29230.1.
CCDSiCCDS26778.1.
RefSeqiNP_082427.1. NM_028151.2.
UniGeneiMm.291029.

Genome annotation databases

EnsembliENSMUST00000022281; ENSMUSP00000022281; ENSMUSG00000016018.
GeneIDi72198.
KEGGimmu:72198.
UCSCiuc007rws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012158 mRNA. Translation: BAB28066.1.
BC029230 mRNA. Translation: AAH29230.1.
CCDSiCCDS26778.1.
RefSeqiNP_082427.1. NM_028151.2.
UniGeneiMm.291029.

3D structure databases

ProteinModelPortaliQ9CZU3.
SMRiQ9CZU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215213. 4 interactors.
IntActiQ9CZU3. 3 interactors.
MINTiMINT-4126258.
STRINGi10090.ENSMUSP00000022281.

PTM databases

iPTMnetiQ9CZU3.
PhosphoSitePlusiQ9CZU3.

Proteomic databases

EPDiQ9CZU3.
MaxQBiQ9CZU3.
PaxDbiQ9CZU3.
PeptideAtlasiQ9CZU3.
PRIDEiQ9CZU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022281; ENSMUSP00000022281; ENSMUSG00000016018.
GeneIDi72198.
KEGGimmu:72198.
UCSCiuc007rws.1. mouse.

Organism-specific databases

CTDi23517.
MGIiMGI:1919448. Skiv2l2.

Phylogenomic databases

eggNOGiKOG0948. Eukaryota.
COG4581. LUCA.
GeneTreeiENSGT00820000127042.
HOGENOMiHOG000163047.
HOVERGENiHBG104255.
InParanoidiQ9CZU3.
KOiK12598.
OMAiDKGKWKG.
OrthoDBiEOG091G01TA.
PhylomeDBiQ9CZU3.
TreeFamiTF300597.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiSkiv2l2. mouse.
PROiQ9CZU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016018.
GenevisibleiQ9CZU3. MM.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR025696. rRNA_proc-arch_dom.
IPR016438. Ski2.
IPR012961. Ski2_C.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF08148. DSHCT. 1 hit.
PF00271. Helicase_C. 1 hit.
PF13234. rRNA_proc-arch. 1 hit.
[Graphical view]
PIRSFiPIRSF005198. Antiviral_helicase_SKI2. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM01142. DSHCT. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSK2L2_MOUSE
AccessioniPrimary (citable) accession number: Q9CZU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.