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Protein

Ras-related protein Rab-3B

Gene

Rab3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379GTPBy similarity
Nucleotide bindingi48 – 547GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity
Nucleotide bindingi165 – 1673GTPBy similarity

GO - Molecular functioni

  • GDP binding Source: MGI
  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3B
Gene namesi
Name:Rab3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917158. Rab3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Ras-related protein Rab-3BPRO_0000121082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei188 – 1881PhosphoserineBy similarity
Modified residuei190 – 1901PhosphoserineBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity
Modified residuei219 – 2191Cysteine methyl esterBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9CZT8.
MaxQBiQ9CZT8.
PaxDbiQ9CZT8.
PRIDEiQ9CZT8.

PTM databases

iPTMnetiQ9CZT8.
PhosphoSiteiQ9CZT8.

Expressioni

Gene expression databases

BgeeiQ9CZT8.
CleanExiMM_RAB3B.
ExpressionAtlasiQ9CZT8. baseline and differential.
GenevisibleiQ9CZT8. MM.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.1 Publication

GO - Molecular functioni

  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

Protein-protein interaction databases

BioGridi213749. 8 interactions.
IntActiQ9CZT8. 9 interactions.
MINTiMINT-1341069.
STRINGi10090.ENSMUSP00000003502.

Structurei

3D structure databases

ProteinModelPortaliQ9CZT8.
SMRiQ9CZT8. Positions 18-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9CZT8.
KOiK06108.
OrthoDBiEOG7JQBPC.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTDGKTG IKDASDQNFD YMFKLLIIGN SSVGKTSFLF RYADDTFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHEKR VKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWATQI KTYSWDNAQV ILVGNKCDME EERVVPTEKG
160 170 180 190 200
RLLAEQLGFD FFEASAKENI SVRQAFERLV DAICDKMSDS MDTDPSVLGA
210
SKTTRLSDTP PLLQQNCSC
Length:219
Mass (Da):24,757
Last modified:June 1, 2001 - v1
Checksum:i494B3A0686D325C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312036 mRNA. Translation: AAG60046.1.
AF307514 Genomic DNA. Translation: AAL09395.1.
AK012165 mRNA. Translation: BAB28071.1.
AK082959 mRNA. Translation: BAC38710.1.
BC051918 mRNA. Translation: AAH51918.2.
BC057173 mRNA. Translation: AAH57173.1.
CCDSiCCDS18459.1.
RefSeqiNP_076026.1. NM_023537.5.
UniGeneiMm.41580.

Genome annotation databases

EnsembliENSMUST00000003502; ENSMUSP00000003502; ENSMUSG00000003411.
ENSMUST00000106650; ENSMUSP00000102261; ENSMUSG00000003411.
GeneIDi69908.
KEGGimmu:69908.
UCSCiuc008ubu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312036 mRNA. Translation: AAG60046.1.
AF307514 Genomic DNA. Translation: AAL09395.1.
AK012165 mRNA. Translation: BAB28071.1.
AK082959 mRNA. Translation: BAC38710.1.
BC051918 mRNA. Translation: AAH51918.2.
BC057173 mRNA. Translation: AAH57173.1.
CCDSiCCDS18459.1.
RefSeqiNP_076026.1. NM_023537.5.
UniGeneiMm.41580.

3D structure databases

ProteinModelPortaliQ9CZT8.
SMRiQ9CZT8. Positions 18-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213749. 8 interactions.
IntActiQ9CZT8. 9 interactions.
MINTiMINT-1341069.
STRINGi10090.ENSMUSP00000003502.

PTM databases

iPTMnetiQ9CZT8.
PhosphoSiteiQ9CZT8.

Proteomic databases

EPDiQ9CZT8.
MaxQBiQ9CZT8.
PaxDbiQ9CZT8.
PRIDEiQ9CZT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003502; ENSMUSP00000003502; ENSMUSG00000003411.
ENSMUST00000106650; ENSMUSP00000102261; ENSMUSG00000003411.
GeneIDi69908.
KEGGimmu:69908.
UCSCiuc008ubu.1. mouse.

Organism-specific databases

CTDi5865.
MGIiMGI:1917158. Rab3b.

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ9CZT8.
KOiK06108.
OrthoDBiEOG7JQBPC.
TreeFamiTF313199.

Miscellaneous databases

NextBioi330587.
PROiQ9CZT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZT8.
CleanExiMM_RAB3B.
ExpressionAtlasiQ9CZT8. baseline and differential.
GenevisibleiQ9CZT8. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Schluter O.M., Benseler F., Suedhof T.C.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvOla.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-35; 73-83; 122-136 AND 179-186, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2."
    Fukuda M.
    J. Biol. Chem. 278:15373-15380(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIMS1; RIMS2; RPH3A AND RPH3AL.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiRAB3B_MOUSE
AccessioniPrimary (citable) accession number: Q9CZT8
Secondary accession number(s): Q80WV9, Q920F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.